Cas_Csd1 - PFAM28P - GREMLIN Contacts

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Cas_Csd1 - CRISPR-associated protein (Cas_Csd1)

PFAM:	PF09709	Sequences: LYEYYERLAADGESLPPPGHSTKKISFEIVLDEDGNFLGVIEDLEGKGKKKPRPRTVPQSVKRTSGIAPNFLWDKLEYVLGDDKKGKKHEAFKELLEEWLEESPDDHPGLKAVLAFLEKWDPEKAEKPPIFKELKEELLDGANVVFRVEGDGDLVHEDPAVREAWIRYYASKLSEEGEEDTGLCLVTGEEAPIARLHPKIKGAQSSGAKLVSFNDDAFTSYGRKEQGENAPVSEEAAFKYTTALNWLLASRQRIRIGDATVVFWAESGDEAEDLFADLFDPDDEAVRKLLEAIRGGRPPDLDPDTRFYVLGLSPNAGRLSVRFWREGTFGEFLERIAQWFEDLAIVRPPKKEPGAPSLWRLLRATANGKGKSDNIPPNLAGRLLRAILDGTPYPRDLLQAALRRIRADQGEWEKTLGINYLRAALIKAYLNRNYRLKEEITMSLDEENTNRAYLLGRLFAVLEKIQEDALGINATIADRYYGAASATPASVFPTLLRLLQHHLAKLRKEKPGLAVNLEKLIGEIMDKLDDEFPAHLNLELQGRFALGYYHQRQAFF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	556 (544)
Sequences:	3494 (3058)
Seq/√Len:	131.1
META:	0.775

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
32_D	36_N	6.599	1.00
461_V	524_I	4.195	1.00
182_G	193_I	4.175	1.00
203_A	208_A	3.796	1.00
464_K	468_D	3.746	1.00
97_E	118_E	3.655	1.00
97_E	114_L	3.487	1.00
109_G	158_D	3.348	1.00
191_A	233_S	3.156	1.00
233_S	236_A	3.082	1.00
94_E	98_E	3.081	1.00
63_R	74_D	3.066	1.00
67_I	91_A	3.011	1.00
2_Y	6_E	2.894	1.00
215_D	218_F	2.850	1.00
113_V	155_V	2.818	1.00
468_D	513_L	2.810	1.00
454_L	527_K	2.706	1.00
515_V	519_K	2.672	1.00
465_I	521_I	2.655	1.00
339_W	393_Y	2.632	1.00
481_Y	545_A	2.615	1.00
444_L	457_R	2.579	1.00
342_D	432_R	2.544	1.00
106_D	158_D	2.537	1.00
187_T	236_A	2.532	1.00
462_L	496_L	2.523	1.00
446_E	523_E	2.500	1.00
327_G	331_E	2.384	1.00
89_H	93_K	2.331	1.00
445_D	448_N	2.293	1.00
250_S	253_R	2.251	1.00
198_P	237_A	2.242	1.00
537_N	540_L	2.202	1.00
449_T	527_K	2.170	1.00
238_F	242_T	2.160	1.00
356_P	421_L	2.151	1.00
109_G	148_V	2.092	1.00
6_E	239_K	2.068	1.00
163_E	167_R	2.053	1.00
463_E	548_Y	2.051	1.00
457_R	551_Q	2.044	1.00
62_K	199_K	2.044	1.00
468_D	517_L	2.039	1.00
111_K	115_A	2.020	1.00
449_T	454_L	2.008	1.00
90_E	94_E	1.995	1.00
522_G	549_Y	1.995	1.00
458_L	521_I	1.968	1.00
197_H	240_Y	1.965	1.00
338_Q	342_D	1.953	1.00
20_H	166_I	1.953	1.00
214_N	219_T	1.951	1.00
343_L	361_L	1.933	1.00
446_E	554_A	1.933	1.00
194_A	234_E	1.927	1.00
151_D	158_D	1.902	1.00
450_N	540_L	1.897	1.00
29_I	37_F	1.891	1.00
210_L	321_V	1.875	1.00
341_E	344_A	1.872	1.00
513_L	516_N	1.867	1.00
512_G	516_N	1.840	1.00
65_S	68_A	1.839	1.00
512_G	515_V	1.837	1.00
426_I	542_G	1.835	1.00
204_Q	207_G	1.818	1.00
513_L	517_L	1.808	1.00
209_K	212_S	1.807	1.00
61_V	70_N	1.806	1.00
