GREMLIN Database
DUF2062 - Uncharacterized protein conserved in bacteria (DUF2062)
PFAM: PF09835 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 148 (142)
Sequences: 18962 (13963)
Seq/√Len: 1171.7
META: 0.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
84_L122_V3.1101.00
31_I47_L3.0761.00
29_V131_G3.0411.00
23_L53_L2.8771.00
25_V135_V2.8121.00
44_A58_A2.3161.00
80_L123_L2.3021.00
77_A123_L2.2431.00
75_Y79_R2.2091.00
79_R83_W2.1291.00
136_R140_R2.1061.00
25_V61_G1.9991.00
26_A128_A1.9261.00
66_N69_T1.9021.00
49_L55_L1.7741.00
34_T40_Q1.7361.00
129_L133_F1.7181.00
41_T63_W1.6921.00
30_F128_A1.6791.00
25_V131_G1.6731.00
19_R23_L1.6471.00
31_I43_L1.6341.00
77_A120_S1.6241.00
27_L53_L1.6151.00
36_L43_L1.6001.00
30_F124_A1.5581.00
79_R82_A1.5211.00
33_F127_L1.5071.00
41_T45_A1.4881.00
85_L118_L1.4641.00
41_T59_L1.4641.00
40_Q65_S1.4521.00
98_F101_S1.4421.00
99_E102_W1.4321.00
137_L141_R1.4071.00
48_A58_A1.3981.00
72_P75_Y1.3951.00
108_L111_D1.3721.00
26_A132_Y1.3581.00
45_A55_L1.3481.00
16_L20_S1.3291.00
29_V127_L1.3011.00
132_Y136_R1.2911.00
19_R132_Y1.2901.00
138_L142_Y1.2821.00
54_N57_A1.2691.00
140_R144_R1.2571.00
22_A136_R1.2441.00
137_L140_R1.2381.00
24_G53_L1.2381.00
139_W143_R1.2301.00
21_I57_A1.2141.00
96_A99_E1.1621.00
7_L10_R1.1401.00
110_G114_L1.1391.00
97_L100_L1.1371.00
97_L101_S1.1351.00
78_Y82_A1.1341.00
104_W107_E1.1251.00
27_L47_L1.1141.00
109_L113_G1.1131.00
33_F73_I1.1091.00
133_F137_L1.0971.00
6_Y9_L1.0851.00
65_S73_I1.0851.00
36_L40_Q1.0681.00
26_A129_L1.0671.00
135_V139_W1.0521.00
95_S98_F1.0461.00
141_R144_R1.0401.00
46_L50_L1.0271.00
74_Y116_L1.0231.00
19_R136_R1.0221.00
76_A80_L1.0201.00
116_L120_S0.9941.00
69_T72_P0.9941.00
5_R8_L0.9861.00
72_P76_A0.9831.00
5_R9_L0.9811.00
84_L118_L0.9761.00
85_L115_P0.9691.00
70_I74_Y0.9691.00
31_I34_T0.9681.00
32_G61_G0.9661.00
106_L110_G0.9611.00
82_A87_G0.9551.00
126_V129_L0.9521.00
130_L134_L0.9431.00
76_A123_L0.9371.00
57_A61_G0.9331.00
6_Y13_L0.9251.00
39_L42_L0.9171.00
103_E107_E0.9141.00
112_I115_P0.9121.00
59_L62_T0.9111.00
123_L127_L0.8931.00
24_G57_A0.8911.00
111_D114_L0.8911.00
6_Y10_R0.8881.00
65_S68_L0.8881.00
21_I139_W0.8851.00
65_S70_I0.8831.00
33_F77_A0.8801.00
22_A26_A0.8791.00
31_I36_L0.8781.00
60_L63_W0.8771.00
48_A55_L0.8711.00
22_A132_Y0.8671.00
82_A89_P0.8631.00
9_L13_L0.8601.00
131_G135_V0.8501.00
95_S99_E0.8501.00
