XK-related - PFAM28P - GREMLIN Contacts

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XK-related - XK-related protein

PFAM:	PF09815	Sequences: FFVVLSLLLYLADLGTDLWLAVQYFLEGQYLWFGLTLAFVLLPSLVVQLFSLRWFRADLSRDRTPLLLLLHLLQLGPLIRYWDALKYGLKSRRKEEEEERGYYEGKLLFEEADLSMLRLFEAFLESAPQLLLQLYILLEVLQGVSIVLSLLSISWALVSYHRALRLSLPDKLNLGWLALLCQFLWRLFTIASRVLALALFASVFPLWVLLVLLLHWLVMTFWLVFQQTDFCGSKCEERLYRAVVGAIYIFCWFNVKEGPTRYRMAIYYTVMLLENVLLLLLWYLLLVVLLGFLLGIIFMLVYYRFLHPN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	309 (308)
Sequences:	595 (366)
Seq/√Len:	20.8
META:	0.061

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
13_D	17_D	5.946	1.00
220_T	245_G	5.349	1.00
48_Q	71_H	3.917	1.00
21_A	33_F	3.827	1.00
121_E	125_E	3.776	1.00
200_F	278_L	3.546	1.00
228_T	237_E	3.073	0.99
17_D	149_S	2.932	0.99
71_H	80_R	2.858	0.99
303_Y	307_H	2.780	0.99
71_H	76_G	2.753	0.99
186_R	197_L	2.741	0.99
51_S	54_W	2.678	0.99
193_R	274_E	2.480	0.98
13_D	125_E	2.452	0.97
44_S	74_Q	2.414	0.97
186_R	189_T	2.379	0.97
34_G	38_A	2.362	0.97
24_Y	36_T	2.317	0.96
17_D	125_E	2.262	0.96
48_Q	76_G	2.241	0.95
36_T	133_Q	2.030	0.92
121_E	129_Q	2.021	0.92
134_L	196_A	2.014	0.92
186_R	251_C	1.994	0.92
193_R	215_H	1.993	0.92
113_D	116_M	1.938	0.90
20_L	24_Y	1.932	0.90
216_W	254_N	1.888	0.89
240_Y	253_F	1.887	0.89
268_Y	292_F	1.858	0.88
229_D	306_L	1.829	0.88
38_A	42_L	1.819	0.87
143_G	218_V	1.815	0.87
32_W	48_Q	1.806	0.87
36_T	39_F	1.791	0.86
69_L	90_K	1.776	0.86
215_H	274_E	1.764	0.86
268_Y	274_E	1.761	0.85
278_L	282_W	1.747	0.85
255_V	267_Y	1.739	0.85
132_L	136_I	1.712	0.84
51_S	71_H	1.689	0.83
113_D	254_N	1.685	0.83
132_L	250_F	1.673	0.82
113_D	121_E	1.668	0.82
103_Y	110_E	1.639	0.81
265_A	269_T	1.624	0.80
302_Y	307_H	1.614	0.80
231_C	237_E	1.611	0.80
126_S	129_Q	1.611	0.80
215_H	275_N	1.609	0.80
186_R	274_E	1.588	0.79
122_A	126_S	1.537	0.76
283_Y	289_L	1.523	0.76
181_C	306_L	1.504	0.75
155_W	248_Y	1.503	0.75
258_G	263_R	1.501	0.75
28_G	73_L	1.491	0.74
120_F	129_Q	1.477	0.73
15_G	19_W	1.476	0.73
272_L	276_V	1.470	0.73
97_E	100_R	1.453	0.72
212_L	249_I	1.429	0.71
189_T	295_G	1.428	0.71
108_L	270_V	1.414	0.70
21_A	38_A	1.414	0.70
115_S	142_Q	1.410	0.70
268_Y	275_N	1.403	0.69
202_S	282_W	1.397	0.69
195_L	203_V	1.380	0.68
54_W	237_E	1.378	0.68
192_S	212_L	1.374	0.68
247_I	250_F	1.340	0.66