365_T	401_A	1.802	1.00
287_R	291_E	1.794	1.00
216_D	219_T	1.793	1.00
493_P	497_R	1.787	1.00
444_L	551_Q	1.770	1.00
325_R	389_D	1.767	1.00
25_I	73_W	1.767	1.00
464_K	555_F	1.762	1.00
357_S	360_R	1.754	1.00
36_N	119_K	1.750	1.00
79_V	92_F	1.737	1.00
450_N	543_R	1.737	1.00
454_L	524_I	1.731	1.00
115_A	118_E	1.721	1.00
337_A	341_E	1.716	1.00
77_E	88_K	1.713	1.00
198_P	207_G	1.713	1.00
60_S	70_N	1.702	1.00
110_L	161_V	1.700	1.00
32_D	38_L	1.678	1.00
465_I	517_L	1.677	1.00
61_V	68_A	1.676	1.00
369_K	374_N	1.671	1.00
408_D	422_R	1.664	1.00
510_K	513_L	1.662	1.00
184_C	236_A	1.659	1.00
522_G	552_R	1.652	1.00
213_F	230_A	1.635	1.00
83_D	86_G	1.621	1.00
154_L	157_E	1.621	1.00
33_E	108_P	1.604	1.00
213_F	229_N	1.601	1.00
358_L	387_I	1.595	1.00
474_A	479_R	1.594	1.00
128_P	131_F	1.592	1.00
67_I	78_Y	1.590	1.00
382_R	396_D	1.580	1.00
30_V	39_G	1.574	1.00
496_L	549_Y	1.565	1.00
552_R	556_F	1.561	1.00
335_R	390_G	1.551	1.00
219_T	225_E	1.549	1.00
71_F	165_W	1.544	1.00
145_V	156_H	1.539	1.00
446_E	520_L	1.531	1.00
451_R	528_L	1.528	1.00
406_R	544_F	1.521	1.00
532_F	542_G	1.519	1.00
448_N	454_L	1.514	1.00
28_E	154_L	1.502	1.00
308_Y	324_W	1.491	1.00
121_D	124_K	1.468	1.00
187_T	233_S	1.461	1.00
29_I	80_L	1.448	1.00
465_I	506_L	1.438	1.00
100_L	110_L	1.432	1.00
203_A	207_G	1.430	1.00
345_I	423_A	1.423	1.00
75_K	88_K	1.414	1.00
28_E	147_R	1.405	1.00
371_K	374_N	1.405	1.00
92_F	117_L	1.399	1.00
335_R	338_Q	1.398	1.00
465_I	503_L	1.391	1.00
59_Q	196_L	1.391	1.00
35_G	112_A	1.382	1.00
189_E	235_E	1.382	1.00
472_I	475_T	1.381	1.00
359_W	372_S	1.380	1.00
259_A	313_S	1.372	1.00
464_K	517_L	1.366	1.00
274_L	278_L	1.362	1.00
159_P	163_E	1.354	1.00
266_E	306_R	1.351	1.00
64_T	67_I	1.344	1.00
67_I	88_K	1.336	1.00
62_K	196_L	1.328	1.00
461_V	520_L	1.327	1.00
451_R	454_L	1.327	1.00
195_R	228_E	1.317	1.00
343_L	428_A	1.314	1.00
516_N	520_L	1.313	1.00
510_K	516_N	1.313	1.00
467_E	471_G	1.305	1.00
106_D	160_A	1.305	1.00
516_N	519_K	1.300	1.00
37_F	40_V	1.296	1.00
215_D	219_T	1.294	1.00
522_G	553_Q	1.292	1.00
27_F	43_D	1.289	1.00
499_L	521_I	1.281	1.00
344_A	442_M	1.279	1.00
64_T	68_A	1.278	1.00
464_K	556_F	1.278	1.00
3_E	6_E	1.277	1.00
465_I	499_L	1.274	1.00
460_A	552_R	1.271	1.00
497_R	544_F	1.271	1.00
476_I	498_L	1.265	1.00
401_A	425_L	1.258	1.00
106_D	109_G	1.248	1.00
461_V	555_F	1.246	1.00
522_G	526_D	1.243	1.00
83_D	87_K	1.243	1.00
91_A	94_E	1.238	1.00
2_Y	239_K	1.238	1.00
487_T	490_S	1.235	1.00
372_S	375_I	1.234	1.00
214_N	217_A	1.233	1.00
367_N	370_G	1.230	1.00
