GREMLIN Database
DUF2382 - Domain of unknown function (DUF2382)
PFAM: PF09557 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 111 (111)
Sequences: 13448 (8548)
Seq/√Len: 811.3
META: 0.914

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_V108_E3.3511.00
43_V92_E2.8201.00
32_T101_S2.6021.00
34_T97_T2.4701.00
38_R93_V2.4311.00
34_T99_T2.4091.00
43_V90_R2.1961.00
47_R88_R2.1461.00
36_P95_T2.0891.00
28_T103_T2.0411.00
25_Y110_E2.0071.00
30_P103_T1.9851.00
39_R72_E1.9411.00
32_T99_T1.9391.00
5_E106_R1.8791.00
41_E94_V1.8221.00
8_L102_D1.7941.00
38_R95_T1.7871.00
3_L109_V1.7851.00
30_P101_S1.7841.00
39_R96_E1.7571.00
9_R80_R1.7241.00
16_E19_R1.6511.00
9_R78_E1.5861.00
14_E71_T1.5771.00
17_T72_E1.5411.00
40_E91_K1.5081.00
41_E92_E1.5071.00
46_R85_E1.4941.00
36_P97_T1.4421.00
45_E90_R1.4111.00
22_V89_V1.3931.00
8_L104_V1.3881.00
29_E106_R1.3871.00
45_E88_R1.3511.00
55_A58_A1.3491.00
74_E82_V1.3451.00
24_K107_E1.3371.00
74_E80_R1.2891.00
16_E69_P1.2881.00
52_P82_V1.2391.00
53_V58_A1.2181.00
47_R86_E1.2121.00
13_R76_V1.1881.00
19_R67_E1.1471.00
76_V80_R1.1411.00
37_L75_P1.1401.00
79_K102_D1.1111.00
48_P85_E1.1011.00
61_F64_E1.0981.00
61_F66_I1.0821.00
72_E75_P1.0591.00
54_T57_D1.0461.00
15_V74_E1.0351.00
39_R94_V0.9891.00
42_V70_L0.9841.00
50_D53_V0.9721.00
13_R74_E0.9641.00
52_P80_R0.9621.00
74_E84_V0.9621.00
53_V57_D0.9541.00
26_V107_E0.9281.00
30_P34_T0.9261.00
23_R110_E0.9261.00
75_P79_K0.9211.00
50_D82_V0.8931.00
87_V109_V0.8891.00
60_A63_E0.8861.00
19_R69_P0.8771.00
78_E81_A0.8711.00
72_E84_V0.8691.00
54_T58_A0.8691.00
7_E82_V0.8671.00
21_R65_T0.8661.00
51_R54_T0.8601.00
21_R67_E0.8581.00
68_V89_V0.8521.00
49_V83_V0.8481.00
58_A61_F0.8481.00
51_R57_D0.8431.00
58_A62_E0.8411.00
40_E93_V0.8381.00
25_Y108_E0.8341.00
23_R65_T0.8311.00
30_P36_P0.8271.00
56_A59_A0.8181.00
66_I69_P0.8071.00
7_E80_R0.8021.00
14_E38_R0.7981.00
35_V75_P0.7951.00
11_G76_V0.7881.00
53_V56_A0.7771.00
10_V33_V0.7741.00
11_G14_E0.7741.00
55_A59_A0.7561.00
12_K35_V0.7311.00
51_R86_E0.7261.00
69_P75_P0.7211.00
12_K73_E0.7191.00
84_V87_V0.7091.00
60_A64_E0.7041.00
98_E101_S0.7031.00
57_D71_T0.6991.00
28_T105_R0.6931.00
31_V104_V0.6891.00
42_V68_V0.6861.00
17_T70_L0.6811.00
11_G78_E0.6711.00
16_E71_T0.6601.00
53_V83_V0.6561.00
49_V53_V0.6541.00
27_V30_P0.6511.00
98_E102_D0.6481.00
75_P78_E0.6431.00
74_E78_E0.6391.00
4_V83_V0.6361.00
20_V42_V0.6301.00
70_L107_E0.6291.00
5_E84_V0.6291.00
83_V86_E0.6271.00
8_L11_G0.6181.00
65_T68_V0.6071.00
37_L98_E0.5941.00
97_T100_V0.5931.00
49_V85_E0.5881.00
48_P52_P0.5831.00
44_V89_V0.5791.00
24_K70_L0.5791.00
9_R13_R0.5761.00
59_A62_E0.5761.00
49_V52_P0.5741.00
59_A66_I0.5711.00
51_R55_A0.5681.00
90_R93_V0.5661.00
54_T59_A0.5641.00
30_P102_D0.5631.00
71_T81_A0.5611.00
53_V60_A0.5591.00
64_E68_V0.5571.00
3_L27_V0.5571.00
93_V96_E0.5561.00
33_V36_P0.5531.00
26_V61_F0.5531.00
3_L7_E0.5521.00
4_V81_A0.5511.00
7_E84_V0.5491.00
20_V70_L0.5431.00
96_E99_T0.5401.00
12_K37_L0.5401.00
62_E65_T0.5381.00
16_E24_K0.5371.00
77_V102_D0.5341.00
14_E19_R0.5211.00
4_V7_E0.5191.00
108_E111_V0.5171.00
42_V91_K0.5171.00
2_P83_V0.5151.00
67_E88_R0.5111.00
18_G42_V0.5091.00
21_R25_Y0.5091.00
4_V107_E0.5051.00
27_V106_R0.5041.00
39_R43_V0.5021.00
15_V72_E0.5001.00
31_V35_V0.5001.00
3_L84_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fx5A 1 0.3694 2.2 0.918 Contact Map
4pkyB 2 0.1712 0.8 0.937 Contact Map
1pybA 2 0.3333 0.7 0.939 Contact Map
4a8xB 1 0.0901 0.7 0.941 Contact Map
1tr8A 4 0.2973 0.6 0.942 Contact Map
1m3wA 3 0.0991 0.6 0.943 Contact Map
3n40P 1 0.5135 0.5 0.946 Contact Map
4k0dA 3 0.3063 0.5 0.947 Contact Map
3ibjA 2 0.3063 0.4 0.949 Contact Map
2i4lA 2 0.3604 0.4 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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