GREMLIN Database
Cas_GSU0053 - CRISPR-associated protein GSU0053 (Cas_GSU0053)
PFAM: PF09617 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 169 (167)
Sequences: 2358 (1699)
Seq/√Len: 131.5
META: 0.925

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_Q161_S4.5541.00
61_W89_E3.8841.00
17_F46_V3.5591.00
11_G15_D3.1841.00
73_P135_P2.8271.00
31_A42_R2.6511.00
34_T42_R2.3751.00
115_G118_L2.3021.00
137_S142_V2.2811.00
76_R84_L2.2141.00
25_L28_A2.1461.00
22_F48_S2.1031.00
117_A132_K2.0681.00
107_K111_K2.0621.00
86_S89_E2.0241.00
56_L159_L1.9541.00
94_L130_L1.9271.00
85_T90_A1.9151.00
95_A142_V1.8801.00
58_P89_E1.8641.00
43_V166_V1.8351.00
90_A98_Y1.8161.00
145_S149_G1.8151.00
74_Y86_S1.8041.00
97_A146_R1.7951.00
20_P46_V1.7691.00
134_D137_S1.7311.00
75_V94_L1.7291.00
45_L48_S1.6781.00
47_D52_Q1.6701.00
51_S55_R1.6501.00
37_G41_T1.6451.00
115_G119_K1.6291.00
100_R146_R1.6201.00
78_D84_L1.6171.00
83_G86_S1.5721.00
56_L140_F1.5591.00
68_G88_L1.5421.00
83_G89_E1.5291.00
64_A74_Y1.4791.00
116_K120_A1.4721.00
77_V99_I1.4651.00
66_D84_L1.4621.00
41_T167_D1.4491.00
61_W66_D1.4431.00
100_R145_S1.4331.00
67_D71_A1.4291.00
24_D27_A1.4251.00
108_P111_K1.3881.00
112_S115_G1.3591.00
54_N57_E1.3441.00
65_Y68_G1.3411.00
97_A100_R1.3291.00
113_E116_K1.3281.00
131_F138_L1.3021.00
24_D28_A1.2991.00
47_D51_S1.2571.00
78_D82_E1.2551.00
26_G29_T1.2431.00
68_G71_A1.2361.00
138_L155_L1.2301.00
8_Q14_G1.2241.00
68_G72_L1.1920.99
111_K118_L1.1910.99
29_T42_R1.1590.99
116_K119_K1.1480.99
30_Y33_E1.1420.99
138_L158_A1.1330.99
34_T40_G1.1310.99
87_S134_D1.1270.99
117_A120_A1.1230.99
42_R167_D1.1230.99
121_A155_L1.1210.99
165_A168_V1.1150.99
149_G152_G1.1070.99
22_F45_L1.1060.99
114_L133_L1.0970.99
66_D76_R1.0830.99
47_D55_R1.0420.99
44_V165_A1.0410.99
94_L142_V1.0400.98
101_D145_S1.0390.98
101_D146_R1.0380.98
148_L153_A1.0270.98
115_G150_G1.0230.98
97_A101_D1.0100.98
58_P69_V1.0080.98
36_R40_G1.0070.98
126_N129_A0.9940.98
113_E118_L0.9880.98
104_L109_F0.9680.98
87_S99_I0.9590.97
44_V168_V0.9560.97
107_K113_E0.9430.97
130_L142_V0.9410.97
72_L87_S0.9380.97
147_P150_G0.9360.97
115_G121_A0.9230.97
60_L70_L0.9160.97
157_R161_S0.9100.96
75_V99_I0.9060.96
118_L121_A0.9040.96
7_L163_I0.9030.96
124_P127_A0.8950.96
110_R115_G0.8930.96
52_Q55_R0.8930.96
114_L117_A0.8760.96
6_E13_P0.8730.96
142_V156_P0.8710.96
103_E107_K0.8550.95
68_G74_Y0.8510.95
105_D108_P0.8500.95
18_F21_T0.8270.94
111_K115_G0.8190.94
45_L50_Q0.8170.94
88_L136_T0.8090.93
95_A137_S0.7880.92
56_L59_A0.7880.92
103_E106_G0.7780.92
100_R152_G0.7770.92
33_E36_R0.7750.92
136_T140_F0.7700.92
123_D126_N0.7690.92
151_G154_K0.7680.91
155_L158_A0.7670.91
127_A155_L0.7660.91
106_G110_R0.7640.91
48_S51_S0.7630.91
8_Q13_P0.7620.91
135_P144_D0.7600.91
64_A72_L0.7570.91