201_A	209_L	1.339	0.66
182_Q	248_Y	1.336	0.66
252_W	299_M	1.328	0.65
18_L	22_V	1.318	0.65
115_S	188_F	1.317	0.64
21_A	40_V	1.309	0.64
181_C	298_F	1.304	0.64
81_Y	216_W	1.297	0.63
196_A	201_A	1.293	0.63
46_V	138_L	1.292	0.63
24_Y	216_W	1.291	0.63
239_L	245_G	1.286	0.63
15_G	21_A	1.284	0.62
25_F	33_F	1.271	0.62
14_L	28_G	1.265	0.61
14_L	17_D	1.254	0.61
296_I	299_M	1.254	0.61
43_P	215_H	1.245	0.60
228_T	231_C	1.228	0.59
40_V	280_L	1.215	0.58
77_P	114_L	1.214	0.58
274_E	292_F	1.209	0.58
221_F	252_W	1.198	0.57
69_L	286_L	1.189	0.56
37_L	42_L	1.188	0.56
13_D	16_T	1.187	0.56
44_S	53_R	1.181	0.56
23_Q	26_L	1.180	0.56
146_I	153_I	1.180	0.56
69_L	180_L	1.179	0.56
113_D	117_L	1.179	0.56
54_W	71_H	1.178	0.56
129_Q	142_Q	1.169	0.55
142_Q	155_W	1.168	0.55
282_W	285_L	1.158	0.54
185_W	219_M	1.157	0.54
125_E	129_Q	1.151	0.54
266_I	273_L	1.150	0.54
28_G	45_L	1.147	0.54
194_V	202_S	1.139	0.53
36_T	132_L	1.138	0.53
38_A	180_L	1.134	0.53
117_L	216_W	1.133	0.53
247_I	253_F	1.132	0.53
127_A	201_A	1.127	0.52
281_L	291_G	1.126	0.52
194_V	251_C	1.119	0.52
20_L	36_T	1.118	0.52
24_Y	43_P	1.117	0.52
51_S	80_R	1.116	0.52
118_R	125_E	1.112	0.51
114_L	247_I	1.110	0.51
129_Q	132_L	1.106	0.51
51_S	117_L	1.103	0.51
145_S	152_S	1.102	0.51
193_R	197_L	1.101	0.51
40_V	85_L	1.100	0.51
145_S	149_S	1.097	0.50
47_V	196_A	1.096	0.50
161_H	260_T	1.094	0.50
32_W	135_Y	1.092	0.50
85_L	270_V	1.084	0.49
6_S	274_E	1.082	0.49
130_L	146_I	1.080	0.49
117_L	237_E	1.080	0.49
23_Q	27_E	1.075	0.49
147_V	276_V	1.069	0.48
170_D	202_S	1.060	0.48
254_N	303_Y	1.059	0.48
126_S	149_S	1.049	0.47
37_L	58_D	1.047	0.47
215_H	248_Y	1.042	0.47
4_V	28_G	1.041	0.47
2_F	9_L	1.030	0.46
252_W	256_K	1.029	0.46
133_Q	299_M	1.021	0.45
132_L	163_A	1.018	0.45
15_G	277_L	1.007	0.44
116_M	253_F	0.994	0.44
147_V	191_A	0.994	0.44
13_D	149_S	0.991	0.43
151_L	200_F	0.988	0.43
181_C	221_F	0.984	0.43
10_Y	17_D	0.977	0.42
5_L	65_P	0.975	0.42
53_R	220_T	0.969	0.42
25_F	252_W	0.969	0.42
216_W	242_A	0.962	0.41
185_W	258_G	0.961	0.41
10_Y	189_T	0.958	0.41
116_M	237_E	0.958	0.41
219_M	248_Y	0.957	0.41
118_R	303_Y	0.955	0.41
237_E	253_F	0.950	0.41
34_G	270_V	0.948	0.41
269_T	293_L	0.947	0.41
42_L	75_L	0.946	0.40
34_G	180_L	0.945	0.40
13_D	39_F	0.944	0.40
24_Y	124_L	0.942	0.40
211_V	274_E	0.939	0.40
178_A	285_L	0.938	0.40
303_Y	308_P	0.936	0.40
