GREMLIN Database
HtrL_YibB - Bacterial protein of unknown function (HtrL_YibB)
PFAM: PF09612 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 261 (242)
Sequences: 1857 (1613)
Seq/√Len: 103.7
META: 0.942

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_E54_K4.0191.00
57_R62_T3.4401.00
5_I137_I3.3811.00
25_D29_E3.2201.00
32_K56_I2.9391.00
180_K183_E2.9251.00
9_L139_A2.9151.00
47_E66_V2.8591.00
51_E55_E2.8221.00
44_F122_D2.6921.00
127_N134_F2.5661.00
7_T43_I2.5401.00
121_N125_I2.5331.00
44_F123_A2.5251.00
47_E50_E2.4861.00
113_V227_D2.4451.00
28_L52_F2.3431.00
30_W33_N2.2941.00
42_V123_A2.2681.00
88_P91_K2.1911.00
46_D49_L2.1341.00
80_K83_K2.1271.00
4_T131_S2.1271.00
124_I205_S2.1011.00
217_E221_N2.0091.00
50_E66_V1.9781.00
194_G227_D1.9511.00
216_E220_N1.9491.00
67_I72_F1.9181.00
40_N131_S1.8901.00
135_F198_G1.8361.00
121_N124_I1.8171.00
141_I195_G1.7981.00
210_L242_F1.7731.00
90_W93_Q1.7731.00
68_D71_D1.7471.00
128_P134_F1.7151.00
78_Y108_E1.6971.00
200_H203_S1.6871.00
122_D126_L1.6721.00
31_F139_A1.6501.00
94_I97_W1.6481.00
199_G203_S1.6031.00
135_F196_F1.5721.00
11_D15_G1.5591.00
52_F56_I1.5511.00
121_N205_S1.5141.00
105_K109_Y1.5101.00
214_L237_K1.5041.00
117_M207_F1.4931.00
225_G228_Q1.4791.00
145_H148_Y1.4741.00
113_V194_G1.4701.00
11_D48_E1.4631.00
177_D180_K1.4581.00
69_L72_F1.4371.00
109_Y113_V1.4341.00
207_F242_F1.4191.00
144_V147_G1.4091.00
63_K128_P1.4051.00
121_N208_N1.4031.00
78_Y82_Q1.3841.00
148_Y151_H1.3821.00
30_W143_R1.3731.00
137_I196_F1.3460.99
41_M62_T1.3330.99
148_Y152_D1.3290.99
51_E54_K1.3290.99
79_D83_K1.3260.99
93_Q96_W1.3230.99
145_H149_F1.3220.99
87_S91_K1.3140.99
17_L102_P1.3030.99
197_F204_I1.3020.99
238_N241_L1.2960.99
120_L204_I1.2870.99
29_E32_K1.2780.99
114_M211_Y1.2710.99
217_E237_K1.2630.99
173_I176_F1.2620.99
156_P159_L1.2610.99
12_I112_L1.2520.99
58_K61_N1.2500.99
172_E175_G1.2490.99
67_I122_D1.2200.99
45_T64_I1.2180.99
154_K157_N1.2150.99
47_E68_D1.2050.99
210_L213_E1.1880.99
90_W94_I1.1850.99
82_Q86_N1.1850.99
146_D151_H1.1830.99
199_G204_I1.1530.98
144_V149_F1.1530.98
235_Y242_F1.1300.98
155_W158_K1.1280.98
63_K129_F1.1240.98
98_L101_S1.1210.98
213_E217_E1.1160.98
144_V148_Y1.1140.98
164_I167_F1.1000.98
226_T229_S1.0970.98
69_L73_F1.0960.98
33_N36_K1.0910.98
13_G16_E1.0720.97
132_D200_H1.0720.97
147_G152_D1.0660.97
31_F53_V1.0610.97
44_F126_L1.0550.97
67_I71_D1.0530.97
42_V65_I1.0530.97
179_K183_E1.0530.97
129_F134_F1.0520.97
130_N201_K1.0510.97
206_K241_L1.0440.97
132_D201_K1.0400.97
70_E73_F1.0300.97
85_R90_W1.0200.96
210_L238_N1.0150.96
124_I204_I1.0150.96
4_T127_N1.0030.96
