Exosortase_EpsH - PFAM28P - GREMLIN Contacts

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Exosortase_EpsH - Transmembrane exosortase (Exosortase_EpsH)

PFAM:	PF09721	Sequences: AALLLALYWPTLAWLVRQWSTDEDYSHGFLVPPIALYLLWRRRRRARPPRPSWWGLLLLLLGLGLLLLLGRLGAELFLSRLSLVLLLAGLVLLLLGWRALRALAFPLLFLLFMVPLPAFLLNALTFPLQLLAAELAVALLRLLGIPVLREGNVIDLPGGTLEVAEACSGIRSLIALLALGLLYAYLFRRSLWRRALLLVLAAIPIAILANGLRIALLGLLAYYFGPEAAEGFFHDFAGWVFFVLALLLLFLLLWLL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	256 (250)
Sequences:	20015 (16505)
Seq/√Len:	1043.9
META:	0.94

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
20_S	29_F	3.488	1.00
42_R	45_R	3.234	1.00
155_D	160_T	3.178	1.00
143_L	215_A	2.894	1.00
190_S	193_R	2.855	1.00
135_L	211_G	2.715	1.00
132_A	214_I	2.649	1.00
95_L	99_A	2.612	1.00
137_V	149_R	2.568	1.00
98_R	101_R	2.513	1.00
134_E	138_A	2.414	1.00
39_L	103_L	2.413	1.00
109_F	178_A	2.407	1.00
130_L	134_E	2.310	1.00
201_A	252_L	2.164	1.00
137_V	141_R	2.159	1.00
180_G	202_A	2.140	1.00
9_W	13_A	2.097	1.00
88_A	100_L	2.080	1.00
105_F	185_Y	2.064	1.00
161_L	218_G	2.020	1.00
140_L	218_G	2.019	1.00
232_F	236_F	1.968	1.00
129_Q	165_E	1.915	1.00
138_A	142_L	1.908	1.00
139_L	215_A	1.902	1.00
92_L	97_W	1.878	1.00
12_L	83_L	1.854	1.00
13_A	17_R	1.780	1.00
37_Y	41_R	1.772	1.00
16_V	29_F	1.770	1.00
150_E	155_D	1.768	1.00
8_Y	82_S	1.765	1.00
181_L	199_V	1.763	1.00
92_L	100_L	1.736	1.00
45_R	102_A	1.665	1.00
191_L	194_R	1.662	1.00
134_E	149_R	1.638	1.00
137_V	154_I	1.638	1.00
17_R	21_T	1.611	1.00
29_F	33_P	1.565	1.00
71_R	79_S	1.564	1.00
126_F	130_L	1.560	1.00
191_L	196_L	1.555	1.00
40_W	43_R	1.551	1.00
34_I	182_L	1.546	1.00
162_E	165_E	1.535	1.00
123_A	127_P	1.521	1.00
220_L	224_F	1.508	1.00
219_L	223_Y	1.499	1.00
147_V	154_I	1.497	1.00
14_W	18_Q	1.493	1.00
133_A	149_R	1.484	1.00
14_W	17_R	1.475	1.00
31_V	178_A	1.443	1.00
130_L	152_N	1.423	1.00
109_F	182_L	1.420	1.00
239_W	243_V	1.408	1.00
97_W	101_R	1.402	1.00
133_A	152_N	1.396	1.00
208_L	211_G	1.366	1.00
139_L	211_G	1.361	1.00
138_A	141_R	1.359	1.00
70_G	73_G	1.355	1.00
99_A	102_A	1.344	1.00
104_A	108_L	1.343	1.00
24_D	171_R	1.335	1.00
50_R	53_W	1.321	1.00
141_R	147_V	1.319	1.00
67_L	71_R	1.319	1.00
91_V	107_L	1.318	1.00
98_R	102_A	1.317	1.00
137_V	147_V	1.303	1.00
158_G	222_Y	1.299	1.00
224_F	228_A	1.296	1.00
112_F	181_L	1.293	1.00
177_L	199_V	1.292	1.00
184_A	194_R	1.282	1.00