126_S	152_S	0.930	0.39
54_W	117_L	0.929	0.39
12_A	15_G	0.927	0.39
25_F	135_Y	0.927	0.39
201_A	219_M	0.927	0.39
187_L	294_L	0.925	0.39
185_W	193_R	0.923	0.39
113_D	240_Y	0.922	0.39
273_L	289_L	0.921	0.39
24_Y	31_L	0.914	0.38
268_Y	299_M	0.911	0.38
215_H	219_M	0.910	0.38
185_W	207_W	0.909	0.38
267_Y	271_M	0.909	0.38
17_D	129_Q	0.907	0.38
123_F	134_L	0.906	0.38
132_L	222_W	0.902	0.38
247_I	256_K	0.902	0.38
48_Q	278_L	0.897	0.37
297_I	306_L	0.890	0.37
132_L	202_S	0.882	0.36
138_L	218_V	0.881	0.36
43_P	232_G	0.877	0.36
152_S	274_E	0.876	0.36
223_L	272_L	0.873	0.36
249_I	274_E	0.873	0.36
237_E	261_R	0.869	0.36
48_Q	54_W	0.867	0.36
248_Y	253_F	0.867	0.36
66_L	84_A	0.861	0.35
164_L	168_L	0.860	0.35
237_E	240_Y	0.859	0.35
272_L	292_F	0.854	0.35
244_V	255_V	0.853	0.35
129_Q	136_I	0.851	0.35
231_C	236_E	0.849	0.34
131_L	187_L	0.847	0.34
273_L	281_L	0.845	0.34
80_R	222_W	0.844	0.34
41_L	284_L	0.841	0.34
11_L	17_D	0.840	0.34
89_L	192_S	0.837	0.34
51_S	216_W	0.836	0.34
34_G	134_L	0.829	0.33
138_L	143_G	0.828	0.33
41_L	208_V	0.828	0.33
193_R	275_N	0.826	0.33
119_L	122_A	0.826	0.33
203_V	218_V	0.820	0.33
116_M	230_F	0.816	0.32
184_L	278_L	0.816	0.32
138_L	197_L	0.813	0.32
42_L	126_S	0.811	0.32
22_V	26_L	0.810	0.32
53_R	236_E	0.809	0.32
22_V	269_T	0.808	0.32
207_W	210_L	0.807	0.32
10_Y	13_D	0.807	0.32
111_E	209_L	0.807	0.32
107_L	110_E	0.807	0.32
4_V	45_L	0.806	0.32
171_K	174_L	0.805	0.32
38_A	41_L	0.805	0.32
10_Y	15_G	0.805	0.32
186_R	268_Y	0.802	0.32
24_Y	58_D	0.796	0.31
160_Y	216_W	0.796	0.31
162_R	179_L	0.795	0.31
105_G	190_I	0.791	0.31
109_F	290_L	0.787	0.31
164_L	167_S	0.785	0.31
73_L	190_I	0.779	0.30
240_Y	282_W	0.779	0.30
99_E	203_V	0.779	0.30
88_G	91_S	0.776	0.30
200_F	263_R	0.776	0.30
25_F	218_V	0.776	0.30
127_A	171_K	0.775	0.30
49_L	269_T	0.774	0.30
118_R	121_E	0.770	0.30
70_L	158_V	0.769	0.30
10_Y	16_T	0.768	0.30
208_V	263_R	0.765	0.30
146_I	248_Y	0.764	0.30
12_A	190_I	0.763	0.29
54_W	228_T	0.761	0.29
138_L	296_I	0.760	0.29
99_E	158_V	0.755	0.29
8_L	65_P	0.755	0.29
180_L	280_L	0.754	0.29
270_V	278_L	0.754	0.29
10_Y	19_W	0.753	0.29
276_V	280_L	0.753	0.29
48_Q	51_S	0.751	0.29
185_W	299_M	0.751	0.29
80_R	267_Y	0.750	0.29
50_F	78_L	0.749	0.29
35_L	50_F	0.748	0.29
52_L	56_R	0.742	0.28
35_L	52_L	0.739	0.28
231_C	256_K	0.738	0.28
76_G	241_R	0.737	0.28
151_L	284_L	0.733	0.28
