GREMLIN Database
Cas_Csd1 - CRISPR-associated protein (Cas_Csd1)
PFAM: PF09709 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 556 (544)
Sequences: 3494 (3058)
Seq/√Len: 131.1
META: 0.775

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_D36_N6.5991.00
461_V524_I4.1951.00
182_G193_I4.1751.00
203_A208_A3.7961.00
464_K468_D3.7461.00
97_E118_E3.6551.00
97_E114_L3.4871.00
109_G158_D3.3481.00
191_A233_S3.1561.00
233_S236_A3.0821.00
94_E98_E3.0811.00
63_R74_D3.0661.00
67_I91_A3.0111.00
2_Y6_E2.8941.00
215_D218_F2.8501.00
113_V155_V2.8181.00
468_D513_L2.8101.00
454_L527_K2.7061.00
515_V519_K2.6721.00
465_I521_I2.6551.00
339_W393_Y2.6321.00
481_Y545_A2.6151.00
444_L457_R2.5791.00
342_D432_R2.5441.00
106_D158_D2.5371.00
187_T236_A2.5321.00
462_L496_L2.5231.00
446_E523_E2.5001.00
327_G331_E2.3841.00
89_H93_K2.3311.00
445_D448_N2.2931.00
250_S253_R2.2511.00
198_P237_A2.2421.00
537_N540_L2.2021.00
449_T527_K2.1701.00
238_F242_T2.1601.00
356_P421_L2.1511.00
109_G148_V2.0921.00
6_E239_K2.0681.00
163_E167_R2.0531.00
463_E548_Y2.0511.00
457_R551_Q2.0441.00
62_K199_K2.0441.00
468_D517_L2.0391.00
111_K115_A2.0201.00
449_T454_L2.0081.00
90_E94_E1.9951.00
522_G549_Y1.9951.00
458_L521_I1.9681.00
197_H240_Y1.9651.00
338_Q342_D1.9531.00
20_H166_I1.9531.00
214_N219_T1.9511.00
343_L361_L1.9331.00
446_E554_A1.9331.00
194_A234_E1.9271.00
151_D158_D1.9021.00
450_N540_L1.8971.00
29_I37_F1.8911.00
210_L321_V1.8751.00
341_E344_A1.8721.00
513_L516_N1.8671.00
512_G516_N1.8401.00
65_S68_A1.8391.00
512_G515_V1.8371.00
426_I542_G1.8351.00
204_Q207_G1.8181.00
513_L517_L1.8081.00
209_K212_S1.8071.00
61_V70_N1.8061.00
365_T401_A1.8021.00
287_R291_E1.7941.00
216_D219_T1.7931.00
493_P497_R1.7871.00
444_L551_Q1.7701.00
325_R389_D1.7671.00
25_I73_W1.7671.00
464_K555_F1.7621.00
357_S360_R1.7541.00
36_N119_K1.7501.00
79_V92_F1.7371.00
450_N543_R1.7371.00
454_L524_I1.7311.00
115_A118_E1.7211.00
337_A341_E1.7161.00
77_E88_K1.7131.00
198_P207_G1.7131.00
60_S70_N1.7021.00
110_L161_V1.7001.00
32_D38_L1.6781.00
465_I517_L1.6771.00
61_V68_A1.6761.00
369_K374_N1.6711.00
408_D422_R1.6641.00
510_K513_L1.6621.00
184_C236_A1.6591.00
522_G552_R1.6521.00
213_F230_A1.6351.00
83_D86_G1.6211.00
154_L157_E1.6211.00
33_E108_P1.6041.00
213_F229_N1.6011.00
358_L387_I1.5951.00
474_A479_R1.5941.00
128_P131_F1.5921.00
67_I78_Y1.5901.00
382_R396_D1.5801.00
30_V39_G1.5741.00
496_L549_Y1.5651.00