56_L	63_L	1.281	1.00
225_G	228_A	1.279	1.00
132_A	211_G	1.268	1.00
118_A	122_N	1.265	1.00
42_R	185_Y	1.264	1.00
4_L	83_L	1.260	1.00
62_G	85_L	1.260	1.00
100_L	104_A	1.250	1.00
6_A	9_W	1.226	1.00
148_L	155_D	1.223	1.00
220_L	228_A	1.202	1.00
145_I	219_L	1.197	1.00
184_A	199_V	1.187	1.00
10_P	14_W	1.174	1.00
35_A	39_L	1.166	1.00
77_F	80_R	1.160	1.00
69_L	72_L	1.155	1.00
91_V	100_L	1.154	1.00
183_Y	187_F	1.145	1.00
91_V	95_L	1.141	1.00
35_A	110_L	1.135	1.00
153_V	162_E	1.112	1.00
196_L	200_L	1.109	1.00
176_L	245_A	1.105	1.00
41_R	45_R	1.102	1.00
145_I	223_Y	1.101	1.00
52_S	97_W	1.097	1.00
49_P	54_W	1.095	1.00
49_P	52_S	1.093	1.00
176_L	202_A	1.089	1.00
42_R	102_A	1.082	1.00
139_L	143_L	1.081	1.00
85_L	88_A	1.069	1.00
10_P	13_A	1.068	1.00
198_L	253_L	1.066	1.00
75_E	78_L	1.065	1.00
36_L	40_W	1.059	1.00
140_L	145_I	1.056	1.00
16_V	20_S	1.056	1.00
156_L	222_Y	1.050	1.00
247_L	251_L	1.044	1.00
136_A	211_G	1.043	1.00
90_L	94_L	1.042	1.00
227_E	230_E	1.040	1.00
41_R	44_R	1.038	1.00
76_L	80_R	1.031	1.00
91_V	103_L	1.029	1.00
79_S	82_S	1.025	1.00
59_L	62_G	1.025	1.00
56_L	93_L	1.018	1.00
134_E	141_R	1.018	1.00
136_A	215_A	1.018	1.00
129_Q	152_N	1.017	1.00
18_Q	22_D	1.017	1.00
192_W	197_L	1.015	1.00
150_E	153_V	1.015	1.00
103_L	106_P	1.014	1.00
211_G	215_A	1.012	1.00
101_R	104_A	1.008	1.00
202_A	206_A	1.005	1.00
33_P	36_L	1.005	1.00
13_A	16_V	1.005	1.00
215_A	219_L	0.997	1.00
185_Y	194_R	0.996	1.00
49_P	53_W	0.991	1.00
177_L	203_I	0.989	1.00
76_L	79_S	0.989	1.00
11_T	79_S	0.979	1.00
131_L	207_I	0.976	1.00
149_R	154_I	0.975	1.00
68_L	72_L	0.972	1.00
192_W	196_L	0.972	1.00
208_L	212_L	0.970	1.00
58_L	62_G	0.969	1.00
209_A	245_A	0.966	1.00
112_F	178_A	0.963	1.00
136_A	214_I	0.963	1.00
153_V	160_T	0.962	1.00
131_L	135_L	0.957	1.00
180_G	249_L	0.956	1.00
11_T	15_L	0.956	1.00
100_L	107_L	0.942	1.00
176_L	206_A	0.940	1.00
6_A	10_P	0.939	1.00
134_E	137_V	0.939	1.00
131_L	134_E	0.937	1.00
31_V	109_F	0.934	1.00
233_F	237_A	0.932	1.00
44_R	47_R	0.923	1.00
85_L	89_G	0.919	1.00
67_L	70_G	0.918	1.00
3_L	7_L	0.909	1.00
68_L	71_R	0.907	1.00
189_R	193_R	0.894	1.00
229_A	232_F	0.893	1.00
62_G	86_L	0.891	1.00
60_L	63_L	0.887	1.00
127_P	131_L	0.886	1.00
19_W	28_G	0.886	1.00
77_F	81_L	0.883	1.00
205_I	245_A	0.883	1.00
48_P	51_P	0.882	1.00
183_Y	253_L	0.880	1.00
226_P	230_E	0.880	1.00
40_W	44_R	0.877	1.00
60_L	64_G	0.875	1.00
74_A	77_F	0.869	1.00
