GREMLIN Database
DUF2057 - Uncharacterized protein conserved in bacteria (DUF2057)
PFAM: PF09829 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 193 (192)
Sequences: 1096 (853)
Seq/√Len: 61.5
META: 0.339

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_N36_H8.8361.00
183_D186_T6.5831.00
174_M177_Y3.3151.00
174_M178_W3.1871.00
176_K193_W2.8681.00
42_Y179_Y2.8611.00
101_D105_Q2.8351.00
91_F95_P2.8241.00
123_R128_E2.6431.00
178_W182_A2.5511.00
120_Q123_R2.2321.00
4_L10_L2.2281.00
175_L190_F2.0521.00
125_Y128_E2.0491.00
37_Q133_N2.0431.00
143_V147_A2.0421.00
112_D132_Y2.0411.00
58_V92_A2.0111.00
39_V62_P1.9541.00
179_Y191_L1.8921.00
144_A148_A1.8721.00
35_E66_T1.8431.00
120_Q128_E1.7901.00
32_D36_H1.6950.99
145_A149_A1.6730.99
153_A156_A1.6670.99
142_A145_A1.6030.99
178_W181_Q1.5990.99
185_E189_R1.5780.99
33_P36_H1.5770.99
187_R193_W1.5160.98
172_E189_R1.5090.98
39_V129_L1.4800.98
174_M182_A1.4740.98
188_K192_Q1.4710.98
175_L182_A1.4320.98
46_F88_A1.4250.98
13_V29_L1.4220.98
61_D113_V1.4090.97
132_Y136_G1.4010.97
39_V114_L1.3780.97
124_D128_E1.3690.97
169_N172_E1.3400.96
33_P71_D1.3190.96
151_A154_A1.3130.96
31_L36_H1.3000.96
40_V65_V1.2990.96
79_L82_I1.2770.95
116_K120_Q1.2760.95
35_E68_D1.2620.95
172_E183_D1.2610.95
64_V132_Y1.2550.95
141_A146_A1.2330.94
140_A145_A1.2120.94
177_Y182_A1.2100.94
143_V146_A1.2050.94
130_A134_R1.2030.94
75_L97_W1.1850.93
118_G123_R1.1760.93
33_P72_G1.1690.93
12_A79_L1.1560.92
176_K180_L1.1450.92
144_A149_A1.1400.92
15_G126_E1.1310.91
60_S95_P1.1310.91
7_E44_K1.1270.91
152_A155_A1.1260.91
122_G125_Y1.1200.91
141_A148_A1.1160.91
37_Q124_D1.1050.90
45_L179_Y1.1010.90
154_A161_A1.0910.90
185_E188_K1.0900.90
63_I95_P1.0900.90
37_Q118_G1.0890.90
127_K130_A1.0860.89
149_A153_A1.0810.89
41_R60_S1.0770.89
42_Y58_V1.0680.89
143_V148_A1.0650.89
156_A164_T1.0540.88
142_A146_A1.0540.88
97_W179_Y1.0540.88
151_A160_A1.0520.88
112_D139_A1.0510.88
162_A165_A1.0510.88
171_A174_M1.0510.88
147_A152_A1.0500.88
41_R95_P1.0350.87
176_K189_R1.0340.87
141_A144_A1.0320.87
37_Q64_V1.0260.87
167_S172_E1.0260.87
181_Q187_R1.0150.86
163_A169_N0.9990.85
150_A155_A0.9920.85
171_A178_W0.9840.84
184_P187_R0.9830.84
140_A144_A0.9820.84
64_V129_L0.9760.84
140_A143_V0.9740.84
148_A154_A0.9710.83
174_M181_Q0.9620.83
148_A152_A0.9600.83
70_S73_Q0.9550.82
100_V106_P0.9530.82
64_V112_D0.9460.82
14_N32_D0.9440.82
67_F107_I0.9420.82
169_N173_Q0.9390.81
11_L62_P0.9280.81
177_Y180_L0.9280.81
172_E176_K0.9270.81
37_Q179_Y0.9250.80
147_A150_A0.9250.80
145_A150_A0.9240.80
40_V77_L0.9210.80
121_L125_Y0.9120.79
114_L133_N0.9100.79
46_F179_Y0.9020.79
135_S139_A0.9020.79
121_L128_E0.8730.76
66_T110_K0.8710.76
92_A95_P0.8710.76
37_Q114_L0.8580.75
45_L57_L0.8570.75
124_D127_K0.8550.75
41_R59_K0.8540.75
151_A156_A0.8520.75
10_L29_L0.8520.75
168_Q171_A0.8490.74
82_I88_A0.8450.74
11_L41_R0.8430.74
16_Q26_A0.8430.74
1_T10_L0.8400.74
182_A191_L0.8390.73
150_A154_A0.8360.73
69_A139_A0.8250.72
153_A163_A0.8220.72
82_I91_F0.8140.71
155_A159_A0.8130.71
3_T74_T0.8090.71
42_Y46_F0.8070.71
78_S100_V0.8060.70
12_A129_L0.8010.70
142_A150_A0.7970.70
66_T77_L0.7940.69
47_R50_S0.7930.69
75_L92_A0.7880.69
