GREMLIN Database
RE_MjaI - MjaI restriction endonuclease
PFAM: PF09568 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 164 (164)
Sequences: 1352 (871)
Seq/√Len: 68.0
META: 0.947

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_E72_E4.6181.00
12_Q15_R3.3381.00
34_L84_I3.2331.00
59_K62_E3.2051.00
73_E77_D3.1081.00
2_W10_R3.0571.00
8_N14_T2.7501.00
28_E44_N2.7141.00
57_Y75_C2.6461.00
33_T88_F2.6241.00
38_E84_I2.3501.00
63_L67_I2.3371.00
50_E76_I2.3301.00
47_E51_E2.2221.00
110_R116_D2.1711.00
100_Q104_I2.0651.00
16_P21_Q2.0631.00
39_E43_E2.0291.00
157_K163_K2.0271.00
38_E80_Y1.9911.00
57_Y72_E1.9331.00
31_P36_E1.8131.00
81_D85_N1.7701.00
64_K68_E1.7591.00
13_L18_V1.7451.00
29_C36_E1.7331.00
158_K162_G1.7221.00
95_E99_G1.7011.00
135_V156_E1.6550.99
22_V25_L1.6400.99
4_L56_L1.6210.99
50_E54_E1.6030.99
138_K141_L1.5920.99
8_N82_L1.5860.99
63_L66_E1.5580.99
1_E10_R1.5420.99
9_Q14_T1.5400.99
72_E76_I1.5370.99
7_A63_L1.4230.98
148_I152_I1.4230.98
34_L85_N1.3720.98
35_E38_E1.3700.98
149_E152_I1.3650.98
38_E85_N1.3610.98
53_G72_E1.3610.98
40_W46_P1.3520.98
11_A15_R1.3280.97
56_L79_V1.3120.97
8_N79_V1.3120.97
156_E160_Y1.2760.96
38_E42_F1.2570.96
143_E146_E1.2500.96
8_N78_Y1.2220.96
61_T64_K1.2050.95
159_K164_V1.1970.95
131_Q134_P1.1960.95
156_E163_K1.1900.95
144_L148_I1.1890.95
88_F92_R1.1870.95
12_Q17_R1.1790.95
9_Q12_Q1.1640.94
33_T36_E1.1490.94
25_L45_V1.1360.93
37_W41_Y1.1320.93
24_E27_R1.1050.92
57_Y61_T1.0910.92
27_R111_P1.0690.91
8_N11_A1.0480.90
25_L28_E1.0320.90
60_I63_L1.0260.89
102_A108_K1.0230.89
3_I60_I1.0190.89
76_I80_Y1.0170.89
72_E75_C1.0070.88
153_I156_E0.9960.88
95_E98_L0.9950.88
40_W48_A0.9950.88
30_S36_E0.9880.87
21_Q25_L0.9830.87
145_S150_V0.9830.87
42_F80_Y0.9800.87
52_L79_V0.9640.86
56_L75_C0.9540.85
35_E39_E0.9530.85
128_I151_Q0.9380.85
158_K161_G0.9280.84
158_K164_V0.9220.83
13_L56_L0.9140.83
49_I79_V0.9090.83
100_Q103_K0.9020.82
137_Y140_K0.8950.82
61_T65_A0.8920.81
122_D133_K0.8880.81
50_E103_K0.8860.81
2_W9_Q0.8830.81
40_W44_N0.8710.80
53_G76_I0.8700.80
108_K127_Y0.8660.79
147_E150_V0.8640.79
2_W6_L0.8640.79
50_E80_Y0.8600.79
73_E149_E0.8600.79
26_I29_C0.8570.79
62_E74_D0.8570.79
92_R95_E0.8560.79
47_E163_K0.8490.78
146_E150_V0.8460.78
19_V37_W0.8460.78
140_K143_E0.8450.78
136_T139_S0.8430.78
51_E55_K0.8360.77
6_L25_L0.8350.77
110_R124_F0.8290.76
18_V55_K0.8250.76
137_Y144_L0.8210.76
139_S142_P0.8190.76
14_T18_V0.8180.75
160_Y164_V0.8160.75
138_K142_P0.8150.75
137_Y146_E0.8010.74
113_P116_D0.7920.73
101_L125_I0.7910.73
70_I95_E0.7770.72
108_K124_F0.7760.72
34_L38_E0.7760.72
65_A69_E0.7740.71
81_D86_R0.7730.71
23_S86_R0.7720.71
150_V153_I0.7610.70