68_D72_F1.0020.96
149_F153_K1.0000.96
87_S90_W0.9900.96
74_Y77_Y0.9770.95
145_H150_T0.9760.95
145_H151_H0.9710.95
134_F201_K0.9690.95
32_K36_K0.9660.95
53_V62_T0.9650.95
36_K56_I0.9640.95
165_H169_I0.9610.95
45_T53_V0.9590.95
178_Y182_N0.9540.95
154_K159_L0.9510.95
27_Y140_G0.9470.94
63_K66_V0.9450.94
80_K220_N0.9440.94
65_I72_F0.9330.94
40_N61_N0.9270.94
116_K138_D0.9200.94
45_T49_L0.9180.94
150_T153_K0.9180.94
207_F231_F0.9160.93
166_F169_I0.9140.93
63_K126_L0.9130.93
54_K64_I0.9110.93
154_K158_K0.9080.93
178_Y181_I0.9060.93
208_N212_Y0.9060.93
155_W159_L0.9060.93
77_Y216_E0.8930.93
79_D82_Q0.8900.92
26_H29_E0.8900.92
163_K243_N0.8890.92
148_Y153_K0.8800.92
162_D168_C0.8620.91
168_C192_I0.8610.91
165_H243_N0.8560.91
177_D184_I0.8550.91
185_I189_V0.8530.91
140_G228_Q0.8500.91
210_L241_L0.8490.91
226_T232_T0.8320.90
115_S119_F0.8320.90
86_N91_K0.8310.90
42_V128_P0.8310.90
164_I207_F0.8240.89
116_K140_G0.8230.89
157_N160_D0.8200.89
182_N185_I0.8200.89
203_S206_K0.8170.89
29_E48_E0.8140.89
32_K55_E0.8110.88
110_N226_T0.8110.88
54_K59_K0.8030.88
211_Y230_I0.8030.88
16_E21_K0.8020.88
144_V151_H0.8010.88
41_M57_R0.8000.88
49_L64_I0.7960.88
124_I134_F0.7950.87
67_I70_E0.7910.87
163_K166_F0.7890.87
184_I221_N0.7890.87
162_D200_H0.7840.87
9_L24_F0.7800.86
170_N173_I0.7770.86
210_L234_M0.7690.86
164_I169_I0.7660.85
91_K94_I0.7650.85
22_R27_Y0.7650.85
192_I235_Y0.7630.85
215_L230_I0.7600.85
172_E176_F0.7580.85
127_N131_S0.7480.84
96_W99_K0.7470.84
173_I178_Y0.7460.84
10_F68_D0.7450.84
4_T40_N0.7440.84
137_I141_I0.7430.84
165_H168_C0.7420.84
34_L137_I0.7410.84
163_K168_C0.7400.83
144_V150_T0.7400.83
28_L32_K0.7380.83
146_D150_T0.7340.83
234_M242_F0.7320.83
168_C171_P0.7310.83
25_D52_F0.7270.82
214_L234_M0.7270.82
53_V57_R0.7250.82
172_E178_Y0.7230.82
11_D14_R0.7200.82
17_L21_K0.7140.81
223_L228_Q0.7130.81
206_K210_L0.7120.81
88_P99_K0.7120.81
122_D125_I0.7110.81
113_V226_T0.7100.81
78_Y107_P0.7090.81
76_E80_K0.7070.81
56_I60_E0.7060.80
230_I234_M0.7060.80
111_P227_D0.7040.80
53_V64_I0.7040.80
44_F65_I0.7010.80
133_Y200_H0.7000.80
38_D61_N0.6980.80
149_F152_D0.6970.80
4_T7_T0.6960.80
75_Y78_Y0.6930.79
232_T236_Y0.6910.79
40_N129_F0.6890.79
110_N113_V0.6860.79
183_E186_G0.6820.78
67_I73_F0.6810.78
85_R88_P0.6780.78
193_R196_F0.6750.77
235_Y244_L0.6750.77
167_F171_P0.6740.77
18_S21_K0.6730.77
89_E93_Q0.6720.77
228_Q232_T0.6710.77
43_I139_A0.6700.77
121_N209_D0.6680.77
147_G151_H0.6680.77
215_L224_M0.6670.77
125_I205_S0.6670.77
70_E79_D0.6640.76
91_K104_A0.6610.76
218_T233_I0.6600.76
97_W100_E0.6600.76
179_K182_N0.6590.76
206_K209_D0.6580.76
