GREMLIN Database
PGPGW - Putative transmembrane protein (PGPGW)
PFAM: PF09656 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 53 (52)
Sequences: 10549 (6064)
Seq/√Len: 840.9
META: 0.948

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
18_M23_G2.6611.00
17_A21_L2.5001.00
5_A40_F2.3861.00
5_A9_F2.1671.00
11_L35_I2.0461.00
25_G30_P1.9831.00
18_M28_V1.9691.00
4_V39_E1.6771.00
26_I30_P1.6601.00
47_L51_R1.6141.00
9_F40_F1.5041.00
19_L25_G1.4591.00
44_R48_D1.4471.00
14_L18_M1.4341.00
12_L32_G1.4151.00
34_A38_T1.3671.00
41_A45_R1.2731.00
18_M21_L1.2391.00
15_G29_I1.1601.00
11_L28_V1.1261.00
4_V35_I1.1081.00
15_G19_L1.0371.00
12_L29_I1.0321.00
4_V38_T1.0241.00
46_L49_R1.0121.00
49_R52_R0.9931.00
37_A47_L0.9901.00
9_F36_L0.9861.00
11_L31_L0.9791.00
19_L29_I0.9741.00
19_L26_I0.9681.00
24_P27_L0.9211.00
25_G28_V0.9171.00
3_V7_V0.9091.00
27_L30_P0.8681.00
45_R49_R0.8581.00
20_V28_V0.8551.00
16_I20_V0.8521.00
34_A47_L0.8261.00
41_A46_L0.7871.00
3_V6_V0.7861.00
41_A44_R0.7861.00
48_D51_R0.7711.00
9_F13_L0.7701.00
7_V35_I0.7351.00
8_G32_G0.7301.00
2_I6_V0.7281.00
23_G28_V0.7281.00
33_L50_A0.7231.00
17_A20_V0.7151.00
13_L17_A0.7121.00
19_L27_L0.7081.00
42_W46_L0.7051.00
38_T41_A0.7031.00
5_A39_E0.6971.00
20_V25_G0.6971.00
34_A37_A0.6921.00
48_D52_R0.6911.00
15_G18_M0.6801.00
47_L50_A0.6791.00
16_I19_L0.6631.00
12_L36_L0.6591.00
38_T44_R0.6511.00
2_I5_A0.6391.00
12_L21_L0.6221.00
6_V10_T0.6201.00
11_L32_G0.6191.00
10_T14_L0.6111.00
32_G36_L0.6001.00
45_R48_D0.5971.00
24_P28_V0.5801.00
14_L28_V0.5761.00
7_V10_T0.5741.00
37_A44_R0.5311.00
33_L46_L0.5191.00
10_T41_A0.5131.00
27_L31_L0.5101.00
43_A46_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ciyA 1 0.9057 3.3 0.852 Contact Map
2qc3A 1 0.6981 3.2 0.853 Contact Map
3qe7A 2 0.9811 3.1 0.854 Contact Map
1ji6A 1 0.9057 3 0.856 Contact Map
4o6mA 2 1 2.9 0.857 Contact Map
2j4tA 1 0.1887 2.9 0.858 Contact Map
2cuyA 2 0.6981 2.7 0.86 Contact Map
2mpnA 2 1 2.4 0.862 Contact Map
2qjyA 2 0.3585 2.1 0.868 Contact Map
4mndA 2 0.8868 1.9 0.871 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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