GREMLIN Database
Peptidase_M76 - Peptidase M76 family
PFAM: PF09768 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 171 (168)
Sequences: 559 (394)
Seq/√Len: 30.4
META: 0.24

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
104_N128_H4.4491.00
29_C83_C4.1691.00
93_R158_E3.6911.00
41_C58_C3.6551.00
133_R157_D3.0701.00
137_I156_V2.8381.00
74_H78_H2.8111.00
55_I76_L2.6861.00
75_E78_H2.6321.00
91_N94_H2.6181.00
65_Q69_E2.6141.00
97_C163_C2.5811.00
92_L146_C2.5160.99
88_D91_N2.2950.99
95_H143_N2.2860.99
21_L76_L2.2660.99
137_I153_E2.2490.99
81_D101_R2.2470.99
49_F82_H2.0870.98
36_I72_L2.0520.98
3_C38_C2.0040.97
136_A156_V1.9720.97
103_A108_D1.9390.97
74_H102_A1.8640.96
24_L29_C1.8200.95
57_L62_I1.8130.95
28_G83_C1.8010.95
82_H89_W1.7360.94
152_A156_V1.7270.93
89_W98_S1.7090.93
118_G121_F1.7040.93
16_T73_A1.6630.92
166_D169_P1.6580.92
78_H99_E1.6230.91
14_S69_E1.4840.87
22_E77_I1.4700.86
88_D94_H1.4670.86
114_E135_R1.4370.85
75_E99_E1.4300.85
75_E102_A1.4070.84
78_H139_S1.3720.82
22_E26_K1.3540.81
22_E33_P1.3330.80
87_V98_S1.3160.79
143_N146_C1.2920.78
115_L151_E1.2880.78
31_V80_Y1.2730.77
62_I68_V1.2730.77
154_K158_E1.2720.77
50_D53_L1.2680.77
100_I160_W1.2450.75
74_H99_E1.2440.75
96_A156_V1.2280.74
114_E134_R1.2260.74
132_V136_A1.2100.73
32_D83_C1.2020.73
80_Y168_R1.1820.71
134_R138_L1.1710.71
14_S20_L1.1560.70
148_D157_D1.1330.68
99_E102_A1.1290.68
99_E139_S1.1270.68
74_H139_S1.1270.68
103_A136_A1.1220.67
100_I163_C1.1210.67
79_A106_S1.0850.65
133_R160_W1.0630.63
6_M9_W1.0610.63
121_F124_F1.0450.62
60_N116_L1.0450.62
41_C60_N1.0430.62
11_L36_I1.0420.62
9_W13_Y1.0260.60
43_G124_F1.0180.60
23_A26_K1.0140.59
96_A136_A1.0060.59
40_P59_Q0.9920.58
78_H102_A0.9830.57
29_C32_D0.9800.57
17_V20_L0.9750.56
5_K12_K0.9710.56
127_Q130_E0.9470.54
147_K151_E0.9310.53
75_E139_S0.9300.53
93_R159_V0.9260.53
28_G79_A0.9220.52
106_S135_R0.9150.52
18_K22_E0.9140.52
21_L30_P0.9100.51
140_V143_N0.9030.51
68_V164_F0.9000.50
18_K25_K0.8970.50
100_I115_L0.8930.50
108_D135_R0.8920.50
158_E164_F0.8900.50
114_E127_Q0.8900.50
106_S114_E0.8860.49
128_H132_V0.8810.49
85_A168_R0.8810.49
131_C163_C0.8760.49
55_I142_A0.8760.49
19_F54_G0.8730.48
17_V73_A0.8690.48
9_W55_I0.8690.48
48_G72_L0.8670.48
102_A109_C0.8490.46
25_K30_P0.8460.46
64_S67_H0.8420.46
2_R5_K0.8310.45
32_D35_N0.8270.45
141_M149_D0.8270.45
31_V103_A0.8240.44
56_V103_A0.8230.44
129_Q164_F0.8180.44
91_N133_R0.8000.43
140_V146_C0.7990.42
117_R134_R0.7930.42
37_S80_Y0.7900.42
5_K9_W0.7890.42
10_L69_E0.7880.42
96_A152_A0.7750.41
101_R105_L0.7740.40
39_E50_D0.7720.40
108_D114_E0.7630.40
19_F161_D0.7550.39
36_I77_I0.7520.39
108_D117_R0.7490.39
12_K25_K0.7490.39
80_Y147_K0.7480.39
46_S67_H0.7440.38
12_K22_E0.7430.38
36_I61_H0.7380.38
7_V57_L0.7370.38
68_V72_L0.7330.37