69_P	74_D	1.224	1.00
347_R	354_G	1.217	1.00
131_F	134_L	1.215	1.00
331_E	335_R	1.213	1.00
464_K	467_E	1.210	1.00
398_L	426_I	1.206	0.99
338_Q	435_R	1.205	0.99
365_T	400_A	1.203	0.99
368_G	371_K	1.201	0.99
145_V	154_L	1.196	0.99
97_E	101_E	1.194	0.99
63_R	78_Y	1.191	0.99
235_E	239_K	1.190	0.99
525_M	546_L	1.184	0.99
428_A	432_R	1.182	0.99
519_K	523_E	1.181	0.99
342_D	435_R	1.179	0.99
286_V	289_L	1.175	0.99
94_E	97_E	1.174	0.99
484_A	492_F	1.173	0.99
464_K	513_L	1.169	0.99
33_E	149_E	1.165	0.99
476_I	495_L	1.165	0.99
360_R	363_R	1.158	0.99
52_P	55_R	1.143	0.99
194_A	237_A	1.142	0.99
137_E	140_D	1.140	0.99
95_L	98_E	1.137	0.99
93_K	97_E	1.133	0.99
306_R	326_E	1.129	0.99
79_V	144_V	1.127	0.99
366_A	375_I	1.123	0.99
76_L	144_V	1.122	0.99
244_L	262_V	1.118	0.99
29_I	79_V	1.118	0.99
185_L	231_P	1.114	0.99
364_A	419_N	1.112	0.99
429_Y	433_N	1.109	0.99
28_E	145_V	1.109	0.99
520_L	551_Q	1.105	0.99
501_H	504_A	1.102	0.99
525_M	532_F	1.100	0.99
369_K	372_S	1.089	0.99
275_F	279_F	1.089	0.99
477_A	500_Q	1.089	0.99
348_P	351_K	1.086	0.99
498_L	501_H	1.084	0.99
291_E	294_R	1.083	0.99
444_L	453_Y	1.082	0.99
454_L	528_L	1.082	0.99
517_L	520_L	1.077	0.99
65_S	69_P	1.075	0.99
183_L	190_E	1.073	0.99
368_G	374_N	1.073	0.99
450_N	454_L	1.072	0.99
256_I	261_V	1.069	0.99
478_D	504_A	1.069	0.99
30_V	147_R	1.069	0.99
342_D	431_N	1.061	0.99
338_Q	390_G	1.058	0.99
130_I	133_E	1.056	0.99
500_Q	518_E	1.055	0.99
80_L	144_V	1.055	0.99
540_L	543_R	1.054	0.99
467_E	552_R	1.052	0.99
69_P	91_A	1.049	0.99
92_F	96_L	1.048	0.99
462_L	476_I	1.047	0.99
288_K	291_E	1.047	0.99
6_E	235_E	1.046	0.99
63_R	68_A	1.045	0.99
526_D	553_Q	1.045	0.99
197_H	232_V	1.043	0.99
408_D	419_N	1.041	0.98
198_P	241_T	1.041	0.98
209_K	227_G	1.034	0.98
139_L	142_A	1.033	0.98
120_W	128_P	1.032	0.98
224_K	228_E	1.030	0.98
114_L	118_E	1.026	0.98
69_P	95_L	1.025	0.98
216_D	220_S	1.023	0.98
385_R	389_D	1.021	0.98
201_K	206_S	1.021	0.98
523_E	526_D	1.020	0.98
203_A	206_S	1.017	0.98
129_P	132_K	1.015	0.98
399_Q	403_R	1.015	0.98
342_D	428_A	1.011	0.98
506_L	514_A	1.011	0.98
147_R	154_L	1.010	0.98
201_K	207_G	1.008	0.98
448_N	543_R	1.006	0.98
225_E	228_E	1.005	0.98
273_D	276_A	1.004	0.98
506_L	517_L	1.002	0.98
255_R	260_T	1.000	0.98
492_F	532_F	0.998	0.98
511_P	514_A	0.997	0.98
271_A	274_L	0.995	0.98
489_A	534_A	0.994	0.98
503_L	514_A	0.993	0.98
60_S	64_T	0.991	0.98
447_E	527_K	0.991	0.98
255_R	261_V	0.991	0.98
311_G	323_F	0.989	0.98
163_E	166_I	0.985	0.98
525_M	528_L	0.982	0.98
63_R	69_P	0.981	0.98
