GREMLIN Database
DUF2029 - Protein of unknown function (DUF2029)
PFAM: PF09594 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 239 (232)
Sequences: 53075 (45012)
Seq/√Len: 2955.2
META: 0.905

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
90_A102_L3.4511.00
125_R128_A2.9241.00
87_A103_L2.8901.00
153_R157_R2.4501.00
150_D154_A2.4491.00
90_A98_L2.4001.00
158_V161_R2.3581.00
35_L39_R2.2301.00
23_L27_L2.2091.00
128_A131_A2.2011.00
70_T77_D2.1801.00
100_G104_G2.1171.00
194_T197_W2.1051.00
83_L106_A2.0401.00
86_L102_L1.9891.00
36_A40_L1.9861.00
18_P21_A1.9551.00
97_V131_A1.9411.00
96_P125_R1.9091.00
69_L73_L1.8951.00
150_D153_R1.8791.00
154_A157_R1.8731.00
83_L102_L1.7681.00
197_W200_L1.7591.00
114_L118_L1.7531.00
149_P152_W1.7401.00
143_P148_G1.7371.00
9_L13_P1.7271.00
70_T78_L1.7261.00
159_L162_A1.7221.00
37_A85_A1.7171.00
152_W156_L1.7161.00
37_A81_L1.6961.00
151_G154_A1.6711.00
157_R160_P1.6581.00
210_V214_R1.6521.00
126_W130_A1.6321.00
95_R98_L1.6251.00
149_P153_R1.6191.00
39_R43_R1.5881.00
33_A82_A1.5731.00
91_L99_A1.5721.00
10_L13_P1.5721.00
52_A55_L1.5511.00
60_L64_F1.5501.00
181_L184_R1.5431.00
124_R127_R1.5381.00
221_L224_L1.5231.00
98_L102_L1.5061.00
82_A86_L1.4891.00
61_A65_P1.4821.00
119_L123_R1.4651.00
7_A11_F1.4541.00
152_W155_F1.4481.00
63_A66_P1.4451.00
89_L93_R1.4451.00
115_L118_L1.4381.00
151_G155_F1.4221.00
104_G135_T1.4141.00
20_P24_A1.4011.00
209_A213_W1.3901.00
88_L92_R1.3901.00
131_A135_T1.3751.00
212_A216_R1.3561.00
106_A113_P1.3501.00
144_L149_P1.3481.00
30_S34_L1.3461.00
30_S33_A1.3261.00
87_A99_A1.3231.00
76_V80_L1.3211.00
222_L225_A1.3191.00
158_V162_A1.3151.00
129_L132_A1.3131.00
130_A133_A1.2901.00
171_G174_S1.2771.00
24_A27_L1.2771.00
193_P197_W1.2761.00
21_A24_A1.2721.00
157_R161_R1.2491.00
123_R126_W1.2301.00
70_T75_Q1.2171.00
153_R156_L1.2151.00
30_S70_T1.2121.00
221_L225_A1.2041.00
20_P23_L1.1981.00
200_L204_A1.1871.00
180_G184_R1.1761.00
195_L198_A1.1731.00
161_R164_G1.1591.00
29_L33_A1.1561.00
50_R54_A1.1521.00
36_A39_R1.1501.00
80_L108_A1.1491.00
19_Y23_L1.1461.00
7_A76_V1.1461.00
64_F67_V1.1451.00
107_A114_L1.1431.00
61_A64_F1.1371.00
220_R223_A1.1341.00
90_A99_A1.1281.00
53_L56_A1.1281.00
140_V143_P1.1241.00
180_G183_A1.1191.00
227_A230_A1.1171.00
114_L117_L1.1151.00
219_D222_L1.1061.00
144_L148_G1.1041.00
85_A89_L1.1021.00
228_L231_A1.0981.00
196_A200_L1.0951.00
60_L63_A1.0901.00
179_P184_R1.0891.00
101_V135_T1.0821.00
26_W30_S1.0791.00
178_L182_L1.0781.00
3_Y7_A1.0761.00
