GREMLIN Database
Transmemb_17 - Predicted membrane protein
PFAM: PF09799 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 108 (107)
Sequences: 633 (467)
Seq/√Len: 45.1
META: 0.352

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_G68_L3.4411.00
6_N49_E3.4361.00
56_G71_F3.2151.00
101_A105_V3.1151.00
83_V87_L3.0111.00
84_Y89_Q2.7681.00
59_G63_E2.7571.00
60_N63_E2.7081.00
85_F88_W2.4111.00
1_M84_Y1.9850.99
97_V101_A1.8730.99
61_L103_L1.8360.99
3_L56_G1.7440.98
42_L46_L1.7050.98
6_N52_R1.6400.97
54_Y58_K1.6010.97
38_E84_Y1.5710.96
21_L43_F1.5710.96
96_E100_N1.5330.96
82_L103_L1.5220.96
55_L74_L1.4710.95
36_A40_A1.4690.95
13_Y100_N1.4100.94
101_A106_F1.3980.93
57_Y61_L1.3810.93
46_L85_F1.3610.92
93_L96_E1.3440.92
19_L42_L1.3330.91
87_L99_L1.2780.90
71_F75_T1.2080.87
49_E52_R1.2030.87
49_E61_L1.1940.86
88_W92_V1.1920.86
3_L7_G1.1890.86
30_Y38_E1.1840.86
52_R75_T1.1820.86
48_L74_L1.1770.85
13_Y42_L1.1730.85
38_E92_V1.1550.84
53_L96_E1.1150.82
98_I102_I1.1140.82
4_Y8_Y1.0980.81
10_F20_L1.0850.80
24_K89_Q1.0750.80
61_L85_F1.0750.80
5_F70_G1.0730.80
68_L71_F1.0630.79
33_Y73_L1.0420.77
48_L107_L1.0370.77
9_Y20_L1.0320.77
41_L47_L1.0320.77
26_Q47_L1.0300.77
75_T107_L1.0280.76
24_K93_L1.0280.76
34_Y38_E1.0040.75
69_A73_L0.9940.74
44_L100_N0.9820.73
4_Y10_F0.9770.73
16_A99_L0.9590.71
51_I57_Y0.9580.71
10_F45_L0.9480.70
14_F75_T0.9460.70
2_L58_K0.9290.69
15_L18_L0.9260.69
89_Q92_V0.9180.68
52_R71_F0.9120.67
39_V46_L0.8990.66
86_L104_L0.8970.66
6_N61_L0.8930.66
22_I85_F0.8870.65
8_Y21_L0.8860.65
41_L49_E0.8830.65
100_N103_L0.8700.64
6_N10_F0.8640.63
46_L50_A0.8620.63
24_K96_E0.8410.61
91_Y97_V0.8320.60
22_I34_Y0.8300.60
30_Y68_L0.8180.59
75_T85_F0.7930.57
31_P90_T0.7910.56
48_L79_Q0.7830.56
33_Y46_L0.7830.56
6_N64_K0.7740.55
2_L74_L0.7660.54
6_N9_Y0.7650.54
84_Y92_V0.7640.54
4_Y53_L0.7630.54
4_Y106_F0.7630.54
18_L22_I0.7550.53
12_L76_L0.7550.53
61_L82_L0.7510.53
8_Y16_A0.7490.52
72_L76_L0.7490.52
66_P70_G0.7430.52
71_F107_L0.7270.50
23_Y93_L0.7260.50
4_Y73_L0.7140.49
21_L52_R0.7110.49
17_E42_L0.7100.49
8_Y22_I0.7090.48
41_L73_L0.7080.48
13_Y31_P0.6980.47
39_V72_L0.6930.47
91_Y98_I0.6760.45
41_L85_F0.6720.45
92_V105_V0.6630.44
35_L77_P0.6630.44
3_L76_L0.6630.44
87_L90_T0.6620.44
37_L51_I0.6580.44
3_L73_L0.6560.43
17_E21_L0.6530.43
74_L77_P0.6520.43
55_L70_G0.6510.43
32_D69_A0.6480.43
23_Y28_L0.6450.42
86_L100_N0.6350.41
49_E53_L0.6340.41
73_L100_N0.6290.41
80_L88_W0.6240.40
31_P34_Y0.6220.40
22_I98_I0.6200.40
11_P49_E0.6170.40
39_V43_F0.6140.39
16_A23_Y0.6100.39
17_E96_E0.6070.39
35_L41_L0.6060.39
76_L80_L0.6040.38
16_A20_L0.6020.38
20_L103_L0.6010.38
27_V63_E0.5980.38
12_L19_L0.5960.38
1_M11_P0.5910.37
31_P85_F0.5860.37
69_A74_L0.5790.36
63_E73_L0.5710.35
28_L93_L0.5700.35
12_L95_L0.5690.35
16_A26_Q0.5650.35
32_D102_I0.5640.35
66_P75_T0.5620.35
13_Y45_L0.5600.34
77_P89_Q0.5580.34
65_V78_S0.5570.34
14_F43_F0.5480.33
45_L104_L0.5460.33
12_L70_G0.5450.33
19_L76_L0.5340.32
48_L92_V0.5260.32
61_L65_V0.5220.31
5_F78_S0.5090.30
12_L32_D0.5070.30
2_L11_P0.5070.30
10_F103_L0.5030.30
18_L70_G0.5030.30
7_G11_P0.5030.30
45_L78_S0.5020.30
37_L44_L0.5020.30
71_F94_P0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jq6A 3 0.4074 1.2 0.936 Contact Map
2rmgA 1 0.1667 1 0.938 Contact Map
4pypA 1 0.9444 1 0.939 Contact Map
1b9uA 1 0.3148 0.9 0.94 Contact Map
3wu2Y 1 0.1019 0.7 0.944 Contact Map
2h3oA 1 0.2407 0.7 0.944 Contact Map
2m67A 1 0.4815 0.7 0.945 Contact Map
4pgrA 1 0.5463 0.7 0.945 Contact Map
3wqjA 3 0.5 0.7 0.946 Contact Map
1g0yI 1 0.1944 0.6 0.947 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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