552_R556_F1.5611.00
335_R390_G1.5511.00
219_T225_E1.5491.00
71_F165_W1.5441.00
145_V156_H1.5391.00
446_E520_L1.5311.00
451_R528_L1.5281.00
406_R544_F1.5211.00
532_F542_G1.5191.00
448_N454_L1.5141.00
28_E154_L1.5021.00
308_Y324_W1.4911.00
121_D124_K1.4681.00
187_T233_S1.4611.00
29_I80_L1.4481.00
465_I506_L1.4381.00
100_L110_L1.4321.00
203_A207_G1.4301.00
345_I423_A1.4231.00
75_K88_K1.4141.00
28_E147_R1.4051.00
371_K374_N1.4051.00
92_F117_L1.3991.00
335_R338_Q1.3981.00
465_I503_L1.3911.00
59_Q196_L1.3911.00
35_G112_A1.3821.00
189_E235_E1.3821.00
472_I475_T1.3811.00
359_W372_S1.3801.00
259_A313_S1.3721.00
464_K517_L1.3661.00
274_L278_L1.3621.00
159_P163_E1.3541.00
266_E306_R1.3511.00
64_T67_I1.3441.00
67_I88_K1.3361.00
62_K196_L1.3281.00
461_V520_L1.3271.00
451_R454_L1.3271.00
195_R228_E1.3171.00
343_L428_A1.3141.00
516_N520_L1.3131.00
510_K516_N1.3131.00
467_E471_G1.3051.00
106_D160_A1.3051.00
516_N519_K1.3001.00
37_F40_V1.2961.00
215_D219_T1.2941.00
522_G553_Q1.2921.00
27_F43_D1.2891.00
499_L521_I1.2811.00
344_A442_M1.2791.00
64_T68_A1.2781.00
464_K556_F1.2781.00
3_E6_E1.2771.00
465_I499_L1.2741.00
460_A552_R1.2711.00
497_R544_F1.2711.00
476_I498_L1.2651.00
401_A425_L1.2581.00
106_D109_G1.2481.00
461_V555_F1.2461.00
522_G526_D1.2431.00
83_D87_K1.2431.00
91_A94_E1.2381.00
2_Y239_K1.2381.00
487_T490_S1.2351.00
372_S375_I1.2341.00
214_N217_A1.2331.00
367_N370_G1.2301.00
69_P74_D1.2241.00
347_R354_G1.2171.00
131_F134_L1.2151.00
331_E335_R1.2131.00
464_K467_E1.2101.00
398_L426_I1.2060.99
338_Q435_R1.2050.99
365_T400_A1.2030.99
368_G371_K1.2010.99
145_V154_L1.1960.99
97_E101_E1.1940.99
63_R78_Y1.1910.99
235_E239_K1.1900.99
525_M546_L1.1840.99
428_A432_R1.1820.99
519_K523_E1.1810.99
342_D435_R1.1790.99
286_V289_L1.1750.99
94_E97_E1.1740.99
484_A492_F1.1730.99
464_K513_L1.1690.99
33_E149_E1.1650.99
476_I495_L1.1650.99
360_R363_R1.1580.99
52_P55_R1.1430.99
194_A237_A1.1420.99
137_E140_D1.1400.99
95_L98_E1.1370.99
93_K97_E1.1330.99
306_R326_E1.1290.99
79_V144_V1.1270.99
366_A375_I1.1230.99
76_L144_V1.1220.99
244_L262_V1.1180.99
29_I79_V1.1180.99
185_L231_P1.1140.99
364_A419_N1.1120.99
429_Y433_N1.1090.99
28_E145_V1.1090.99
520_L551_Q1.1050.99
501_H504_A1.1020.99
525_M532_F1.1000.99
369_K372_S1.0890.99
275_F279_F1.0890.99
477_A500_Q1.0890.99
348_P351_K1.0860.99
498_L501_H1.0840.99
291_E294_R1.0830.99
444_L453_Y1.0820.99
454_L528_L1.0820.99
517_L520_L1.0770.99
