GREMLIN Database
Unstab_antitox - Putative addiction module component
PFAM: PF09720 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 54 (53)
Sequences: 48616 (32113)
Seq/√Len: 4411.1
META: 0.983

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_L42_D2.9421.00
41_L48_G2.1971.00
39_A43_A2.1771.00
7_R17_S2.1201.00
40_E45_P2.1071.00
33_E36_R1.7511.00
11_A18_L1.7401.00
27_E30_W1.6921.00
31_A34_L1.6891.00
49_I53_E1.6641.00
31_A35_E1.6141.00
3_P6_E1.5391.00
40_E46_V1.4841.00
33_E37_R1.3951.00
11_A15_W1.3621.00
9_E13_E1.3531.00
12_E16_D1.3431.00
50_P53_E1.2751.00
30_W34_L1.2671.00
8_A18_L1.2091.00
38_L41_L1.2081.00
28_A32_A1.1371.00
49_I54_V1.1221.00
21_E24_P1.1091.00
10_L14_L1.0921.00
40_E44_G1.0781.00
26_V30_W1.0351.00
32_A36_R1.0081.00
35_E38_L1.0051.00
28_A31_A0.9681.00
44_G47_K0.9671.00
36_R40_E0.9591.00
30_W33_E0.9501.00
9_E12_E0.9101.00
41_L46_V0.9021.00
31_A38_L0.8891.00
13_E16_D0.8851.00
34_L38_L0.8841.00
8_A15_W0.8741.00
35_E39_A0.8641.00
8_A12_E0.8631.00
22_A25_E0.8551.00
21_E25_E0.8421.00
12_E15_W0.8341.00
2_L10_L0.8201.00
4_P7_R0.7941.00
29_A33_E0.7561.00
40_E43_A0.7551.00
11_A14_L0.7501.00
41_L47_K0.7461.00
26_V31_A0.7331.00
39_A42_D0.7201.00
10_L13_E0.7021.00
29_A32_A0.7001.00
32_A35_E0.6891.00
4_P18_L0.6571.00
51_W54_V0.6521.00
27_E31_A0.6461.00
10_L17_S0.6461.00
8_A11_A0.6361.00
4_P37_R0.6321.00
36_R39_A0.6311.00
25_E28_A0.6301.00
5_E9_E0.6191.00
49_I52_E0.6191.00
13_E51_W0.6011.00
6_E9_E0.5971.00
15_W19_D0.5941.00
16_D19_D0.5881.00
26_V34_L0.5731.00
11_A17_S0.5691.00
24_P30_W0.5661.00
45_P48_G0.5611.00
4_P19_D0.5411.00
42_D45_P0.5351.00
13_E17_S0.5271.00
41_L44_G0.5261.00
23_D26_V0.5251.00
12_E19_D0.5021.00
34_L51_W0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bqhA 1 0.9074 11 0.784 Contact Map
1dtlA 1 0.6667 9 0.792 Contact Map
1nyaA 1 0.537 7.1 0.802 Contact Map
4n5xA 1 0.4259 6.2 0.807 Contact Map
3j04B 1 0.537 6 0.808 Contact Map
1wdcC 1 0.537 6 0.808 Contact Map
2mysC 1 0.7593 5.6 0.811 Contact Map
2lhiA 1 0.9815 5.5 0.811 Contact Map
2kgrA 1 0.9815 5.5 0.811 Contact Map
2je6I 3 0.3704 5.4 0.812 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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