18_F90_A0.7520.91
50_Q162_E0.7490.90
128_A145_S0.7470.90
139_L159_L0.7470.90
41_T166_V0.7460.90
35_R39_D0.7450.90
127_A153_A0.7440.90
78_D83_G0.7410.90
100_R149_G0.7390.90
27_A168_V0.7330.89
129_A158_A0.7260.89
113_E120_A0.7210.89
121_A127_A0.7210.89
145_S150_G0.7170.88
144_D148_L0.7160.88
59_A71_A0.7160.88
45_L56_L0.7150.88
101_D150_G0.7110.88
12_G15_D0.7100.88
63_A66_D0.6970.87
65_Y71_A0.6950.87
118_L142_V0.6950.87
34_T62_D0.6940.87
95_A152_G0.6930.87
55_R58_P0.6910.87
46_V165_A0.6890.86
15_D43_V0.6880.86
115_G120_A0.6850.86
47_D143_W0.6710.85
106_G109_F0.6690.85
100_R153_A0.6590.84
111_K116_K0.6520.83
160_S165_A0.6510.83
80_D83_G0.6490.83
95_A144_D0.6480.83
22_F28_A0.6460.83
79_F84_L0.6420.82
3_L56_L0.6410.82
49_V160_S0.6410.82
69_V72_L0.6410.82
36_R39_D0.6400.82
88_L127_A0.6390.82
113_E117_A0.6330.81
112_S116_K0.6310.81
120_A126_N0.6280.81
34_T39_D0.6280.81
161_S166_V0.6210.80
117_A126_N0.6210.80
102_S106_G0.6180.80
65_Y104_L0.6150.79
149_G154_K0.6150.79
144_D147_P0.6150.79
15_D30_Y0.6130.79
95_A134_D0.6070.79
125_R129_A0.6060.78
20_P47_D0.6050.78
51_S54_N0.6040.78
4_R14_G0.6020.78
104_L112_S0.6010.78
90_A99_I0.5980.78
53_A157_R0.5960.77
43_V156_P0.5920.77
106_G112_S0.5890.77
2_L14_G0.5890.77
75_V142_V0.5800.75
117_A129_A0.5740.75
103_E112_S0.5730.75
113_E132_K0.5690.74
76_R88_L0.5680.74
79_F82_E0.5680.74
10_V58_P0.5680.74
2_L10_V0.5630.73
16_R33_E0.5630.73
66_D69_V0.5610.73
2_L158_A0.5610.73
97_A145_S0.5600.73
13_P28_A0.5600.73
42_R169_R0.5570.72
74_Y134_D0.5550.72
90_A94_L0.5550.72
67_D76_R0.5540.72
49_V157_R0.5530.72
142_V155_L0.5470.71
32_I42_R0.5360.70
19_P27_A0.5360.70
128_A132_K0.5350.69
30_Y43_V0.5280.68
74_Y137_S0.5270.68
85_T98_Y0.5270.68
52_Q96_D0.5260.68
129_A132_K0.5250.68
119_K147_P0.5250.68
62_D65_Y0.5240.68
77_V146_R0.5230.68
68_G76_R0.5220.68
107_K110_R0.5210.67
7_L83_G0.5200.67
23_P26_G0.5180.67
146_R149_G0.5180.67
45_L162_E0.5180.67
102_S145_S0.5170.67
87_S136_T0.5170.67
162_E166_V0.5160.67
65_Y69_V0.5140.66
96_D143_W0.5120.66
64_A76_R0.5110.66
91_P98_Y0.5100.66
111_K120_A0.5090.66
33_E50_Q0.5070.65
23_P29_T0.5060.65
95_A155_L0.5050.65
20_P27_A0.5050.65
130_L155_L0.5040.65
31_A48_S0.5020.65
77_V85_T0.5010.64
94_L137_S0.5010.64
147_P152_G0.5010.64
114_L118_L0.5000.64
102_S105_D0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2irmA 1 0.4675 3.9 0.959 Contact Map
2mpvA 1 0.6036 3.8 0.959 Contact Map
1bh9A 1 0.2367 3 0.962 Contact Map
2g48C 1 0.1183 2.9 0.962 Contact Map
1zzaA 1 0.3195 2.8 0.962 Contact Map
2k5jA 2 0.4734 2.4 0.964 Contact Map
3t91A 3 0.355 2.1 0.965 Contact Map
2isnA 2 0.3905 1.9 0.965 Contact Map
1vsy3 1 0.3314 1.8 0.966 Contact Map
1d3bB 1 0.213 1.8 0.966 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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