GREMLIN Database
DUF2065 - Uncharacterized protein conserved in bacteria (DUF2065)
PFAM: PF09838 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 56 (55)
Sequences: 12757 (7571)
Seq/√Len: 1020.9
META: 0.934

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_G35_D2.7641.00
28_A31_L2.3351.00
16_P23_W2.2241.00
28_A32_E2.2061.00
24_R35_D2.1371.00
25_R28_A2.0651.00
34_P37_Q2.0321.00
19_F22_A1.9261.00
29_R32_E1.8301.00
22_A25_R1.7501.00
4_A7_L1.7361.00
40_F44_V1.7291.00
25_R29_R1.6971.00
6_G52_L1.6601.00
36_G40_F1.4551.00
27_L31_L1.4401.00
9_L45_S1.3991.00
17_F46_M1.3541.00
23_W27_L1.2911.00
21_G25_R1.2551.00
6_G53_L1.2531.00
44_V48_A1.2231.00
5_L8_V1.1671.00
17_F43_L1.1621.00
8_V11_I1.0971.00
3_A53_L1.0691.00
41_I44_V1.0621.00
51_L55_L1.0171.00
22_A26_M0.9771.00
17_F50_L0.9561.00
20_P24_R0.9171.00
10_V50_L0.9151.00
29_R33_L0.9091.00
37_Q40_F0.8661.00
43_L47_L0.8451.00
21_G24_R0.8431.00
24_R38_L0.8351.00
2_L6_G0.8011.00
22_A29_R0.7841.00
41_I45_S0.7731.00
27_L30_L0.7721.00
47_L51_L0.7711.00
3_A6_G0.7631.00
14_L18_L0.7551.00
15_L26_M0.7331.00
33_L37_Q0.7311.00
10_V49_G0.7291.00
24_R28_A0.7251.00
4_A8_V0.7201.00
48_A52_L0.7111.00
24_R31_L0.7031.00
13_G46_M0.6931.00
26_M41_I0.6861.00
10_V46_M0.6841.00
30_L38_L0.6821.00
3_A7_L0.6561.00
44_V47_L0.6421.00
13_G42_G0.6391.00
40_F45_S0.6321.00
13_G17_F0.6311.00
9_L48_A0.6171.00
12_E38_L0.6081.00
23_W38_L0.6021.00
2_L52_L0.5991.00
10_V53_L0.5951.00
2_L5_L0.5871.00
38_L42_G0.5801.00
14_L46_M0.5751.00
44_V51_L0.5701.00
1_L4_A0.5701.00
30_L33_L0.5591.00
6_G50_L0.5581.00
23_W41_I0.5441.00
29_R37_Q0.5401.00
50_L54_W0.5341.00
16_P39_R0.5191.00
10_V17_F0.5101.00
1_L39_R0.5091.00
48_A51_L0.5051.00
36_G39_R0.5051.00
39_R46_M0.5021.00
7_L10_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rp9A 2 0.9821 6.4 0.82 Contact Map
4mrsA 2 1 4.2 0.834 Contact Map
2e84A 1 0 4.1 0.835 Contact Map
1z1nX 1 0 3.6 0.839 Contact Map
4pl0A 2 1 3.2 0.844 Contact Map
3zdqA 2 1 3.1 0.845 Contact Map
4q4hB 1 0.9821 2.8 0.848 Contact Map
1jb0B 1 0.9464 2.7 0.85 Contact Map
4q4hA 1 0.9643 2.6 0.851 Contact Map
4o6yA 2 0.9464 2.5 0.853 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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