65_S69_P1.0750.99
183_L190_E1.0730.99
368_G374_N1.0730.99
450_N454_L1.0720.99
256_I261_V1.0690.99
478_D504_A1.0690.99
30_V147_R1.0690.99
342_D431_N1.0610.99
338_Q390_G1.0580.99
130_I133_E1.0560.99
500_Q518_E1.0550.99
80_L144_V1.0550.99
540_L543_R1.0540.99
467_E552_R1.0520.99
69_P91_A1.0490.99
92_F96_L1.0480.99
462_L476_I1.0470.99
288_K291_E1.0470.99
6_E235_E1.0460.99
63_R68_A1.0450.99
526_D553_Q1.0450.99
197_H232_V1.0430.99
408_D419_N1.0410.98
198_P241_T1.0410.98
209_K227_G1.0340.98
139_L142_A1.0330.98
120_W128_P1.0320.98
224_K228_E1.0300.98
114_L118_E1.0260.98
69_P95_L1.0250.98
216_D220_S1.0230.98
385_R389_D1.0210.98
201_K206_S1.0210.98
523_E526_D1.0200.98
203_A206_S1.0170.98
129_P132_K1.0150.98
399_Q403_R1.0150.98
342_D428_A1.0110.98
506_L514_A1.0110.98
147_R154_L1.0100.98
201_K207_G1.0080.98
448_N543_R1.0060.98
225_E228_E1.0050.98
273_D276_A1.0040.98
506_L517_L1.0020.98
255_R260_T1.0000.98
492_F532_F0.9980.98
511_P514_A0.9970.98
271_A274_L0.9950.98
489_A534_A0.9940.98
503_L514_A0.9930.98
60_S64_T0.9910.98
447_E527_K0.9910.98
255_R261_V0.9910.98
311_G323_F0.9890.98
163_E166_I0.9850.98
525_M528_L0.9820.98
63_R69_P0.9810.98
16_P22_T0.9800.98
11_D14_S0.9770.98
34_D115_A0.9760.98
95_L99_W0.9760.98
196_L226_Q0.9750.98
462_L492_F0.9730.98
62_K209_K0.9720.98
22_T56_T0.9700.98
334_E338_Q0.9650.98
359_W363_R0.9630.97
521_I525_M0.9590.97
60_S63_R0.9530.97
552_R555_F0.9520.97
398_L402_L0.9520.97
124_K127_K0.9490.97
201_K245_N0.9490.97
340_F355_A0.9440.97
155_V161_V0.9410.97
120_W125_A0.9400.97
504_A508_K0.9390.97
99_W164_A0.9380.97
293_I337_A0.9370.97
392_P433_N0.9370.97
398_L542_G0.9370.97
277_D281_P0.9350.97
506_L513_L0.9300.97
479_R483_A0.9290.97
503_L506_L0.9260.97
463_E552_R0.9250.97
384_L388_L0.9240.97
31_L37_F0.9240.97
3_E266_E0.9230.97
448_N530_D0.9230.97
366_A374_N0.9220.97
148_V158_D0.9210.97
371_K375_I0.9190.97
195_R226_Q0.9190.97
237_A241_T0.9160.97
272_E278_L0.9150.97
471_G475_T0.9120.97
96_L100_L0.9070.96
528_L534_A0.9060.96
111_K114_L0.9040.96
485_S545_A0.9040.96
272_E277_D0.9030.96
122_P125_A0.9010.96
500_Q503_L0.9000.96
481_Y485_S0.8990.96
63_R67_I0.8960.96
520_L555_F0.8940.96
405_I422_R0.8920.96
193_I231_P0.8920.96
246_W249_A0.8890.96
395_R433_N0.8880.96
211_V232_V0.8880.96
213_F226_Q0.8850.96
368_G373_D0.8840.96
485_S497_R0.8840.96
15_L246_W0.8840.96
255_R259_A0.8830.96
45_E48_G0.8830.96
266_E308_Y0.8810.96
199_K207_G0.8780.96
53_R56_T0.8770.96