38_C96_A0.7290.37
134_R144_P0.7230.37
20_L30_P0.7220.37
47_G71_T0.7200.36
17_V24_L0.7190.36
30_P76_L0.7160.36
148_D151_E0.7150.36
44_T137_I0.7100.36
112_K116_L0.7050.35
59_Q84_R0.7040.35
96_A140_V0.7040.35
42_D142_A0.7010.35
155_A158_E0.6900.34
10_L14_S0.6870.34
85_A124_F0.6850.34
71_T87_V0.6770.33
18_K168_R0.6770.33
126_K133_R0.6740.33
108_D143_N0.6710.33
67_H140_V0.6700.33
101_R109_C0.6700.33
81_D96_A0.6670.33
136_A152_A0.6660.33
52_E145_N0.6640.32
163_C169_P0.6630.32
113_R127_Q0.6630.32
54_G168_R0.6620.32
153_E162_S0.6610.32
104_N164_F0.6580.32
105_L135_R0.6570.32
138_L161_D0.6520.32
67_H113_R0.6520.32
149_D153_E0.6490.31
53_L112_K0.6480.31
9_W65_Q0.6440.31
43_G46_S0.6420.31
8_D91_N0.6410.31
99_E136_A0.6400.31
134_R143_N0.6390.31
2_R59_Q0.6380.31
136_A140_V0.6350.30
19_F95_H0.6340.30
15_P167_T0.6330.30
167_T170_F0.6310.30
35_N59_Q0.6280.30
11_L33_P0.6270.30
83_C103_A0.6250.30
63_R116_L0.6220.30
89_W104_N0.6180.29
126_K129_Q0.6170.29
28_G80_Y0.6160.29
48_G135_R0.6160.29
99_E109_C0.6140.29
140_V156_V0.6110.29
83_C163_C0.6090.29
55_I68_V0.6090.29
39_E56_V0.6060.28
2_R141_M0.6040.28
9_W12_K0.6040.28
92_L148_D0.6040.28
43_G165_N0.6030.28
7_V18_K0.6000.28
63_R67_H0.5980.28
35_N77_I0.5930.28
11_L21_L0.5930.28
6_M65_Q0.5900.27
55_I62_I0.5870.27
94_H135_R0.5790.27
162_S168_R0.5770.27
15_P57_L0.5760.27
57_L61_H0.5760.27
97_C100_I0.5740.26
153_E157_D0.5730.26
36_I162_S0.5730.26
20_L40_P0.5720.26
62_I164_F0.5690.26
24_L83_C0.5680.26
62_I113_R0.5670.26
12_K157_D0.5660.26
55_I141_M0.5620.26
32_D103_A0.5610.26
40_P55_I0.5600.26
43_G122_F0.5600.26
7_V93_R0.5570.25
95_H146_C0.5570.25
24_L80_Y0.5540.25
123_K130_E0.5540.25
92_L155_A0.5480.25
89_W95_H0.5470.25
5_K161_D0.5430.25
106_S170_F0.5430.25
44_T61_H0.5380.24
79_A135_R0.5380.24
19_F165_N0.5350.24
21_L40_P0.5330.24
51_P159_V0.5320.24
33_P165_N0.5310.24
42_D84_R0.5300.24
98_S101_R0.5300.24
81_D166_D0.5280.24
20_L77_I0.5260.24
68_V73_A0.5250.23
2_R13_Y0.5230.23
130_E165_N0.5180.23
141_M146_C0.5160.23
20_L51_P0.5160.23
105_L114_E0.5160.23
79_A102_A0.5130.23
133_R144_P0.5130.23
59_Q110_R0.5130.23
115_L165_N0.5080.23
67_H158_E0.5070.22
97_C109_C0.5060.22
60_N128_H0.5050.22
4_E40_P0.5050.22
71_T168_R0.5030.22
114_E117_R0.5020.22
7_V36_I0.5000.22
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2x3cA 2 0.6784 75.9 0.92 Contact Map
1g12A 1 0.6842 45.5 0.934 Contact Map
1eb6A 1 0.7135 40.7 0.936 Contact Map
3cqbA 4 0.5205 23.6 0.943 Contact Map
4jiuA 1 0.5906 14.4 0.949 Contact Map
4dv8A 1 0.8713 11.9 0.95 Contact Map
4jixA 2 0.6199 10.1 0.952 Contact Map
5a0rA 1 0.7076 6.4 0.956 Contact Map
1r1hA 1 0.848 4.7 0.959 Contact Map
4qhjA 2 0.5906 4.5 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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