DUF2391 - PFAM28P - GREMLIN Contacts

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DUF2391 - Putative integral membrane protein (DUF2391)

PFAM:	PF09622	Sequences: DLARGFAGALLFGLPLLMTMEMWWLGFYMDPLRLLLLLALTFPLLVGLSRYAGFRRTRTASWRDDVLDAVEALAIGIVASALVLLLLGVITPDMPLSEIVGKIALQAVPASIGALLARSQLGGGRDDDDEEEGEREREAGYLGELFLMAAGALFLAFNVAPTEEMILIAYKMTPWHLLALIALSLLLMHAIVYAVGFRGQEERPEGTGLWQAFLRFTLVGYAVALLVSAYMLWTFGRLDGDPLTEWLSATVVLGFPAAIGAAAARLIL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	268 (265)
Sequences:	570 (468)
Seq/√Len:	28.7
META:	0.725

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
230_Y	234_T	4.985	1.00
229_A	238_L	4.110	1.00
178_L	182_A	3.720	1.00
5_G	75_I	3.649	1.00
41_T	111_S	3.459	1.00
6_F	79_A	3.308	1.00
156_A	257_A	3.282	1.00
89_V	171_K	3.230	1.00
225_L	254_G	3.202	1.00
148_M	220_G	3.183	1.00
149_A	223_V	3.132	1.00
81_A	103_I	3.096	1.00
224_A	257_A	2.887	1.00
159_V	165_M	2.787	1.00
108_V	157_F	2.675	1.00
87_L	168_I	2.643	1.00
149_A	227_V	2.560	0.99
163_E	237_R	2.420	0.99
254_G	257_A	2.360	0.99
49_S	65_D	2.238	0.98
120_Q	158_N	2.227	0.98
238_L	246_W	2.145	0.98
35_L	178_L	2.092	0.97
32_L	35_L	2.040	0.97
192_V	262_A	1.982	0.96
86_L	179_A	1.968	0.96
218_L	229_A	1.955	0.96
24_W	27_F	1.933	0.96
86_L	183_L	1.932	0.96
177_L	248_S	1.903	0.95
73_L	107_A	1.893	0.95
26_G	101_G	1.868	0.95
88_G	176_H	1.799	0.94
116_L	150_A	1.796	0.94
49_S	59_T	1.788	0.94
94_M	98_E	1.763	0.93
109_P	157_F	1.752	0.93
16_L	156_A	1.746	0.93
75_I	114_A	1.738	0.93
20_M	24_W	1.712	0.92
252_V	256_P	1.698	0.92
36_L	40_L	1.696	0.92
44_L	157_F	1.682	0.91
181_I	212_A	1.661	0.91
59_T	65_D	1.654	0.91
179_A	183_L	1.621	0.90
98_E	102_K	1.604	0.89
94_M	99_I	1.587	0.89
143_G	147_L	1.571	0.88
29_M	47_G	1.556	0.88
67_L	156_A	1.551	0.88
22_M	165_M	1.547	0.87
261_A	264_A	1.517	0.86
78_V	153_L	1.516	0.86
30_D	35_L	1.509	0.86
82_L	85_L	1.493	0.86
29_M	105_L	1.489	0.85
196_G	268_L	1.464	0.84
229_A	250_T	1.459	0.84
105_L	116_L	1.448	0.84
55_R	59_T	1.447	0.84
158_N	266_L	1.440	0.83
16_L	22_M	1.440	0.83
75_I	173_T	1.428	0.83
119_S	268_L	1.352	0.79
42_F	70_V	1.351	0.79
176_H	179_A	1.327	0.78
173_T	176_H	1.311	0.77
144_E	192_V	1.291	0.76
12_F	15_P	1.281	0.75
163_E	167_L	1.276	0.75
29_M	234_T	1.271	0.75
103_I	169_A	1.268	0.75
59_T	80_S	1.263	0.74
60_A	64_D	1.258	0.74
263_A	268_L	1.248	0.73
54_F	72_A	1.247	0.73
44_L	149_A	1.235	0.73
155_L	222_A	1.219	0.72
45_L	115_L	1.208	0.71
4_R	8_G	1.204	0.71
94_M	102_K	1.198	0.70
163_E	166_I	1.193	0.70
34_L	112_I	1.178	0.69
148_M	216_F	1.176	0.69