39_G42_E0.8770.96
226_Q229_N0.8760.96
483_A487_T0.8720.96
196_L227_G0.8700.95
497_R501_H0.8690.95
395_R399_Q0.8670.95
199_K209_K0.8660.95
1_L5_Y0.8630.95
397_L425_L0.8610.95
469_A472_I0.8600.95
9_A13_E0.8560.95
103_S164_A0.8560.95
467_E556_F0.8540.95
192_P234_E0.8540.95
93_K96_L0.8530.95
503_L518_E0.8510.95
261_V323_F0.8510.95
159_P162_R0.8510.95
398_L429_Y0.8490.95
47_K50_K0.8480.95
131_F135_K0.8480.95
513_L520_L0.8470.95
490_S494_T0.8440.95
347_R350_K0.8440.95
462_L499_L0.8410.95
474_A504_A0.8400.94
148_V151_D0.8380.94
348_P352_E0.8350.94
191_A235_E0.8340.94
518_E552_R0.8320.94
398_L425_L0.8320.94
310_L321_V0.8290.94
4_Y8_L0.8290.94
455_L489_A0.8280.94
98_E172_K0.8270.94
520_L523_E0.8260.94
370_G374_N0.8260.94
202_G205_S0.8260.94
30_V149_E0.8240.94
361_L421_L0.8240.94
306_R328_T0.8230.94
267_S305_T0.8220.94
128_P132_K0.8220.94
200_I245_N0.8210.94
46_G49_K0.8210.94
126_E129_P0.8200.94
365_T376_P0.8200.94
494_T498_L0.8190.94
410_G417_G0.8190.94
553_Q556_F0.8180.94
473_N478_D0.8160.94
363_R372_S0.8160.94
214_N221_Y0.8130.93
234_E238_F0.8130.93
208_A319_L0.8120.93
533_P536_L0.8120.93
196_L209_K0.8100.93
71_F95_L0.8100.93
65_S78_Y0.8100.93
395_R429_Y0.8080.93
383_L425_L0.8070.93
493_P542_G0.8040.93
199_K202_G0.8040.93
470_L498_L0.8030.93
343_L424_A0.8020.93
8_L15_L0.8020.93
386_A391_T0.8000.93
508_K512_G0.7990.93
274_L279_F0.7980.93
186_V236_A0.7960.93
308_Y326_E0.7950.93
471_G474_A0.7940.93
137_E141_G0.7930.93
448_N452_A0.7920.93
25_I145_V0.7920.93
433_N539_E0.7910.93
248_L260_T0.7900.92
458_L524_I0.7870.92
62_K70_N0.7860.92
314_P320_S0.7860.92
496_L525_M0.7860.92
327_G330_G0.7800.92
60_S73_W0.7770.92
362_L379_L0.7770.92
216_D224_K0.7770.92
366_A369_K0.7710.92
463_E478_D0.7700.92
28_E44_L0.7700.92
75_K143_N0.7690.91
50_K54_P0.7680.91
390_G432_R0.7680.91
215_D221_Y0.7670.91
470_L474_A0.7670.91
130_I134_L0.7650.91
204_Q212_S0.7650.91
414_K417_G0.7620.91
64_T91_A0.7610.91
21_S60_S0.7610.91
99_W110_L0.7600.91
261_V384_L0.7600.91
109_G155_V0.7590.91
327_G332_F0.7590.91
452_A541_Q0.7580.91
506_L515_V0.7560.91
370_G373_D0.7540.91
507_R518_E0.7540.91
523_E527_K0.7520.91
430_L440_I0.7520.91
331_E334_E0.7510.90
248_L262_V0.7500.90
346_V351_K0.7490.90
255_R258_D0.7470.90
477_A481_Y0.7470.90
368_G375_I0.7470.90
39_G149_E0.7460.90
400_A403_R0.7440.90
64_T70_N0.7420.90
109_G151_D0.7420.90
138_L141_G0.7420.90
414_K418_I0.7410.90
464_K520_L0.7390.90
