GREMLIN Database
Cas_Csy1 - CRISPR-associated protein (Cas_Csy1)
PFAM: PF09611 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 378 (373)
Sequences: 824 (694)
Seq/√Len: 35.9
META: 0.633

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
319_Q350_D5.3211.00
176_E180_K5.2841.00
17_Q65_N4.9031.00
14_R70_D4.7631.00
151_P155_A4.1981.00
17_Q68_A3.8471.00
82_K90_A3.8351.00
10_D14_R3.8291.00
21_V24_P3.4801.00
318_A346_E3.3341.00
17_Q64_G2.8821.00
204_P212_S2.7491.00
306_G324_D2.6911.00
203_K207_I2.5511.00
318_A347_I2.5431.00
317_L337_R2.5391.00
251_R298_E2.5251.00
327_R331_D2.4841.00
203_K212_S2.4731.00
88_L110_R2.4351.00
370_G373_E2.3481.00
24_P28_T2.2960.99
307_W324_D2.2880.99
18_I116_A2.2800.99
275_I279_D2.1880.99
133_Y145_L2.1860.99
162_I219_Y2.1810.99
14_R71_V2.1710.99
273_N277_I2.1310.99
11_A14_R2.1170.99
88_L95_L2.1140.99
24_P27_F2.0830.99
8_L74_F2.0720.99
64_G68_A2.0670.99
204_P207_I2.0310.99
28_T36_S2.0090.98
137_G142_D1.9880.98
356_N377_W1.9810.98
64_G70_D1.9790.98
353_R374_H1.9480.98
25_L32_A1.9050.98
25_L34_G1.8960.98
64_G67_A1.8890.98
88_L114_L1.8780.98
316_P319_Q1.8770.98
167_F172_K1.8300.97
11_A70_D1.8010.97
66_A69_L1.7910.97
177_A184_H1.7750.97
91_G110_R1.7670.96
196_V217_K1.7600.96
327_R334_F1.7420.96
316_P350_D1.7280.96
10_D70_D1.7210.96
4_P8_L1.7160.96
14_R17_Q1.7070.96
31_D207_I1.7050.96
296_A322_W1.7000.96
203_K215_G1.6970.96
28_T152_S1.6960.95
318_A350_D1.6890.95
156_H160_Q1.6880.95
308_S324_D1.6830.95
321_L337_R1.6790.95
12_A71_V1.6640.95
137_G140_D1.6590.95
65_N68_A1.6540.95
255_R258_V1.6500.95
84_L95_L1.6450.95
317_L320_Q1.6190.94
262_R266_K1.6170.94
331_D334_F1.6150.94
172_K176_E1.6140.94
17_Q32_A1.5960.94
66_A70_D1.5930.94
280_R283_E1.5900.94
349_K374_H1.5790.93
200_G204_P1.5750.93
65_N70_D1.5730.93
27_F199_F1.5540.93
258_V262_R1.5440.93
168_S171_A1.5410.93
269_P277_I1.5310.92
31_D63_V1.5290.92
67_A70_D1.5250.92
203_K206_N1.5160.92
2_Y13_K1.5150.92
209_Q213_E1.5080.92
327_R343_W1.5000.91
282_D285_V1.4650.90
157_A161_R1.4440.90
3_E6_T1.4410.90
80_D87_H1.4360.90
17_Q71_V1.4330.89
150_F155_A1.4060.89
248_F292_L1.3960.88
50_L54_N1.3760.87
136_V144_H1.3680.87
335_A339_E1.3630.87
163_N215_G1.3630.87
199_F203_K1.3590.87
265_L359_L1.3560.87
14_R68_A1.3490.86
293_L296_A1.3480.86
146_L239_K1.3360.86
158_L221_L1.3350.86
157_A160_Q1.3230.85
17_Q67_A1.3200.85