2_L109_V0.7880.69
79_L132_Y0.7820.68
142_A147_A0.7790.68
136_G139_A0.7780.68
157_A162_A0.7760.68
132_Y137_G0.7750.67
107_I110_K0.7740.67
120_Q125_Y0.7740.67
46_F84_N0.7720.67
158_V165_A0.7700.67
177_Y189_R0.7680.67
14_N183_D0.7660.67
42_Y47_R0.7570.66
161_A165_A0.7520.65
186_T189_R0.7500.65
9_E41_R0.7420.64
76_T86_R0.7410.64
105_Q110_K0.7400.64
46_F79_L0.7380.64
33_P67_F0.7360.63
149_A155_A0.7270.62
8_I79_L0.7230.62
161_A164_T0.7210.62
180_L193_W0.7200.62
78_S103_N0.7180.61
154_A157_A0.7120.61
154_A166_Q0.7080.60
176_K192_Q0.7050.60
20_G27_K0.7010.60
18_V77_L0.6990.59
84_N87_E0.6970.59
75_L179_Y0.6950.59
143_V161_A0.6930.59
39_V64_V0.6910.59
124_D179_Y0.6850.58
13_V54_E0.6810.57
115_P181_Q0.6790.57
188_K191_L0.6760.57
177_Y181_Q0.6740.57
12_A57_L0.6700.56
188_K193_W0.6670.56
5_P122_G0.6670.56
176_K190_F0.6660.56
2_L31_L0.6600.55
65_V99_L0.6590.55
143_V149_A0.6570.55
12_A58_V0.6570.55
118_G121_L0.6560.55
40_V79_L0.6560.55
65_V73_Q0.6530.54
82_I95_P0.6520.54
151_A158_V0.6510.54
40_V129_L0.6500.54
89_K104_G0.6480.54
4_L23_F0.6460.54
38_I156_A0.6450.53
70_S105_Q0.6450.53
67_F139_A0.6430.53
171_A177_Y0.6430.53
154_A158_V0.6390.53
79_L91_F0.6390.53
171_A189_R0.6370.52
85_E89_K0.6360.52
122_G128_E0.6340.52
45_L55_H0.6320.52
104_G136_G0.6270.51
146_A149_A0.6210.51
156_A160_A0.6210.51
145_A148_A0.6200.51
5_P42_Y0.6180.50
154_A167_S0.6170.50
152_A159_A0.6170.50
144_A147_A0.6130.50
152_A160_A0.6120.50
182_A188_K0.6050.49
108_A153_A0.6030.49
140_A148_A0.6020.49
145_A152_A0.6010.48
133_N139_A0.5940.48
6_E42_Y0.5920.47
147_A151_A0.5900.47
156_A166_Q0.5860.47
126_E129_L0.5860.47
132_Y179_Y0.5850.47
62_P66_T0.5820.46
157_A161_A0.5800.46
165_A171_A0.5780.46
55_H64_V0.5770.46
67_F112_D0.5730.45
8_I186_T0.5720.45
58_V61_D0.5720.45
9_E38_I0.5720.45
93_K151_A0.5710.45
99_L107_I0.5700.45
161_A170_T0.5680.45
131_E134_R0.5640.44
47_R51_D0.5640.44
11_L60_S0.5580.44
164_T168_Q0.5580.44
90_K93_K0.5570.43
60_S66_T0.5510.43
174_M193_W0.5510.43
87_E180_L0.5480.42
26_A103_N0.5480.42
16_Q90_K0.5470.42
178_W186_T0.5470.42
54_E85_E0.5460.42
2_L10_L0.5460.42
8_I21_S0.5430.42
27_K64_V0.5420.42
88_A129_L0.5420.42
67_F80_P0.5410.42
67_F99_L0.5400.42
114_L118_G0.5400.42
9_E16_Q0.5360.41
163_A168_Q0.5340.41
167_S171_A0.5340.41
36_H44_K0.5310.41
147_A153_A0.5300.40
31_L34_G0.5280.40
140_A146_A0.5270.40
71_D106_P0.5260.40
171_A181_Q0.5250.40
43_E57_L0.5230.40
170_T173_Q0.5190.39
156_A161_A0.5180.39
66_T88_A0.5170.39
11_L39_V0.5160.39
183_D189_R0.5160.39
17_K25_G0.5160.39
12_A192_Q0.5130.39
156_A159_A0.5120.38
49_G62_P0.5090.38
8_I67_F0.5060.38
7_E121_L0.5060.38
190_F193_W0.5040.38
69_A73_Q0.5040.38
95_P111_Q0.5020.37
111_Q121_L0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jttC 1 0.1347 13.9 0.94 Contact Map
3kd4A 3 0.3938 13.7 0.94 Contact Map
2k6wA 1 0.3782 13.4 0.941 Contact Map
1x9lA 1 0.399 11.4 0.943 Contact Map
2c34A 1 0.3264 10.8 0.943 Contact Map
2q1fA 1 0.5078 9.8 0.944 Contact Map
1tg7A 1 0.4352 7.5 0.947 Contact Map
2bgoA 1 0.2953 7.4 0.947 Contact Map
2xwxA 2 0.3161 7.3 0.947 Contact Map
2yn5A 3 0.3161 6.2 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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