2_L	54_F	1.167	0.68
192_V	217_T	1.157	0.68
103_I	178_L	1.155	0.67
119_S	188_M	1.154	0.67
140_G	147_L	1.152	0.67
159_V	163_E	1.151	0.67
169_A	248_S	1.147	0.67
64_D	172_M	1.139	0.66
147_L	195_V	1.134	0.66
40_L	198_R	1.127	0.65
56_R	130_E	1.126	0.65
118_R	147_L	1.123	0.65
181_I	244_T	1.114	0.65
128_D	131_E	1.111	0.64
236_G	239_D	1.103	0.64
19_T	23_W	1.102	0.64
256_P	265_R	1.094	0.63
263_A	267_I	1.090	0.63
74_A	77_I	1.088	0.63
184_S	224_A	1.086	0.63
98_E	101_G	1.082	0.62
75_I	117_A	1.079	0.62
241_D	249_A	1.074	0.62
222_A	236_G	1.072	0.62
153_L	169_A	1.069	0.61
95_P	100_V	1.067	0.61
211_Q	215_R	1.066	0.61
50_R	60_A	1.064	0.61
77_I	107_A	1.058	0.60
69_A	237_R	1.055	0.60
191_I	267_I	1.047	0.60
14_L	259_I	1.046	0.60
131_E	134_E	1.043	0.59
81_A	173_T	1.042	0.59
46_V	69_A	1.031	0.58
55_R	67_L	1.030	0.58
176_H	181_I	1.029	0.58
5_G	114_A	1.028	0.58
239_D	261_A	1.020	0.58
142_L	186_L	1.019	0.58
38_L	182_A	1.014	0.57
229_A	246_W	1.005	0.56
231_M	236_G	1.003	0.56
61_S	64_D	1.000	0.56
262_A	266_L	0.993	0.56
161_P	197_F	0.990	0.55
27_F	102_K	0.987	0.55
262_A	265_R	0.981	0.55
68_D	180_L	0.978	0.54
50_R	119_S	0.976	0.54
155_L	188_M	0.973	0.54
41_T	73_L	0.970	0.54
104_A	228_S	0.967	0.54
179_A	182_A	0.965	0.53
256_P	262_A	0.965	0.53
264_A	267_I	0.957	0.53
10_L	37_L	0.957	0.53
11_L	106_Q	0.955	0.53
152_A	257_A	0.954	0.53
189_H	192_V	0.953	0.52
236_G	242_P	0.953	0.52
216_F	220_G	0.950	0.52
260_G	265_R	0.949	0.52
61_S	169_A	0.943	0.52
44_L	112_I	0.940	0.51
14_L	251_V	0.925	0.50
32_L	142_L	0.916	0.50
168_I	171_K	0.914	0.49
69_A	112_I	0.914	0.49
5_G	11_L	0.909	0.49
2_L	5_G	0.909	0.49
77_I	104_A	0.893	0.48
182_A	186_L	0.887	0.47
5_G	70_V	0.886	0.47
117_A	200_Q	0.886	0.47
5_G	8_G	0.883	0.47
139_A	143_G	0.883	0.47
226_L	246_W	0.882	0.47
44_L	90_I	0.879	0.47
46_V	66_V	0.879	0.47
190_A	195_V	0.878	0.47
37_L	147_L	0.874	0.46
62_W	67_L	0.872	0.46
69_A	111_S	0.868	0.46
224_A	228_S	0.868	0.46
132_E	169_A	0.855	0.45
78_V	124_G	0.850	0.44
91_T	258_A	0.849	0.44
86_L	168_I	0.847	0.44
214_L	240_G	0.846	0.44
36_L	234_T	0.843	0.44
5_G	9_A	0.840	0.44
11_L	155_L	0.838	0.44
203_R	212_A	0.836	0.43
67_L	71_E	0.828	0.43
85_L	176_H	0.827	0.43
16_L	200_Q	0.827	0.43
133_G	226_L	0.821	0.42
77_I	139_A	0.819	0.42
133_G	223_V	0.815	0.42
241_D	251_V	0.814	0.42
112_I	150_A	0.814	0.42
156_A	228_S	0.813	0.42
13_G	118_R	0.812	0.42
16_L	247_L	0.811	0.42
29_M	36_L	0.810	0.41
68_D	120_Q	0.809	0.41
111_S	173_T	0.807	0.41
173_T	182_A	0.802	0.41
76_G	231_M	0.800	0.41
209_L	212_A	0.789	0.40
100_V	243_L	0.786	0.40
