GREMLIN Database
DUF2357 - Domain of unknown function (DUF2357)
PFAM: PF09823 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 251 (246)
Sequences: 1796 (1509)
Seq/√Len: 96.2
META: 0.811

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_D40_E5.1151.00
162_D167_R4.0631.00
86_R205_E4.0211.00
236_L240_R3.8011.00
104_H163_T3.7221.00
167_R226_G3.6751.00
165_E235_S3.3351.00
93_E212_R3.3211.00
6_F13_L3.1861.00
30_E38_Y2.9981.00
104_H237_V2.7891.00
174_E227_R2.7681.00
184_K210_E2.7231.00
184_K207_E2.6941.00
162_D226_G2.6401.00
180_L206_L2.4181.00
243_G246_E2.3991.00
177_L214_E2.3641.00
96_L216_L2.3631.00
222_F225_V2.2981.00
110_E158_E2.2941.00
13_L29_L2.2541.00
58_F68_F2.2401.00
100_L219_H2.2121.00
221_F225_V2.1821.00
112_E156_R2.0441.00
228_L231_L2.0051.00
99_I247_V1.9301.00
228_L232_P1.8901.00
168_F172_A1.8811.00
111_E153_L1.8611.00
174_E217_L1.8261.00
173_L213_L1.7971.00
96_L100_L1.7451.00
47_E51_E1.7381.00
181_E210_E1.6551.00
114_V118_R1.6541.00
77_T80_E1.6281.00
123_D126_T1.6061.00
167_R229_T1.5991.00
16_E23_K1.5951.00
164_P235_S1.5881.00
14_E28_T1.5541.00
123_D155_E1.5521.00
170_K174_E1.5271.00
122_V126_T1.5171.00
110_E156_R1.4941.00
19_Y22_K1.4701.00
31_V35_K1.4631.00
104_H166_N1.4511.00
73_T185_E1.4311.00
233_L248_Y1.4130.99
53_C57_L1.3960.99
114_V154_V1.3740.99
99_I103_P1.3740.99
30_E39_R1.3700.99
115_P118_R1.3680.99
113_Y151_R1.3520.99
42_Y46_L1.3510.99
79_Y83_A1.3410.99
6_F31_V1.3390.99
100_L221_F1.3340.99
98_R102_N1.3260.99
78_L82_F1.3260.99
100_L222_F1.3120.99
93_E216_L1.3030.99
105_R161_V1.2930.99
236_L239_Q1.2920.99
12_T28_T1.2850.99
49_I53_C1.2780.99
44_A47_E1.2630.99
44_A48_D1.2610.99
111_E123_D1.2540.99
43_R47_E1.2470.99
135_N150_E1.2430.99
119_V152_I1.2420.99
233_L236_L1.2340.99
5_N13_L1.2270.99
91_E249_R1.2260.99
174_E177_L1.2130.98
14_E26_E1.2060.98
170_K225_V1.2040.98
238_L243_G1.1950.98
136_R139_L1.1950.98
105_R159_E1.1930.98
248_Y251_W1.1920.98
45_M49_I1.1890.98
242_P246_E1.1880.98
166_N237_V1.1870.98
177_L210_E1.1850.98
113_Y183_L1.1750.98
81_W179_R1.1560.98
79_Y107_L1.1470.98
116_I152_I1.1410.98
30_E41_D1.1330.98
219_H222_F1.1180.97
50_T54_T1.1140.97
31_V235_S1.1140.97
172_A176_F1.1130.97
104_H241_R1.1080.97
55_D80_E1.0990.97
92_L172_A1.0940.97
114_V119_V1.0860.97
42_Y66_Q1.0820.97
184_K188_E1.0740.97
13_L64_T1.0700.97
163_T167_R1.0640.96
214_E217_L1.0640.96
33_S41_D1.0610.96
56_L60_F1.0410.96
80_E84_F1.0390.96
9_Y63_P1.0230.96
49_I92_L1.0190.95
114_V156_R1.0190.95
129_Q153_L1.0070.95
14_E65_Y1.0050.95
46_L54_T1.0050.95
247_V250_A0.9990.95
18_R21_G0.9990.95
187_L206_L0.9910.95
41_D165_E0.9860.95
218_S223_R0.9780.94
168_F171_H0.9690.94
