GREMLIN Database
DUF2069 - Predicted membrane protein (DUF2069)
PFAM: PF09842 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 104 (100)
Sequences: 5636 (3534)
Seq/√Len: 353.4
META: 0.876

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_A92_L3.6251.00
44_P48_R3.0771.00
5_S91_L2.6581.00
45_G53_T2.5261.00
13_C36_V2.4991.00
72_A83_L2.4871.00
61_V92_L2.2951.00
51_R103_R1.9261.00
67_E85_E1.8961.00
68_G86_V1.8281.00
80_L83_L1.7781.00
15_A20_L1.7491.00
66_A70_V1.7241.00
65_F69_V1.6681.00
72_A86_V1.6591.00
5_S95_A1.6151.00
51_R55_Q1.6141.00
65_F89_S1.5691.00
76_P79_R1.5621.00
51_R100_V1.5521.00
12_L84_L1.5501.00
38_P64_Y1.4631.00
94_A98_L1.4251.00
75_D78_S1.4151.00
71_R75_D1.3981.00
65_F86_V1.2711.00
40_L44_P1.2601.00
42_P57_A1.2561.00
55_Q59_L1.2471.00
6_L46_L1.2351.00
29_G32_L1.2231.00
18_L33_A1.2141.00
50_R53_T1.2041.00
59_L62_L1.1961.00
3_L46_L1.1711.00
3_L7_L1.1601.00
49_G99_Y1.1451.00
68_G89_S1.1441.00
80_L84_L1.1391.00
79_R83_L1.1041.00
66_A69_V1.1001.00
69_V86_V1.0811.00
71_R82_A1.0801.00
68_G85_E1.0661.00
17_E35_K1.0491.00
83_L87_A1.0411.00
92_L96_A1.0331.00
8_A88_L1.0091.00
14_L36_V1.0081.00
58_S96_A1.0081.00
30_S33_A1.0021.00
41_L44_P1.0001.00
93_F97_V0.9911.00
7_L11_A0.9781.00
46_L54_Y0.9761.00
74_S77_G0.9591.00
52_Y55_Q0.9561.00
14_L18_L0.9471.00
46_L92_L0.9351.00
52_Y56_W0.9291.00
82_A86_V0.9281.00
4_A8_A0.9271.00
83_L86_V0.9261.00
35_K67_E0.9181.00
54_Y99_Y0.9071.00
28_G32_L0.9051.00
42_P60_L0.9031.00
75_D79_R0.8921.00
81_L85_E0.8911.00
61_V89_S0.8761.00
3_L47_L0.8691.00
91_L95_A0.8641.00
39_L42_P0.8631.00
45_G50_R0.8541.00
5_S92_L0.8441.00
55_Q100_V0.8441.00
95_A98_L0.8391.00
68_G82_A0.8321.00
97_V102_L0.8291.00
42_P53_T0.8271.00
49_G54_Y0.8221.00
44_P50_R0.8221.00
90_L94_A0.8211.00
53_T56_W0.8181.00
98_L102_L0.8131.00
67_E71_R0.8091.00
84_L88_L0.8051.00
16_W22_P0.7991.00
70_V73_W0.7981.00
42_P52_Y0.7971.00
12_L81_L0.7861.00
24_R30_S0.7851.00
13_C16_W0.7751.00
58_S97_V0.7531.00
97_V100_V0.7521.00
60_L64_Y0.7501.00
59_L100_V0.7351.00
13_C17_E0.7260.99
24_R27_P0.7220.99
35_K71_R0.7210.99
20_L81_L0.7160.99
27_P30_S0.7110.99
6_L92_L0.7100.99
74_S79_R0.7000.99
23_L28_G0.6980.99
33_A37_L0.6870.99
62_L65_F0.6850.99
7_L43_L0.6850.99
10_I36_V0.6800.99
24_R28_G0.6790.99
69_V73_W0.6760.99
50_R54_Y0.6750.99
86_V89_S0.6660.99
17_E20_L0.6660.99
19_W22_P0.6660.99
46_L53_T0.6500.99
72_A82_A0.6490.99
16_W20_L0.6450.99
62_L97_V0.6410.99
28_G31_W0.6340.99
12_L20_L0.6340.99
98_L101_R0.6320.99
65_F73_W0.6220.98
33_A44_P0.6160.98
17_E67_E0.5920.98
12_L88_L0.5850.98
71_R74_S0.5830.98
58_S61_V0.5770.97
15_A19_W0.5750.97
6_L43_L0.5740.97
65_F90_L0.5730.97
61_V96_A0.5730.97
7_L47_L0.5640.97
61_V93_F0.5600.97
49_G103_R0.5520.97
21_A24_R0.5460.96
23_L30_S0.5450.96
93_F96_A0.5420.96
77_G80_L0.5360.96
70_V74_S0.5330.96
7_L10_I0.5300.96
37_L40_L0.5300.96
6_L13_C0.5280.96
10_I40_L0.5180.95
11_A14_L0.5150.95
85_E88_L0.5130.95
92_L99_Y0.5120.95
96_A102_L0.5030.94
10_I13_C0.5000.94
62_L66_A0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p02A 1 0.4615 2.1 0.92 Contact Map
4ryoA 1 0.7596 1.3 0.93 Contact Map
4qncA 2 0.7019 1.3 0.93 Contact Map
4i5sA 2 0.0769 1.2 0.931 Contact Map
3giaA 1 0.9231 1.2 0.931 Contact Map
2m20A 2 0.2885 1.1 0.933 Contact Map
2h8aA 3 0.2885 1.1 0.933 Contact Map
4il3A 1 0.2981 1 0.935 Contact Map
1m56C 2 0.375 1 0.936 Contact Map
4al0A 3 0.3173 0.9 0.936 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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