16_P	22_T	0.980	0.98
11_D	14_S	0.977	0.98
34_D	115_A	0.976	0.98
95_L	99_W	0.976	0.98
196_L	226_Q	0.975	0.98
462_L	492_F	0.973	0.98
62_K	209_K	0.972	0.98
22_T	56_T	0.970	0.98
334_E	338_Q	0.965	0.98
359_W	363_R	0.963	0.97
521_I	525_M	0.959	0.97
60_S	63_R	0.953	0.97
552_R	555_F	0.952	0.97
398_L	402_L	0.952	0.97
124_K	127_K	0.949	0.97
201_K	245_N	0.949	0.97
340_F	355_A	0.944	0.97
155_V	161_V	0.941	0.97
120_W	125_A	0.940	0.97
504_A	508_K	0.939	0.97
99_W	164_A	0.938	0.97
293_I	337_A	0.937	0.97
392_P	433_N	0.937	0.97
398_L	542_G	0.937	0.97
277_D	281_P	0.935	0.97
506_L	513_L	0.930	0.97
479_R	483_A	0.929	0.97
503_L	506_L	0.926	0.97
463_E	552_R	0.925	0.97
384_L	388_L	0.924	0.97
31_L	37_F	0.924	0.97
3_E	266_E	0.923	0.97
448_N	530_D	0.923	0.97
366_A	374_N	0.922	0.97
148_V	158_D	0.921	0.97
371_K	375_I	0.919	0.97
195_R	226_Q	0.919	0.97
237_A	241_T	0.916	0.97
272_E	278_L	0.915	0.97
471_G	475_T	0.912	0.97
96_L	100_L	0.907	0.96
528_L	534_A	0.906	0.96
111_K	114_L	0.904	0.96
485_S	545_A	0.904	0.96
272_E	277_D	0.903	0.96
122_P	125_A	0.901	0.96
500_Q	503_L	0.900	0.96
481_Y	485_S	0.899	0.96
63_R	67_I	0.896	0.96
520_L	555_F	0.894	0.96
405_I	422_R	0.892	0.96
193_I	231_P	0.892	0.96
246_W	249_A	0.889	0.96
395_R	433_N	0.888	0.96
211_V	232_V	0.888	0.96
213_F	226_Q	0.885	0.96
368_G	373_D	0.884	0.96
485_S	497_R	0.884	0.96
15_L	246_W	0.884	0.96
255_R	259_A	0.883	0.96
45_E	48_G	0.883	0.96
266_E	308_Y	0.881	0.96
199_K	207_G	0.878	0.96
53_R	56_T	0.877	0.96
39_G	42_E	0.877	0.96
226_Q	229_N	0.876	0.96
483_A	487_T	0.872	0.96
196_L	227_G	0.870	0.95
497_R	501_H	0.869	0.95
395_R	399_Q	0.867	0.95
199_K	209_K	0.866	0.95
1_L	5_Y	0.863	0.95
397_L	425_L	0.861	0.95
469_A	472_I	0.860	0.95
9_A	13_E	0.856	0.95
103_S	164_A	0.856	0.95
467_E	556_F	0.854	0.95
192_P	234_E	0.854	0.95
93_K	96_L	0.853	0.95
503_L	518_E	0.851	0.95
261_V	323_F	0.851	0.95
159_P	162_R	0.851	0.95
398_L	429_Y	0.849	0.95
47_K	50_K	0.848	0.95
131_F	135_K	0.848	0.95
513_L	520_L	0.847	0.95
490_S	494_T	0.844	0.95
347_R	350_K	0.844	0.95
462_L	499_L	0.841	0.95
474_A	504_A	0.840	0.94
148_V	151_D	0.838	0.94
348_P	352_E	0.835	0.94
191_A	235_E	0.834	0.94
518_E	552_R	0.832	0.94
398_L	425_L	0.832	0.94
310_L	321_V	0.829	0.94
4_Y	8_L	0.829	0.94
455_L	489_A	0.828	0.94
98_E	172_K	0.827	0.94
520_L	523_E	0.826	0.94
370_G	374_N	0.826	0.94
202_G	205_S	0.826	0.94
30_V	149_E	0.824	0.94
361_L	421_L	0.824	0.94
306_R	328_T	0.823	0.94
267_S	305_T	0.822	0.94
128_P	132_K	0.822	0.94
200_I	245_N	0.821	0.94
46_G	49_K	0.821	0.94
126_E	129_P	0.820	0.94