121_L	125_T	0.857	1.00
84_V	111_L	0.856	1.00
241_F	245_A	0.855	1.00
85_L	111_L	0.852	1.00
75_E	79_S	0.850	1.00
59_L	89_G	0.849	1.00
237_A	241_F	0.846	1.00
50_R	54_W	0.845	1.00
227_E	231_G	0.843	1.00
157_P	160_T	0.842	1.00
189_R	194_R	0.831	1.00
70_G	82_S	0.829	1.00
157_P	222_Y	0.827	1.00
216_L	237_A	0.824	1.00
230_E	235_D	0.824	1.00
229_A	233_F	0.824	1.00
51_P	54_W	0.824	1.00
46_A	49_P	0.820	1.00
216_L	220_L	0.818	1.00
4_L	86_L	0.817	1.00
119_F	123_A	0.813	1.00
18_Q	21_T	0.811	1.00
188_R	193_R	0.811	1.00
240_V	244_L	0.810	1.00
48_P	52_S	0.798	1.00
11_T	67_L	0.798	1.00
86_L	90_L	0.793	1.00
132_A	136_A	0.793	1.00
143_L	219_L	0.792	1.00
235_D	239_W	0.791	1.00
159_G	221_A	0.785	1.00
220_L	233_F	0.784	1.00
180_G	206_A	0.782	1.00
62_G	65_L	0.778	1.00
190_S	194_R	0.777	1.00
246_L	250_F	0.774	1.00
70_G	78_L	0.767	1.00
100_L	103_L	0.767	1.00
232_F	235_D	0.762	1.00
233_F	236_F	0.761	1.00
99_A	103_L	0.758	1.00
48_P	53_W	0.758	1.00
119_F	122_N	0.756	1.00
168_S	172_S	0.755	1.00
188_R	191_L	0.754	1.00
78_L	81_L	0.753	1.00
197_L	201_A	0.749	1.00
57_L	60_L	0.747	1.00
58_L	61_L	0.744	1.00
89_G	92_L	0.741	1.00
63_L	89_G	0.741	1.00
173_L	206_A	0.739	1.00
34_I	178_A	0.738	1.00
130_L	133_A	0.736	1.00
135_L	138_A	0.735	1.00
152_N	162_E	0.734	1.00
127_P	130_L	0.733	1.00
84_V	114_V	0.733	1.00
212_L	216_L	0.733	1.00
228_A	231_G	0.726	1.00
12_L	16_V	0.711	1.00
205_I	248_L	0.704	1.00
217_L	220_L	0.704	1.00
67_L	73_G	0.703	1.00
248_L	251_L	0.701	1.00
17_R	20_S	0.700	1.00
69_L	73_G	0.698	1.00
57_L	61_L	0.697	1.00
62_G	89_G	0.695	1.00
83_L	87_L	0.690	1.00
248_L	252_L	0.689	1.00
141_R	144_G	0.688	1.00
221_A	229_A	0.688	1.00
246_L	249_L	0.682	1.00
71_R	74_A	0.682	1.00
200_L	204_P	0.677	1.00
243_V	247_L	0.674	1.00
15_L	18_Q	0.673	1.00
67_L	79_S	0.670	1.00
82_S	86_L	0.667	1.00
193_R	197_L	0.665	1.00
131_L	211_G	0.661	1.00
8_Y	12_L	0.660	1.00
58_L	89_G	0.659	1.00
80_R	84_V	0.658	1.00
46_A	51_P	0.656	1.00
20_S	23_E	0.654	1.00
161_L	221_A	0.653	1.00
5_L	9_W	0.649	1.00
136_A	140_L	0.649	1.00
136_A	218_G	0.643	1.00
152_N	156_L	0.638	1.00
105_F	109_F	0.635	1.00
140_L	147_V	0.635	1.00
88_A	107_L	0.634	1.00
55_G	59_L	0.633	1.00
184_A	202_A	0.633	1.00
238_G	242_F	0.632	1.00
43_R	46_A	0.631	1.00
105_F	181_L	0.630	1.00
27_H	31_V	0.630	1.00
236_F	240_V	0.627	1.00
61_L	65_L	0.624	1.00
167_C	234_H	0.621	1.00
201_A	205_I	0.615	1.00
246_L	253_L	0.615	1.00
