GREMLIN Database
Spore_III_AB - Stage III sporulation protein AB (spore_III_AB)
PFAM: PF09548 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 170 (170)
Sequences: 2729 (2406)
Seq/√Len: 184.6
META: 0.752

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_E130_E3.2621.00
89_W114_G3.1901.00
36_A70_F3.1751.00
40_L54_A2.9011.00
9_I166_V2.6401.00
134_E137_E2.4551.00
76_R91_E2.3971.00
34_I137_E2.2291.00
106_D139_E2.1401.00
118_G125_Q2.1341.00
26_R106_D2.1221.00
146_E150_N2.1131.00
12_C162_G2.0301.00
121_D124_G2.0121.00
76_R92_A2.0051.00
84_S87_E1.9541.00
72_E95_E1.9501.00
43_E49_T1.9331.00
59_A71_E1.9051.00
34_I140_E1.8901.00
55_L73_A1.8701.00
13_T159_V1.8631.00
31_R144_E1.8621.00
103_K106_D1.8421.00
48_R122_R1.7991.00
113_L129_L1.6861.00
147_Q151_E1.6411.00
152_K156_S1.6351.00
4_G7_L1.6321.00
97_W107_K1.5991.00
41_E133_L1.5541.00
30_L106_D1.5471.00
64_G67_S1.5461.00
145_E149_K1.5411.00
69_F73_A1.5391.00
145_E148_K1.5271.00
45_S126_L1.5211.00
37_L129_L1.5051.00
94_E111_L1.4661.00
56_E74_A1.4561.00
141_E145_E1.4401.00
21_R25_R1.4331.00
90_E111_L1.4141.00
90_E94_E1.3831.00
88_A92_A1.3781.00
56_E78_E1.3731.00
5_A166_V1.3631.00
29_Q101_A1.3591.00
105_E139_E1.3121.00
19_L22_R1.3111.00
24_K28_R1.3081.00
141_E144_E1.2901.00
27_P147_Q1.2561.00
42_T120_S1.2531.00
72_E96_L1.2471.00
24_K147_Q1.2461.00
20_A158_G1.2331.00
31_R140_E1.2311.00
120_S124_G1.2071.00
93_L107_K1.2051.00
158_G162_G1.1951.00
43_E57_R1.1931.00
72_E75_E1.1901.00
38_Q133_L1.1871.00
13_T17_F1.1821.00
120_S125_Q1.1791.00
42_T124_G1.1711.00
30_L143_A1.1551.00
64_G68_E1.1321.00
19_L154_Y1.1321.00
160_L164_L1.1271.00
19_L23_L1.1141.00
140_E144_E1.1121.00
4_G11_A1.1091.00
156_S160_L1.1041.00
90_E115_K1.0961.00
34_I133_L1.0931.00
12_C161_G1.0871.00
107_K111_L1.0831.00
154_Y158_G1.0631.00
109_I132_A1.0591.00
25_R28_R1.0561.00
9_I163_L1.0551.00
33_L110_L1.0501.00
130_E133_L1.0431.00
144_E147_Q1.0381.00
93_L110_L1.0371.00
23_L143_A1.0301.00
97_W100_T1.0221.00
138_R141_E1.0010.99
74_A78_E1.0000.99
135_Q138_R1.0000.99
9_I12_C0.9970.99
139_E142_E0.9820.99
76_R95_E0.9740.99
24_K151_E0.9560.99
137_E141_E0.9530.99
72_E92_A0.9500.99
26_R143_A0.9500.99
123_E126_L0.9490.99
30_L136_L0.9480.99
50_P53_E0.9470.99
33_L100_T0.9430.99
16_G20_A0.9400.99
86_G115_K0.9380.99
105_E142_E0.9380.99
44_I122_R0.9370.99
4_G8_I0.9310.99
36_A66_V0.9240.99
94_E107_K0.9230.99
108_E112_Q0.9200.99
71_E75_E0.9160.99
137_E140_E0.9070.99
29_Q65_P0.9060.99
86_G90_E0.9020.99
126_L130_E0.9010.99
13_T158_G0.8990.99
44_I54_A0.8940.99
92_A96_L0.8900.99
5_A9_I0.8890.99
17_F155_R0.8690.98
91_E95_E0.8680.98
37_L132_A0.8630.98
27_P140_E0.8550.98
129_L133_L0.8550.98
39_L43_E0.8510.98
76_R79_E0.8430.98
161_G164_L0.8410.98
32_E63_E0.8390.98
153_L157_L0.8260.98
41_E127_K0.8260.98
138_R142_E0.8180.98
15_I19_L0.8120.98
62_L65_P0.8080.97
