GREMLIN Database
Chrome_Resist - Chromate resistance exported protein
PFAM: PF09828 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 132 (130)
Sequences: 17830 (7787)
Seq/√Len: 682.9
META: 0.966

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_R66_K4.1091.00
51_E67_R3.3281.00
55_H67_R2.9031.00
120_R123_P2.8061.00
65_L75_L2.6071.00
70_L75_L2.3351.00
84_G97_A2.2091.00
80_E94_A2.1481.00
5_E32_P2.1041.00
52_F68_F1.9571.00
103_I124_V1.9521.00
36_E40_V1.9451.00
116_E119_E1.9281.00
113_D116_E1.8991.00
111_F120_R1.8771.00
77_R80_E1.8611.00
77_R94_A1.8381.00
120_R127_A1.8341.00
71_D76_A1.8321.00
62_E83_H1.8121.00
58_R63_T1.7881.00
14_C64_L1.7871.00
29_L42_A1.7251.00
44_P51_E1.6991.00
28_F45_F1.6741.00
116_E120_R1.6451.00
84_G93_L1.6431.00
14_C60_T1.6251.00
101_L105_L1.5561.00
94_A97_A1.5431.00
55_H66_K1.5341.00
118_L122_M1.4901.00
107_L121_G1.4851.00
12_I121_G1.4521.00
111_F116_E1.4481.00
36_E39_A1.4311.00
110_L130_A1.3931.00
62_E79_A1.3631.00
43_I51_E1.3551.00
52_F64_L1.3391.00
72_D129_Y1.3211.00
85_A101_L1.3211.00
17_L61_F1.2961.00
19_R122_M1.2741.00
102_A131_W1.2611.00
91_K101_L1.2581.00
46_D54_H1.2471.00
7_P12_I1.2461.00
29_L40_V1.2151.00
107_L117_L1.2151.00
22_I64_L1.1991.00
110_L120_R1.1951.00
55_H58_R1.1881.00
76_A80_E1.1771.00
108_S117_L1.1761.00
115_H119_E1.1651.00
38_P50_A1.1461.00
2_V40_V1.1421.00
44_P50_A1.1251.00
105_L108_S1.0961.00
92_D98_A1.0891.00
52_F67_R1.0511.00
99_G106_G1.0271.00
20_R126_D1.0221.00
65_L79_A1.0201.00
103_I128_L0.9951.00
15_P118_L0.9911.00
34_P37_V0.9851.00
17_L70_L0.9751.00
126_D130_A0.9641.00
117_L121_G0.9641.00
2_V31_V0.9641.00
104_S107_L0.9591.00
104_S125_Y0.9381.00
90_R93_L0.9271.00
47_M50_A0.9271.00
100_L125_Y0.9251.00
19_R26_A0.9141.00
89_D92_D0.8881.00
98_A101_L0.8821.00
62_E87_T0.8801.00
84_G94_A0.8771.00
88_K91_K0.8651.00
22_I68_F0.8621.00
84_G92_D0.8621.00
37_V40_V0.8611.00
81_I100_L0.8581.00
65_L76_A0.8571.00
35_D38_P0.8501.00
61_F79_A0.8441.00
60_T64_L0.8371.00
83_H90_R0.8271.00
119_E123_P0.8161.00
44_P47_M0.8121.00
7_P117_L0.8061.00
64_L68_F0.8031.00
52_F60_T0.8001.00
51_E55_H0.7981.00
55_H63_T0.7961.00
30_F118_L0.7901.00
111_F117_L0.7811.00
103_I106_G0.7741.00
104_S121_G0.7731.00
63_T67_R0.7721.00
96_E99_G0.7661.00
46_D59_C0.7651.00
60_T63_T0.7521.00
54_H86_D0.7511.00
8_K105_L0.7451.00
63_T66_K0.7411.00
21_F129_Y0.7341.00
2_V42_A0.7291.00
29_L36_E0.7221.00
15_P28_F0.7151.00
47_M53_T0.7101.00
109_R130_A0.6951.00
95_P98_A0.6951.00
32_P36_E0.6941.00
38_P47_M0.6931.00
37_V47_M0.6911.00
44_P53_T0.6821.00
111_F123_P0.6821.00
83_H87_T0.6751.00
19_R24_P0.6741.00
98_A102_A0.6721.00
7_P118_L0.6701.00
107_L111_F0.6701.00
10_D54_H0.6641.00
80_E92_D0.6621.00
8_K108_S0.6591.00
66_K76_A0.6511.00
91_K98_A0.6491.00
32_P35_D0.6481.00
54_H59_C0.6421.00
53_T63_T0.6371.00
78_L81_I0.6291.00
123_P127_A0.6211.00
57_D90_R0.6211.00
7_P15_P0.6201.00
59_C87_T0.6191.00
81_I97_A0.6191.00
65_L70_L0.6161.00
107_L127_A0.6141.00
102_A105_L0.6141.00
19_R119_E0.6131.00
6_R117_L0.6121.00
122_M126_D0.6051.00
107_L110_L0.6011.00
11_R86_D0.6011.00
112_A117_L0.6001.00
110_L123_P0.5971.00
12_I15_P0.5941.00
34_P38_P0.5941.00
5_E8_K0.5931.00
112_A116_E0.5921.00
78_L82_V0.5911.00
38_P49_G0.5911.00
83_H92_D0.5791.00
100_L128_L0.5751.00
103_I127_A0.5671.00
100_L104_S0.5671.00
37_V42_A0.5651.00
107_L124_V0.5621.00
12_I125_Y0.5621.00
31_V37_V0.5551.00
18_I22_I0.5541.00
80_E93_L0.5531.00
119_E122_M0.5531.00
8_K104_S0.5521.00
13_A125_Y0.5491.00
7_P122_M0.5491.00
96_E102_A0.5481.00
121_G124_V0.5451.00
110_L127_A0.5411.00
96_E131_W0.5371.00
8_K101_L0.5351.00
57_D91_K0.5321.00
5_E34_P0.5301.00
124_V127_A0.5291.00
5_E31_V0.5281.00
109_R131_W0.5271.00
43_I52_F0.5271.00
108_S131_W0.5251.00
10_D14_C0.5231.00
106_G127_A0.5190.99
105_L109_R0.5190.99
43_I68_F0.5180.99
72_D76_A0.5130.99
4_R11_R0.5120.99
104_S108_S0.5100.99
11_R54_H0.5070.99
13_A82_V0.5070.99
46_D86_D0.5030.99
49_G53_T0.5020.99
37_V44_P0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2eb0A 2 0.8409 18.2 0.928 Contact Map
4rpaA 3 0.9167 18.1 0.928 Contact Map
1k20A 2 0.8712 16.6 0.929 Contact Map
2oviA 2 0.5 16.3 0.93 Contact Map
2hawA 2 0.9167 15.8 0.93 Contact Map
4gxbB 1 0.1136 13.2 0.933 Contact Map
2qb7A 1 0.8636 13.1 0.933 Contact Map
3fm2A 2 0.5606 10.9 0.935 Contact Map
2xijA 2 0.9621 9.3 0.937 Contact Map
4r3uA 2 0.9621 6.5 0.941 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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