13_P16_L1.0761.00
174_S177_G1.0721.00
208_A212_A1.0661.00
127_R131_A1.0631.00
211_L214_R1.0541.00
27_L30_S1.0531.00
198_A201_A1.0421.00
205_L209_A1.0381.00
197_W201_A1.0291.00
179_P182_L1.0251.00
136_A140_V1.0201.00
123_R129_L1.0191.00
169_G173_Q1.0171.00
86_L89_L1.0131.00
51_R55_L1.0071.00
37_A82_A1.0071.00
137_A141_A1.0031.00
119_L122_L1.0011.00
27_L31_L1.0011.00
104_G108_A0.9981.00
86_L90_A0.9981.00
179_P185_L0.9951.00
179_P183_A0.9911.00
201_A204_A0.9801.00
53_L57_L0.9641.00
36_A82_A0.9631.00
62_L65_P0.9611.00
30_S78_L0.9601.00
136_A139_L0.9601.00
40_L89_L0.9521.00
220_R224_L0.9461.00
219_D223_A0.9421.00
229_L232_L0.9381.00
223_A227_A0.9331.00
174_S179_P0.9311.00
127_R130_A0.9271.00
132_A135_T0.9271.00
161_R165_R0.9221.00
177_G180_G0.9211.00
108_A139_L0.9151.00
12_A16_L0.9141.00
211_L215_A0.9101.00
169_G172_N0.9041.00
40_L82_A0.9041.00
54_A57_L0.9021.00
168_A173_Q0.9021.00
223_A226_A0.9021.00
143_P146_L0.8941.00
151_G156_L0.8931.00
170_V173_Q0.8901.00
178_L183_A0.8871.00
89_L92_R0.8781.00
194_T198_A0.8721.00
209_A212_A0.8711.00
59_L63_A0.8651.00
23_L30_S0.8651.00
149_P154_A0.8641.00
51_R54_A0.8611.00
207_L211_L0.8581.00
78_L82_A0.8581.00
217_R220_R0.8571.00
149_P155_F0.8501.00
6_L108_A0.8451.00
144_L147_L0.8421.00
126_W129_L0.8381.00
208_A211_L0.8381.00
201_A205_L0.8331.00
168_A171_G0.8321.00
3_Y77_D0.8321.00
40_L86_L0.8321.00
177_G181_L0.8241.00
50_R53_L0.8221.00
69_L72_A0.8191.00
138_A142_L0.8181.00
175_L179_P0.8151.00
200_L203_L0.8111.00
227_A231_A0.8101.00
22_A26_W0.8041.00
213_W216_R0.8041.00
169_G174_S0.8041.00
135_T139_L0.8031.00
207_L210_V0.8021.00
44_R92_R0.7921.00
196_A199_V0.7891.00
52_A56_A0.7871.00
225_A228_L0.7861.00
155_F159_L0.7851.00
125_R131_A0.7831.00
204_A208_A0.7821.00
154_A158_V0.7781.00
181_L185_L0.7771.00
84_L116_L0.7761.00
24_A28_L0.7751.00
21_A25_L0.7731.00
170_V174_S0.7721.00
141_A145_L0.7721.00
130_A134_A0.7711.00
178_L181_L0.7691.00
139_L143_P0.7681.00
156_L160_P0.7641.00
60_L65_P0.7611.00
212_A215_A0.7601.00
172_N175_L0.7591.00
17_L21_A0.7461.00
224_L228_L0.7441.00
68_L72_A0.7401.00
90_A95_R0.7401.00
206_A210_V0.7351.00
103_L107_A0.7331.00
91_L96_P0.7331.00
211_L216_R0.7291.00
177_G183_A0.7251.00
176_L179_P0.7241.00
62_L66_P0.7241.00
6_L109_K0.7221.00
210_V213_W0.7191.00
125_R129_L0.7181.00
162_A165_R0.7171.00
210_V215_A0.7151.00
80_L112_L0.7131.00
128_A132_A0.7131.00
37_A78_L0.7091.00
81_L85_A0.7051.00
218_R224_L0.7011.00
137_A140_V0.7011.00
167_L170_V0.7001.00
8_A11_F0.6881.00
168_A172_N0.6881.00