35_L	39_F	0.731	0.28
15_G	18_L	0.730	0.28
15_G	125_E	0.728	0.28
292_F	299_M	0.726	0.28
267_Y	279_L	0.726	0.28
281_L	301_V	0.723	0.27
208_V	234_K	0.722	0.27
203_V	301_V	0.721	0.27
160_Y	240_Y	0.718	0.27
276_V	297_I	0.718	0.27
162_R	174_L	0.710	0.27
183_F	212_L	0.709	0.27
258_G	308_P	0.706	0.26
197_L	278_L	0.705	0.26
45_L	266_I	0.704	0.26
151_L	183_F	0.704	0.26
200_F	204_F	0.703	0.26
63_R	72_L	0.702	0.26
146_I	217_L	0.702	0.26
152_S	279_L	0.700	0.26
36_T	275_N	0.699	0.26
293_L	296_I	0.695	0.26
152_S	166_L	0.695	0.26
148_L	152_S	0.693	0.26
254_N	260_T	0.689	0.26
180_L	183_F	0.688	0.26
138_L	242_A	0.687	0.25
195_L	262_Y	0.684	0.25
26_L	72_L	0.683	0.25
295_G	302_Y	0.682	0.25
180_L	235_C	0.682	0.25
286_L	290_L	0.681	0.25
254_N	302_Y	0.678	0.25
32_W	71_H	0.677	0.25
143_G	290_L	0.675	0.25
143_G	174_L	0.674	0.25
230_F	237_E	0.673	0.25
222_W	226_Q	0.672	0.25
44_S	123_F	0.671	0.25
54_W	80_R	0.670	0.25
160_Y	245_G	0.669	0.25
121_E	142_Q	0.669	0.25
101_G	190_I	0.665	0.24
137_L	265_A	0.665	0.24
35_L	127_A	0.664	0.24
76_G	186_R	0.657	0.24
160_Y	226_Q	0.656	0.24
218_V	284_L	0.654	0.24
54_W	216_W	0.653	0.24
101_G	207_W	0.652	0.24
122_A	133_Q	0.651	0.24
82_W	194_V	0.646	0.23
21_A	194_V	0.644	0.23
292_F	296_I	0.643	0.23
88_G	130_L	0.642	0.23
286_L	297_I	0.641	0.23
188_F	298_F	0.639	0.23
226_Q	279_L	0.638	0.23
70_L	209_L	0.638	0.23
288_V	291_G	0.636	0.23
200_F	251_C	0.634	0.23
6_S	13_D	0.633	0.23
218_V	286_L	0.633	0.23
281_L	304_R	0.631	0.23
193_R	282_W	0.629	0.23
112_A	157_L	0.628	0.23
30_Y	301_V	0.624	0.22
284_L	291_G	0.621	0.22
11_L	78_L	0.621	0.22
75_L	78_L	0.621	0.22
30_Y	45_L	0.619	0.22
6_S	252_W	0.618	0.22
78_L	305_F	0.615	0.22
253_F	295_G	0.615	0.22
100_R	137_L	0.615	0.22
216_W	237_E	0.614	0.22
149_S	270_V	0.614	0.22
70_L	119_L	0.611	0.22
36_T	42_L	0.610	0.22
14_L	22_V	0.610	0.22
46_V	191_A	0.609	0.22
73_L	138_L	0.608	0.22
211_V	278_L	0.608	0.22
17_D	121_E	0.608	0.22
9_L	155_W	0.606	0.22
79_I	291_G	0.606	0.22
237_E	260_T	0.605	0.22
14_L	30_Y	0.604	0.22
130_L	182_Q	0.604	0.22
52_L	55_F	0.603	0.22
137_L	146_I	0.601	0.21
167_S	234_K	0.600	0.21
161_H	189_T	0.599	0.21
259_P	306_L	0.599	0.21
71_H	216_W	0.598	0.21
230_F	244_V	0.597	0.21
300_L	309_N	0.596	0.21
7_L	25_F	0.596	0.21
133_Q	145_S	0.595	0.21
18_L	21_A	0.592	0.21
41_L	85_L	0.591	0.21
141_L	145_S	0.591	0.21
