GREMLIN Database
Cas_Csy2 - CRISPR-associated protein (Cas_Csy2)
PFAM: PF09614 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 296 (296)
Sequences: 841 (663)
Seq/√Len: 38.5
META: 0.655

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_M53_V5.2261.00
61_Q94_H4.2431.00
54_V166_G4.1011.00
129_L134_I3.7641.00
5_H96_E3.5661.00
1_L120_V3.5501.00
98_S163_L3.1901.00
58_F93_C3.1181.00
233_V265_S3.1061.00
20_W60_L3.0741.00
8_V129_L3.0301.00
16_S19_T3.0161.00
168_A281_L3.0101.00
32_V101_I2.6521.00
2_L100_V2.6501.00
102_E284_R2.5951.00
237_A258_R2.5911.00
277_S280_Q2.5851.00
255_T258_R2.5831.00
54_V168_A2.5501.00
38_K126_G2.4871.00
4_P140_P2.4561.00
75_R84_T2.4481.00
288_D291_N2.4471.00
156_F160_R2.3931.00
236_Q263_V2.3791.00
208_P215_V2.2721.00
239_S242_Y2.2500.99
34_A38_K2.2470.99
29_L285_Y2.2320.99
61_Q92_R2.2300.99
9_Q135_L2.2020.99
209_D214_K2.1890.99
172_R175_L2.1860.99
172_R268_E2.0810.99
32_V51_V2.0390.99
55_C272_P2.0040.99
65_G70_S1.9790.99
171_E265_S1.9050.98
207_E218_Q1.8860.98
180_M184_Q1.8820.98
31_F129_L1.8480.98
79_D83_K1.8430.98
180_M192_A1.8370.98
241_L258_R1.8210.98
242_Y246_E1.7880.97
62_T69_Y1.7830.97
78_L84_T1.7690.97
8_V95_L1.7520.97
252_D255_T1.7220.97
22_F55_C1.7220.97
1_L142_L1.6940.96
24_A295_L1.6830.96
64_K69_Y1.6150.95
3_L124_L1.6110.95
60_L93_C1.6110.95
96_E182_E1.5940.95
10_N92_R1.5780.94
6_L100_V1.5720.94
31_F128_R1.5610.94
36_E48_F1.5430.94
206_A215_V1.5370.94
170_V270_I1.5100.93
157_R160_R1.5070.93
48_F101_I1.5070.93
128_R133_S1.5020.93
209_D216_E1.4810.92
74_T78_L1.4770.92
179_H198_D1.4700.92
11_A95_L1.4180.91
2_L98_S1.4140.90
154_K158_K1.4040.90
31_F124_L1.3960.90
175_L268_E1.3790.89
55_C58_F1.3670.89
181_Q184_Q1.3640.89
20_W33_H1.3250.87
114_E118_E1.3200.87
52_G168_A1.3190.87
23_P30_G1.2810.85
81_D85_A1.2790.85
176_L196_W1.2760.85
54_V272_P1.2710.85
24_A191_D1.2670.85
20_W91_G1.2430.84
250_A255_T1.2220.83
2_L143_L1.2190.82
26_T30_G1.2170.82
196_W206_A1.2080.82
75_R85_A1.2040.82
33_H285_Y1.2020.82
179_H182_E1.1980.81
198_D201_R1.1880.81
73_L91_G1.1870.81
21_G30_G1.1780.80
109_D112_D1.1740.80
16_S27_A1.1720.80
24_A33_H1.1610.79
53_V65_G1.1590.79
244_P257_F1.1550.79
55_C274_R1.1520.79
39_L48_F1.1500.79
3_L101_I1.1470.78
166_G172_R1.1470.78
124_L129_L1.1430.78
1_L8_V1.1420.78
53_V206_A1.1390.78
204_H219_Y1.1270.77
167_F176_L1.1250.77
50_G284_R1.1220.77