365_T	376_P	0.820	0.94
494_T	498_L	0.819	0.94
410_G	417_G	0.819	0.94
553_Q	556_F	0.818	0.94
473_N	478_D	0.816	0.94
363_R	372_S	0.816	0.94
214_N	221_Y	0.813	0.93
234_E	238_F	0.813	0.93
208_A	319_L	0.812	0.93
533_P	536_L	0.812	0.93
196_L	209_K	0.810	0.93
71_F	95_L	0.810	0.93
65_S	78_Y	0.810	0.93
395_R	429_Y	0.808	0.93
383_L	425_L	0.807	0.93
493_P	542_G	0.804	0.93
199_K	202_G	0.804	0.93
470_L	498_L	0.803	0.93
343_L	424_A	0.802	0.93
8_L	15_L	0.802	0.93
386_A	391_T	0.800	0.93
508_K	512_G	0.799	0.93
274_L	279_F	0.798	0.93
186_V	236_A	0.796	0.93
308_Y	326_E	0.795	0.93
471_G	474_A	0.794	0.93
137_E	141_G	0.793	0.93
448_N	452_A	0.792	0.93
25_I	145_V	0.792	0.93
433_N	539_E	0.791	0.93
248_L	260_T	0.790	0.92
458_L	524_I	0.787	0.92
62_K	70_N	0.786	0.92
314_P	320_S	0.786	0.92
496_L	525_M	0.786	0.92
327_G	330_G	0.780	0.92
60_S	73_W	0.777	0.92
362_L	379_L	0.777	0.92
216_D	224_K	0.777	0.92
366_A	369_K	0.771	0.92
463_E	478_D	0.770	0.92
28_E	44_L	0.770	0.92
75_K	143_N	0.769	0.91
50_K	54_P	0.768	0.91
390_G	432_R	0.768	0.91
215_D	221_Y	0.767	0.91
470_L	474_A	0.767	0.91
130_I	134_L	0.765	0.91
204_Q	212_S	0.765	0.91
414_K	417_G	0.762	0.91
64_T	91_A	0.761	0.91
21_S	60_S	0.761	0.91
99_W	110_L	0.760	0.91
261_V	384_L	0.760	0.91
109_G	155_V	0.759	0.91
327_G	332_F	0.759	0.91
452_A	541_Q	0.758	0.91
506_L	515_V	0.756	0.91
370_G	373_D	0.754	0.91
507_R	518_E	0.754	0.91
523_E	527_K	0.752	0.91
430_L	440_I	0.752	0.91
331_E	334_E	0.751	0.90
248_L	262_V	0.750	0.90
346_V	351_K	0.749	0.90
255_R	258_D	0.747	0.90
477_A	481_Y	0.747	0.90
368_G	375_I	0.747	0.90
39_G	149_E	0.746	0.90
400_A	403_R	0.744	0.90
64_T	70_N	0.742	0.90
109_G	151_D	0.742	0.90
138_L	141_G	0.742	0.90
414_K	418_I	0.741	0.90
464_K	520_L	0.739	0.90
98_E	168_Y	0.737	0.90
459_F	477_A	0.737	0.90
73_W	155_V	0.734	0.89
24_K	54_P	0.733	0.89
472_I	478_D	0.731	0.89
480_Y	494_T	0.729	0.89
523_E	553_Q	0.728	0.89
312_L	321_V	0.728	0.89
113_V	161_V	0.728	0.89
25_I	60_S	0.727	0.89
377_P	381_G	0.725	0.89
179_E	190_E	0.724	0.89
449_T	529_D	0.723	0.89
356_P	420_Y	0.722	0.89
475_T	478_D	0.722	0.89
26_S	44_L	0.721	0.89
511_P	515_V	0.721	0.89
520_L	527_K	0.720	0.89
307_F	332_F	0.720	0.89
438_E	441_T	0.719	0.88
365_T	397_L	0.718	0.88
438_E	442_M	0.717	0.88
52_P	56_T	0.717	0.88
128_P	134_L	0.717	0.88
204_Q	208_A	0.717	0.88
33_E	36_N	0.717	0.88
65_S	204_Q	0.715	0.88
127_K	132_K	0.715	0.88
468_D	510_K	0.714	0.88
105_D	111_K	0.713	0.88
74_D	79_V	0.712	0.88
24_K	53_R	0.709	0.88
452_A	536_L	0.706	0.88
481_Y	542_G	0.703	0.87
