GREMLIN Database
XK-related - XK-related protein
PFAM: PF09815 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 309 (308)
Sequences: 595 (366)
Seq/√Len: 20.8
META: 0.061

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
13_D17_D5.9461.00
220_T245_G5.3491.00
48_Q71_H3.9171.00
21_A33_F3.8271.00
121_E125_E3.7761.00
200_F278_L3.5461.00
228_T237_E3.0730.99
17_D149_S2.9320.99
71_H80_R2.8580.99
303_Y307_H2.7800.99
71_H76_G2.7530.99
186_R197_L2.7410.99
51_S54_W2.6780.99
193_R274_E2.4800.98
13_D125_E2.4520.97
44_S74_Q2.4140.97
186_R189_T2.3790.97
34_G38_A2.3620.97
24_Y36_T2.3170.96
17_D125_E2.2620.96
48_Q76_G2.2410.95
36_T133_Q2.0300.92
121_E129_Q2.0210.92
134_L196_A2.0140.92
186_R251_C1.9940.92
193_R215_H1.9930.92
113_D116_M1.9380.90
20_L24_Y1.9320.90
216_W254_N1.8880.89
240_Y253_F1.8870.89
268_Y292_F1.8580.88
229_D306_L1.8290.88
38_A42_L1.8190.87
143_G218_V1.8150.87
32_W48_Q1.8060.87
36_T39_F1.7910.86
69_L90_K1.7760.86
215_H274_E1.7640.86
268_Y274_E1.7610.85
278_L282_W1.7470.85
255_V267_Y1.7390.85
132_L136_I1.7120.84
51_S71_H1.6890.83
113_D254_N1.6850.83
132_L250_F1.6730.82
113_D121_E1.6680.82
103_Y110_E1.6390.81
265_A269_T1.6240.80
302_Y307_H1.6140.80
231_C237_E1.6110.80
126_S129_Q1.6110.80
215_H275_N1.6090.80
186_R274_E1.5880.79
122_A126_S1.5370.76
283_Y289_L1.5230.76
181_C306_L1.5040.75
155_W248_Y1.5030.75
258_G263_R1.5010.75
28_G73_L1.4910.74
120_F129_Q1.4770.73
15_G19_W1.4760.73
272_L276_V1.4700.73
97_E100_R1.4530.72
212_L249_I1.4290.71
189_T295_G1.4280.71
108_L270_V1.4140.70
21_A38_A1.4140.70
115_S142_Q1.4100.70
268_Y275_N1.4030.69
202_S282_W1.3970.69
195_L203_V1.3800.68
54_W237_E1.3780.68
192_S212_L1.3740.68
247_I250_F1.3400.66
201_A209_L1.3390.66
182_Q248_Y1.3360.66
252_W299_M1.3280.65
18_L22_V1.3180.65
115_S188_F1.3170.64
21_A40_V1.3090.64
181_C298_F1.3040.64
81_Y216_W1.2970.63
196_A201_A1.2930.63
46_V138_L1.2920.63
24_Y216_W1.2910.63
239_L245_G1.2860.63
15_G21_A1.2840.62
25_F33_F1.2710.62
14_L28_G1.2650.61
14_L17_D1.2540.61
296_I299_M1.2540.61
43_P215_H1.2450.60
228_T231_C1.2280.59
40_V280_L1.2150.58
77_P114_L1.2140.58
274_E292_F1.2090.58
221_F252_W1.1980.57
69_L286_L1.1890.56
37_L42_L1.1880.56
13_D16_T1.1870.56
44_S53_R1.1810.56
23_Q26_L1.1800.56
146_I153_I1.1800.56
69_L180_L1.1790.56
113_D117_L1.1790.56
54_W71_H1.1780.56
129_Q142_Q1.1690.55
142_Q155_W1.1680.55
282_W285_L1.1580.54
185_W219_M1.1570.54
125_E129_Q1.1510.54
266_I273_L1.1500.54
28_G45_L1.1470.54