208_G	211_Q	0.785	0.40
215_R	268_L	0.785	0.40
92_P	187_L	0.780	0.39
119_S	263_A	0.778	0.39
191_I	268_L	0.776	0.39
233_W	266_L	0.774	0.39
188_M	222_A	0.773	0.39
265_R	268_L	0.772	0.39
226_L	229_A	0.772	0.39
29_M	118_R	0.769	0.38
68_D	121_L	0.768	0.38
64_D	231_M	0.766	0.38
62_W	254_G	0.756	0.37
13_G	24_W	0.753	0.37
99_I	268_L	0.753	0.37
9_A	110_A	0.750	0.37
2_L	13_G	0.747	0.37
216_F	264_A	0.742	0.36
130_E	134_E	0.741	0.36
175_W	179_A	0.740	0.36
191_I	263_A	0.740	0.36
12_F	256_P	0.739	0.36
47_G	209_L	0.738	0.36
37_L	119_S	0.738	0.36
103_I	244_T	0.736	0.36
81_A	174_P	0.734	0.36
191_I	227_V	0.734	0.36
119_S	198_R	0.734	0.36
70_V	75_I	0.733	0.36
193_Y	251_V	0.731	0.36
49_S	171_K	0.727	0.35
144_E	216_F	0.726	0.35
36_L	230_Y	0.724	0.35
43_P	77_I	0.722	0.35
55_R	115_L	0.720	0.35
233_W	237_R	0.718	0.35
74_A	246_W	0.715	0.35
168_I	180_L	0.712	0.34
42_F	87_L	0.708	0.34
3_A	130_E	0.708	0.34
30_D	33_R	0.706	0.34
115_L	168_I	0.702	0.34
52_A	257_A	0.701	0.34
66_V	208_G	0.700	0.33
66_V	130_E	0.699	0.33
15_P	19_T	0.699	0.33
55_R	119_S	0.696	0.33
208_G	213_F	0.695	0.33
104_A	166_I	0.695	0.33
96_L	121_L	0.694	0.33
165_M	170_Y	0.694	0.33
40_L	93_D	0.693	0.33
188_M	220_G	0.693	0.33
64_D	77_I	0.692	0.33
222_A	247_L	0.691	0.33
85_L	179_A	0.691	0.33
5_G	49_S	0.688	0.33
77_I	117_A	0.687	0.33
85_L	242_P	0.684	0.32
116_L	154_F	0.680	0.32
193_Y	196_G	0.678	0.32
43_P	215_R	0.675	0.32
38_L	163_E	0.669	0.31
166_I	203_R	0.667	0.31
148_M	261_A	0.666	0.31
144_E	188_M	0.666	0.31
5_G	63_R	0.665	0.31
36_L	214_L	0.662	0.31
115_L	150_A	0.660	0.31
33_R	239_D	0.659	0.31
189_H	213_F	0.658	0.31
47_G	52_A	0.654	0.30
41_T	61_S	0.653	0.30
241_D	246_W	0.653	0.30
109_P	192_V	0.653	0.30
41_T	108_V	0.651	0.30
138_E	250_T	0.648	0.30
244_T	251_V	0.647	0.30
42_F	46_V	0.647	0.30
49_S	153_L	0.647	0.30
165_M	252_V	0.646	0.30
22_M	105_L	0.645	0.30
93_D	172_M	0.643	0.30
122_G	198_R	0.642	0.30
232_L	235_F	0.641	0.30
48_L	74_A	0.639	0.29
110_A	148_M	0.638	0.29
140_G	159_V	0.634	0.29
105_L	144_E	0.634	0.29
10_L	157_F	0.632	0.29
76_G	80_S	0.629	0.29
196_G	200_Q	0.629	0.29
128_D	226_L	0.626	0.29
144_E	148_M	0.625	0.28
8_G	21_E	0.624	0.28
78_V	179_A	0.623	0.28
11_L	38_L	0.621	0.28
144_E	158_N	0.621	0.28
199_G	258_A	0.618	0.28
178_L	227_V	0.618	0.28
119_S	267_I	0.617	0.28
45_L	51_Y	0.617	0.28
112_I	248_S	0.615	0.28
107_A	240_G	0.614	0.28
20_M	23_W	0.613	0.28
12_F	252_V	0.613	0.28
56_R	182_A	0.610	0.28
243_L	246_W	0.610	0.28
213_F	216_F	0.610	0.28
107_A	197_F	0.610	0.28
35_L	41_T	0.610	0.28
82_L	130_E	0.609	0.27