32_A68_A1.3180.85
17_Q70_D1.3140.85
169_E172_K1.3050.84
24_P63_V1.2980.84
264_F280_R1.2860.84
338_R341_G1.2770.83
64_G212_S1.2680.83
202_T215_G1.2510.82
10_D13_K1.2430.81
7_W11_A1.2370.81
19_S62_V1.2250.80
24_P36_S1.2220.80
159_Y163_N1.2210.80
279_D299_I1.2010.79
17_Q33_K1.2010.79
228_W356_N1.1970.79
150_F197_Q1.1950.79
38_Y60_L1.1900.78
165_D189_R1.1860.78
26_K33_K1.1850.78
32_A126_H1.1840.78
14_R69_L1.1820.78
128_L202_T1.1800.78
371_D374_H1.1710.77
107_E111_E1.1700.77
33_K38_Y1.1670.77
317_L321_L1.1660.77
296_A300_Q1.1550.76
14_R64_G1.1490.76
320_Q327_R1.1440.76
136_V141_G1.1430.76
52_T151_P1.1330.75
11_A71_V1.1270.75
150_F159_Y1.1230.74
164_E170_E1.1200.74
176_E179_K1.1160.74
352_A374_H1.1150.74
199_F207_I1.1120.74
18_I62_V1.1100.73
26_K35_S1.1080.73
350_D353_R1.1020.73
264_F268_V1.1000.73
66_A203_K1.0980.73
264_F355_L1.0930.72
30_P207_I1.0930.72
125_S129_A1.0850.72
62_V70_D1.0830.72
26_K38_Y1.0830.72
28_T151_P1.0810.71
200_G205_Q1.0790.71
201_G204_P1.0740.71
200_G212_S1.0710.71
94_D97_A1.0690.71
72_Y116_A1.0640.70
8_L112_G1.0630.70
20_L70_D1.0620.70
201_G212_S1.0590.70
263_A270_D1.0580.70
25_L36_S1.0530.69
32_A35_S1.0510.69
236_L313_C1.0510.69
110_R114_L1.0420.69
15_A20_L1.0390.68
24_P152_S1.0380.68
133_Y144_H1.0370.68
132_V143_Y1.0330.68
11_A17_Q1.0250.67
100_S109_W1.0220.67
134_F144_H1.0200.67
17_Q62_V1.0200.67
136_V142_D1.0180.67
26_K37_L1.0180.67
268_V277_I1.0150.66
31_D64_G1.0150.66
302_L308_S1.0150.66
258_V265_L1.0060.66
19_S38_Y1.0010.65
29_H74_F0.9910.65
14_R65_N0.9870.64
212_S215_G0.9860.64
143_Y299_I0.9840.64
170_E186_G0.9810.64
273_N278_R0.9810.64
96_L110_R0.9800.64
280_R284_L0.9760.63
331_D343_W0.9740.63
199_F218_N0.9720.63
27_F200_G0.9670.63
352_A371_D0.9650.62
292_L322_W0.9620.62
175_R190_E0.9590.62
294_Q297_A0.9580.62
73_K213_E0.9500.61
17_Q31_D0.9500.61
336_E340_K0.9480.61
174_A184_H0.9460.61
308_S320_Q0.9410.61
12_A15_A0.9400.60
26_K36_S0.9380.60
66_A71_V0.9360.60
207_I212_S0.9340.60
32_A172_K0.9320.60
200_G207_I0.9290.60
321_L341_G0.9200.59
334_F338_R0.9200.59
292_L321_L0.9150.58
68_A71_V0.9110.58
22_T60_L0.9060.58
18_I68_A0.9050.57
201_G205_Q0.9040.57
261_L355_L0.9030.57
89_E117_L0.9020.57
214_R228_W0.9000.57
270_D274_N0.8990.57
164_E168_S0.8980.57
203_K208_S0.8930.56
356_N359_L0.8880.56
62_V69_L0.8870.56
31_D203_K0.8810.55
52_T58_F0.8800.55