207_E211_R0.9650.94
113_Y153_L0.9620.94
184_K206_L0.9620.94
81_W84_F0.9610.94
90_D94_E0.9590.94
31_V53_C0.9580.94
186_R191_K0.9570.94
183_L187_L0.9440.93
234_N242_P0.9410.93
200_P204_K0.9350.93
79_Y82_F0.9350.93
138_V143_G0.9350.93
177_L181_E0.9330.93
230_G234_N0.9280.93
140_L146_G0.9210.92
47_E50_T0.9200.92
111_E155_E0.9150.92
78_L182_D0.9140.92
134_P139_L0.9070.92
137_L140_L0.9050.92
48_D51_E0.9020.91
34_T41_D0.8970.91
164_P168_F0.8910.91
168_F231_L0.8890.91
207_E210_E0.8880.91
97_E101_R0.8810.90
140_L148_L0.8760.90
242_P245_R0.8760.90
16_E24_L0.8730.90
10_V130_L0.8710.90
2_G15_L0.8710.90
53_C159_E0.8650.90
16_E26_E0.8630.90
101_R185_E0.8600.89
29_L82_F0.8550.89
46_L79_Y0.8550.89
54_T80_E0.8450.89
172_A247_V0.8410.88
181_E214_E0.8400.88
38_Y41_D0.8370.88
170_K217_L0.8350.88
2_G95_A0.8280.88
168_F243_G0.8250.87
142_R191_K0.8250.87
182_D214_E0.8220.87
35_K42_Y0.8210.87
210_E214_E0.8190.87
120_K223_R0.8180.87
49_I56_L0.8120.87
170_K173_L0.8050.86
96_L169_V0.8030.86
74_D213_L0.7980.86
20_D24_L0.7960.85
62_S241_R0.7920.85
187_L190_K0.7800.84
106_R163_T0.7750.84
170_K221_F0.7750.84
180_L213_L0.7740.84
135_N139_L0.7730.84
99_I159_E0.7730.84
228_L251_W0.7710.84
10_V32_F0.7680.83
129_Q133_H0.7640.83
216_L219_H0.7600.83
177_L213_L0.7590.83
69_E207_E0.7580.83
10_V13_L0.7580.83
234_N239_Q0.7520.82
203_L208_E0.7510.82
82_F85_L0.7510.82
29_L127_L0.7500.82
136_R140_L0.7420.81
12_T30_E0.7410.81
102_N213_L0.7390.81
13_L33_S0.7330.80
32_F39_R0.7270.80
137_L141_P0.7240.80
72_E182_D0.7230.79
187_L202_L0.7220.79
13_L31_V0.7210.79
178_R211_R0.7190.79
116_I168_F0.7170.79
18_R26_E0.7170.79
103_P221_F0.7120.78
189_K203_L0.7070.78
59_D64_T0.7050.78
212_R216_L0.7050.78
159_E206_L0.7040.78
38_Y80_E0.7010.77
17_I25_G0.6990.77
176_F206_L0.6970.77
33_S42_Y0.6970.77
150_E204_K0.6950.77
181_E207_E0.6940.77
98_R101_R0.6940.77
13_L41_D0.6920.76
50_T55_D0.6910.76
59_D62_S0.6900.76
183_L186_R0.6890.76
40_E76_P0.6870.76
234_N241_R0.6860.76
74_D183_L0.6850.76
20_D23_K0.6850.76
106_R160_T0.6810.75
109_E155_E0.6810.75
189_K193_S0.6790.75
45_M236_L0.6790.75
42_Y149_P0.6780.75
89_S212_R0.6730.74
119_V126_T0.6730.74
17_I189_K0.6730.74
70_P112_E0.6700.74
237_V247_V0.6690.74
38_Y42_Y0.6690.74
166_N169_V0.6690.74
204_K208_E0.6680.74
16_E224_E0.6660.74
56_L239_Q0.6650.74
214_E218_S0.6650.74
189_K207_E0.6630.73
235_S238_L0.6620.73
183_L206_L0.6590.73
201_R205_E0.6580.73
57_L65_Y0.6580.73
19_Y24_L0.6570.73
113_Y133_H0.6560.73
76_P171_H0.6540.72
134_P137_L0.6530.72
30_E77_T0.6530.72
126_T152_I0.6510.72
129_Q187_L0.6500.72
231_L238_L0.6490.72
57_L80_E0.6440.71
239_Q248_Y0.6440.71
163_T168_F0.6410.71
4_I18_R0.6400.71
