GREMLIN Database
TrbC_Ftype - Type-F conjugative transfer system pilin assembly protein
PFAM: PF09673 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 112 (110)
Sequences: 1858 (1420)
Seq/√Len: 135.4
META: 0.851

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_G39_P4.1751.00
32_V40_T2.9731.00
74_A100_Y2.7471.00
3_V12_L2.6431.00
15_L75_F2.4941.00
103_V107_Y2.4811.00
2_F63_L2.4391.00
1_V75_F2.3701.00
16_A26_L2.3281.00
9_E46_E2.2311.00
28_L40_T2.1531.00
5_F43_R2.0921.00
3_V26_L2.0461.00
4_S72_V2.0251.00
99_V108_A1.9151.00
19_A24_A1.8941.00
75_F108_A1.8901.00
67_F76_V1.8811.00
3_V28_L1.8321.00
103_V108_A1.8181.00
74_A98_K1.8081.00
11_S15_L1.7791.00
2_F69_I1.7301.00
7_M12_L1.7001.00
32_V43_R1.6921.00
25_V58_Q1.6581.00
31_L37_L1.5641.00
97_D102_D1.5271.00
2_F76_V1.4291.00
39_P42_K1.4161.00
3_V7_M1.4031.00
36_S39_P1.3481.00
11_S102_D1.3191.00
9_E43_R1.3121.00
69_I74_A1.2541.00
76_V98_K1.2401.00
19_A26_L1.2231.00
9_E13_R1.2211.00
45_Q49_G1.1820.99
18_Q106_D1.1490.99
5_F32_V1.1470.99
104_S107_Y1.1320.99
8_P11_S1.1230.99
67_F78_V1.0930.99
20_A53_R1.0840.99
78_V81_D1.0790.99
2_F67_F1.0130.98
13_R48_L1.0120.98
31_L59_I1.0020.98
48_L57_V0.9950.98
3_V15_L0.9870.98
13_R50_K0.9800.98
11_S14_R0.9740.98
1_V15_L0.9620.98
106_D110_E0.9610.98
27_V63_L0.9590.98
62_R66_R0.9560.98
41_A45_Q0.9460.97
20_A54_G0.9420.97
14_R102_D0.9350.97
16_A55_V0.9340.97
76_V96_F0.9320.97
87_G93_P0.9260.97
44_I57_V0.9120.97
89_G93_P0.8970.97
85_C90_C0.8930.96
37_L40_T0.8920.96
99_V111_T0.8810.96
8_P102_D0.8720.96
33_G36_S0.8530.95
42_K45_Q0.8520.95
42_K46_E0.8500.95
6_S72_V0.8390.95
14_R18_Q0.8300.95
18_Q21_R0.8280.95
87_G90_C0.8250.94
46_E49_G0.8190.94
12_L43_R0.8130.94
43_R47_L0.8080.94
29_R65_R0.7790.93
75_F99_V0.7780.93
28_L57_V0.7760.92
10_A14_R0.7710.92
75_F105_L0.7700.92
3_V57_V0.7680.92
38_K41_A0.7620.92
4_S57_V0.7550.91
43_R46_E0.7460.91
67_F96_F0.7430.91
18_Q22_A0.7400.91
91_A95_P0.7390.90
87_G91_A0.7300.90
88_G92_A0.7290.90
38_K42_K0.7270.90
2_F64_F0.7230.90
31_L36_S0.7180.89
5_F28_L0.7110.89
90_C93_P0.7060.88
12_L16_A0.7030.88
1_V108_A0.7030.88
96_F109_L0.6810.87
5_F33_G0.6800.86
12_L28_L0.6630.85
20_A42_K0.6600.85
72_V91_A0.6570.85
66_R79_K0.6520.84
1_V105_L0.6490.84
67_F109_L0.6480.84
48_L53_R0.6410.83
58_Q67_F0.6370.83
107_Y111_T0.6350.83
47_L63_L0.6350.83
13_R59_I0.6350.83
33_G43_R0.6320.82
77_L102_D0.6310.82
58_Q74_A0.6260.82
1_V19_A0.6230.81
25_V56_G0.6200.81
16_A53_R0.6110.80
10_A85_C0.6080.80
7_M31_L0.6050.79
7_M11_S0.6030.79
6_S32_V0.6020.79
62_R65_R0.6000.79
5_F40_T0.5980.79
88_G94_P0.5840.77
99_V103_V0.5810.77
16_A20_A0.5790.76
77_L97_D0.5770.76
48_L55_V0.5770.76
28_L64_F0.5750.76
82_A85_C0.5740.76
31_L40_T0.5740.76
32_V62_R0.5640.75
77_L81_D0.5640.75
21_R106_D0.5520.73
99_V107_Y0.5490.73
31_L34_G0.5450.72
16_A48_L0.5440.72
89_G94_P0.5410.71
28_L32_V0.5410.71
15_L102_D0.5400.71
68_G89_G0.5390.71
69_I98_K0.5380.71
102_D105_L0.5360.71
75_F102_D0.5360.71
17_R53_R0.5330.70
34_G57_V0.5310.70
1_V26_L0.5250.69
92_A95_P0.5240.69
102_D107_Y0.5230.69
8_P18_Q0.5220.69
89_G92_A0.5160.68
22_A109_L0.5150.68
33_G40_T0.5140.68
28_L43_R0.5110.67
97_D109_L0.5110.67
91_A94_P0.5100.67
16_A47_L0.5090.67
20_A23_G0.5080.67
5_F15_L0.5070.67
89_G95_P0.5070.67
15_L27_V0.5020.66
42_K59_I0.5010.66
73_P101_G0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kcaA 2 0.8393 77.8 0.849 Contact Map
4hqzA 1 0.9018 66.5 0.861 Contact Map
3erwA 1 0.875 66 0.862 Contact Map
2hyxA 2 0.9018 65 0.863 Contact Map
3fw2A 2 0.8661 64.9 0.863 Contact Map
3hczA 2 0.8661 63.2 0.864 Contact Map
2es7A 1 0.75 62.7 0.864 Contact Map
3kcmA 1 0.875 62.3 0.865 Contact Map
4kcbA 1 0 61.2 0.866 Contact Map
1qmvA 3 0.8929 61.1 0.866 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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