202_T212_S0.8730.55
234_P299_I0.8720.55
73_K207_I0.8720.55
357_A360_E0.8710.55
12_A113_F0.8650.54
18_I128_L0.8650.54
87_H95_L0.8620.54
347_I351_F0.8600.54
11_A64_G0.8590.54
239_K243_P0.8570.53
233_K305_A0.8550.53
71_V75_L0.8520.53
74_F348_A0.8520.53
25_L35_S0.8470.53
350_D374_H0.8450.52
174_A188_Y0.8450.52
135_P277_I0.8450.52
20_L116_A0.8440.52
208_S212_S0.8440.52
300_Q304_P0.8430.52
231_R234_P0.8400.52
243_P248_F0.8390.52
15_A19_S0.8370.52
261_L350_D0.8350.51
73_K212_S0.8340.51
321_L334_F0.8320.51
86_D89_E0.8310.51
14_R18_I0.8300.51
64_G172_K0.8290.51
14_R20_L0.8270.51
12_A17_Q0.8250.51
343_W347_I0.8220.50
215_G285_V0.8210.50
25_L37_L0.8210.50
278_R373_E0.8160.50
4_P9_P0.8120.49
14_R62_V0.8050.49
155_A199_F0.8010.49
149_L201_G0.8010.49
15_A112_G0.8000.48
254_V355_L0.8000.48
18_I65_N0.7990.48
18_I33_K0.7940.48
26_K34_G0.7930.48
341_G348_A0.7930.48
163_N219_Y0.7900.48
28_T52_T0.7890.47
65_N73_K0.7850.47
71_V113_F0.7840.47
67_A205_Q0.7820.47
11_A113_F0.7820.47
275_I282_D0.7810.47
159_Y217_K0.7810.47
171_A187_G0.7760.46
286_D376_E0.7710.46
260_E280_R0.7710.46
339_E347_I0.7670.46
31_D209_Q0.7660.45
63_V71_V0.7620.45
202_T205_Q0.7590.45
305_A324_D0.7580.45
64_G203_K0.7570.45
21_V63_V0.7560.45
34_G63_V0.7550.45
37_L62_V0.7540.44
84_L124_S0.7530.44
151_P283_E0.7520.44
264_F271_D0.7510.44
62_V68_A0.7490.44
205_Q212_S0.7460.44
168_S172_K0.7450.44
12_A21_V0.7440.44
65_N71_V0.7440.44
73_K209_Q0.7430.44
21_V129_A0.7420.43
321_L327_R0.7410.43
374_H377_W0.7390.43
206_N211_N0.7380.43
346_E349_K0.7350.43
219_Y329_E0.7340.43
69_L73_K0.7320.43
198_K213_E0.7300.42
239_K326_Y0.7290.42
47_D53_H0.7260.42
91_G344_Q0.7230.42
104_E158_L0.7230.42
243_P247_F0.7220.42
263_A267_S0.7170.41
47_D54_N0.7140.41
307_W354_W0.7110.41
271_D276_E0.7080.41
63_V68_A0.7070.40
342_D346_E0.7050.40
295_Y352_A0.7040.40
373_E376_E0.7030.40
14_R66_A0.7010.40
30_P50_L0.7010.40
126_H129_A0.7010.40
255_R273_N0.6970.40
341_G344_Q0.6910.39
324_D354_W0.6910.39
275_I278_R0.6900.39
24_P127_T0.6900.39
91_G215_G0.6890.39
90_A124_S0.6850.39
320_Q331_D0.6840.39
18_I126_H0.6840.39
72_Y209_Q0.6840.39
270_D280_R0.6820.38
29_H92_D0.6810.38
96_L107_E0.6800.38
26_K307_W0.6790.38
360_E369_L0.6780.38
15_A24_P0.6770.38
170_E173_A0.6750.38
25_L68_A0.6740.38
66_A85_L0.6730.38
33_K67_A0.6730.38
64_G167_F0.6730.38
100_S113_F0.6720.38
