GREMLIN Database
CPW_WPC - Plasmodium falciparum domain of unknown function (CPW_WPC)
PFAM: PF09717 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 59 (58)
Sequences: 674 (564)
Seq/√Len: 74.1
META: 0.375

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
1_C58_C3.8091.00
31_C52_C2.9861.00
13_W24_P2.9861.00
48_W54_V2.6531.00
41_T44_E2.6041.00
3_R49_A2.0781.00
5_Y49_A2.0241.00
23_A32_G1.8861.00
37_F48_W1.7861.00
40_M44_E1.7641.00
47_A51_K1.6451.00
27_Y30_P1.6391.00
27_Y31_C1.6381.00
35_I48_W1.6181.00
49_A55_S1.5910.99
23_A27_Y1.5040.99
4_D7_A1.3410.98
44_E56_W1.2350.97
12_G57_P1.2320.97
43_E47_A1.2000.96
7_A56_W1.1120.94
25_S37_F1.1090.94
9_C21_C1.0900.93
33_R53_G1.0810.93
31_C45_K1.0720.93
11_E57_P1.0380.92
24_P27_Y1.0020.90
20_T39_N1.0020.90
22_V39_N0.9720.89
3_R22_V0.9700.89
32_G35_I0.9550.88
3_R55_S0.9510.88
4_D19_G0.9230.86
13_W54_V0.9180.86
48_W53_G0.8780.83
16_G20_T0.8590.82
17_G41_T0.8220.79
49_A54_V0.8210.79
12_G51_K0.8170.79
14_T38_S0.7930.76
13_W48_W0.7830.76
25_S34_K0.7790.75
5_Y46_K0.7600.73
20_T33_R0.7370.71
16_G19_G0.7290.70
16_G34_K0.7100.68
42_P46_K0.7040.68
28_N39_N0.6940.66
3_R13_W0.6890.66
46_K49_A0.6760.64
21_C45_K0.6750.64
16_G22_V0.6710.64
26_S53_G0.6610.63
43_E46_K0.6540.62
26_S45_K0.6460.61
7_A46_K0.6460.61
11_E48_W0.6440.61
12_G32_G0.6360.60
15_E25_S0.6310.59
45_K52_C0.6240.58
1_C6_S0.6160.57
15_E18_G0.6140.57
29_G54_V0.6070.56
15_E39_N0.6030.56
27_Y54_V0.5940.55
15_E47_A0.5930.54
46_K50_K0.5920.54
27_Y37_F0.5840.53
1_C15_E0.5660.51
18_G39_N0.5630.51
43_E55_S0.5520.49
20_T34_K0.5430.48
21_C31_C0.5420.48
18_G33_R0.5410.48
12_G46_K0.5400.48
11_E19_G0.5370.47
8_P20_T0.5330.47
45_K49_A0.5300.47
8_P40_M0.5250.46
5_Y43_E0.5240.46
2_E51_K0.5180.45
2_E5_Y0.5120.44
8_P44_E0.5080.44
24_P33_R0.5040.43
6_S18_G0.5010.43
2_E50_K0.5000.43
17_G56_W0.5000.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3v64C 1 0.4915 15.9 0.838 Contact Map
3s94A 1 0.4068 7.4 0.86 Contact Map
1ijqA 1 0.3898 5.4 0.869 Contact Map
1b1vA 1 0.3898 4.5 0.874 Contact Map
1ahlA 1 0.4915 4.1 0.876 Contact Map
3u2sG 1 0.7458 3.9 0.878 Contact Map
3p5bL 1 0.4237 3.7 0.878 Contact Map
3v65B 1 0.3898 3.4 0.881 Contact Map
1bhpA 3 0.2542 2.9 0.885 Contact Map
4xlwB 2 0.7119 2.7 0.887 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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