GREMLIN Database
Exosortase_EpsH - Transmembrane exosortase (Exosortase_EpsH)
PFAM: PF09721 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 256 (250)
Sequences: 20015 (16505)
Seq/√Len: 1043.9
META: 0.94

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_S29_F3.4881.00
42_R45_R3.2341.00
155_D160_T3.1781.00
143_L215_A2.8941.00
190_S193_R2.8551.00
135_L211_G2.7151.00
132_A214_I2.6491.00
95_L99_A2.6121.00
137_V149_R2.5681.00
98_R101_R2.5131.00
134_E138_A2.4141.00
39_L103_L2.4131.00
109_F178_A2.4071.00
130_L134_E2.3101.00
201_A252_L2.1641.00
137_V141_R2.1591.00
180_G202_A2.1401.00
9_W13_A2.0971.00
88_A100_L2.0801.00
105_F185_Y2.0641.00
161_L218_G2.0201.00
140_L218_G2.0191.00
232_F236_F1.9681.00
129_Q165_E1.9151.00
138_A142_L1.9081.00
139_L215_A1.9021.00
92_L97_W1.8781.00
12_L83_L1.8541.00
13_A17_R1.7801.00
37_Y41_R1.7721.00
16_V29_F1.7701.00
150_E155_D1.7681.00
8_Y82_S1.7651.00
181_L199_V1.7631.00
92_L100_L1.7361.00
45_R102_A1.6651.00
191_L194_R1.6621.00
134_E149_R1.6381.00
137_V154_I1.6381.00
17_R21_T1.6111.00
29_F33_P1.5651.00
71_R79_S1.5641.00
126_F130_L1.5601.00
191_L196_L1.5551.00
40_W43_R1.5511.00
34_I182_L1.5461.00
162_E165_E1.5351.00
123_A127_P1.5211.00
220_L224_F1.5081.00
219_L223_Y1.4991.00
147_V154_I1.4971.00
14_W18_Q1.4931.00
133_A149_R1.4841.00
14_W17_R1.4751.00
31_V178_A1.4431.00
130_L152_N1.4231.00
109_F182_L1.4201.00
239_W243_V1.4081.00
97_W101_R1.4021.00
133_A152_N1.3961.00
208_L211_G1.3661.00
139_L211_G1.3611.00
138_A141_R1.3591.00
70_G73_G1.3551.00
99_A102_A1.3441.00
104_A108_L1.3431.00
24_D171_R1.3351.00
50_R53_W1.3211.00
141_R147_V1.3191.00
67_L71_R1.3191.00
91_V107_L1.3181.00
98_R102_A1.3171.00
137_V147_V1.3031.00
158_G222_Y1.2991.00
224_F228_A1.2961.00
112_F181_L1.2931.00
177_L199_V1.2921.00
184_A194_R1.2821.00
56_L63_L1.2811.00
225_G228_A1.2791.00
132_A211_G1.2681.00
118_A122_N1.2651.00
42_R185_Y1.2641.00
4_L83_L1.2601.00
62_G85_L1.2601.00
100_L104_A1.2501.00
6_A9_W1.2261.00
148_L155_D1.2231.00
220_L228_A1.2021.00
145_I219_L1.1971.00
184_A199_V1.1871.00
10_P14_W1.1741.00
35_A39_L1.1661.00
77_F80_R1.1601.00
69_L72_L1.1551.00
91_V100_L1.1541.00
183_Y187_F1.1451.00
91_V95_L1.1411.00
35_A110_L1.1351.00
153_V162_E1.1121.00
196_L200_L1.1091.00
176_L245_A1.1051.00
41_R45_R1.1021.00
145_I223_Y1.1011.00
52_S97_W1.0971.00
49_P54_W1.0951.00
49_P52_S1.0931.00
176_L202_A1.0891.00
42_R102_A1.0821.00
139_L143_L1.0811.00
85_L88_A1.0691.00
10_P13_A1.0681.00
198_L253_L1.0661.00
75_E78_L1.0651.00
36_L40_W1.0591.00
140_L145_I1.0561.00
16_V20_S1.0561.00
156_L222_Y1.0501.00
247_L251_L1.0441.00
136_A211_G1.0431.00
90_L94_L1.0421.00
227_E230_E1.0401.00
41_R44_R1.0381.00
76_L80_R1.0311.00
