GREMLIN Database
Spore_II_R - Stage II sporulation protein R (spore_II_R)
PFAM: PF09551 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 126 (125)
Sequences: 3331 (2810)
Seq/√Len: 251.3
META: 0.804

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
103_T107_G4.1961.00
46_R98_E2.8091.00
13_D110_Q2.7781.00
27_A63_V2.6201.00
23_K67_N2.5931.00
52_N55_E2.3731.00
61_E73_V2.0701.00
42_I46_R1.9251.00
64_L69_Y1.8581.00
42_I98_E1.8421.00
12_S17_D1.8031.00
79_N96_E1.7991.00
57_E75_V1.7941.00
4_I77_L1.7921.00
76_E103_T1.7751.00
11_N17_D1.7571.00
63_V66_E1.7451.00
3_V92_L1.7431.00
61_E65_K1.7371.00
35_L52_N1.7031.00
82_F99_A1.6911.00
57_E61_E1.6721.00
41_S44_E1.6361.00
63_V67_N1.6211.00
4_I49_I1.6141.00
79_N98_E1.6081.00
80_E101_R1.5941.00
28_V102_I1.5931.00
60_A73_V1.5581.00
9_I103_T1.5551.00
15_E19_A1.5361.00
20_L64_L1.5271.00
53_L75_V1.5201.00
11_N106_E1.5161.00
81_Y96_E1.5081.00
39_A48_I1.4851.00
86_T91_T1.4661.00
31_Y59_I1.4571.00
31_Y55_E1.4561.00
35_L48_I1.4451.00
27_A30_E1.4351.00
62_E66_E1.4291.00
20_L69_Y1.4211.00
39_A45_A1.3801.00
53_L100_L1.3641.00
61_E72_P1.3081.00
84_T91_T1.3051.00
27_A59_I1.3011.00
25_R29_L1.2501.00
74_K103_T1.2301.00
3_V7_H1.2041.00
57_E74_K1.1941.00
84_T94_A1.1901.00
59_I63_V1.1801.00
48_I52_N1.1721.00
71_Y104_I1.1601.00
16_E69_Y1.1281.00
4_I46_R1.1211.00
9_I101_R1.1091.00
64_L73_V1.1071.00
73_V104_I1.1041.00
64_L71_Y1.0961.00
53_L57_E1.0631.00
64_L104_I1.0581.00
22_L26_D1.0321.00
54_P57_E1.0231.00
47_E51_E1.0101.00
22_L25_R0.9961.00
20_L104_I0.9821.00
49_I77_L0.9631.00
40_K44_E0.9631.00
32_L36_L0.9601.00
36_L45_A0.9571.00
114_C121_C0.9431.00
58_E62_E0.9351.00
32_L35_L0.9231.00
23_K63_V0.9191.00
28_V56_I0.9121.00
11_N71_Y0.9101.00
27_A62_E0.8911.00
17_D71_Y0.8881.00
27_A31_Y0.8821.00
11_N14_S0.8821.00
81_Y94_A0.8801.00
55_E58_E0.8771.00
19_A23_K0.8590.99
24_V63_V0.8500.99
22_L110_Q0.8260.99
31_Y35_L0.8190.99
27_A66_E0.8180.99
80_E99_A0.8110.99
36_L49_I0.8100.99
76_E80_E0.8070.99
9_I80_E0.8060.99
32_L56_I0.7960.99
83_P92_L0.7880.99
77_L100_L0.7880.99
75_V100_L0.7860.99
44_E47_E0.7610.99
28_V59_I0.7590.99
50_K53_L0.7590.99
16_E19_A0.7500.99
46_R50_K0.7350.98
7_H85_K0.7350.98
9_I85_K0.7270.98
32_L116_L0.7270.98
8_V102_I0.7210.98
60_A63_V0.7170.98
56_I75_V0.7150.98
34_P37_A0.7150.98
6_L87_Y0.7120.98
32_L49_I0.7120.98
75_V102_I0.7110.98
51_E54_P0.7070.98
4_I42_I0.7040.98
43_E47_E0.6910.98
24_V64_L0.6880.97
29_L125_A0.6820.97
86_T92_L0.6820.97
24_V27_A0.6790.97
46_R77_L0.6770.97
72_P104_I0.6670.97
7_H101_R0.6630.97
43_E46_R0.6610.97
50_K54_P0.6600.97
115_V119_P0.6600.97
60_A75_V0.6480.96
55_E59_I0.6470.96
76_E101_R0.6470.96
82_F116_L0.6440.96
28_V31_Y0.6400.96
34_P48_I0.6370.96
60_A64_L0.6370.96
57_E73_V0.6310.96
31_Y36_L0.6220.95
55_E62_E0.6190.95
36_L116_L0.6160.95
7_H73_V0.6110.95
40_K50_K0.6050.95
86_T89_D0.6040.95
47_E50_K0.6010.94
20_L71_Y0.5950.94
7_H80_E0.5920.94
39_A44_E0.5910.94
78_G101_R0.5890.94
6_L45_A0.5860.94
9_I78_G0.5850.94
35_L55_E0.5850.94
116_L124_D0.5830.94
84_T92_L0.5760.93
54_P58_E0.5710.93
15_E110_Q0.5680.93
80_E85_K0.5680.93
66_E106_E0.5670.93
69_Y104_I0.5570.92
58_E61_E0.5550.92
6_L116_L0.5520.92
10_A110_Q0.5470.91
18_Q22_L0.5470.91
6_L29_L0.5440.91
80_E103_T0.5440.91
85_K99_A0.5440.91
92_L115_V0.5430.91
28_V32_L0.5400.91
14_S17_D0.5370.91
8_V25_R0.5370.91
31_Y100_L0.5370.91
87_Y114_C0.5350.90
100_L103_T0.5330.90
33_T125_A0.5320.90
2_E116_L0.5310.90
18_Q112_W0.5260.90
4_I98_E0.5180.89
50_K77_L0.5170.89
37_A40_K0.5170.89
3_V80_E0.5150.89
86_T90_I0.5140.89
52_N56_I0.5110.88
29_L101_R0.5110.88
59_I62_E0.5080.88
64_L67_N0.5080.88
49_I83_P0.5080.88
5_R82_F0.5070.88
33_T37_A0.5050.88
58_E65_K0.5030.87
60_A102_I0.5020.87
4_I100_L0.5010.87
31_Y34_P0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3somA 5 0.5714 26 0.934 Contact Map
1usuB 1 0.3968 24.5 0.935 Contact Map
3sc0A 2 0.5635 12.7 0.943 Contact Map
2b5dX 3 0.7222 9.9 0.946 Contact Map
3n72A 2 0.4603 9.7 0.946 Contact Map
4lkbF 4 0.4921 9.5 0.946 Contact Map
1x05A 1 0.381 9 0.947 Contact Map
3pe0A 1 0.9444 8.5 0.947 Contact Map
4qn1A 1 0.7302 7.9 0.948 Contact Map
2yjeM 1 0 7.5 0.949 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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