GREMLIN Database
ABC_cobalt - ABC-type cobalt transport system, permease component
PFAM: PF09819 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 124 (121)
Sequences: 3233 (2032)
Seq/√Len: 184.7
META: 0.757

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
51_A64_A5.0161.00
97_V117_L3.8161.00
62_L95_E3.7211.00
7_A63_L3.6501.00
101_F110_V3.0941.00
69_A87_G2.5091.00
66_L88_L2.4461.00
32_G35_G2.1321.00
13_F46_L2.0951.00
53_L111_A2.0571.00
13_F47_A2.0371.00
52_A61_A1.9761.00
82_L85_L1.7191.00
103_Y106_W1.6741.00
38_G41_Y1.6561.00
108_L112_L1.5911.00
29_A32_G1.5621.00
65_E68_A1.5601.00
21_G72_E1.5301.00
112_L116_A1.5231.00
81_L85_L1.5201.00
107_G110_V1.4871.00
25_N28_S1.4851.00
6_A55_I1.4161.00
62_L88_L1.3631.00
97_V110_V1.3621.00
81_L84_L1.3321.00
9_L54_I1.3311.00
97_V114_A1.3291.00
70_L84_L1.3271.00
14_G17_F1.3271.00
17_F47_A1.2881.00
103_Y107_G1.2861.00
94_A118_A1.2831.00
73_A83_T1.2791.00
20_W43_V1.2681.00
93_G117_L1.2631.00
115_G119_G1.2501.00
32_G36_L1.2501.00
6_A64_A1.2391.00
14_G18_W1.2381.00
41_Y122_A1.2301.00
93_G121_A1.1851.00
17_F21_G1.1821.00
11_V15_V1.1781.00
19_A22_P1.1771.00
13_F50_L1.1571.00
22_P25_N1.1571.00
89_V121_A1.1451.00
49_V114_A1.1231.00
94_A114_A1.1191.00
14_G71_V1.1111.00
23_L27_L1.1091.00
52_A60_A1.0951.00
52_A98_F1.0941.00
75_L78_Q1.0831.00
68_A72_E1.0831.00
49_V111_A1.0751.00
73_A78_Q1.0691.00
48_G65_E1.0671.00
65_E69_A1.0591.00
70_L73_A1.0501.00
73_A81_L1.0311.00
13_F17_F1.0281.00
6_A63_L1.0261.00
117_L121_A0.9950.99
82_L86_S0.9810.99
15_V18_W0.9650.99
18_W75_L0.9630.99
6_A51_A0.9610.99
18_W21_G0.9560.99
3_I63_L0.9420.99
17_F44_W0.9260.99
62_L92_L0.9160.99
26_A29_A0.9150.99
23_L40_L0.9140.99
37_G41_Y0.9100.99
24_Y27_L0.9050.99
97_V113_L0.9040.99
77_S83_T0.9010.99
61_A94_A0.8810.99
47_A64_A0.8810.99
24_Y28_S0.8720.98
112_L115_G0.8510.98
72_E90_Q0.8440.98
52_A106_W0.8410.98
21_G24_Y0.8400.98
55_I64_A0.8300.98
15_V19_A0.8130.98
79_W83_T0.7930.97
96_L99_A0.7900.97
6_A67_V0.7790.97
44_W65_E0.7770.97
117_L120_L0.7720.97
104_R109_P0.7710.97
10_A51_A0.7670.97
48_G52_A0.7660.97
17_F72_E0.7570.96
46_L50_L0.7520.96
31_L35_G0.7390.96
44_W68_A0.7290.95
2_D57_K0.7210.95
21_G77_S0.7200.95
25_N37_G0.7190.95
48_G94_A0.7180.95
63_L67_V0.7160.95
16_V20_W0.7090.95
78_Q83_T0.7090.95
96_L100_L0.7040.94
65_E90_Q0.7020.94
52_A62_L0.6950.94
6_A54_I0.6930.94
28_S32_G0.6910.94
97_V100_L0.6890.94
111_A115_G0.6890.94
36_L40_L0.6870.94
18_W77_S0.6860.94
52_A94_A0.6840.94
61_A98_F0.6670.93
55_I58_P0.6630.93
47_A65_E0.6610.92
69_A84_L0.6580.92
43_V46_L0.6580.92
6_A9_L0.6580.92
87_G90_Q0.6570.92
47_A68_A0.6560.92
106_W110_V0.6540.92
73_A79_W0.6520.92
23_L26_A0.6520.92
104_R107_G0.6410.91
86_S90_Q0.6390.91
13_F18_W0.6350.91
42_G69_A0.6340.91
23_L28_S0.6300.91
4_V8_V0.6260.90
16_V19_A0.6190.90
66_L84_L0.6170.90
55_I60_A0.6090.89
5_V9_L0.6080.89
105_R110_V0.6050.89
97_V102_R0.6030.89
25_N78_Q0.6020.88
114_A118_A0.6020.88
38_G119_G0.5990.88
109_P112_L0.5970.88
25_N31_L0.5960.88
113_L116_A0.5890.87
27_L92_L0.5880.87
98_F114_A0.5830.87
8_V12_A0.5800.87
101_F105_R0.5800.87
58_P103_Y0.5790.86
92_L100_L0.5780.86
24_Y79_W0.5750.86
41_Y45_L0.5630.85
48_G90_Q0.5610.85
107_G112_L0.5600.85
29_A35_G0.5580.84
114_A117_L0.5550.84
110_V114_A0.5530.84
4_V20_W0.5490.83
84_L91_G0.5490.83
66_L86_S0.5440.83
45_L118_A0.5420.83
65_E72_E0.5420.83
117_L122_A0.5400.82
101_F113_L0.5350.82
29_A37_G0.5280.81
10_A66_L0.5270.81
28_S37_G0.5260.81
86_S89_V0.5250.81
85_L89_V0.5220.80
32_G37_G0.5210.80
50_L53_L0.5200.80
8_V81_L0.5180.80
7_A19_A0.5170.80
16_V41_Y0.5170.80
113_L117_L0.5140.79
72_E87_G0.5090.79
74_L77_S0.5040.78
38_G85_L0.5020.78
52_A88_L0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3rlbA 1 0.8952 77.5 0.842 Contact Map
4z7fA 2 0.8629 76.9 0.843 Contact Map
3p5nA 2 0.9032 69.1 0.852 Contact Map
4huqS 1 0.8468 68.9 0.852 Contact Map
4hzuS 1 0.879 66.1 0.855 Contact Map
4rfsS 1 0.9194 59.8 0.861 Contact Map
4tkrA 2 0.871 56.9 0.863 Contact Map
4dveA 3 0.9032 16.2 0.898 Contact Map
4m5bA 1 0.879 8 0.911 Contact Map
3orgA 2 0.9839 3.6 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0061 seconds.