199_K	205_S	0.701	0.87
266_E	326_E	0.700	0.87
485_S	493_P	0.700	0.87
405_I	408_D	0.700	0.87
274_L	277_D	0.699	0.87
209_K	241_T	0.697	0.87
110_L	114_L	0.696	0.87
19_G	234_E	0.696	0.87
486_A	497_R	0.695	0.87
59_Q	64_T	0.694	0.87
362_L	375_I	0.694	0.87
100_L	114_L	0.693	0.87
342_D	433_N	0.693	0.87
61_V	64_T	0.693	0.87
23_K	57_V	0.693	0.87
95_L	165_W	0.690	0.86
204_Q	209_K	0.688	0.86
23_K	199_K	0.687	0.86
131_F	139_L	0.686	0.86
364_A	421_L	0.686	0.86
499_L	502_H	0.686	0.86
313_S	322_R	0.685	0.86
369_K	373_D	0.685	0.86
68_A	88_K	0.684	0.86
496_L	499_L	0.682	0.86
368_G	372_S	0.682	0.86
4_Y	7_R	0.681	0.86
489_A	493_P	0.680	0.86
206_S	316_A	0.679	0.85
102_E	114_L	0.679	0.85
202_G	207_G	0.678	0.85
309_V	388_L	0.677	0.85
510_K	514_A	0.676	0.85
1_L	7_R	0.675	0.85
211_V	240_Y	0.675	0.85
149_E	152_G	0.675	0.85
468_D	516_N	0.675	0.85
465_I	514_A	0.674	0.85
103_S	106_D	0.673	0.85
497_R	500_Q	0.673	0.85
462_L	479_R	0.671	0.85
106_D	111_K	0.670	0.85
276_A	280_D	0.669	0.85
99_W	168_Y	0.669	0.85
494_T	497_R	0.666	0.84
498_L	505_K	0.666	0.84
443_S	526_D	0.666	0.84
101_E	118_E	0.665	0.84
503_L	521_I	0.661	0.84
345_I	424_A	0.659	0.84
197_H	237_A	0.659	0.84
21_S	57_V	0.658	0.84
378_N	382_R	0.658	0.84
108_P	111_K	0.658	0.84
364_A	408_D	0.657	0.84
23_K	26_S	0.657	0.84
8_L	13_E	0.656	0.83
323_F	389_D	0.655	0.83
364_A	401_A	0.655	0.83
63_R	75_K	0.654	0.83
28_E	42_E	0.653	0.83
468_D	506_L	0.651	0.83
204_Q	316_A	0.650	0.83
10_A	14_S	0.649	0.83
56_T	145_V	0.649	0.83
62_K	215_D	0.648	0.83
536_L	541_Q	0.648	0.83
31_L	116_F	0.647	0.83
453_Y	457_R	0.643	0.82
23_K	60_S	0.642	0.82
150_G	153_D	0.642	0.82
404_R	408_D	0.642	0.82
373_D	376_P	0.641	0.82
503_L	517_L	0.639	0.82
61_V	65_S	0.639	0.82
24_K	56_T	0.638	0.82
97_E	102_E	0.638	0.82
393_Y	432_R	0.638	0.82
66_G	69_P	0.637	0.82
507_R	514_A	0.636	0.82
246_W	250_S	0.636	0.82
496_L	500_Q	0.635	0.81
167_R	189_E	0.634	0.81
21_S	24_K	0.633	0.81
57_V	73_W	0.632	0.81
18_P	234_E	0.632	0.81
30_V	38_L	0.632	0.81
40_V	48_G	0.630	0.81
65_S	70_N	0.630	0.81
276_A	279_F	0.630	0.81
201_K	205_S	0.629	0.81
203_A	319_L	0.628	0.81
2_Y	235_E	0.627	0.81
470_L	473_N	0.626	0.81
17_P	166_I	0.626	0.81
344_A	354_G	0.626	0.81
511_P	516_N	0.626	0.81
2_Y	236_A	0.625	0.80
474_A	478_D	0.625	0.80
335_R	388_L	0.624	0.80
361_L	425_L	0.623	0.80
9_A	14_S	0.623	0.80
498_L	502_H	0.623	0.80
136_E	139_L	0.622	0.80
164_A	168_Y	0.622	0.80
462_L	501_H	0.622	0.80
519_K	556_F	0.622	0.80
26_S	142_A	0.621	0.80
402_L	426_I	0.620	0.80
514_A	518_E	0.620	0.80
259_A	311_G	0.620	0.80