168_A174_S0.6831.00
225_A229_L0.6821.00
107_A132_A0.6791.00
133_A136_A0.6791.00
228_L232_L0.6781.00
184_R187_G0.6771.00
29_L79_L0.6741.00
224_L227_A0.6741.00
27_L34_L0.6721.00
96_P100_G0.6711.00
143_P152_W0.6701.00
55_L58_L0.6701.00
232_L235_L0.6671.00
25_L29_L0.6601.00
77_D80_L0.6581.00
177_G182_L0.6581.00
3_Y76_V0.6571.00
160_P163_L0.6561.00
33_A79_L0.6511.00
33_A37_A0.6501.00
144_L152_W0.6461.00
19_Y22_A0.6391.00
77_D110_K0.6371.00
69_L75_Q0.6361.00
131_A134_A0.6361.00
42_L46_G0.6331.00
72_A75_Q0.6311.00
42_L45_L0.6291.00
71_L74_G0.6261.00
17_L25_L0.6261.00
123_R127_R0.6241.00
163_L166_V0.6211.00
230_A233_L0.6201.00
145_L149_P0.6171.00
147_L151_G0.6141.00
185_L189_G0.6141.00
214_R218_R0.6121.00
55_L59_L0.6101.00
220_R225_A0.6101.00
160_P164_G0.6091.00
26_W31_L0.6051.00
175_L180_G0.6051.00
229_L233_L0.6041.00
97_V101_V0.6011.00
113_P116_L0.5991.00
158_V163_L0.5961.00
124_R128_A0.5961.00
37_A40_L0.5951.00
24_A39_R0.5931.00
167_L172_N0.5931.00
77_D81_L0.5911.00
28_L32_A0.5911.00
186_L189_G0.5901.00
32_A36_A0.5891.00
65_P69_L0.5801.00
34_L67_V0.5801.00
199_V203_L0.5741.00
101_V104_G0.5741.00
144_L151_G0.5691.00
83_L87_A0.5691.00
24_A31_L0.5681.00
185_L190_L0.5681.00
4_P8_A0.5681.00
138_A141_A0.5651.00
44_R89_L0.5641.00
67_V70_T0.5641.00
155_F158_V0.5621.00
87_A106_A0.5611.00
118_L122_L0.5561.00
98_L101_V0.5551.00
22_A25_L0.5551.00
218_R221_L0.5541.00
56_A59_L0.5541.00
199_V202_L0.5531.00
106_A110_K0.5501.00
226_A230_A0.5461.00
34_L41_L0.5451.00
193_P196_A0.5431.00
181_L186_L0.5431.00
100_G132_A0.5421.00
23_L26_W0.5401.00
167_L171_G0.5391.00
30_S37_A0.5351.00
41_L44_R0.5341.00
31_L34_L0.5341.00
176_L180_G0.5341.00
61_A66_P0.5311.00
154_A160_P0.5291.00
90_A93_R0.5271.00
120_L128_A0.5261.00
37_A41_L0.5231.00
4_P7_A0.5221.00
56_A60_L0.5181.00
43_R89_L0.5151.00
134_A137_A0.5141.00
159_L163_L0.5141.00
87_A91_L0.5131.00
41_L85_A0.5101.00
214_R217_R0.5081.00
107_A136_A0.5071.00
217_R221_L0.5061.00
87_A102_L0.5021.00
146_L149_P0.5001.00
6_L110_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wajA 1 0.8787 86.2 0.851 Contact Map
3rceA 1 0.7866 80 0.862 Contact Map
2l2tA 2 0.1841 2.2 0.942 Contact Map
2l6wA 2 0.1632 1.7 0.945 Contact Map
4tquN 1 0.5021 1.7 0.946 Contact Map
3m73A 3 0.6025 1.5 0.947 Contact Map
4ogqG 1 0.1548 1.5 0.947 Contact Map
3j2wE 1 0.1925 1.5 0.947 Contact Map
4httA 1 0.8159 1.4 0.949 Contact Map
4nyqA 1 0.2218 1.3 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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