27_F197_Q0.6720.38
159_Y214_R0.6720.38
257_L261_L0.6710.37
141_G255_R0.6710.37
20_L134_F0.6700.37
19_S70_D0.6690.37
359_L369_L0.6680.37
67_A212_S0.6680.37
34_G68_A0.6680.37
204_P215_G0.6650.37
315_L322_W0.6640.37
33_K68_A0.6610.37
22_T120_K0.6600.37
203_K209_Q0.6590.37
27_F135_P0.6570.36
99_L106_A0.6570.36
18_I32_A0.6560.36
339_E348_A0.6550.36
29_H166_R0.6540.36
202_T206_N0.6530.36
82_K87_H0.6530.36
88_L113_F0.6530.36
233_K239_K0.6510.36
30_P112_G0.6500.36
306_G323_L0.6460.35
25_L38_Y0.6460.35
288_I355_L0.6450.35
369_L375_R0.6450.35
173_A178_R0.6450.35
17_Q204_P0.6420.35
244_R250_R0.6390.35
100_S103_P0.6390.35
151_P354_W0.6370.35
324_D351_F0.6330.34
244_R352_A0.6320.34
162_I168_S0.6300.34
306_G311_S0.6290.34
276_E280_R0.6280.34
10_D59_A0.6280.34
241_I319_Q0.6260.34
261_L356_N0.6260.34
347_I350_D0.6260.34
153_S156_H0.6250.34
152_S286_D0.6240.34
17_Q66_A0.6240.34
57_D193_N0.6230.34
300_Q337_R0.6230.34
27_F218_N0.6210.34
285_V289_I0.6210.34
31_D66_A0.6160.33
268_V271_D0.6150.33
173_A177_A0.6150.33
271_D274_N0.6110.33
69_L95_L0.6110.33
25_L113_F0.6110.33
5_E103_P0.6100.33
51_G74_F0.6100.33
14_R67_A0.6090.33
68_A85_L0.6080.33
191_Y228_W0.6080.33
78_E81_G0.6070.32
33_K168_S0.6050.32
64_G71_V0.6050.32
337_R340_K0.6050.32
314_R345_D0.6040.32
274_N290_D0.6030.32
174_A177_A0.6030.32
200_G218_N0.6020.32
261_L266_K0.6010.32
179_K190_E0.6010.32
202_T207_I0.6000.32
76_K84_L0.5990.32
207_I221_L0.5990.32
264_F269_P0.5980.32
63_V113_F0.5970.32
175_R182_K0.5970.32
51_G54_N0.5950.32
194_L223_S0.5950.32
109_W126_H0.5930.31
50_L95_L0.5930.31
85_L99_L0.5930.31
135_P144_H0.5920.31
326_Y344_Q0.5920.31
351_F354_W0.5900.31
161_R234_P0.5890.31
282_D376_E0.5880.31
64_G204_P0.5850.31
152_S238_V0.5830.31
262_R361_K0.5800.30
201_G206_N0.5790.30
283_E371_D0.5780.30
252_L257_L0.5770.30
32_A64_G0.5770.30
68_A203_K0.5760.30
303_L324_D0.5760.30
286_D289_I0.5750.30
238_V248_F0.5750.30
85_L116_A0.5740.30
238_V243_P0.5740.30
79_V105_Q0.5730.30
259_R342_D0.5720.30
277_I280_R0.5720.30
34_G129_A0.5720.30
209_Q212_S0.5720.30
104_E140_D0.5700.30
32_A62_V0.5680.30
229_K232_D0.5680.30
48_G88_L0.5680.30
332_E357_A0.5670.29
318_A355_L0.5670.29
21_V35_S0.5650.29
64_G322_W0.5640.29
150_F200_G0.5640.29
334_F343_W0.5630.29
63_V209_Q0.5630.29
272_K283_E0.5610.29
63_V212_S0.5610.29
306_G354_W0.5600.29
105_Q120_K0.5580.29
