Spore_III_AE - PFAM28P - GREMLIN Contacts

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Spore_III_AE - Stage III sporulation protein AE (spore_III_AE)

PFAM:	PF09546	Sequences: FSFKELVKDLLKNGELGLSLKEILKGLLKYLFKEVLANLKLLGKLLVLAVLCALLKNLQSAFENGSVSKIAYYVCYLVLITLALNSFSSAIGLAKEAIDNMVDFMKALLPVLLTLLAASGGVTSAAVFHPLILFLINLIGTLIKNVLLPLIFLSAVLSIVNNLSEEYKLSKLAGLLKKIVVWLLGLLLTVFLGVLSIQGIIAAVADGVTLRTAKFAVGNFIPVVGGALSDAADTVLGSSLLLKNAVGIAGLIILLLICLFPLLKILALALIYKLAAALIQPIGDKRIVKCLDSIGKSLGLLLAALATVALMFFISITIIIAAG	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	323 (318)
Sequences:	2172 (1685)
Seq/√Len:	94.5
META:	0.725

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
93_L	97_A	3.995	1.00
49_A	279_I	3.617	1.00
94_A	305_L	3.374	1.00
262_L	302_L	3.323	1.00
9_D	15_E	3.257	1.00
273_K	292_D	3.119	1.00
42_L	275_A	3.042	1.00
108_L	250_G	2.970	1.00
177_K	296_K	2.948	1.00
69_K	286_R	2.861	1.00
147_L	304_A	2.767	1.00
104_F	257_I	2.717	1.00
238_S	317_T	2.701	1.00
265_I	305_L	2.675	1.00
146_V	183_L	2.630	1.00
177_K	181_V	2.628	1.00
99_D	103_D	2.585	1.00
99_D	144_K	2.570	1.00
72_Y	286_R	2.564	1.00
179_I	183_L	2.544	1.00
182_W	186_L	2.530	1.00
86_S	272_Y	2.521	1.00
246_V	250_G	2.513	1.00
151_I	304_A	2.492	1.00
5_E	9_D	2.468	1.00
147_L	180_V	2.374	1.00
143_I	184_L	2.358	1.00
34_E	264_K	2.355	1.00
170_S	280_Q	2.329	1.00
258_C	309_A	2.277	1.00
19_S	22_E	2.262	1.00
147_L	183_L	2.254	1.00
155_A	297_S	2.244	1.00
52_C	75_C	2.221	1.00
273_K	295_G	2.202	1.00
158_S	293_S	2.196	1.00
4_K	8_K	2.129	1.00
175_L	277_A	2.128	1.00
269_A	299_G	2.109	1.00
72_Y	76_Y	2.058	1.00
40_K	44_K	2.031	1.00
43_G	46_L	1.972	1.00
106_K	141_T	1.968	1.00
251_L	313_F	1.957	1.00
96_E	100_N	1.944	1.00
94_A	301_L	1.919	1.00
45_L	79_L	1.909	1.00
104_F	253_I	1.907	1.00
193_G	197_I	1.897	1.00
80_I	159_I	1.834	1.00
48_L	75_C	1.834	1.00
142_L	187_L	1.817	1.00
188_L	307_T	1.749	1.00
25_K	29_K	1.739	1.00
142_L	183_L	1.712	1.00
266_L	270_L	1.707	1.00
155_A	294_I	1.688	1.00
185_G	215_F	1.675	1.00
7_V	249_A	1.672	1.00
217_V	221_I	1.672	1.00
178_K	182_W	1.663	1.00
21_K	25_K	1.661	1.00
12_K	15_E	1.639	1.00
135_L	194_V	1.618	1.00
124_S	206_D	1.611	1.00
285_K	289_K	1.600	1.00
240_L	244_N	1.599	1.00
122_V	126_A	1.584	1.00
98_I	308_V	1.580	1.00
45_L	275_A	1.564	1.00
238_S	314_I	1.561	1.00
70_I	74_V	1.539	1.00
235_V	310_L	1.530	1.00
247_G	320_I	1.526	1.00
175_L	274_L	1.514	1.00
266_L	302_L	1.512	1.00
188_L	227_A	1.509	1.00
226_G	230_D	1.505	1.00