194_V202_S1.1390.53
36_T132_L1.1380.53
38_A180_L1.1340.53
117_L216_W1.1330.53
247_I253_F1.1320.53
127_A201_A1.1270.52
281_L291_G1.1260.52
194_V251_C1.1190.52
20_L36_T1.1180.52
24_Y43_P1.1170.52
51_S80_R1.1160.52
118_R125_E1.1120.51
114_L247_I1.1100.51
129_Q132_L1.1060.51
51_S117_L1.1030.51
145_S152_S1.1020.51
193_R197_L1.1010.51
40_V85_L1.1000.51
145_S149_S1.0970.50
47_V196_A1.0960.50
161_H260_T1.0940.50
32_W135_Y1.0920.50
85_L270_V1.0840.49
6_S274_E1.0820.49
130_L146_I1.0800.49
117_L237_E1.0800.49
23_Q27_E1.0750.49
147_V276_V1.0690.48
170_D202_S1.0600.48
254_N303_Y1.0590.48
126_S149_S1.0490.47
37_L58_D1.0470.47
215_H248_Y1.0420.47
4_V28_G1.0410.47
2_F9_L1.0300.46
252_W256_K1.0290.46
133_Q299_M1.0210.45
132_L163_A1.0180.45
15_G277_L1.0070.44
116_M253_F0.9940.44
147_V191_A0.9940.44
13_D149_S0.9910.43
151_L200_F0.9880.43
181_C221_F0.9840.43
10_Y17_D0.9770.42
5_L65_P0.9750.42
53_R220_T0.9690.42
25_F252_W0.9690.42
216_W242_A0.9620.41
185_W258_G0.9610.41
10_Y189_T0.9580.41
116_M237_E0.9580.41
219_M248_Y0.9570.41
118_R303_Y0.9550.41
237_E253_F0.9500.41
34_G270_V0.9480.41
269_T293_L0.9470.41
42_L75_L0.9460.40
34_G180_L0.9450.40
13_D39_F0.9440.40
24_Y124_L0.9420.40
211_V274_E0.9390.40
178_A285_L0.9380.40
303_Y308_P0.9360.40
126_S152_S0.9300.39
54_W117_L0.9290.39
12_A15_G0.9270.39
25_F135_Y0.9270.39
201_A219_M0.9270.39
187_L294_L0.9250.39
185_W193_R0.9230.39
113_D240_Y0.9220.39
273_L289_L0.9210.39
24_Y31_L0.9140.38
268_Y299_M0.9110.38
215_H219_M0.9100.38
185_W207_W0.9090.38
267_Y271_M0.9090.38
17_D129_Q0.9070.38
123_F134_L0.9060.38
132_L222_W0.9020.38
247_I256_K0.9020.38
48_Q278_L0.8970.37
297_I306_L0.8900.37
132_L202_S0.8820.36
138_L218_V0.8810.36
43_P232_G0.8770.36
152_S274_E0.8760.36
223_L272_L0.8730.36
249_I274_E0.8730.36
237_E261_R0.8690.36
48_Q54_W0.8670.36
248_Y253_F0.8670.36
66_L84_A0.8610.35
164_L168_L0.8600.35
237_E240_Y0.8590.35
272_L292_F0.8540.35
244_V255_V0.8530.35
129_Q136_I0.8510.35
231_C236_E0.8490.34
131_L187_L0.8470.34
273_L281_L0.8450.34
80_R222_W0.8440.34
41_L284_L0.8410.34
11_L17_D0.8400.34
89_L192_S0.8370.34
51_S216_W0.8360.34
34_G134_L0.8290.33
138_L143_G0.8280.33
41_L208_V0.8280.33
193_R275_N0.8260.33
119_L122_A0.8260.33
203_V218_V0.8200.33
116_M230_F0.8160.32
184_L278_L0.8160.32
138_L197_L0.8130.32
42_L126_S0.8110.32
22_V26_L0.8100.32
53_R236_E0.8090.32
22_V269_T0.8080.32
207_W210_L0.8070.32
10_Y13_D0.8070.32
111_E209_L0.8070.32
107_L110_E0.8070.32
4_V45_L0.8060.32
