GREMLIN Database
Spore_YabQ - Spore cortex protein YabQ (Spore_YabQ)
PFAM: PF09578 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 78 (76)
Sequences: 3100 (2525)
Seq/√Len: 289.6
META: 0.804

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_L42_A3.6161.00
46_V66_L3.5851.00
15_D73_Y3.2111.00
26_H34_E2.7331.00
15_D18_R2.1691.00
71_L75_L2.1631.00
6_L45_L2.1231.00
50_L62_V1.9541.00
21_R31_T1.9451.00
54_N62_V1.8541.00
35_D59_R1.7241.00
31_T34_E1.6841.00
39_W43_A1.6411.00
6_L49_F1.6221.00
50_L54_N1.5961.00
11_G73_Y1.5421.00
17_Y35_D1.5251.00
4_I65_G1.4171.00
70_F74_F1.3931.00
13_L42_A1.3821.00
13_L41_L1.3361.00
18_R21_R1.3291.00
11_G74_F1.2671.00
14_Y17_Y1.2521.00
47_F51_L1.1951.00
3_S49_F1.1931.00
20_L26_H1.1861.00
21_R35_D1.1581.00
65_G69_G1.1341.00
6_L53_V1.1261.00
59_R63_F1.1241.00
10_L38_F1.1221.00
27_G30_L1.1191.00
5_L8_I1.0961.00
20_L24_F1.0941.00
61_Y65_G1.0731.00
21_R34_E1.0441.00
32_F36_L1.0081.00
38_F70_F0.9981.00
17_Y34_E0.9971.00
29_I32_F0.9951.00
3_S65_G0.9811.00
63_F67_L0.9781.00
48_Y52_L0.9691.00
51_L56_G0.9281.00
29_I33_I0.8991.00
30_L34_E0.8851.00
38_F42_A0.8681.00
49_F54_N0.8601.00
2_A53_V0.8481.00
2_A6_L0.8451.00
19_I23_L0.8211.00
14_Y38_F0.8191.00
50_L58_L0.8030.99
58_L62_V0.7930.99
16_L20_L0.7920.99
54_N57_E0.7890.99
11_G70_F0.7720.99
28_R32_F0.7620.99
14_Y35_D0.7560.99
6_L46_V0.7550.99
3_S14_Y0.7460.99
27_G31_T0.7350.99
40_L44_L0.7160.99
39_W50_L0.7120.99
58_L63_F0.7110.99
24_F27_G0.7110.99
47_F56_G0.7110.99
28_R41_L0.7030.99
28_R31_T0.6980.99
60_F64_L0.6960.99
13_L17_Y0.6940.98
17_Y26_H0.6930.98
3_S6_L0.6870.98
68_L71_L0.6830.98
50_L61_Y0.6820.98
36_L39_W0.6670.98
26_H31_T0.6660.98
32_F39_W0.6540.98
19_I70_F0.6530.98
54_N58_L0.6410.97
63_F70_F0.6220.97
48_Y51_L0.6210.97
3_S62_V0.6160.97
45_L49_F0.6080.97
71_L74_F0.6050.96
53_V60_F0.6040.96
43_A47_F0.6020.96
4_I68_L0.6010.96
17_Y38_F0.5950.96
14_Y42_A0.5880.96
21_R26_H0.5870.96
25_R33_I0.5790.95
43_A58_L0.5700.95
2_A55_D0.5670.95
14_Y21_R0.5600.95
42_A46_V0.5570.94
44_L48_Y0.5570.94
11_G15_D0.5490.94
8_I72_L0.5450.94
10_L16_L0.5440.94
6_L66_L0.5440.94
33_I36_L0.5390.93
9_L13_L0.5330.93
47_F50_L0.5280.93
8_I75_L0.5280.93
59_R65_G0.5280.93
50_L66_L0.5250.92
57_E65_G0.5220.92
3_S66_L0.5210.92
12_L32_F0.5190.92
12_L73_Y0.5160.92
11_G51_L0.5140.92
20_L23_L0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2y69J 1 0.3333 3.8 0.874 Contact Map
4p02B 1 0.2949 3.5 0.877 Contact Map
3ar4A 1 0.3462 3.4 0.878 Contact Map
1v54J 1 0.3462 3.3 0.878 Contact Map
4us3A 1 0.9359 3 0.881 Contact Map
2qksA 4 1 2.9 0.883 Contact Map
4xp4A 1 0.9872 2.8 0.884 Contact Map
3pjsK 4 0.9487 2.5 0.886 Contact Map
1p7bA 3 0.9487 2.5 0.887 Contact Map
3rlbA 1 0.9872 2.4 0.887 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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