91_V103_L1.0291.00
79_S82_S1.0251.00
59_L62_G1.0251.00
56_L93_L1.0181.00
134_E141_R1.0181.00
136_A215_A1.0181.00
129_Q152_N1.0171.00
18_Q22_D1.0171.00
192_W197_L1.0151.00
150_E153_V1.0151.00
103_L106_P1.0141.00
211_G215_A1.0121.00
101_R104_A1.0081.00
202_A206_A1.0051.00
33_P36_L1.0051.00
13_A16_V1.0051.00
215_A219_L0.9971.00
185_Y194_R0.9961.00
49_P53_W0.9911.00
177_L203_I0.9891.00
76_L79_S0.9891.00
11_T79_S0.9791.00
131_L207_I0.9761.00
149_R154_I0.9751.00
68_L72_L0.9721.00
192_W196_L0.9721.00
208_L212_L0.9701.00
58_L62_G0.9691.00
209_A245_A0.9661.00
112_F178_A0.9631.00
136_A214_I0.9631.00
153_V160_T0.9621.00
131_L135_L0.9571.00
180_G249_L0.9561.00
11_T15_L0.9561.00
100_L107_L0.9421.00
176_L206_A0.9401.00
6_A10_P0.9391.00
134_E137_V0.9391.00
131_L134_E0.9371.00
31_V109_F0.9341.00
233_F237_A0.9321.00
44_R47_R0.9231.00
85_L89_G0.9191.00
67_L70_G0.9181.00
3_L7_L0.9091.00
68_L71_R0.9071.00
189_R193_R0.8941.00
229_A232_F0.8931.00
62_G86_L0.8911.00
60_L63_L0.8871.00
127_P131_L0.8861.00
19_W28_G0.8861.00
77_F81_L0.8831.00
205_I245_A0.8831.00
48_P51_P0.8821.00
183_Y253_L0.8801.00
226_P230_E0.8801.00
40_W44_R0.8771.00
60_L64_G0.8751.00
74_A77_F0.8691.00
121_L125_T0.8571.00
84_V111_L0.8561.00
241_F245_A0.8551.00
85_L111_L0.8521.00
75_E79_S0.8501.00
59_L89_G0.8491.00
237_A241_F0.8461.00
50_R54_W0.8451.00
227_E231_G0.8431.00
157_P160_T0.8421.00
189_R194_R0.8311.00
70_G82_S0.8291.00
157_P222_Y0.8271.00
216_L237_A0.8241.00
230_E235_D0.8241.00
229_A233_F0.8241.00
51_P54_W0.8241.00
46_A49_P0.8201.00
216_L220_L0.8181.00
4_L86_L0.8171.00
119_F123_A0.8131.00
18_Q21_T0.8111.00
188_R193_R0.8111.00
240_V244_L0.8101.00
48_P52_S0.7981.00
11_T67_L0.7981.00
86_L90_L0.7931.00
132_A136_A0.7931.00
143_L219_L0.7921.00
235_D239_W0.7911.00
159_G221_A0.7851.00
220_L233_F0.7841.00
180_G206_A0.7821.00
62_G65_L0.7781.00
190_S194_R0.7771.00
246_L250_F0.7741.00
70_G78_L0.7671.00
100_L103_L0.7671.00
232_F235_D0.7621.00
233_F236_F0.7611.00
99_A103_L0.7581.00
48_P53_W0.7581.00
119_F122_N0.7561.00
168_S172_S0.7551.00
188_R191_L0.7541.00
78_L81_L0.7531.00
197_L201_A0.7491.00
57_L60_L0.7471.00
58_L61_L0.7441.00
89_G92_L0.7411.00
63_L89_G0.7411.00
173_L206_A0.7391.00
34_I178_A0.7381.00
130_L133_A0.7361.00
135_L138_A0.7351.00
152_N162_E0.7341.00
127_P130_L0.7331.00
84_V114_V0.7331.00
212_L216_L0.7331.00
228_A231_G0.7261.00
12_L16_V0.7111.00
205_I248_L0.7041.00
217_L220_L0.7041.00
67_L73_G0.7031.00
248_L251_L0.7011.00
17_R20_S0.7001.00
69_L73_G0.6981.00
57_L61_L0.6971.00
62_G89_G0.6951.00
83_L87_L0.6901.00
248_L252_L0.6891.00
141_R144_G0.6881.00
221_A229_A0.6881.00
246_L249_L0.6821.00
71_R74_A0.6821.00
200_L204_P0.6771.00
243_V247_L0.6741.00
