GREMLIN Database
DUF2080 - Putative transposon-encoded protein (DUF2080)
PFAM: PF09853 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 50 (48)
Sequences: 1628 (910)
Seq/√Len: 131.4
META: 0.98

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_E48_K3.0651.00
19_E41_K2.9181.00
23_T30_K2.7961.00
8_L12_D2.4691.00
31_V44_V2.1351.00
20_K32_D2.1271.00
21_K41_K1.8111.00
23_T32_D1.7581.00
25_F32_D1.7541.00
33_C44_V1.6951.00
7_K13_N1.6731.00
7_K11_V1.6501.00
42_V46_I1.5991.00
25_F28_G1.5121.00
22_V33_C1.4351.00
15_E40_K1.3061.00
37_Y40_K1.2091.00
29_A38_L1.2050.99
18_F44_V1.2040.99
17_F43_Y1.1670.99
31_V42_V1.0130.98
16_G37_Y0.9550.97
41_K47_L0.9410.97
18_F31_V0.9380.97
18_F37_Y0.9290.97
20_K28_G0.8990.96
2_K9_L0.8400.95
24_P38_L0.8240.94
9_L45_I0.8220.94
18_F32_D0.8200.94
8_L11_V0.8000.93
5_K11_V0.7870.92
20_K25_F0.7640.91
28_G33_C0.7590.91
4_K9_L0.7490.90
4_K7_K0.7480.90
16_G28_G0.7370.90
3_I18_F0.7270.89
5_K8_L0.7040.87
28_G47_L0.7010.87
26_G39_G0.6950.87
18_F33_C0.6870.86
46_I49_D0.6870.86
22_V29_A0.6800.86
16_G33_C0.6700.85
13_N17_F0.6630.84
30_K43_Y0.6610.84
12_D15_E0.6570.84
20_K30_K0.6370.82
35_K38_L0.6320.81
27_T38_L0.6220.80
19_E48_K0.6190.80
20_K31_V0.6190.80
18_F46_I0.6150.79
13_N48_K0.6090.79
13_N34_P0.6020.78
16_G22_V0.5970.77
4_K8_L0.5860.76
30_K33_C0.5730.75
21_K39_G0.5710.74
41_K48_K0.5680.74
18_F34_P0.5660.74
6_K37_Y0.5560.72
3_I6_K0.5520.72
29_A35_K0.5460.71
3_I37_Y0.5450.71
10_L17_F0.5270.68
22_V31_V0.5070.65
2_K5_K0.5070.65
5_K13_N0.5010.64
15_E36_E0.5000.64
22_V42_V0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mrnA 2 0.98 69.5 0.744 Contact Map
1mvfD 1 0.6 68.4 0.747 Contact Map
3zvkE 2 0.68 64.9 0.752 Contact Map
3tndB 3 0.66 10.9 0.837 Contact Map
4ujrS 1 1 9.4 0.841 Contact Map
3o27A 2 0.72 8.8 0.844 Contact Map
1vx79 1 0.96 8.2 0.846 Contact Map
2l66A 2 0.66 7.5 0.848 Contact Map
4wpmA 1 0.9 6.2 0.854 Contact Map
3j61f 1 1 5.4 0.858 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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