GREMLIN Database
Phage_holin_6_1 - Bacteriophage holin of superfamily 6 (Holin_LLH)
PFAM: PF09682 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 101 (95)
Sequences: 2477 (2137)
Seq/√Len: 219.2
META: 0.873

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_K89_D4.3921.00
60_K63_E2.5701.00
73_K85_D2.4161.00
65_K69_L2.3781.00
53_Q93_E2.1931.00
51_A67_Y2.1881.00
84_T87_E2.1321.00
33_T36_Q2.0531.00
22_K26_P1.9141.00
50_A54_L1.8741.00
47_A68_A1.8731.00
7_P10_V1.8101.00
34_A38_E1.7991.00
75_F78_K1.7491.00
72_L88_I1.7061.00
22_K25_K1.6721.00
47_A71_K1.6471.00
31_K35_E1.5321.00
69_L89_D1.5191.00
75_F79_K1.4911.00
47_A51_A1.4831.00
57_D60_K1.4201.00
69_L73_K1.4041.00
23_Y26_P1.3971.00
66_E70_E1.3961.00
44_A72_L1.3861.00
19_L23_Y1.3821.00
93_E96_V1.3731.00
73_K77_K1.3461.00
45_K49_K1.3231.00
52_E96_V1.3221.00
44_A91_L1.3171.00
38_E41_A1.3131.00
67_Y70_E1.2821.00
44_A68_A1.2521.00
52_E100_K1.2471.00
71_K90_A1.2441.00
95_A98_E1.2401.00
96_V100_K1.2321.00
43_I72_L1.2311.00
45_K98_E1.1851.00
55_Y59_G1.1551.00
71_K75_F1.1551.00
48_V53_Q1.1481.00
70_E74_E1.1361.00
38_E42_E1.1311.00
33_T37_L1.1011.00
63_E66_E1.0661.00
23_Y27_Y1.0341.00
51_A55_Y1.0341.00
18_A22_K0.9841.00
35_E39_K0.9721.00
53_Q97_K0.9681.00
25_K29_K0.9591.00
27_Y31_K0.9421.00
74_E78_K0.9351.00
10_V14_T0.9280.99
56_K60_K0.9270.99
76_L88_I0.9050.99
71_K74_E0.8800.99
76_L81_I0.8660.99
44_A48_V0.8650.99
39_K42_E0.8600.99
50_A53_Q0.8590.99
23_Y29_K0.8460.99
7_P14_T0.8380.99
37_L40_I0.8310.99
32_T36_Q0.8290.99
55_Y61_G0.8270.99
77_K82_K0.8230.99
40_I91_L0.8080.99
51_A59_G0.8070.99
69_L88_I0.8050.99
14_T18_A0.7980.98
53_Q100_K0.7890.98
41_A45_K0.7870.98
11_A14_T0.7800.98
6_T11_A0.7750.98
49_K97_K0.7680.98
20_L23_Y0.7670.98
47_A72_L0.7660.98
65_K93_E0.7540.98
92_I96_V0.7520.98
76_L79_K0.7230.97
63_E67_Y0.7190.97
24_L28_L0.7160.97
48_V52_E0.7120.97
69_L85_D0.7060.97
91_L94_A0.6970.96
49_K94_A0.6940.96
53_Q96_V0.6920.96
48_V95_A0.6760.96
50_A67_Y0.6710.96
65_K92_I0.6660.95
37_L41_A0.6650.95
86_E89_D0.6600.95
29_K33_T0.6580.95
46_I90_A0.6570.95
56_K64_K0.6550.95
19_L25_K0.6530.95
59_G63_E0.6430.94
35_E38_E0.6390.94
32_T37_L0.6380.94
61_G64_K0.6380.94
61_G68_A0.6380.94
73_K88_I0.6370.94
19_L22_K0.6250.94
16_L21_T0.6170.93
44_A53_Q0.6090.93
52_E61_G0.6090.93
76_L84_T0.6010.92
52_E64_K0.5970.92
51_A68_A0.5960.92
7_P11_A0.5910.92
62_E66_E0.5900.91
65_K96_V0.5850.91
76_L80_G0.5830.91
96_V99_L0.5820.91
72_L76_L0.5810.91
30_A33_T0.5760.90
43_I75_F0.5730.90
89_D96_V0.5670.90
59_G67_Y0.5670.90
40_I83_I0.5630.89
31_K34_A0.5600.89
68_A72_L0.5470.88
56_K59_G0.5460.88
17_A26_P0.5370.87
42_E46_I0.5210.86
32_T40_I0.5190.85
90_A97_K0.5130.85
48_V99_L0.5120.85
21_T26_P0.5100.84
14_T21_T0.5070.84
94_A98_E0.5070.84
74_E77_K0.5050.84
76_L83_I0.5040.84
15_L22_K0.5020.83
8_I14_T0.5020.83
5_L9_L0.5000.83
67_Y71_K0.5000.83
12_I16_L0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2k19A 1 0.495 13.4 0.854 Contact Map
2m7gA 1 0.5842 11.8 0.858 Contact Map
4r3zC 1 0 11.1 0.86 Contact Map
4xlyA 2 0.8416 9.3 0.864 Contact Map
1qzmA 1 0.4455 9.1 0.865 Contact Map
4gitA 2 0.4356 9.1 0.865 Contact Map
1w26A 1 0.3663 7.8 0.869 Contact Map
2y0oA 2 0.3465 7.7 0.869 Contact Map
2kv5A 1 0.3267 7.1 0.871 Contact Map
2nscA 2 0.3663 6.6 0.873 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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