100_L	111_K	0.619	0.80
347_R	352_E	0.618	0.80
292_A	297_R	0.617	0.80
84_K	87_K	0.617	0.80
83_D	88_K	0.617	0.80
110_L	113_V	0.616	0.79
27_F	142_A	0.615	0.79
46_G	50_K	0.615	0.79
520_L	554_A	0.614	0.79
401_A	405_I	0.614	0.79
179_E	192_P	0.614	0.79
431_N	440_I	0.614	0.79
338_Q	341_E	0.613	0.79
275_F	280_D	0.613	0.79
461_V	517_L	0.612	0.79
67_I	70_N	0.611	0.79
42_E	147_R	0.610	0.79
478_D	544_F	0.610	0.79
316_A	320_S	0.610	0.79
167_R	171_S	0.610	0.79
378_N	381_G	0.607	0.79
8_L	11_D	0.607	0.79
65_S	91_A	0.606	0.78
19_G	170_A	0.606	0.78
199_K	206_S	0.605	0.78
100_L	103_S	0.605	0.78
27_F	42_E	0.604	0.78
195_R	227_G	0.603	0.78
205_S	208_A	0.603	0.78
466_Q	476_I	0.600	0.78
148_V	155_V	0.600	0.78
62_K	75_K	0.598	0.77
45_E	52_P	0.598	0.77
278_L	281_P	0.598	0.77
134_L	138_L	0.597	0.77
127_K	130_I	0.594	0.77
78_Y	89_H	0.593	0.77
464_K	516_N	0.593	0.77
477_A	499_L	0.592	0.77
167_R	170_A	0.591	0.77
194_A	197_H	0.591	0.77
6_E	10_A	0.590	0.77
215_D	226_Q	0.590	0.77
201_K	214_N	0.588	0.76
68_A	91_A	0.587	0.76
187_T	191_A	0.586	0.76
468_D	556_F	0.586	0.76
202_G	316_A	0.586	0.76
202_G	206_S	0.586	0.76
206_S	209_K	0.586	0.76
357_S	363_R	0.585	0.76
75_K	214_N	0.584	0.76
44_L	54_P	0.584	0.76
426_I	430_L	0.583	0.76
96_L	114_L	0.583	0.76
48_G	52_P	0.583	0.76
434_Y	437_K	0.581	0.75
66_G	78_Y	0.580	0.75
515_V	556_F	0.578	0.75
340_F	358_L	0.578	0.75
466_Q	502_H	0.576	0.75
7_R	11_D	0.575	0.75
380_A	383_L	0.574	0.75
440_I	546_L	0.573	0.74
3_E	7_R	0.571	0.74
63_R	70_N	0.571	0.74
60_S	67_I	0.571	0.74
128_P	135_K	0.570	0.74
2_Y	187_T	0.570	0.74
91_A	95_L	0.570	0.74
157_E	162_R	0.569	0.74
59_Q	62_K	0.568	0.74
224_K	227_G	0.566	0.74
358_L	362_L	0.566	0.74
45_E	49_K	0.566	0.74
196_L	199_K	0.565	0.73
275_F	278_L	0.565	0.73
531_E	535_H	0.565	0.73
534_A	539_E	0.565	0.73
215_D	225_E	0.564	0.73
325_R	332_F	0.564	0.73
528_L	550_H	0.560	0.73
10_A	13_E	0.560	0.73
466_Q	473_N	0.558	0.73
506_L	510_K	0.558	0.73
489_A	539_E	0.557	0.72
309_V	332_F	0.557	0.72
203_A	209_K	0.557	0.72
88_K	91_A	0.557	0.72
61_V	67_I	0.556	0.72
495_L	502_H	0.556	0.72
70_N	317_G	0.555	0.72
214_N	218_F	0.554	0.72
261_V	311_G	0.554	0.72
339_W	342_D	0.553	0.72
467_E	555_F	0.553	0.72
193_I	197_H	0.553	0.72
469_A	506_L	0.553	0.72
67_I	75_K	0.552	0.72
370_G	408_D	0.550	0.71
479_R	501_H	0.549	0.71
362_L	380_A	0.549	0.71
245_N	248_L	0.548	0.71
201_K	217_A	0.548	0.71
184_C	187_T	0.548	0.71
57_V	145_V	0.548	0.71
162_R	166_I	0.547	0.71
352_E	355_A	0.546	0.71
85_K	88_K	0.545	0.71
11_D	15_L	0.545	0.71