257_F269_W1.1200.77
209_D212_G1.1180.77
87_I237_A1.1120.76
58_F193_L1.1090.76
236_Q293_L1.1030.76
8_V131_G1.0930.75
180_M260_V1.0920.75
100_V111_D1.0860.74
241_L245_G1.0850.74
237_A292_G1.0800.74
219_Y222_R1.0780.74
49_D104_E1.0770.74
131_G134_I1.0720.74
32_V53_V1.0530.72
155_E235_Y1.0530.72
251_R259_F1.0500.72
39_L161_R1.0460.72
194_D239_S1.0430.71
65_G68_V1.0340.71
25_M28_F1.0340.71
276_K280_Q1.0320.71
10_N94_H1.0310.71
254_T290_E1.0300.70
183_L195_A1.0290.70
33_H60_L1.0180.70
287_Y292_G1.0130.69
87_I160_R1.0090.69
79_D84_T1.0050.69
97_V181_Q1.0050.69
173_R265_S1.0040.68
6_L134_I0.9890.67
236_Q292_G0.9700.66
46_L49_D0.9490.64
64_K242_Y0.9430.64
91_G269_W0.9400.63
14_I71_F0.9400.63
151_D228_L0.9380.63
187_N190_A0.9370.63
42_G139_R0.9350.63
285_Y296_C0.9330.63
176_L179_H0.9320.63
263_V293_L0.9280.62
51_V101_I0.9230.62
8_V207_E0.9230.62
136_S186_Q0.9210.62
196_W266_L0.9160.61
265_S269_W0.9120.61
74_T92_R0.9060.60
141_E162_R0.9040.60
31_F101_I0.9010.60
252_D259_F0.8990.60
239_S259_F0.8980.60
114_E182_E0.8970.60
15_S93_C0.8970.60
150_E186_Q0.8920.59
41_A44_L0.8850.59
97_V127_M0.8850.59
103_V142_L0.8810.58
251_R269_W0.8810.58
250_A257_F0.8720.57
279_D284_R0.8680.57
100_V274_R0.8670.57
148_D243_P0.8620.57
26_T235_Y0.8560.56
100_V123_L0.8550.56
74_T84_T0.8520.56
258_R262_S0.8490.55
243_P246_E0.8480.55
175_L227_W0.8470.55
229_V267_G0.8460.55
73_L88_I0.8410.55
7_R96_E0.8380.54
52_G275_L0.8380.54
264_Y269_W0.8370.54
52_G56_H0.8360.54
110_E113_R0.8360.54
4_P137_I0.8340.54
146_P155_E0.8330.54
14_I18_L0.8300.54
196_W285_Y0.8230.53
241_L281_L0.8220.53
72_I84_T0.8140.52
1_L16_S0.8110.52
110_E119_Q0.8110.52
59_Q93_C0.8100.52
174_D178_E0.8090.52
4_P9_Q0.8070.52
174_D268_E0.8060.52
169_L231_I0.8030.51
220_S223_P0.8010.51
62_T93_C0.7930.50
150_E154_K0.7920.50
179_H247_V0.7890.50
65_G69_Y0.7880.50
78_L265_S0.7870.50
77_P165_P0.7860.50
232_P262_S0.7850.50
196_W265_S0.7790.49
205_R220_S0.7780.49
60_L202_L0.7770.49
151_D162_R0.7720.49
219_Y266_L0.7710.48
180_M183_L0.7690.48
180_M190_A0.7660.48
31_F127_M0.7650.48
96_E124_L0.7630.48
51_V293_L0.7620.48
49_D102_E0.7550.47
116_L278_L0.7540.47
28_F97_V0.7540.47
136_S182_E0.7520.47
100_V282_L0.7500.47
2_L51_V0.7500.47
174_D188_P0.7500.47
15_S90_E0.7490.46
21_G26_T0.7440.46
113_R144_S0.7440.46
33_H228_L0.7440.46
206_A218_Q0.7430.46
14_I28_F0.7410.46
