GREMLIN Database
DUF2073 - Uncharacterized protein conserved in archaea (DUF2073)
PFAM: PF09846 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 105 (100)
Sequences: 1536 (1018)
Seq/√Len: 101.8
META: 0.955

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_L76_L5.5331.00
36_R39_E4.7721.00
73_G76_L4.1081.00
72_L75_L3.0211.00
64_K70_K2.7411.00
96_D101_E2.5831.00
11_R15_D2.3171.00
36_R40_D2.2691.00
14_L41_T2.0601.00
26_E79_G2.0001.00
7_M40_D1.9561.00
18_K44_E1.9401.00
40_D44_E1.8481.00
64_K68_F1.8141.00
56_A95_K1.7991.00
8_E11_R1.7771.00
30_K77_D1.6901.00
90_V97_P1.6721.00
68_F74_K1.5431.00
5_S8_E1.5331.00
65_K69_G1.4261.00
40_D43_E1.4211.00
18_K80_G1.4171.00
51_K88_S1.4071.00
31_P56_A1.3761.00
25_L56_A1.3710.99
7_M39_E1.3710.99
11_R40_D1.3100.99
69_G74_K1.3080.99
36_R44_E1.2340.99
34_E57_V1.2000.99
65_K72_L1.1990.99
64_K67_F1.1690.98
63_K78_R1.1480.98
94_K97_P1.1470.98
6_S9_R1.1360.98
38_I87_A1.1340.98
69_G72_L1.1320.98
12_K16_I1.1290.98
43_E46_D1.1250.98
66_G83_I1.0780.97
22_I38_I1.0350.96
31_P35_A1.0270.96
22_I100_I1.0210.96
7_M15_D0.9580.95
54_E85_G0.9540.94
5_S15_D0.9510.94
43_E80_G0.9220.93
69_G73_G0.9210.93
70_K73_G0.9200.93
67_F72_L0.9050.93
66_G70_K0.9020.93
64_K74_K0.8990.92
8_E15_D0.8940.92
58_I91_K0.8940.92
22_I53_I0.8790.92
65_K74_K0.8740.91
64_K72_L0.8690.91
2_E30_K0.8580.91
23_V59_P0.8570.91
27_G91_K0.8560.90
28_R59_P0.8250.89
78_R96_D0.8220.89
68_F73_G0.8120.88
92_E99_K0.8110.88
33_E37_L0.8080.88
51_K89_I0.8040.88
22_I93_I0.7920.87
32_E36_R0.7880.86
83_I89_I0.7660.85
60_P63_K0.7640.85
38_I41_T0.7540.84
18_K43_E0.7510.84
68_F72_L0.7490.84
4_L12_K0.7470.83
3_G69_G0.7400.83
63_K71_L0.7310.82
35_A38_I0.7270.82
13_I84_I0.7210.81
20_N30_K0.7210.81
9_R95_K0.7110.80
57_V77_D0.7030.80
22_I54_E0.7010.79
13_I23_V0.6970.79
9_R33_E0.6970.79
36_R53_I0.6870.78
39_E81_L0.6760.77
16_I96_D0.6740.77
31_P57_V0.6710.76
13_I16_I0.6710.76
26_E80_G0.6680.76
66_G75_L0.6660.76
10_I20_N0.6630.75
64_K71_L0.6590.75
36_R49_K0.6450.73
16_I24_I0.6430.73
45_I51_K0.6420.73
34_E80_G0.6420.73
51_K90_V0.6400.73
12_K27_G0.6380.73
69_G75_L0.6380.73
10_I36_R0.6370.73
25_L84_I0.6350.72
62_K76_L0.6330.72
9_R26_E0.6270.71
55_L87_A0.6230.71
10_I69_G0.6200.70
7_M36_R0.6190.70
58_I81_L0.6140.70
11_R44_E0.6130.70
55_L69_G0.6120.70
66_G74_K0.6100.69
16_I27_G0.6090.69
59_P81_L0.6070.69
83_I90_V0.6030.68
17_V49_K0.6030.68
11_R39_E0.6010.68
61_D65_K0.5990.68
72_L77_D0.5980.68
15_D19_E0.5980.68
88_S96_D0.5820.66
38_I42_M0.5770.65
55_L58_I0.5740.65
12_K23_V0.5720.64
29_L33_E0.5710.64
41_T95_K0.5660.64
68_F71_L0.5640.63
23_V78_R0.5610.63
19_E46_D0.5550.62
40_D57_V0.5540.62
7_M11_R0.5520.62
86_P97_P0.5520.62
20_N42_M0.5430.60
63_K74_K0.5430.60
61_D64_K0.5320.59
25_L59_P0.5230.58
57_V60_P0.5230.58
27_G94_K0.5190.57
2_E81_L0.5190.57
6_S10_I0.5150.56
35_A42_M0.5130.56
16_I77_D0.5120.56
64_K73_G0.5100.56
8_E36_R0.5100.56
16_I19_E0.5100.56
42_M45_I0.5050.55
27_G97_P0.5020.55
13_I29_L0.5020.55
18_K47_P0.5010.54
66_G69_G0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r79A 5 0.6 7.5 0.931 Contact Map
1t7sA 3 0.781 7.2 0.931 Contact Map
3pshA 1 0.6952 6.7 0.932 Contact Map
1s99A 2 0.5333 6.5 0.932 Contact Map
4hn9A 1 0.6762 6.5 0.932 Contact Map
4mo9A 1 0.7619 6.4 0.933 Contact Map
4bjqA 2 0.4762 6.1 0.933 Contact Map
1i6zA 1 0.7714 5.7 0.934 Contact Map
4ljsA 1 0.5429 5.6 0.935 Contact Map
2l3uA 1 0.4857 4.9 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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