171_K174_L0.8050.32
38_A41_L0.8050.32
10_Y15_G0.8050.32
186_R268_Y0.8020.32
24_Y58_D0.7960.31
160_Y216_W0.7960.31
162_R179_L0.7950.31
105_G190_I0.7910.31
109_F290_L0.7870.31
164_L167_S0.7850.31
73_L190_I0.7790.30
240_Y282_W0.7790.30
99_E203_V0.7790.30
88_G91_S0.7760.30
200_F263_R0.7760.30
25_F218_V0.7760.30
127_A171_K0.7750.30
49_L269_T0.7740.30
118_R121_E0.7700.30
70_L158_V0.7690.30
10_Y16_T0.7680.30
208_V263_R0.7650.30
146_I248_Y0.7640.30
12_A190_I0.7630.29
54_W228_T0.7610.29
138_L296_I0.7600.29
99_E158_V0.7550.29
8_L65_P0.7550.29
180_L280_L0.7540.29
270_V278_L0.7540.29
10_Y19_W0.7530.29
276_V280_L0.7530.29
48_Q51_S0.7510.29
185_W299_M0.7510.29
80_R267_Y0.7500.29
50_F78_L0.7490.29
35_L50_F0.7480.29
52_L56_R0.7420.28
35_L52_L0.7390.28
231_C256_K0.7380.28
76_G241_R0.7370.28
151_L284_L0.7330.28
35_L39_F0.7310.28
15_G18_L0.7300.28
15_G125_E0.7280.28
292_F299_M0.7260.28
267_Y279_L0.7260.28
281_L301_V0.7230.27
208_V234_K0.7220.27
203_V301_V0.7210.27
160_Y240_Y0.7180.27
276_V297_I0.7180.27
162_R174_L0.7100.27
183_F212_L0.7090.27
258_G308_P0.7060.26
197_L278_L0.7050.26
45_L266_I0.7040.26
151_L183_F0.7040.26
200_F204_F0.7030.26
63_R72_L0.7020.26
146_I217_L0.7020.26
152_S279_L0.7000.26
36_T275_N0.6990.26
293_L296_I0.6950.26
152_S166_L0.6950.26
148_L152_S0.6930.26
254_N260_T0.6890.26
180_L183_F0.6880.26
138_L242_A0.6870.25
195_L262_Y0.6840.25
26_L72_L0.6830.25
295_G302_Y0.6820.25
180_L235_C0.6820.25
286_L290_L0.6810.25
254_N302_Y0.6780.25
32_W71_H0.6770.25
143_G290_L0.6750.25
143_G174_L0.6740.25
230_F237_E0.6730.25
222_W226_Q0.6720.25
44_S123_F0.6710.25
54_W80_R0.6700.25
160_Y245_G0.6690.25
121_E142_Q0.6690.25
101_G190_I0.6650.24
137_L265_A0.6650.24
35_L127_A0.6640.24
76_G186_R0.6570.24
160_Y226_Q0.6560.24
218_V284_L0.6540.24
54_W216_W0.6530.24
101_G207_W0.6520.24
122_A133_Q0.6510.24
82_W194_V0.6460.23
21_A194_V0.6440.23
292_F296_I0.6430.23
88_G130_L0.6420.23
286_L297_I0.6410.23
188_F298_F0.6390.23
226_Q279_L0.6380.23
70_L209_L0.6380.23
288_V291_G0.6360.23
200_F251_C0.6340.23
6_S13_D0.6330.23
218_V286_L0.6330.23
281_L304_R0.6310.23
193_R282_W0.6290.23
112_A157_L0.6280.23
30_Y301_V0.6240.22
284_L291_G0.6210.22
11_L78_L0.6210.22
75_L78_L0.6210.22
30_Y45_L0.6190.22
6_S252_W0.6180.22
78_L305_F0.6150.22
253_F295_G0.6150.22
100_R137_L0.6150.22
216_W237_E0.6140.22
149_S270_V0.6140.22
70_L119_L0.6110.22
36_T42_L0.6100.22
14_L22_V0.6100.22
46_V191_A0.6090.22
73_L138_L0.6080.22
211_V278_L0.6080.22