63_Y72_I0.7380.45
192_A196_W0.7340.45
11_A17_P0.7320.45
31_F167_F0.7290.45
31_F134_I0.7270.44
102_E235_Y0.7250.44
178_E240_P0.7230.44
64_K67_Y0.7220.44
238_I290_E0.7210.44
123_L282_L0.7200.44
39_L46_L0.7160.44
116_L120_V0.7130.43
204_H222_R0.7120.43
187_N216_E0.7090.43
7_R57_D0.7090.43
81_D97_V0.7070.43
71_F269_W0.7060.43
33_H220_S0.7060.43
64_K70_S0.7050.43
96_E127_M0.7030.42
8_V28_F0.7030.42
8_V237_A0.7030.42
19_T22_F0.7010.42
137_I140_P0.7000.42
59_Q157_R0.6980.42
268_E271_S0.6970.42
58_F81_D0.6970.42
249_N268_E0.6960.42
74_T77_P0.6950.42
143_L240_P0.6940.42
118_E186_Q0.6940.42
76_N90_E0.6910.41
4_P15_S0.6870.41
113_R117_A0.6870.41
73_L87_I0.6860.41
29_L296_C0.6840.41
8_V108_A0.6840.41
19_T90_E0.6830.41
108_A116_L0.6830.41
12_N15_S0.6810.40
59_Q192_A0.6810.40
260_V269_W0.6810.40
54_V158_K0.6780.40
50_G282_L0.6770.40
59_Q94_H0.6770.40
199_L266_L0.6760.40
198_D206_A0.6760.40
207_E210_E0.6730.40
226_G251_R0.6720.40
53_V197_L0.6710.40
102_E228_L0.6690.39
129_L158_K0.6690.39
109_D291_N0.6650.39
139_R178_E0.6650.39
23_P26_T0.6640.39
29_L51_V0.6630.39
81_D218_Q0.6630.39
173_R233_V0.6620.39
63_Y69_Y0.6620.39
122_E216_E0.6610.39
258_R292_G0.6580.38
77_P90_E0.6520.38
111_D253_P0.6510.38
185_Q276_K0.6500.38
175_L252_D0.6480.38
186_Q243_P0.6470.38
156_F275_L0.6450.37
71_F75_R0.6440.37
269_W273_H0.6430.37
150_E213_D0.6430.37
160_R174_D0.6420.37
127_M203_N0.6420.37
101_I276_K0.6410.37
105_G161_R0.6410.37
240_P246_E0.6400.37
287_Y291_N0.6400.37
25_M206_A0.6400.37
18_L264_Y0.6390.37
182_E246_E0.6390.37
289_P292_G0.6380.37
186_Q266_L0.6370.37
251_R267_G0.6350.37
32_V196_W0.6350.37
181_Q276_K0.6340.36
225_K268_E0.6340.36
73_L84_T0.6330.36
192_A265_S0.6300.36
122_E126_G0.6300.36
78_L81_D0.6290.36
65_G228_L0.6290.36
117_A140_P0.6230.36
146_P151_D0.6210.35
182_E243_P0.6210.35
20_W202_L0.6190.35
259_F271_S0.6180.35
16_S264_Y0.6160.35
178_E277_S0.6140.35
22_F165_P0.6130.35
33_H37_R0.6130.35
232_P265_S0.6120.35
53_V97_V0.6110.35
185_Q279_D0.6100.34
124_L137_I0.6070.34
153_E218_Q0.6060.34
41_A120_V0.6060.34
52_G169_L0.6060.34
173_R266_L0.6050.34
139_R290_E0.6020.34
178_E182_E0.5990.34
173_R295_L0.5990.34
275_L281_L0.5980.33
110_E178_E0.5970.33
4_P175_L0.5960.33
83_K86_A0.5960.33
19_T74_T0.5960.33
79_D82_G0.5960.33
8_V151_D0.5940.33
133_S183_L0.5930.33
76_N92_R0.5890.33
90_E226_G0.5880.33