156_L	218_G	0.615	1.00
116_L	120_L	0.608	1.00
155_D	158_G	0.606	1.00
75_E	80_R	0.606	1.00
5_L	12_L	0.602	1.00
173_L	207_I	0.600	1.00
14_W	21_T	0.600	1.00
11_T	80_R	0.599	1.00
189_R	192_W	0.598	1.00
236_F	239_W	0.597	1.00
23_E	26_S	0.594	1.00
241_F	244_L	0.594	1.00
38_L	182_L	0.592	1.00
54_W	57_L	0.591	1.00
28_G	113_M	0.589	1.00
228_A	232_F	0.589	1.00
183_Y	250_F	0.588	1.00
135_L	139_L	0.585	1.00
147_V	156_L	0.582	1.00
88_A	92_L	0.581	1.00
132_A	169_G	0.581	1.00
8_Y	11_T	0.578	1.00
217_L	232_F	0.577	1.00
161_L	222_Y	0.576	1.00
74_A	79_S	0.575	1.00
56_L	59_L	0.574	1.00
96_G	100_L	0.574	1.00
59_L	63_L	0.574	1.00
167_C	210_N	0.572	1.00
216_L	233_F	0.571	1.00
217_L	229_A	0.571	1.00
36_L	39_L	0.570	1.00
231_G	235_D	0.570	1.00
129_Q	136_A	0.563	1.00
88_A	91_V	0.563	1.00
230_E	233_F	0.561	1.00
145_I	222_Y	0.559	1.00
245_A	249_L	0.556	1.00
55_G	63_L	0.553	1.00
210_N	213_R	0.552	1.00
242_F	245_A	0.550	1.00
216_L	241_F	0.549	1.00
118_A	121_L	0.545	1.00
91_V	99_A	0.543	1.00
222_Y	226_P	0.543	1.00
84_V	88_A	0.540	1.00
47_R	53_W	0.539	1.00
55_G	89_G	0.535	1.00
220_L	232_F	0.534	1.00
182_L	185_Y	0.533	1.00
221_A	230_E	0.533	1.00
39_L	43_R	0.530	1.00
163_V	214_I	0.529	1.00
249_L	253_L	0.527	1.00
11_T	14_W	0.522	1.00
72_L	75_E	0.522	1.00
140_L	215_A	0.519	1.00
32_P	113_M	0.518	1.00
221_A	226_P	0.517	1.00
49_P	95_L	0.517	1.00
207_I	211_G	0.515	1.00
66_L	69_L	0.515	1.00
172_S	175_A	0.515	1.00
48_P	98_R	0.514	1.00
136_A	163_V	0.513	1.00
49_P	99_A	0.513	1.00
109_F	113_M	0.513	1.00
57_L	62_G	0.512	1.00
175_A	179_L	0.512	1.00
16_V	19_W	0.511	1.00
171_R	175_A	0.509	1.00
79_S	83_L	0.509	1.00
209_A	241_F	0.509	1.00
206_A	209_A	0.507	1.00
14_W	76_L	0.506	1.00
156_L	159_G	0.505	1.00
239_W	245_A	0.505	1.00
155_D	159_G	0.505	1.00
56_L	64_G	0.504	1.00
68_L	73_G	0.503	1.00
5_L	8_Y	0.503	1.00
133_A	137_V	0.502	1.00
220_L	223_Y	0.501	1.00
66_L	85_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2jwaA	2	0.1719	4	0.943	Contact Map
2ks1B	1	0.168	3	0.946	Contact Map
1kf6D	2	0.2852	2.2	0.949	Contact Map
3orgA	2	0.2695	1.3	0.956	Contact Map
2l2tA	2	0.1641	1.1	0.958	Contact Map
2zxeA	1	0.2305	1	0.959	Contact Map
3ixzA	1	0.2305	0.9	0.96	Contact Map
2k1eA	3	0.375	0.9	0.96	Contact Map
1v54K	1	0.1055	0.9	0.96	Contact Map
4m64A	1	0.2695	0.9	0.96	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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