GREMLIN Database
DUF2393 - Protein of unknown function (DUF2393)
PFAM: PF09624 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 146 (145)
Sequences: 660 (538)
Seq/√Len: 44.7
META: 0.848

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
67_G124_F6.1541.00
48_K72_E3.3291.00
80_C145_C3.2551.00
39_V42_K3.1751.00
76_D118_P2.9731.00
70_K121_S2.9081.00
37_Y41_D2.6521.00
16_I20_S2.4541.00
73_G77_I2.4201.00
84_I126_V2.4021.00
9_I12_R2.3741.00
41_D45_K2.2671.00
83_E107_K2.1871.00
95_Y99_L2.1421.00
14_K17_L2.0170.99
31_L34_V1.9710.99
11_L14_K1.8830.99
62_A129_E1.8710.99
57_L60_T1.8510.99
21_M24_L1.8190.99
7_L11_L1.7150.98
7_L10_L1.7070.98
50_E70_K1.7010.98
47_A143_A1.5600.96
24_L141_L1.5590.96
50_E72_E1.5400.96
8_A15_K1.5110.95
8_A13_K1.5090.95
5_I8_A1.4650.95
82_L141_L1.4270.94
11_L15_K1.4240.94
5_I11_L1.4230.94
108_K132_P1.4040.93
44_T75_F1.3840.93
63_I86_L1.3780.93
50_E69_I1.3510.92
23_F27_L1.3470.92
31_L35_F1.3270.91
37_Y45_K1.3040.90
25_S32_G1.2820.90
87_V140_S1.2800.89
63_I105_F1.2780.89
51_L65_V1.2700.89
9_I15_K1.2680.89
47_A77_I1.2510.88
44_T58_L1.2170.87
12_R15_K1.2150.87
42_K112_I1.2100.87
101_K104_P1.2020.86
82_L119_G1.2010.86
19_L23_F1.1990.86
84_I128_F1.1920.86
20_S24_L1.1910.86
111_I126_V1.1790.85
6_I10_L1.1350.83
20_S23_F1.1190.82
8_A12_R1.1090.81
64_V125_K1.0960.81
117_K120_E1.0960.81
74_K120_E1.0930.80
36_G41_D1.0810.80
131_P137_Y1.0750.79
22_I26_F1.0690.79
94_K97_N1.0550.78
83_E126_V1.0540.78
4_L10_L1.0540.78
52_L74_K1.0360.77
2_I9_I1.0290.76
96_K103_K1.0240.76
113_A122_K1.0230.76
97_N101_K1.0030.74
35_F81_K1.0020.74
11_L16_I0.9990.74
51_L55_K0.9890.73
8_A14_K0.9750.72
88_N100_Y0.9740.72
98_Y101_K0.9730.72
72_E119_G0.9660.71
20_S46_K0.9640.71
8_A11_L0.9620.71
74_K101_K0.9610.71
61_E67_G0.9600.71
65_V82_L0.9540.71
128_F137_Y0.9460.70
24_L94_K0.9380.69
64_V127_I0.9310.69
34_V38_I0.9300.69
9_I14_K0.9080.67
10_L15_K0.9040.66
20_S28_V0.9040.66
3_L42_K0.8840.65
13_K17_L0.8780.64
22_I118_P0.8680.63
111_I132_P0.8630.63
29_L94_K0.8540.62
3_L6_I0.8460.61
37_Y86_L0.8450.61
81_K126_V0.8370.60
23_F31_L0.8370.60
1_F13_K0.8370.60
30_L74_K0.8330.60
31_L70_K0.8250.59
69_I90_G0.8250.59
5_I12_R0.8210.59
14_K20_S0.8150.58
24_L27_L0.8040.57
10_L13_K0.8020.57
138_N145_C0.7890.56
24_L111_I0.7880.56
18_A22_I0.7720.54
13_K16_I0.7700.54
27_L31_L0.7690.54
4_L11_L0.7600.53
78_G113_A0.7580.53
98_Y103_K0.7580.53
22_I39_V0.7510.52
61_E132_P0.7430.51