80_E83_A0.6380.70
109_E156_R0.6380.70
32_F119_V0.6370.70
40_E44_A0.6360.70
224_E227_R0.6360.70
185_E194_A0.6350.70
57_L68_F0.6330.70
12_T29_L0.6310.70
75_P220_P0.6280.69
40_E43_R0.6250.69
87_S222_F0.6240.69
11_G15_L0.6230.69
169_V247_V0.6220.69
236_L251_W0.6210.68
234_N238_L0.6170.68
222_F228_L0.6130.67
149_P228_L0.6120.67
137_L147_S0.6080.67
50_T58_F0.6020.66
222_F226_G0.6010.66
53_C117_D0.6000.66
38_Y205_E0.5960.65
13_L38_Y0.5960.65
45_M176_F0.5930.65
95_A169_V0.5920.65
9_Y79_Y0.5910.65
18_R24_L0.5890.64
27_L169_V0.5860.64
95_A243_G0.5850.64
232_P245_R0.5840.64
6_F12_T0.5820.63
69_E90_D0.5810.63
62_S98_R0.5810.63
19_Y85_L0.5810.63
6_F173_L0.5790.63
51_E208_E0.5790.63
212_R225_V0.5790.63
113_Y129_Q0.5770.63
53_C157_K0.5750.62
6_F29_L0.5740.62
41_D55_D0.5730.62
184_K189_K0.5700.62
133_H149_P0.5680.62
172_A237_V0.5670.61
161_V225_V0.5660.61
42_Y92_L0.5660.61
193_S223_R0.5660.61
103_P161_V0.5640.61
124_S127_L0.5630.61
43_R46_L0.5610.61
112_E154_V0.5610.61
81_W176_F0.5600.60
95_A99_I0.5600.60
185_E188_E0.5590.60
32_F41_D0.5580.60
52_E99_I0.5580.60
225_V247_V0.5570.60
12_T16_E0.5570.60
157_K180_L0.5560.60
240_R248_Y0.5560.60
91_E167_R0.5530.59
238_L244_Y0.5520.59
102_N126_T0.5510.59
173_L216_L0.5510.59
91_E246_E0.5490.59
182_D188_E0.5470.59
182_D186_R0.5470.59
61_L180_L0.5450.58
128_R131_A0.5440.58
53_C251_W0.5440.58
108_V194_A0.5410.58
134_P141_P0.5410.58
45_M87_S0.5410.58
17_I208_E0.5410.58
48_D107_L0.5380.57
173_L205_E0.5370.57
54_T105_R0.5350.57
7_G172_A0.5330.57
10_V58_F0.5330.57
114_V133_H0.5320.57
89_S209_L0.5310.56
29_L228_L0.5310.56
115_P121_R0.5290.56
220_P249_R0.5250.56
36_L218_S0.5230.55
78_L225_V0.5230.55
61_L84_F0.5220.55
226_G235_S0.5190.55
72_E173_L0.5190.55
84_F247_V0.5190.55
176_F180_L0.5180.55
228_L238_L0.5160.54
188_E207_E0.5160.54
36_L175_R0.5150.54
246_E250_A0.5150.54
57_L66_Q0.5150.54
10_V79_Y0.5140.54
12_T238_L0.5130.54
109_E157_K0.5130.54
186_R190_K0.5130.54
134_P138_V0.5110.54
201_R204_K0.5110.54
241_R246_E0.5100.53
96_L173_L0.5100.53
115_P151_R0.5090.53
63_P180_L0.5090.53
127_L130_L0.5080.53
11_G45_M0.5050.53
232_P239_Q0.5020.52
171_H227_R0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ijmA 2 0.3665 12.9 0.95 Contact Map
4dinB 1 0.2629 8.3 0.954 Contact Map
3oiqB 1 0.1195 7.2 0.955 Contact Map
4wlpB 2 0.2351 6.3 0.956 Contact Map
2p22D 1 0.3147 4.9 0.959 Contact Map
2becA 1 0.3944 4.8 0.959 Contact Map
3ijtA 2 0.2151 4.7 0.959 Contact Map
3r6fA 2 0.2112 4.6 0.959 Contact Map
2lxtC 1 0.1036 4.5 0.959 Contact Map
2qcsB 1 0.2709 4.5 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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