263_F	287_R	0.545	0.71
59_Q	63_R	0.545	0.71
241_T	317_G	0.544	0.71
25_I	28_E	0.543	0.70
186_V	232_V	0.543	0.70
9_A	12_G	0.542	0.70
200_I	319_L	0.542	0.70
261_V	322_R	0.542	0.70
443_S	550_H	0.539	0.70
328_T	331_E	0.539	0.70
96_L	113_V	0.538	0.70
191_A	236_A	0.538	0.70
21_S	199_K	0.537	0.70
165_W	168_Y	0.537	0.70
199_K	203_A	0.535	0.69
363_R	368_G	0.535	0.69
59_Q	237_A	0.533	0.69
77_E	85_K	0.532	0.69
500_Q	505_K	0.532	0.69
265_A	269_D	0.532	0.69
496_L	532_F	0.531	0.69
361_L	397_L	0.531	0.69
515_V	553_Q	0.531	0.69
438_E	450_N	0.530	0.69
272_E	276_A	0.529	0.69
354_G	360_R	0.529	0.69
201_K	204_Q	0.529	0.69
545_A	549_Y	0.528	0.68
461_V	464_K	0.528	0.68
402_L	542_G	0.528	0.68
291_E	295_G	0.527	0.68
383_L	397_L	0.527	0.68
71_F	99_W	0.527	0.68
542_G	549_Y	0.525	0.68
445_D	530_D	0.525	0.68
18_P	169_Y	0.525	0.68
436_L	440_I	0.524	0.68
109_G	112_A	0.524	0.68
440_I	543_R	0.523	0.68
433_N	436_L	0.523	0.68
74_D	78_Y	0.521	0.67
344_A	355_A	0.521	0.67
19_G	169_Y	0.521	0.67
63_R	199_K	0.520	0.67
323_F	426_I	0.520	0.67
455_L	533_P	0.519	0.67
105_D	108_P	0.519	0.67
121_D	125_A	0.519	0.67
76_L	142_A	0.518	0.67
367_N	374_N	0.518	0.67
134_L	139_L	0.517	0.67
375_I	379_L	0.516	0.67
89_H	96_L	0.516	0.67
469_A	473_N	0.516	0.67
47_K	53_R	0.515	0.66
327_G	335_R	0.515	0.66
272_E	275_F	0.514	0.66
198_P	203_A	0.512	0.66
410_G	419_N	0.512	0.66
515_V	518_E	0.512	0.66
484_A	532_F	0.511	0.66
200_I	207_G	0.511	0.66
2_Y	233_S	0.511	0.66
516_N	523_E	0.511	0.66
153_D	157_E	0.510	0.66
64_T	78_Y	0.510	0.66
485_S	536_L	0.510	0.66
390_G	469_A	0.509	0.66
70_N	73_W	0.508	0.65
46_G	52_P	0.508	0.65
217_A	221_Y	0.508	0.65
98_E	159_P	0.507	0.65
68_A	95_L	0.506	0.65
59_Q	68_A	0.506	0.65
269_D	305_T	0.506	0.65
160_A	164_A	0.506	0.65
401_A	422_R	0.505	0.65
90_E	97_E	0.505	0.65
404_R	407_A	0.504	0.65
29_I	144_V	0.504	0.65
109_G	160_A	0.503	0.65
539_E	543_R	0.503	0.65
518_E	525_M	0.502	0.65
340_F	357_S	0.502	0.65
293_I	296_G	0.501	0.64
444_L	550_H	0.501	0.64
259_A	381_G	0.500	0.64

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2p25A	2	0.0755	17.4	0.979	Contact Map
2a4xA	2	0.0845	12.3	0.981	Contact Map
2qqzA	2	0.0791	12.1	0.981	Contact Map
1twuA	2	0.0881	11.6	0.981	Contact Map
2mc8A	1	0.0755	11.5	0.981	Contact Map
1ecsA	2	0.0809	11.2	0.981	Contact Map
1u6lA	2	0.0809	10.9	0.981	Contact Map
3rheA	2	0.0773	10.2	0.981	Contact Map
3r6aA	2	0.0881	9.6	0.982	Contact Map
4n04A	2	0.0791	9.5	0.982	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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