22_A135_V0.8401.00
18_P139_W0.8351.00
83_W87_G0.8271.00
17_T20_S0.8261.00
20_S24_G0.8261.00
44_A48_A0.8221.00
64_I67_P0.8191.00
28_G58_A0.8131.00
105_L109_L0.8121.00
133_F136_R0.8041.00
27_L31_I0.8011.00
113_G117_L0.7781.00
15_H20_S0.7771.00
78_Y116_L0.7731.00
121_L125_L0.7561.00
82_A115_P0.7351.00
94_W98_F0.7341.00
114_L118_L0.7301.00
96_A100_L0.7251.00
56_P60_L0.7231.00
140_R143_R0.7221.00
107_E110_G0.7191.00
95_S101_S0.7191.00
104_W108_L0.7191.00
32_G64_I0.7191.00
71_P75_Y0.7171.00
93_S96_A0.7141.00
49_L52_R0.7131.00
33_F123_L0.7131.00
96_A101_S0.7111.00
141_R145_R0.7061.00
27_L51_L0.7031.00
56_P59_L0.7031.00
126_V130_L0.7011.00
98_F102_W0.6881.00
39_L43_L0.6881.00
73_I77_A0.6831.00
134_L138_L0.6811.00
87_G91_P0.6771.00
26_A30_F0.6751.00
9_L12_L0.6731.00
114_L117_L0.6731.00
19_R140_R0.6641.00
138_L141_R0.6571.00
107_E111_D0.6541.00
37_L70_I0.6511.00
134_L137_L0.6501.00
130_L133_F0.6491.00
93_S101_S0.6471.00
20_S23_L0.6451.00
103_E106_L0.6441.00
115_P118_L0.6331.00
18_P140_R0.6301.00
16_L21_I0.6241.00
68_L72_P0.6231.00
89_P92_F0.6111.00
123_L126_V0.6101.00
66_N70_I0.6061.00
12_L15_H0.5931.00
23_L128_A0.5921.00
71_P76_A0.5901.00
93_S99_E0.5881.00
80_L83_W0.5851.00
45_A49_L0.5821.00
42_L46_L0.5821.00
24_G58_A0.5811.00
44_A62_T0.5811.00
120_S123_L0.5791.00
124_A128_A0.5731.00
8_L12_L0.5721.00
47_L51_L0.5651.00
142_Y145_R0.5641.00
32_G65_S0.5631.00
94_W100_L0.5611.00
23_L132_Y0.5601.00
87_G90_L0.5541.00
36_L39_L0.5541.00
41_T62_T0.5531.00
34_T37_L0.5501.00
125_L129_L0.5501.00
34_T120_S0.5481.00
67_P70_I0.5421.00
19_R22_A0.5421.00
122_V125_L0.5401.00
139_W142_Y0.5361.00
34_T43_L0.5351.00
118_L122_V0.5281.00
86_G89_P0.5271.00
38_G41_T0.5251.00
7_L12_L0.5251.00
63_W66_N0.5171.00
136_R144_R0.5161.00
117_L121_L0.5161.00
26_A29_V0.5151.00
67_P71_P0.5121.00
11_L14_W0.5111.00
94_W102_W0.5041.00
18_P22_A0.5041.00
97_L102_W0.5021.00
47_L50_L0.5021.00
31_I44_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2m20A 2 0.2432 32.6 0.889 Contact Map
2l2tA 2 0.2905 31.8 0.89 Contact Map
2ks1B 1 0.2973 19.3 0.901 Contact Map
2kluA 1 0.2703 12.5 0.909 Contact Map
2jwaA 2 0.2973 12 0.91 Contact Map
2kncB 1 0.2973 10.1 0.912 Contact Map
2rddB 1 0.1959 8.7 0.915 Contact Map
1pi7A 1 0.1284 8.4 0.916 Contact Map
2gsmB 1 0.4054 7.6 0.917 Contact Map
2oarA 7 0.6892 6.3 0.92 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0062 seconds.