38_Q41_E0.8020.97
26_R103_K0.8010.97
59_A67_S0.7990.97
85_F88_A0.7990.97
29_Q100_T0.7970.97
27_P31_R0.7890.97
93_L111_L0.7850.97
151_E155_R0.7840.97
130_E134_E0.7800.97
75_E79_E0.7730.97
27_P143_A0.7690.97
42_T128_H0.7680.97
59_A74_A0.7560.96
68_E99_E0.7450.96
142_E146_E0.7450.96
83_E88_A0.7410.96
119_R124_G0.7390.96
55_L58_I0.7340.96
10_L14_L0.7290.95
72_E76_R0.7240.95
40_L129_L0.7230.95
9_I159_V0.7180.95
20_A155_R0.7160.95
54_A58_I0.7150.95
83_E87_E0.7140.95
41_E126_L0.7130.95
127_K131_L0.7120.95
17_F21_R0.7080.95
89_W93_L0.6990.94
124_G128_H0.6970.94
65_P68_E0.6950.94
109_I139_E0.6870.94
144_E148_K0.6870.94
147_Q150_N0.6850.94
25_R29_Q0.6840.94
51_L54_A0.6840.94
73_A88_A0.6830.94
83_E91_E0.6810.93
153_L156_S0.6780.93
30_L140_E0.6770.93
49_T52_P0.6740.93
47_G131_L0.6740.93
132_A136_L0.6670.93
73_A92_A0.6660.93
32_E35_S0.6580.92
41_E45_S0.6570.92
2_L5_A0.6570.92
135_Q139_E0.6540.92
34_I38_Q0.6510.92
113_L132_A0.6500.92
69_F96_L0.6480.92
75_E78_E0.6430.91
33_L69_F0.6400.91
103_K146_E0.6400.91
96_L99_E0.6370.91
73_A85_F0.6370.91
23_L146_E0.6340.91
15_I161_G0.6320.91
76_R83_E0.6280.90
39_L58_I0.6280.90
68_E75_E0.6260.90
112_Q135_Q0.6190.90
33_L70_F0.6170.90
85_F89_W0.6150.89
143_A151_E0.6140.89
68_E71_E0.6140.89
20_A151_E0.6140.89
36_A54_A0.6130.89
150_N154_Y0.6100.89
17_F20_A0.6100.89
29_Q66_V0.6090.89
113_L116_T0.6070.89
32_E64_G0.6050.89
16_G158_G0.6010.88
21_R24_K0.5960.88
38_Q130_E0.5950.88
23_L151_E0.5930.88
128_H132_A0.5880.87
40_L51_L0.5870.87
138_R144_E0.5850.87
97_W104_K0.5840.87
156_S167_I0.5830.87
66_V70_F0.5800.87
18_L22_R0.5790.86
30_L102_L0.5780.86
66_V69_F0.5740.86
116_T128_H0.5730.86
16_G162_G0.5730.86
33_L102_L0.5690.86
40_L117_L0.5680.85
44_I129_L0.5660.85
67_S71_E0.5660.85
142_E148_K0.5640.85
38_Q127_K0.5610.85
46_Y121_D0.5600.85
45_S122_R0.5590.85
103_K139_E0.5580.84
17_F129_L0.5560.84
109_I135_Q0.5550.84
45_S48_R0.5500.84
62_L141_E0.5460.83
18_L21_R0.5440.83
56_E71_E0.5430.83
9_I13_T0.5420.83
114_G125_Q0.5390.82
102_L110_L0.5370.82
51_L55_L0.5330.82
26_R30_L0.5230.80
108_E111_L0.5200.80
49_T57_R0.5190.80
2_L71_E0.5170.80
109_I136_L0.5170.80
8_I12_C0.5140.79
23_L150_N0.5130.79
109_I112_Q0.5110.79
139_E143_A0.5100.79
79_E99_E0.5080.78
22_R25_R0.5080.78
149_K153_L0.5020.78
90_E95_E0.5010.78
164_L168_L0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2whnA 1 0.6353 15.1 0.907 Contact Map
3c1qA 2 0.6941 13.2 0.909 Contact Map
1ykeB 1 0.6824 13.1 0.909 Contact Map
4hhxA 1 0.5882 9.9 0.914 Contact Map
4qinA 2 0.7882 7.2 0.919 Contact Map
1ykhB 1 0.6647 6.8 0.92 Contact Map
4iz7B 1 0.5294 5.4 0.924 Contact Map
4heiA 1 0.5412 5.4 0.924 Contact Map
2i68A 2 0.1059 5.2 0.924 Contact Map
3j8bL 1 0.8412 5.2 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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