98_E168_Y0.7370.90
459_F477_A0.7370.90
73_W155_V0.7340.89
24_K54_P0.7330.89
472_I478_D0.7310.89
480_Y494_T0.7290.89
523_E553_Q0.7280.89
312_L321_V0.7280.89
113_V161_V0.7280.89
25_I60_S0.7270.89
377_P381_G0.7250.89
179_E190_E0.7240.89
449_T529_D0.7230.89
356_P420_Y0.7220.89
475_T478_D0.7220.89
26_S44_L0.7210.89
511_P515_V0.7210.89
520_L527_K0.7200.89
307_F332_F0.7200.89
438_E441_T0.7190.88
365_T397_L0.7180.88
438_E442_M0.7170.88
52_P56_T0.7170.88
128_P134_L0.7170.88
204_Q208_A0.7170.88
33_E36_N0.7170.88
65_S204_Q0.7150.88
127_K132_K0.7150.88
468_D510_K0.7140.88
105_D111_K0.7130.88
74_D79_V0.7120.88
24_K53_R0.7090.88
452_A536_L0.7060.88
481_Y542_G0.7030.87
199_K205_S0.7010.87
266_E326_E0.7000.87
485_S493_P0.7000.87
405_I408_D0.7000.87
274_L277_D0.6990.87
209_K241_T0.6970.87
110_L114_L0.6960.87
19_G234_E0.6960.87
486_A497_R0.6950.87
59_Q64_T0.6940.87
362_L375_I0.6940.87
100_L114_L0.6930.87
342_D433_N0.6930.87
61_V64_T0.6930.87
23_K57_V0.6930.87
95_L165_W0.6900.86
204_Q209_K0.6880.86
23_K199_K0.6870.86
131_F139_L0.6860.86
364_A421_L0.6860.86
499_L502_H0.6860.86
313_S322_R0.6850.86
369_K373_D0.6850.86
68_A88_K0.6840.86
496_L499_L0.6820.86
368_G372_S0.6820.86
4_Y7_R0.6810.86
489_A493_P0.6800.86
206_S316_A0.6790.85
102_E114_L0.6790.85
202_G207_G0.6780.85
309_V388_L0.6770.85
510_K514_A0.6760.85
1_L7_R0.6750.85
211_V240_Y0.6750.85
149_E152_G0.6750.85
468_D516_N0.6750.85
465_I514_A0.6740.85
103_S106_D0.6730.85
497_R500_Q0.6730.85
462_L479_R0.6710.85
106_D111_K0.6700.85
276_A280_D0.6690.85
99_W168_Y0.6690.85
494_T497_R0.6660.84
498_L505_K0.6660.84
443_S526_D0.6660.84
101_E118_E0.6650.84
503_L521_I0.6610.84
345_I424_A0.6590.84
197_H237_A0.6590.84
21_S57_V0.6580.84
378_N382_R0.6580.84
108_P111_K0.6580.84
364_A408_D0.6570.84
23_K26_S0.6570.84
8_L13_E0.6560.83
323_F389_D0.6550.83
364_A401_A0.6550.83
63_R75_K0.6540.83
28_E42_E0.6530.83
468_D506_L0.6510.83
204_Q316_A0.6500.83
10_A14_S0.6490.83
56_T145_V0.6490.83
62_K215_D0.6480.83
536_L541_Q0.6480.83
31_L116_F0.6470.83
453_Y457_R0.6430.82
23_K60_S0.6420.82
150_G153_D0.6420.82
404_R408_D0.6420.82
373_D376_P0.6410.82
503_L517_L0.6390.82
61_V65_S0.6390.82
24_K56_T0.6380.82
97_E102_E0.6380.82
393_Y432_R0.6380.82
66_G69_P0.6370.82
507_R514_A0.6360.82
246_W250_S0.6360.82
496_L500_Q0.6350.81
167_R189_E0.6340.81
21_S24_K0.6330.81
57_V73_W0.6320.81
18_P234_E0.6320.81
30_V38_L0.6320.81
40_V48_G0.6300.81
65_S70_N0.6300.81