38_I76_D0.7410.51
129_E137_Y0.7390.51
89_K138_N0.7360.51
141_L144_E0.7350.51
87_V90_G0.7300.50
139_I145_C0.7260.50
86_L132_P0.7220.49
99_L102_L0.7180.49
58_L85_K0.7120.48
40_L47_A0.7090.48
47_A82_L0.7030.47
106_K113_A0.7030.47
62_A80_C0.7010.47
38_I120_E0.7010.47
90_G95_Y0.7000.47
70_K111_I0.6850.46
41_D78_G0.6850.46
28_V32_G0.6840.46
20_S31_L0.6810.45
45_K61_E0.6790.45
58_L131_P0.6730.45
50_E123_E0.6680.44
90_G93_K0.6670.44
38_I81_K0.6670.44
4_L7_L0.6620.44
19_L76_D0.6610.43
55_K90_G0.6590.43
130_Y137_Y0.6580.43
3_L15_K0.6570.43
42_K91_H0.6560.43
55_K123_E0.6490.42
99_L104_P0.6490.42
73_G124_F0.6450.42
76_D117_K0.6430.42
59_F64_V0.6420.42
21_M27_L0.6370.41
21_M45_K0.6360.41
99_L119_G0.6330.41
39_V84_I0.6310.41
16_I22_I0.6300.41
28_V34_V0.6290.40
32_G64_V0.6260.40
45_K75_F0.6220.40
10_L14_K0.6210.40
5_I10_L0.6210.40
21_M38_I0.6200.40
25_S127_I0.6160.39
39_V43_Y0.6130.39
132_P138_N0.6120.39
52_L106_K0.6080.38
57_L64_V0.6020.38
69_I122_K0.5990.38
59_F80_C0.5990.38
108_K127_I0.5990.38
35_F38_I0.5940.37
38_I42_K0.5920.37
86_L89_K0.5900.37
48_K76_D0.5890.37
14_K19_L0.5880.37
41_D106_K0.5820.36
9_I17_L0.5800.36
69_I113_A0.5740.35
50_E80_C0.5700.35
45_K130_Y0.5700.35
32_G53_S0.5670.35
18_A82_L0.5660.35
109_S132_P0.5630.34
70_K86_L0.5620.34
29_L62_A0.5620.34
11_L21_M0.5620.34
121_S141_L0.5540.34
49_L87_V0.5500.33
79_K113_A0.5440.33
120_E141_L0.5410.33
91_H97_N0.5390.32
67_G116_L0.5380.32
8_A22_I0.5370.32
64_V68_T0.5350.32
53_S93_K0.5340.32
5_I26_F0.5270.31
32_G108_K0.5220.31
19_L28_V0.5210.31
58_L144_E0.5210.31
63_I69_I0.5210.31
106_K132_P0.5200.31
77_I143_A0.5190.31
26_F54_Q0.5180.31
3_L27_L0.5170.31
63_I139_I0.5160.30
53_S64_V0.5160.30
45_K131_P0.5160.30
88_N131_P0.5150.30
45_K49_L0.5120.30
96_K101_K0.5120.30
43_Y87_V0.5110.30
49_L122_K0.5100.30
85_K133_Y0.5090.30
2_I8_A0.5090.30
137_Y143_A0.5020.29
62_A145_C0.5000.29
69_I131_P0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2x3cA 2 0.6301 73.9 0.878 Contact Map
2l0dA 1 0.5959 62.3 0.887 Contact Map
3isyA 1 0.6507 56.2 0.891 Contact Map
3iduA 1 0.6644 45.6 0.898 Contact Map
3cfuA 1 0.7671 44.8 0.898 Contact Map
1yewA 3 0.9589 42.1 0.9 Contact Map
4r4gA 1 0.6849 34.9 0.904 Contact Map
3abzA 3 0.7808 24.4 0.912 Contact Map
2kutA 1 0.6096 23.7 0.912 Contact Map
4phzA 3 0.9384 22.3 0.913 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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