GREMLIN Database
DUF2061 - Predicted membrane protein (DUF2061)
PFAM: PF09834 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 52 (52)
Sequences: 14354 (8092)
Seq/√Len: 1122.1
META: 0.951

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_F33_G3.1541.00
6_S47_H3.0561.00
19_S32_I2.7881.00
4_T41_T2.1241.00
27_K31_S1.9531.00
30_L33_G1.9331.00
36_E40_K1.8511.00
14_D43_L1.6771.00
20_Y29_A1.6441.00
14_D39_T1.5951.00
17_L21_L1.5471.00
20_Y26_L1.5001.00
12_T37_V1.4791.00
46_L50_A1.3771.00
34_L37_V1.3421.00
11_G40_K1.3351.00
44_Y47_H1.3261.00
27_K30_L1.3111.00
28_L31_S1.2571.00
7_W11_G1.2031.00
34_L38_V1.1601.00
8_R12_T1.1081.00
25_S28_L1.1061.00
38_V42_V1.0921.00
28_L36_E1.0361.00
22_I28_L0.9921.00
5_I9_I0.9541.00
7_W44_Y0.9061.00
12_T33_G0.8871.00
15_T36_E0.8821.00
23_T32_I0.8791.00
11_G14_D0.8731.00
42_V46_L0.8711.00
9_I13_L0.8621.00
8_R41_T0.8491.00
12_T16_F0.8471.00
23_T29_A0.8381.00
15_T40_K0.8231.00
4_T44_Y0.8151.00
16_F29_A0.8131.00
39_T43_L0.8101.00
11_G36_E0.8101.00
45_Y49_R0.7971.00
23_T28_L0.7571.00
3_K48_E0.7401.00
7_W47_H0.7201.00
20_Y23_T0.7111.00
2_A5_I0.6991.00
13_L17_L0.6921.00
16_F30_L0.6891.00
10_I43_L0.6881.00
20_Y24_G0.6861.00
6_S10_I0.6721.00
14_D21_L0.6711.00
15_T32_I0.6521.00
31_S34_L0.6461.00
30_L34_L0.6441.00
7_W37_V0.6391.00
7_W41_T0.6321.00
47_H51_W0.6261.00
46_L49_R0.6211.00
18_I35_I0.6171.00
29_A33_G0.6041.00
49_R52_N0.5931.00
25_S31_S0.5851.00
4_T52_N0.5771.00
22_I35_I0.5681.00
10_I13_L0.5681.00
21_L24_G0.5641.00
14_D17_L0.5631.00
25_S29_A0.5451.00
31_S35_I0.5271.00
15_T19_S0.5221.00
5_I8_R0.5101.00
19_S23_T0.5091.00
2_A49_R0.5051.00
44_Y48_E0.5001.00
41_T45_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ciiA 1 0.9808 3.9 0.841 Contact Map
5a63B 1 1 2.3 0.859 Contact Map
2qtsA 4 0.8269 1.9 0.864 Contact Map
4kf7A 1 0.4423 1.7 0.867 Contact Map
4wd8A 3 0.9423 1.6 0.87 Contact Map
4rdqA 5 0.9808 1.5 0.873 Contact Map
2k1oA 2 0.3462 1.3 0.877 Contact Map
2i88A 1 0.9231 1.3 0.878 Contact Map
1colA 1 0.9808 0.9 0.888 Contact Map
3fewX 1 0.9808 0.9 0.888 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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