17_D121_E0.6080.22
9_L155_W0.6060.22
79_I291_G0.6060.22
237_E260_T0.6050.22
14_L30_Y0.6040.22
130_L182_Q0.6040.22
52_L55_F0.6030.22
137_L146_I0.6010.21
167_S234_K0.6000.21
161_H189_T0.5990.21
259_P306_L0.5990.21
71_H216_W0.5980.21
230_F244_V0.5970.21
300_L309_N0.5960.21
7_L25_F0.5960.21
133_Q145_S0.5950.21
18_L21_A0.5920.21
41_L85_L0.5910.21
141_L145_S0.5910.21
154_S245_G0.5900.21
49_L72_L0.5890.21
51_S160_Y0.5880.21
187_L208_V0.5880.21
54_W160_Y0.5870.21
185_W282_W0.5810.21
112_A168_L0.5780.20
67_L275_N0.5770.20
114_L152_S0.5760.20
123_F129_Q0.5750.20
21_A293_L0.5730.20
31_L201_A0.5730.20
279_L286_L0.5720.20
81_Y150_L0.5700.20
218_V298_F0.5680.20
58_D169_P0.5670.20
249_I280_L0.5650.20
70_L74_Q0.5650.20
208_V211_V0.5640.20
60_S218_V0.5640.20
143_G203_V0.5620.20
210_L213_L0.5620.20
148_L198_A0.5620.20
293_L309_N0.5600.20
193_R204_F0.5600.20
113_D230_F0.5590.20
58_D84_A0.5580.20
137_L143_G0.5560.19
243_V289_L0.5540.19
112_A167_S0.5520.19
163_A183_F0.5510.19
28_G287_V0.5510.19
27_E33_F0.5500.19
104_E107_L0.5480.19
116_M242_A0.5470.19
173_N306_L0.5460.19
17_D145_S0.5440.19
271_M278_L0.5440.19
113_D132_L0.5420.19
72_L273_L0.5420.19
53_R78_L0.5410.19
83_D134_L0.5400.19
161_H237_E0.5400.19
123_F130_L0.5390.19
159_S219_M0.5390.19
13_D129_Q0.5390.19
103_Y107_L0.5370.19
80_R160_Y0.5370.19
172_L195_L0.5370.19
8_L153_I0.5370.19
124_L198_A0.5360.19
130_L194_V0.5360.19
14_L18_L0.5300.18
33_F219_M0.5300.18
226_Q237_E0.5250.18
92_R183_F0.5230.18
234_K238_R0.5230.18
126_S247_I0.5220.18
198_A301_V0.5220.18
245_G272_L0.5210.18
219_M223_L0.5200.18
182_Q192_S0.5200.18
283_Y288_V0.5190.18
73_L132_L0.5180.18
164_L261_R0.5170.18
33_F195_L0.5170.18
121_E245_G0.5160.18
44_S280_L0.5160.18
28_G34_G0.5160.18
81_Y114_L0.5140.18
86_K175_G0.5130.18
40_V151_L0.5110.18
111_E179_L0.5090.18
39_F157_L0.5070.18
5_L59_L0.5040.17
33_F37_L0.5030.17
98_E305_F0.5020.17
243_V246_A0.5010.17
9_L50_F0.5010.17
118_R292_F0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hkrA 3 0.2718 7.6 0.967 Contact Map
2kixA 3 0.0939 3.3 0.972 Contact Map
3wu2M 2 0.11 3.1 0.973 Contact Map
2onkC 2 0.1812 2.3 0.974 Contact Map
2mmuA 1 0.0777 2.1 0.975 Contact Map
4p79A 1 0.165 1.5 0.977 Contact Map
3d31C 2 0.1683 1.5 0.977 Contact Map
1hznA 1 0.0939 1.2 0.978 Contact Map
4w6vA 1 0.2913 1.1 0.979 Contact Map
4ogqG 1 0.1197 1 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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