GREMLIN Database
Cas_CXXC_CXXC - CRISPR-associated protein (Cas_CXXC_CXXC)
PFAM: PF09706 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 69 (67)
Sequences: 599 (458)
Seq/√Len: 55.9
META: 0.79

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_C57_C4.0991.00
11_C54_C3.4881.00
11_C57_C3.4141.00
36_S40_K2.5151.00
36_S42_N2.4541.00
56_I59_L2.1201.00
60_I63_C2.0721.00
33_L61_Y1.9781.00
26_L64_S1.8620.99
21_N49_N1.8190.99
31_F58_A1.8080.99
18_K21_N1.7220.99
10_F53_I1.5040.98
53_I56_I1.4220.97
46_N56_I1.4190.97
56_I60_I1.4150.97
33_L65_P1.3850.96
35_G39_R1.3350.95
28_R31_F1.3140.95
34_T53_I1.2890.94
36_S39_R1.2880.94
64_S68_F1.2820.94
8_C54_C1.2650.94
3_K7_N1.2190.92
45_W60_I1.2110.92
8_C11_C1.1940.91
7_N12_G1.1630.90
7_N13_R1.1060.88
7_N20_K1.0910.87
16_S20_K1.0750.86
33_L50_D1.0710.86
8_C57_C1.0570.86
33_L39_R1.0330.84
16_S19_L1.0230.84
45_W61_Y1.0060.83
7_N15_P0.9590.79
6_Y24_S0.9520.79
39_R42_N0.9510.79
9_I49_N0.8860.74
52_P69_T0.8690.72
32_P50_D0.8690.72
44_F55_P0.8580.71
23_L26_L0.8460.70
55_P63_C0.8440.70
14_R20_K0.8330.69
31_F44_F0.8050.66
25_F30_G0.7750.64
4_S19_L0.7700.63
9_I52_P0.7690.63
5_K67_G0.7580.62
38_G64_S0.7450.60
9_I48_N0.7370.60
39_R55_P0.7170.58
41_S63_C0.6990.56
34_T40_K0.6980.55
44_F51_A0.6820.54
50_D61_Y0.6810.54
37_V43_F0.6780.53
32_P36_S0.6780.53
22_D37_V0.6710.53
25_F31_F0.6690.52
30_G63_C0.6560.51
4_S14_R0.6480.50
30_G47_F0.6460.50
28_R62_Q0.6430.50
15_P18_K0.6230.47
41_S49_N0.6130.46
9_I51_A0.6110.46
61_Y68_F0.6100.46
31_F66_L0.6070.46
55_P62_Q0.6050.45
17_K29_T0.6020.45
40_K44_F0.6000.45
48_N51_A0.5980.45
18_K29_T0.5960.44
45_W63_C0.5960.44
37_V44_F0.5940.44
47_F59_L0.5790.43
42_N62_Q0.5670.41
55_P68_F0.5640.41
45_W50_D0.5600.41
15_P19_L0.5590.41
61_Y64_S0.5580.40
39_R67_G0.5570.40
26_L31_F0.5430.39
12_G32_P0.5410.39
15_P21_N0.5310.38
12_G37_V0.5260.37
6_Y45_W0.5210.37
43_F60_I0.5210.37
18_K49_N0.5180.36
34_T46_N0.5160.36
15_P53_I0.5150.36
58_A61_Y0.5140.36
63_C66_L0.5110.36
28_R60_I0.5100.36
47_F52_P0.5100.36
30_G44_F0.5080.35
21_N24_S0.5060.35
43_F51_A0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ovxA 2 0.5507 9.2 0.874 Contact Map
3zmsC 1 0 9 0.875 Contact Map
1dx8A 1 0.8116 8.2 0.877 Contact Map
4a17Y 1 0.5942 4.6 0.891 Contact Map
4w20p 1 0.5942 4.4 0.892 Contact Map
4lqxA 2 0.3623 4.3 0.892 Contact Map
3x1lA 1 0.7536 4.1 0.893 Contact Map
2lt7A 1 0.8261 4 0.894 Contact Map
4ujrc 1 0.5942 4 0.894 Contact Map
2kn9A 1 0.8116 3.7 0.895 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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