GREMLIN Database
Spore_GerQ - Spore coat protein (Spore_GerQ)
PFAM: PF09671 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 76 (75)
Sequences: 534 (251)
Seq/√Len: 28.9
META: 0.648

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_M60_L3.9611.00
27_N32_A2.9041.00
41_A57_R2.7131.00
65_L68_V2.7021.00
50_S55_G2.2720.99
24_F35_F2.1690.98
27_N31_N1.9630.96
40_E50_S1.8030.94
17_L38_I1.7700.93
56_K69_T1.7480.93
20_V49_L1.6660.91
27_N30_W1.6420.91
47_I61_L1.6290.90
51_D56_K1.6250.90
19_T36_K1.6250.90
56_K71_D1.4770.85
26_N32_A1.4530.84
18_A39_I1.4390.84
32_A64_Y1.4270.83
40_E52_P1.4230.83
51_D58_Y1.3950.82
20_V24_F1.3810.81
16_K72_E1.3770.81
20_V47_I1.3740.81
68_V74_I1.2610.75
38_I52_P1.2560.74
23_T66_D1.2540.74
22_M35_F1.2360.73
40_E57_R1.2140.72
6_I61_L1.1900.70
21_Y30_W1.1690.69
36_K71_D1.1100.65
27_N64_Y1.0980.64
22_M65_L1.0880.63
26_N31_N1.0880.63
6_I11_R1.0560.61
28_N31_N1.0510.60
30_W34_V1.0500.60
7_E44_R0.9600.53
23_T31_N0.9510.53
14_K74_I0.9280.51
41_A67_Y0.9170.50
60_L65_L0.9060.49
53_Q75_N0.9040.49
26_N64_Y0.8890.48
4_S11_R0.8790.47
42_A65_L0.8740.47
25_E32_A0.8640.46
11_R46_H0.8640.46
23_T26_N0.8490.45
20_V39_I0.8340.44
25_E31_N0.8140.42
6_I46_H0.8130.42
33_K67_Y0.8040.41
52_P55_G0.8010.41
26_N30_W0.7990.41
51_D54_T0.7970.41
19_T69_T0.7920.40
35_F60_L0.7920.40
8_N11_R0.7780.39
21_Y34_V0.7770.39
39_I47_I0.7500.37
24_F64_Y0.7410.37
9_I59_L0.7390.36
7_E43_G0.7390.36
64_Y73_E0.7370.36
54_T58_Y0.7270.36
50_S57_R0.7260.36
38_I50_S0.7210.35
9_I70_F0.7110.34
24_F73_E0.7060.34
14_K39_I0.7020.34
18_A48_I0.6970.33
28_N32_A0.6960.33
30_W33_K0.6830.32
39_I74_I0.6810.32
24_F61_L0.6750.32
20_V68_V0.6710.32
2_E7_E0.6660.31
42_A62_M0.6590.31
18_A68_V0.6560.31
19_T34_V0.6440.30
13_N70_F0.6440.30
35_F67_Y0.6370.29
31_N34_V0.6290.29
4_S59_L0.6290.29
26_N71_D0.6260.29
12_L41_A0.6000.27
23_T28_N0.5890.26
41_A73_E0.5870.26
30_W51_D0.5680.25
39_I52_P0.5610.25
20_V65_L0.5580.25
57_R73_E0.5520.24
23_T27_N0.5490.24
14_K42_A0.5480.24
9_I62_M0.5470.24
17_L72_E0.5440.24
35_F63_I0.5430.24
27_N66_D0.5380.23
28_N33_K0.5350.23
60_L66_D0.5320.23
17_L36_K0.5290.23
25_E64_Y0.5190.22
29_E71_D0.5170.22
2_E16_K0.5140.22
50_S54_T0.5130.22
54_T63_I0.5090.22
26_N29_E0.5050.22
17_L73_E0.5050.22
36_K53_Q0.5000.21
29_E32_A0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ycyA 5 0.75 32 0.902 Contact Map
1ib8A 1 0.9079 17.6 0.914 Contact Map
4pnoA 3 0.8289 14 0.917 Contact Map
4x9cA 3 0.7632 13.5 0.918 Contact Map
3bmaA 6 0.9474 13.4 0.918 Contact Map
2y90A 3 0.8289 8.4 0.925 Contact Map
4nl2D 3 0.8553 8.1 0.926 Contact Map
3ahuA 3 0.8553 8 0.926 Contact Map
1kq1A 5 0.7895 7.8 0.926 Contact Map
1u1sA 3 0.8421 7.3 0.927 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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