218_T221_N0.6580.76
225_G229_S0.6550.75
22_R31_F0.6520.75
207_F234_M0.6510.75
83_K86_N0.6500.75
127_N130_N0.6440.74
100_E105_K0.6360.73
124_I199_G0.6350.73
92_N95_G0.6300.72
164_I168_C0.6290.72
174_H178_Y0.6270.72
218_T230_I0.6260.72
171_P174_H0.6250.72
106_L109_Y0.6240.72
162_D165_H0.6240.72
9_L35_L0.6230.72
167_F170_N0.6210.71
5_I135_F0.6190.71
6_V120_L0.6170.71
29_E33_N0.6160.71
80_K222_G0.6160.71
92_N99_K0.6150.71
138_D194_G0.6150.71
34_L142_T0.6140.71
238_N242_F0.6130.70
218_T228_Q0.6120.70
189_V192_I0.6100.70
146_D152_D0.6100.70
102_P112_L0.6040.69
110_N225_G0.6020.69
5_I39_N0.6020.69
104_A110_N0.6000.69
26_H30_W0.5940.68
118_F122_D0.5930.68
54_K58_K0.5920.68
185_I223_L0.5910.68
30_W142_T0.5890.67
118_F208_N0.5870.67
30_W139_A0.5860.67
120_L197_F0.5850.67
177_D188_N0.5840.67
123_A126_L0.5810.66
43_I62_T0.5800.66
90_W96_W0.5780.66
54_K61_N0.5780.66
91_K99_K0.5760.66
141_I226_T0.5710.65
189_V232_T0.5700.65
14_R103_E0.5670.64
66_V69_L0.5630.64
156_P160_D0.5600.63
120_L198_G0.5600.63
101_S104_A0.5580.63
4_T129_F0.5570.63
69_L108_E0.5540.63
16_E19_E0.5530.63
70_E74_Y0.5530.63
32_K59_K0.5510.62
83_K87_S0.5490.62
109_Y115_S0.5480.62
165_H200_H0.5460.62
209_D213_E0.5460.62
198_G204_I0.5460.62
7_T34_L0.5460.62
117_M227_D0.5450.61
233_I237_K0.5420.61
102_P113_V0.5410.61
181_I187_S0.5410.61
139_A143_R0.5410.61
120_L124_I0.5400.61
154_K161_K0.5390.61
232_T235_Y0.5360.60
68_D73_F0.5360.60
14_R21_K0.5350.60
23_S26_H0.5350.60
34_L37_L0.5340.60
89_E92_N0.5340.60
147_G150_T0.5340.60
160_D165_H0.5330.60
22_R26_H0.5330.60
31_F35_L0.5320.60
167_F193_R0.5310.59
76_E79_D0.5280.59
120_L134_F0.5270.59
21_K227_D0.5260.59
145_H152_D0.5260.59
118_F121_N0.5250.59
46_D68_D0.5240.58
85_R103_E0.5240.58
89_E94_I0.5230.58
67_I119_F0.5230.58
32_K52_F0.5220.58
113_V139_A0.5210.58
214_L218_T0.5170.57
82_Q85_R0.5140.57
122_D222_G0.5120.57
203_S241_L0.5100.56
180_K221_N0.5090.56
57_R61_N0.5090.56
114_M118_F0.5070.56
43_I197_F0.5060.56
14_R20_G0.5060.56
10_F45_T0.5050.56
162_D169_I0.5050.56
212_Y216_E0.5020.55
47_E55_E0.5020.55
65_I126_L0.5010.55
144_V152_D0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3iohA 2 0.8199 55.8 0.939 Contact Map
1o7qA 1 0.8314 35.5 0.946 Contact Map
4m9dA 2 0.2261 6 0.962 Contact Map
1hulA 2 0.1648 5.7 0.963 Contact Map
1p9bA 2 0.2107 4 0.965 Contact Map
2p6wA 1 0.659 3.9 0.966 Contact Map
3ue9A 2 0.2299 3.4 0.966 Contact Map
3wnwA 6 0.1954 2.8 0.968 Contact Map
3hidA 2 0.2299 2.7 0.968 Contact Map
4aylA 1 0.7165 2.7 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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