15_L18_Q0.6731.00
67_L79_S0.6701.00
82_S86_L0.6671.00
193_R197_L0.6651.00
131_L211_G0.6611.00
8_Y12_L0.6601.00
58_L89_G0.6591.00
80_R84_V0.6581.00
46_A51_P0.6561.00
20_S23_E0.6541.00
161_L221_A0.6531.00
5_L9_W0.6491.00
136_A140_L0.6491.00
136_A218_G0.6431.00
152_N156_L0.6381.00
105_F109_F0.6351.00
140_L147_V0.6351.00
88_A107_L0.6341.00
55_G59_L0.6331.00
184_A202_A0.6331.00
238_G242_F0.6321.00
43_R46_A0.6311.00
105_F181_L0.6301.00
27_H31_V0.6301.00
236_F240_V0.6271.00
61_L65_L0.6241.00
167_C234_H0.6211.00
201_A205_I0.6151.00
246_L253_L0.6151.00
156_L218_G0.6151.00
116_L120_L0.6081.00
155_D158_G0.6061.00
75_E80_R0.6061.00
5_L12_L0.6021.00
173_L207_I0.6001.00
14_W21_T0.6001.00
11_T80_R0.5991.00
189_R192_W0.5981.00
236_F239_W0.5971.00
23_E26_S0.5941.00
241_F244_L0.5941.00
38_L182_L0.5921.00
54_W57_L0.5911.00
28_G113_M0.5891.00
228_A232_F0.5891.00
183_Y250_F0.5881.00
135_L139_L0.5851.00
147_V156_L0.5821.00
88_A92_L0.5811.00
132_A169_G0.5811.00
8_Y11_T0.5781.00
217_L232_F0.5771.00
161_L222_Y0.5761.00
74_A79_S0.5751.00
56_L59_L0.5741.00
96_G100_L0.5741.00
59_L63_L0.5741.00
167_C210_N0.5721.00
216_L233_F0.5711.00
217_L229_A0.5711.00
36_L39_L0.5701.00
231_G235_D0.5701.00
129_Q136_A0.5631.00
88_A91_V0.5631.00
230_E233_F0.5611.00
145_I222_Y0.5591.00
245_A249_L0.5561.00
55_G63_L0.5531.00
210_N213_R0.5521.00
242_F245_A0.5501.00
216_L241_F0.5491.00
118_A121_L0.5451.00
91_V99_A0.5431.00
222_Y226_P0.5431.00
84_V88_A0.5401.00
47_R53_W0.5391.00
55_G89_G0.5351.00
220_L232_F0.5341.00
182_L185_Y0.5331.00
221_A230_E0.5331.00
39_L43_R0.5301.00
163_V214_I0.5291.00
249_L253_L0.5271.00
11_T14_W0.5221.00
72_L75_E0.5221.00
140_L215_A0.5191.00
32_P113_M0.5181.00
221_A226_P0.5171.00
49_P95_L0.5171.00
207_I211_G0.5151.00
66_L69_L0.5151.00
172_S175_A0.5151.00
48_P98_R0.5141.00
136_A163_V0.5131.00
49_P99_A0.5131.00
109_F113_M0.5131.00
57_L62_G0.5121.00
175_A179_L0.5121.00
16_V19_W0.5111.00
171_R175_A0.5091.00
79_S83_L0.5091.00
209_A241_F0.5091.00
206_A209_A0.5071.00
14_W76_L0.5061.00
156_L159_G0.5051.00
239_W245_A0.5051.00
155_D159_G0.5051.00
56_L64_G0.5041.00
68_L73_G0.5031.00
5_L8_Y0.5031.00
133_A137_V0.5021.00
220_L223_Y0.5011.00
66_L85_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2jwaA 2 0.1719 4 0.943 Contact Map
2ks1B 1 0.168 3 0.946 Contact Map
1kf6D 2 0.2852 2.2 0.949 Contact Map
3orgA 2 0.2695 1.3 0.956 Contact Map
2l2tA 2 0.1641 1.1 0.958 Contact Map
2zxeA 1 0.2305 1 0.959 Contact Map
3ixzA 1 0.2305 0.9 0.96 Contact Map
2k1eA 3 0.375 0.9 0.96 Contact Map
1v54K 1 0.1055 0.9 0.96 Contact Map
4m64A 1 0.2695 0.9 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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