154_S	245_G	0.590	0.21
49_L	72_L	0.589	0.21
51_S	160_Y	0.588	0.21
187_L	208_V	0.588	0.21
54_W	160_Y	0.587	0.21
185_W	282_W	0.581	0.21
112_A	168_L	0.578	0.20
67_L	275_N	0.577	0.20
114_L	152_S	0.576	0.20
123_F	129_Q	0.575	0.20
21_A	293_L	0.573	0.20
31_L	201_A	0.573	0.20
279_L	286_L	0.572	0.20
81_Y	150_L	0.570	0.20
218_V	298_F	0.568	0.20
58_D	169_P	0.567	0.20
249_I	280_L	0.565	0.20
70_L	74_Q	0.565	0.20
208_V	211_V	0.564	0.20
60_S	218_V	0.564	0.20
143_G	203_V	0.562	0.20
210_L	213_L	0.562	0.20
148_L	198_A	0.562	0.20
293_L	309_N	0.560	0.20
193_R	204_F	0.560	0.20
113_D	230_F	0.559	0.20
58_D	84_A	0.558	0.20
137_L	143_G	0.556	0.19
243_V	289_L	0.554	0.19
112_A	167_S	0.552	0.19
163_A	183_F	0.551	0.19
28_G	287_V	0.551	0.19
27_E	33_F	0.550	0.19
104_E	107_L	0.548	0.19
116_M	242_A	0.547	0.19
173_N	306_L	0.546	0.19
17_D	145_S	0.544	0.19
271_M	278_L	0.544	0.19
113_D	132_L	0.542	0.19
72_L	273_L	0.542	0.19
53_R	78_L	0.541	0.19
83_D	134_L	0.540	0.19
161_H	237_E	0.540	0.19
123_F	130_L	0.539	0.19
159_S	219_M	0.539	0.19
13_D	129_Q	0.539	0.19
103_Y	107_L	0.537	0.19
80_R	160_Y	0.537	0.19
172_L	195_L	0.537	0.19
8_L	153_I	0.537	0.19
124_L	198_A	0.536	0.19
130_L	194_V	0.536	0.19
14_L	18_L	0.530	0.18
33_F	219_M	0.530	0.18
226_Q	237_E	0.525	0.18
92_R	183_F	0.523	0.18
234_K	238_R	0.523	0.18
126_S	247_I	0.522	0.18
198_A	301_V	0.522	0.18
245_G	272_L	0.521	0.18
219_M	223_L	0.520	0.18
182_Q	192_S	0.520	0.18
283_Y	288_V	0.519	0.18
73_L	132_L	0.518	0.18
164_L	261_R	0.517	0.18
33_F	195_L	0.517	0.18
121_E	245_G	0.516	0.18
44_S	280_L	0.516	0.18
28_G	34_G	0.516	0.18
81_Y	114_L	0.514	0.18
86_K	175_G	0.513	0.18
40_V	151_L	0.511	0.18
111_E	179_L	0.509	0.18
39_F	157_L	0.507	0.18
5_L	59_L	0.504	0.17
33_F	37_L	0.503	0.17
98_E	305_F	0.502	0.17
243_V	246_A	0.501	0.17
9_L	50_F	0.501	0.17
118_R	292_F	0.500	0.17

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4hkrA	3	0.2718	7.6	0.967	Contact Map
2kixA	3	0.0939	3.3	0.972	Contact Map
3wu2M	2	0.11	3.1	0.973	Contact Map
2onkC	2	0.1812	2.3	0.974	Contact Map
2mmuA	1	0.0777	2.1	0.975	Contact Map
4p79A	1	0.165	1.5	0.977	Contact Map
3d31C	2	0.1683	1.5	0.977	Contact Map
1hznA	1	0.0939	1.2	0.978	Contact Map
4w6vA	1	0.2913	1.1	0.979	Contact Map
4ogqG	1	0.1197	1	0.979	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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