276_A279_F0.6300.81
201_K205_S0.6290.81
203_A319_L0.6280.81
2_Y235_E0.6270.81
470_L473_N0.6260.81
17_P166_I0.6260.81
344_A354_G0.6260.81
511_P516_N0.6260.81
2_Y236_A0.6250.80
474_A478_D0.6250.80
335_R388_L0.6240.80
361_L425_L0.6230.80
9_A14_S0.6230.80
498_L502_H0.6230.80
136_E139_L0.6220.80
164_A168_Y0.6220.80
462_L501_H0.6220.80
519_K556_F0.6220.80
26_S142_A0.6210.80
402_L426_I0.6200.80
514_A518_E0.6200.80
259_A311_G0.6200.80
100_L111_K0.6190.80
347_R352_E0.6180.80
292_A297_R0.6170.80
84_K87_K0.6170.80
83_D88_K0.6170.80
110_L113_V0.6160.79
27_F142_A0.6150.79
46_G50_K0.6150.79
520_L554_A0.6140.79
401_A405_I0.6140.79
179_E192_P0.6140.79
431_N440_I0.6140.79
338_Q341_E0.6130.79
275_F280_D0.6130.79
461_V517_L0.6120.79
67_I70_N0.6110.79
42_E147_R0.6100.79
478_D544_F0.6100.79
316_A320_S0.6100.79
167_R171_S0.6100.79
378_N381_G0.6070.79
8_L11_D0.6070.79
65_S91_A0.6060.78
19_G170_A0.6060.78
199_K206_S0.6050.78
100_L103_S0.6050.78
27_F42_E0.6040.78
195_R227_G0.6030.78
205_S208_A0.6030.78
466_Q476_I0.6000.78
148_V155_V0.6000.78
62_K75_K0.5980.77
45_E52_P0.5980.77
278_L281_P0.5980.77
134_L138_L0.5970.77
127_K130_I0.5940.77
78_Y89_H0.5930.77
464_K516_N0.5930.77
477_A499_L0.5920.77
167_R170_A0.5910.77
194_A197_H0.5910.77
6_E10_A0.5900.77
215_D226_Q0.5900.77
201_K214_N0.5880.76
68_A91_A0.5870.76
187_T191_A0.5860.76
468_D556_F0.5860.76
202_G316_A0.5860.76
202_G206_S0.5860.76
206_S209_K0.5860.76
357_S363_R0.5850.76
75_K214_N0.5840.76
44_L54_P0.5840.76
426_I430_L0.5830.76
96_L114_L0.5830.76
48_G52_P0.5830.76
434_Y437_K0.5810.75
66_G78_Y0.5800.75
515_V556_F0.5780.75
340_F358_L0.5780.75
466_Q502_H0.5760.75
7_R11_D0.5750.75
380_A383_L0.5740.75
440_I546_L0.5730.74
3_E7_R0.5710.74
63_R70_N0.5710.74
60_S67_I0.5710.74
128_P135_K0.5700.74
2_Y187_T0.5700.74
91_A95_L0.5700.74
157_E162_R0.5690.74
59_Q62_K0.5680.74
224_K227_G0.5660.74
358_L362_L0.5660.74
45_E49_K0.5660.74
196_L199_K0.5650.73
275_F278_L0.5650.73
531_E535_H0.5650.73
534_A539_E0.5650.73
215_D225_E0.5640.73
325_R332_F0.5640.73
528_L550_H0.5600.73
10_A13_E0.5600.73
466_Q473_N0.5580.73
506_L510_K0.5580.73
489_A539_E0.5570.72
309_V332_F0.5570.72
203_A209_K0.5570.72
88_K91_A0.5570.72
61_V67_I0.5560.72
495_L502_H0.5560.72
70_N317_G0.5550.72
214_N218_F0.5540.72
261_V311_G0.5540.72
339_W342_D0.5530.72
467_E555_F0.5530.72
193_I197_H0.5530.72
469_A506_L0.5530.72
67_I75_K0.5520.72
370_G408_D0.5500.71
479_R501_H0.5490.71
