GREMLIN Database
DUF4870 - Domain of unknown function (DUF4870)
PFAM: PF09685 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 113 (104)
Sequences: 26185 (19380)
Seq/√Len: 1900.3
META: 0.91

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_K102_E3.6561.00
34_K37_K3.1931.00
43_F103_R2.4471.00
42_R46_K2.4101.00
55_L87_A2.3211.00
86_A90_L2.2611.00
97_K100_Q2.1521.00
54_S58_Y2.1281.00
6_A40_F2.1251.00
78_L81_L2.1011.00
105_R111_R2.0881.00
89_V93_I1.9641.00
93_I97_K1.8241.00
87_A91_W1.7881.00
7_M99_Y1.7591.00
11_L95_A1.6741.00
92_I96_I1.6721.00
12_S26_G1.5911.00
47_Q111_R1.5691.00
94_A104_Y1.5491.00
91_W95_A1.5221.00
29_I33_I1.4701.00
46_K50_N1.4371.00
31_W42_R1.3981.00
9_A45_A1.3621.00
44_H103_R1.3571.00
42_R45_A1.3431.00
7_M11_L1.3261.00
94_A106_Y1.3161.00
5_W30_I1.3101.00
10_H106_Y1.3031.00
28_L32_L1.2721.00
38_S41_V1.2621.00
62_L79_L1.2291.00
26_G30_I1.1951.00
13_G91_W1.1911.00
4_T8_L1.1671.00
60_I64_I1.1611.00
23_G56_L1.1351.00
9_A48_A1.1351.00
67_F70_L1.1291.00
51_F55_L1.1291.00
97_K104_Y1.0991.00
81_L85_L1.0931.00
39_P103_R1.0671.00
40_F44_H1.0531.00
93_I96_I1.0511.00
43_F47_Q1.0331.00
59_G62_L1.0281.00
51_F106_Y1.0241.00
9_A41_V1.0211.00
84_G88_L1.0051.00
20_P23_G1.0051.00
5_W34_K0.9911.00
95_A99_Y0.9841.00
65_L69_P0.9781.00
40_F43_F0.9721.00
54_S109_I0.9701.00
50_N110_G0.9661.00
51_F90_L0.9531.00
7_M95_A0.9461.00
81_L84_G0.9421.00
13_G52_Q0.9371.00
96_I99_Y0.9321.00
4_T99_Y0.9261.00
43_F105_R0.9121.00
9_A30_I0.9051.00
105_R110_G0.9031.00
47_Q109_I0.8961.00
35_K42_R0.8891.00
50_N53_I0.8881.00
31_W46_K0.8841.00
59_G63_G0.8841.00
50_N54_S0.8841.00
47_Q105_R0.8771.00
96_I100_Q0.8771.00
8_L12_S0.8691.00
40_F103_R0.8671.00
48_A52_Q0.8421.00
24_F27_P0.8391.00
22_G26_G0.8311.00
69_P72_G0.8211.00
31_W35_K0.8171.00
50_N112_F0.8171.00
93_I104_Y0.8161.00
98_A103_R0.8151.00
59_G80_L0.8121.00
69_P73_F0.8071.00
62_L65_L0.8011.00
60_I63_G0.8001.00
27_P30_I0.7851.00
52_Q87_A0.7681.00
61_V64_I0.7601.00
48_A94_A0.7591.00
25_I29_I0.7441.00
90_L94_A0.7431.00
31_W45_A0.7301.00
83_L87_A0.7081.00
18_L22_G0.7081.00
47_Q110_G0.7051.00
10_H44_H0.7041.00
4_T7_M0.7021.00
52_Q55_L0.6991.00
70_L73_F0.6981.00
44_H47_Q0.6931.00
54_S110_G0.6931.00
51_F94_A0.6891.00
85_L89_V0.6891.00
53_I56_L0.6891.00
52_Q91_W0.6891.00
66_G69_P0.6861.00
78_L82_L0.6801.00
51_F87_A0.6781.00
13_G48_A0.6761.00
31_W34_K0.6661.00
39_P46_K0.6431.00
31_W49_L0.6411.00
59_G84_G0.6381.00
90_L93_I0.6351.00
34_K38_S0.6341.00
44_H98_A0.6251.00
84_G87_A0.6221.00
19_I22_G0.6171.00
27_P31_W0.6131.00
5_W9_A0.6091.00
30_I45_A0.6081.00
59_G65_L0.6041.00
24_F28_L0.6031.00
63_G67_F0.5981.00
61_V65_L0.5891.00
51_F109_I0.5851.00
32_L36_D0.5791.00
3_R40_F0.5771.00
58_Y83_L0.5751.00
6_A9_A0.5731.00
30_I34_K0.5731.00
28_L31_W0.5721.00
80_L84_G0.5721.00
27_P49_L0.5711.00
67_F71_I0.5611.00
49_L53_I0.5571.00
109_I112_F0.5551.00
64_I68_I0.5541.00
66_G70_L0.5541.00
85_L88_L0.5511.00
6_A44_H0.5471.00
10_H13_G0.5391.00
82_L86_A0.5331.00
63_G68_I0.5261.00
43_F46_K0.5241.00
50_N109_I0.5211.00
90_L106_Y0.5191.00
19_I23_G0.5071.00
73_F77_L0.5041.00
41_V45_A0.5031.00
65_L68_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bwzA 2 0.3274 7.9 0.888 Contact Map
4httA 1 0.885 4 0.903 Contact Map
2a9hA 4 0.292 3.1 0.907 Contact Map
2x2zA 1 0.0354 3 0.908 Contact Map
4bw5A 2 0.2832 2.1 0.916 Contact Map
3mktA 1 1 1.8 0.919 Contact Map
4d6uD 1 0.3805 1.7 0.92 Contact Map
4humA 1 0.9912 1.6 0.921 Contact Map
1pp9D 2 0.3805 1.6 0.921 Contact Map
2mfrA 1 0.3982 1.6 0.921 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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