265_L269_P0.5570.29
12_A70_D0.5570.29
12_A69_L0.5560.29
168_S200_G0.5560.29
262_R362_K0.5560.29
64_G200_G0.5550.29
248_F335_A0.5550.29
228_W320_Q0.5540.29
156_H214_R0.5540.29
69_L200_G0.5500.28
341_G345_D0.5500.28
110_R274_N0.5480.28
175_R179_K0.5480.28
260_E270_D0.5470.28
156_H240_S0.5470.28
84_L126_H0.5470.28
14_R73_K0.5450.28
134_F218_N0.5450.28
291_E299_I0.5450.28
24_P72_Y0.5440.28
123_P347_I0.5440.28
260_E283_E0.5440.28
19_S33_K0.5410.28
29_H130_K0.5410.28
74_F339_E0.5410.28
109_W129_A0.5410.28
240_S243_P0.5390.27
2_Y54_N0.5390.27
21_V26_K0.5390.27
201_G218_N0.5390.27
67_A203_K0.5390.27
170_E178_R0.5380.27
19_S71_V0.5350.27
62_V66_A0.5350.27
11_A166_R0.5340.27
285_V376_E0.5330.27
207_I265_L0.5330.27
48_G54_N0.5320.27
86_D193_N0.5320.27
300_Q347_I0.5320.27
17_Q205_Q0.5320.27
230_S352_A0.5310.27
29_H52_T0.5310.27
62_V72_Y0.5300.27
19_S25_L0.5300.27
84_L117_L0.5290.27
313_C331_D0.5280.27
247_F295_Y0.5270.27
128_L361_K0.5260.27
282_D294_Q0.5260.27
23_H26_K0.5250.27
236_L333_A0.5250.27
219_Y319_Q0.5250.27
197_Q200_G0.5250.27
255_R291_E0.5240.26
19_S117_L0.5230.26
9_P16_G0.5230.26
20_L60_L0.5220.26
76_K83_S0.5220.26
4_P60_L0.5220.26
204_P213_E0.5210.26
181_N185_E0.5210.26
26_K63_V0.5210.26
163_N217_K0.5200.26
265_L366_A0.5200.26
33_K65_N0.5180.26
244_R280_R0.5180.26
130_K216_G0.5170.26
230_S355_L0.5160.26
126_H203_K0.5150.26
237_K326_Y0.5140.26
62_V76_K0.5140.26
256_E298_E0.5120.26
18_I25_L0.5120.26
174_A186_G0.5090.25
44_L342_D0.5090.25
33_K166_R0.5090.25
127_T320_Q0.5080.25
358_Q362_K0.5080.25
86_D141_G0.5080.25
178_R181_N0.5080.25
223_S304_P0.5080.25
351_F355_L0.5070.25
258_V355_L0.5070.25
234_P302_L0.5050.25
104_E111_E0.5050.25
168_S374_H0.5050.25
100_S124_S0.5040.25
17_Q25_L0.5030.25
305_A311_S0.5030.25
74_F171_A0.5010.25
253_E312_D0.5000.25
39_V171_A0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pcoA 2 0.2593 14.9 0.977 Contact Map
1ugoA 1 0.2487 12.2 0.977 Contact Map
4rpvA 1 0.3598 11.9 0.978 Contact Map
4p72C 2 0.2593 11.8 0.978 Contact Map
1pd3A 2 0.0899 8.8 0.979 Contact Map
1b7yA 2 0.2672 7.8 0.979 Contact Map
4azsA 6 0.3175 6.8 0.98 Contact Map
2rhqA 2 0.2778 5.3 0.981 Contact Map
3hocA 2 0.0899 5 0.981 Contact Map
4rscA 2 0.1481 4.8 0.981 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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