362_L380_A0.5490.71
245_N248_L0.5480.71
201_K217_A0.5480.71
184_C187_T0.5480.71
57_V145_V0.5480.71
162_R166_I0.5470.71
352_E355_A0.5460.71
85_K88_K0.5450.71
11_D15_L0.5450.71
263_F287_R0.5450.71
59_Q63_R0.5450.71
241_T317_G0.5440.71
25_I28_E0.5430.70
186_V232_V0.5430.70
9_A12_G0.5420.70
200_I319_L0.5420.70
261_V322_R0.5420.70
443_S550_H0.5390.70
328_T331_E0.5390.70
96_L113_V0.5380.70
191_A236_A0.5380.70
21_S199_K0.5370.70
165_W168_Y0.5370.70
199_K203_A0.5350.69
363_R368_G0.5350.69
59_Q237_A0.5330.69
77_E85_K0.5320.69
500_Q505_K0.5320.69
265_A269_D0.5320.69
496_L532_F0.5310.69
361_L397_L0.5310.69
515_V553_Q0.5310.69
438_E450_N0.5300.69
272_E276_A0.5290.69
354_G360_R0.5290.69
201_K204_Q0.5290.69
545_A549_Y0.5280.68
461_V464_K0.5280.68
402_L542_G0.5280.68
291_E295_G0.5270.68
383_L397_L0.5270.68
71_F99_W0.5270.68
542_G549_Y0.5250.68
445_D530_D0.5250.68
18_P169_Y0.5250.68
436_L440_I0.5240.68
109_G112_A0.5240.68
440_I543_R0.5230.68
433_N436_L0.5230.68
74_D78_Y0.5210.67
344_A355_A0.5210.67
19_G169_Y0.5210.67
63_R199_K0.5200.67
323_F426_I0.5200.67
455_L533_P0.5190.67
105_D108_P0.5190.67
121_D125_A0.5190.67
76_L142_A0.5180.67
367_N374_N0.5180.67
134_L139_L0.5170.67
375_I379_L0.5160.67
89_H96_L0.5160.67
469_A473_N0.5160.67
47_K53_R0.5150.66
327_G335_R0.5150.66
272_E275_F0.5140.66
198_P203_A0.5120.66
410_G419_N0.5120.66
515_V518_E0.5120.66
484_A532_F0.5110.66
200_I207_G0.5110.66
2_Y233_S0.5110.66
516_N523_E0.5110.66
153_D157_E0.5100.66
64_T78_Y0.5100.66
485_S536_L0.5100.66
390_G469_A0.5090.66
70_N73_W0.5080.65
46_G52_P0.5080.65
217_A221_Y0.5080.65
98_E159_P0.5070.65
68_A95_L0.5060.65
59_Q68_A0.5060.65
269_D305_T0.5060.65
160_A164_A0.5060.65
401_A422_R0.5050.65
90_E97_E0.5050.65
404_R407_A0.5040.65
29_I144_V0.5040.65
109_G160_A0.5030.65
539_E543_R0.5030.65
518_E525_M0.5020.65
340_F357_S0.5020.65
293_I296_G0.5010.64
444_L550_H0.5010.64
259_A381_G0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2p25A 2 0.0755 17.4 0.979 Contact Map
2a4xA 2 0.0845 12.3 0.981 Contact Map
2qqzA 2 0.0791 12.1 0.981 Contact Map
1twuA 2 0.0881 11.6 0.981 Contact Map
2mc8A 1 0.0755 11.5 0.981 Contact Map
1ecsA 2 0.0809 11.2 0.981 Contact Map
1u6lA 2 0.0809 10.9 0.981 Contact Map
3rheA 2 0.0773 10.2 0.981 Contact Map
3r6aA 2 0.0881 9.6 0.982 Contact Map
4n04A 2 0.0791 9.5 0.982 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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