13_G	110_A	0.609	0.27
165_M	257_A	0.609	0.27
9_A	148_M	0.609	0.27
90_I	132_E	0.606	0.27
89_V	193_Y	0.603	0.27
135_R	229_A	0.603	0.27
89_V	102_K	0.601	0.27
91_T	129_D	0.599	0.27
116_L	120_Q	0.599	0.27
29_M	149_A	0.597	0.27
146_F	228_S	0.596	0.27
135_R	168_I	0.595	0.27
100_V	214_L	0.593	0.26
7_A	194_A	0.592	0.26
27_F	235_F	0.592	0.26
29_M	34_L	0.586	0.26
71_E	263_A	0.586	0.26
46_V	62_W	0.583	0.26
169_A	257_A	0.583	0.26
100_V	244_T	0.581	0.26
74_A	197_F	0.580	0.26
172_M	252_V	0.580	0.26
96_L	100_V	0.580	0.26
21_E	164_E	0.580	0.26
166_I	202_E	0.579	0.26
73_L	145_L	0.576	0.25
259_I	268_L	0.575	0.25
144_E	261_A	0.571	0.25
183_L	187_L	0.568	0.25
170_Y	251_V	0.560	0.25
16_L	208_G	0.560	0.25
157_F	257_A	0.559	0.24
142_L	250_T	0.559	0.24
168_I	202_E	0.558	0.24
82_L	92_P	0.558	0.24
46_V	83_V	0.555	0.24
217_T	265_R	0.554	0.24
24_W	102_K	0.554	0.24
42_F	71_E	0.554	0.24
191_I	238_L	0.552	0.24
34_L	105_L	0.551	0.24
52_A	150_A	0.550	0.24
86_L	90_I	0.550	0.24
76_G	92_P	0.549	0.24
93_D	259_I	0.546	0.24
78_V	187_L	0.543	0.24
92_P	202_E	0.541	0.23
12_F	155_L	0.540	0.23
106_Q	155_L	0.540	0.23
158_N	175_W	0.540	0.23
200_Q	262_A	0.539	0.23
51_Y	139_A	0.539	0.23
18_M	189_H	0.538	0.23
96_L	187_L	0.537	0.23
247_L	250_T	0.530	0.23
183_L	255_F	0.530	0.23
34_L	198_R	0.528	0.23
15_P	26_G	0.526	0.23
22_M	76_G	0.526	0.23
192_V	216_F	0.526	0.23
188_M	268_L	0.525	0.23
22_M	187_L	0.524	0.23
261_A	267_I	0.524	0.23
103_I	185_L	0.523	0.22
130_E	226_L	0.523	0.22
179_A	202_E	0.523	0.22
119_S	191_I	0.523	0.22
80_S	110_A	0.522	0.22
140_G	143_G	0.521	0.22
101_G	225_L	0.521	0.22
24_W	28_Y	0.521	0.22
9_A	114_A	0.519	0.22
2_L	9_A	0.519	0.22
111_S	119_S	0.518	0.22
32_L	231_M	0.518	0.22
40_L	124_G	0.515	0.22
149_A	186_L	0.514	0.22
91_T	175_W	0.513	0.22
18_M	264_A	0.512	0.22
166_I	237_R	0.511	0.22
216_F	261_A	0.511	0.22
228_S	253_L	0.509	0.22
49_S	55_R	0.507	0.22
179_A	231_M	0.505	0.22
26_G	31_P	0.504	0.21
24_W	171_K	0.504	0.21
29_M	66_V	0.503	0.21
183_L	242_P	0.500	0.21
37_L	44_L	0.500	0.21

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1nkzA	4	0.1978	8.7	0.974	Contact Map
3wmmA	3	0.2164	5.8	0.976	Contact Map
3aqpA	1	0.4403	4.7	0.977	Contact Map
3zuxA	1	0.4104	4.6	0.977	Contact Map
4px7A	1	0.3955	4.2	0.977	Contact Map
4dx5A	3	0.4813	3.7	0.978	Contact Map
4jc95	3	0.1567	3.2	0.978	Contact Map
3w9iA	3	0.4515	2.6	0.979	Contact Map
1xrdA	1	0.194	2.4	0.98	Contact Map
2m3eA	1	0.1754	1.9	0.981	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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