50_G54_V0.5880.33
110_E117_A0.5870.33
176_L271_S0.5870.33
20_W269_W0.5870.33
234_G261_E0.5860.33
15_S293_L0.5860.33
90_E229_V0.5850.32
72_I257_F0.5840.32
117_A141_E0.5790.32
119_Q122_E0.5790.32
285_Y289_P0.5760.32
118_E122_E0.5750.32
106_L235_Y0.5750.32
54_V228_L0.5740.32
26_T179_H0.5730.32
77_P267_G0.5730.32
20_W179_H0.5730.32
120_V124_L0.5710.31
86_A248_A0.5710.31
46_L201_R0.5710.31
101_I228_L0.5680.31
8_V25_M0.5680.31
63_Y66_G0.5670.31
57_D103_V0.5660.31
54_V163_L0.5650.31
88_I232_P0.5640.31
234_G283_W0.5620.31
103_V118_E0.5620.31
27_A227_W0.5610.31
1_L19_T0.5610.31
5_H138_K0.5610.31
89_E267_G0.5600.31
248_A254_T0.5580.30
207_E216_E0.5570.30
230_P267_G0.5550.30
199_L203_N0.5540.30
211_D254_T0.5510.30
179_H183_L0.5510.30
1_L43_G0.5490.30
275_L278_L0.5460.29
30_G92_R0.5450.29
226_G230_P0.5430.29
212_G266_L0.5430.29
236_Q239_S0.5420.29
25_M231_I0.5420.29
4_P12_N0.5410.29
286_H290_E0.5380.29
150_E211_D0.5380.29
27_A232_P0.5370.29
14_I91_G0.5350.29
97_V101_I0.5320.28
25_M29_L0.5310.28
144_S243_P0.5300.28
237_A241_L0.5300.28
27_A130_A0.5300.28
77_P226_G0.5280.28
153_E216_E0.5280.28
54_V273_H0.5280.28
171_E228_L0.5280.28
48_F99_L0.5260.28
24_A232_P0.5260.28
21_G24_A0.5260.28
202_L228_L0.5250.28
164_L268_E0.5240.28
107_I116_L0.5240.28
45_D142_L0.5230.28
97_V128_R0.5220.28
170_V252_D0.5210.28
5_H119_Q0.5210.28
86_A168_A0.5210.28
121_A125_A0.5200.28
17_P22_F0.5190.27
92_R252_D0.5190.27
65_G204_H0.5190.27
283_W294_Y0.5180.27
149_E185_Q0.5160.27
24_A30_G0.5160.27
180_M195_A0.5150.27
29_L72_I0.5140.27
35_L99_L0.5130.27
83_K154_K0.5100.27
111_D118_E0.5100.27
174_D265_S0.5100.27
100_V275_L0.5090.27
170_V197_L0.5090.27
123_L182_E0.5080.27
152_R155_E0.5060.27
57_D106_L0.5050.26
8_V18_L0.5040.26
182_E240_P0.5040.26
14_I20_W0.5020.26
192_A215_V0.5020.26
104_E207_E0.5020.26
272_P276_K0.5000.26
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jmtB 1 0.0777 7.5 0.974 Contact Map
3ks6A 1 0.7061 7 0.974 Contact Map
2o55A 1 0.7466 6.8 0.974 Contact Map
3no3A 1 0.7027 6.2 0.975 Contact Map
2vh3A 2 0.348 4.6 0.976 Contact Map
4tp8S 1 0.2601 3.4 0.978 Contact Map
2mofA 1 0.125 3.4 0.978 Contact Map
4r7oA 4 0.7568 3.2 0.978 Contact Map
4qplA 1 0.1892 2.7 0.979 Contact Map
4oecA 1 0.7162 2.7 0.979 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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