12_Q16_P0.7600.70
58_E62_E0.7570.70
125_I130_I0.7560.70
2_W74_D0.7550.69
160_Y163_K0.7540.69
113_P124_F0.7530.69
50_E115_E0.7520.69
107_V113_P0.7480.69
158_K163_K0.7430.68
109_I131_Q0.7410.68
62_E65_A0.7400.68
96_T100_Q0.7380.68
4_L75_C0.7370.68
137_Y148_I0.7330.67
151_Q154_T0.7320.67
46_P80_Y0.7240.66
71_T74_D0.7230.66
33_T39_E0.7220.66
140_K145_S0.7170.65
98_L123_G0.7130.65
82_L86_R0.7120.65
142_P145_S0.7080.64
138_K154_T0.7060.64
53_G75_C0.7040.64
12_Q18_V0.6960.63
67_I131_Q0.6870.62
157_K162_G0.6870.62
37_W87_T0.6860.62
20_G87_T0.6780.61
26_I91_Y0.6770.61
90_G122_D0.6740.61
54_E58_E0.6700.60
26_I31_P0.6660.60
9_Q78_Y0.6660.60
137_Y150_V0.6650.60
8_N25_L0.6630.59
49_I83_V0.6600.59
152_I156_E0.6570.59
25_L64_K0.6540.58
116_D124_F0.6470.58
19_V41_Y0.6450.57
36_E39_E0.6430.57
49_I53_G0.6430.57
150_V154_T0.6420.57
45_V85_N0.6420.57
15_R18_V0.6370.56
31_P38_E0.6340.56
101_L128_I0.6340.56
89_D131_Q0.6330.56
23_S124_F0.6310.56
38_E41_Y0.6210.54
27_R31_P0.6200.54
60_I65_A0.6170.54
10_R63_L0.6170.54
20_G37_W0.6160.54
1_E4_L0.6160.54
80_Y136_T0.6120.53
6_L11_A0.6060.53
68_E164_V0.6030.52
105_L109_I0.6020.52
3_I74_D0.6000.52
13_L19_V0.5980.52
11_A18_V0.5980.52
35_E69_E0.5970.52
25_L40_W0.5970.52
3_I6_L0.5960.52
60_I67_I0.5940.51
35_E101_L0.5930.51
90_G133_K0.5880.51
8_N13_L0.5870.50
14_T78_Y0.5800.50
36_E85_N0.5790.49
70_I74_D0.5760.49
64_K73_E0.5680.48
153_I157_K0.5670.48
53_G57_Y0.5670.48
26_I59_K0.5660.48
43_E124_F0.5630.48
27_R91_Y0.5590.47
2_W7_A0.5590.47
23_S26_I0.5560.47
29_C38_E0.5550.47
53_G56_L0.5500.46
26_I87_T0.5480.46
19_V87_T0.5460.46
84_I89_D0.5420.45
8_N22_V0.5420.45
130_I153_I0.5410.45
101_L112_A0.5390.45
139_S145_S0.5390.45
42_F84_I0.5380.45
13_L21_Q0.5360.44
26_I92_R0.5350.44
144_L150_V0.5300.44
19_V97_I0.5290.44
88_F161_G0.5260.43
152_I157_K0.5240.43
7_A11_A0.5230.43
3_I89_D0.5210.43
30_S95_E0.5210.43
23_S111_P0.5190.42
106_G127_Y0.5190.42
87_T109_I0.5190.42
6_L63_L0.5170.42
62_E84_I0.5160.42
65_A111_P0.5140.42
146_E155_Y0.5140.42
124_F129_G0.5120.42
21_Q114_D0.5120.42
58_E63_L0.5070.41
103_K106_G0.5070.41
102_A105_L0.5060.41
38_E46_P0.5040.41
26_I99_G0.5040.41
1_E6_L0.5030.41
147_E160_Y0.5010.40
78_Y82_L0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fiqA 4 0.6585 14.5 0.941 Contact Map
3fd9A 3 0.5549 12.2 0.943 Contact Map
3h0gD 1 0.4878 11.3 0.944 Contact Map
1y14A 1 0.4817 9.5 0.946 Contact Map
2qc7A 2 0.5671 8.5 0.947 Contact Map
4oc8A 4 0.8232 5.9 0.951 Contact Map
4yk8A 1 0.4634 5.8 0.951 Contact Map
3b5qA 1 0.5732 5.8 0.951 Contact Map
4hfxA 2 0.3537 4.9 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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