307_T	311_M	1.488	1.00
97_A	305_L	1.487	1.00
208_V	241_L	1.483	1.00
45_L	82_L	1.472	1.00
95_K	99_D	1.472	1.00
262_L	306_A	1.439	1.00
117_A	125_A	1.412	0.99
8_K	12_K	1.392	0.99
305_L	309_A	1.382	0.99
46_L	279_I	1.378	0.99
90_A	268_L	1.376	0.99
76_Y	162_N	1.363	0.99
92_G	96_E	1.357	0.99
165_E	286_R	1.343	0.99
234_T	238_S	1.339	0.99
20_L	24_L	1.322	0.99
95_K	148_L	1.322	0.99
5_E	8_K	1.298	0.99
31_L	267_A	1.293	0.99
15_E	18_L	1.292	0.99
113_L	125_A	1.269	0.99
202_A	248_I	1.250	0.99
90_A	265_I	1.246	0.99
215_F	219_N	1.245	0.99
8_K	11_L	1.234	0.99
27_L	259_L	1.225	0.98
124_S	128_F	1.214	0.98
211_R	215_F	1.212	0.98
55_L	62_F	1.212	0.98
124_S	202_A	1.209	0.98
139_I	187_L	1.191	0.98
184_L	304_A	1.187	0.98
96_E	99_D	1.182	0.98
106_K	137_N	1.181	0.98
83_A	272_Y	1.174	0.98
135_L	138_L	1.170	0.98
207_G	233_D	1.165	0.98
259_L	267_A	1.165	0.98
231_A	234_T	1.163	0.98
91_I	301_L	1.162	0.98
223_V	303_A	1.159	0.98
157_L	173_A	1.154	0.98
265_I	298_L	1.149	0.98
201_I	248_I	1.148	0.98
133_L	137_N	1.147	0.98
95_K	144_K	1.141	0.98
105_M	312_F	1.129	0.97
176_L	221_I	1.122	0.97
108_L	112_L	1.120	0.97
23_I	27_L	1.099	0.97
150_L	176_L	1.084	0.97
38_N	268_L	1.083	0.97
29_K	33_K	1.070	0.96
232_A	236_L	1.068	0.96
213_A	216_A	1.062	0.96
217_V	282_I	1.052	0.96
55_L	70_I	1.049	0.96
174_G	177_K	1.048	0.96
272_Y	281_P	1.038	0.96
151_I	300_L	1.036	0.96
73_Y	77_L	1.036	0.96
31_L	35_V	1.035	0.96
115_L	246_V	1.034	0.96
203_A	207_G	1.031	0.95
210_L	213_A	1.023	0.95
179_I	270_L	1.021	0.95
188_L	311_M	1.020	0.95
302_L	306_A	1.016	0.95
116_L	121_G	1.016	0.95
185_G	189_T	1.016	0.95
24_L	190_V	1.009	0.95
53_A	282_I	1.001	0.95
45_L	139_I	0.999	0.95
52_C	251_L	0.995	0.95
209_T	213_A	0.994	0.94
102_V	106_K	0.990	0.94
241_L	244_N	0.987	0.94
120_G	191_F	0.981	0.94
238_S	247_G	0.979	0.94
181_V	185_G	0.978	0.94
30_Y	260_F	0.978	0.94
265_I	302_L	0.969	0.94
72_Y	284_D	0.963	0.93
181_V	252_I	0.962	0.93
191_F	211_R	0.955	0.93
154_S	177_K	0.941	0.93
279_I	288_V	0.938	0.93
171_K	292_D	0.937	0.93
97_A	264_K	0.936	0.93
21_K	33_K	0.935	0.92
183_L	186_L	0.933	0.92
151_I	180_V	0.930	0.92
89_S	263_L	0.921	0.92
29_K	36_L	0.917	0.92
170_S	174_G	0.915	0.92
127_V	202_A	0.914	0.92
60_S	221_I	0.906	0.91
6_L	9_D	0.903	0.91
83_A	294_I	0.899	0.91
244_N	247_G	0.896	0.91
98_I	228_L	0.891	0.91
94_A	148_L	0.887	0.90
6_L	18_L	0.878	0.90
65_G	69_K	0.878	0.90
103_D	106_K	0.877	0.90
264_K	268_L	0.876	0.90
83_A	291_L	0.869	0.89
112_L	138_L	0.869	0.89
73_Y	124_S	0.868	0.89
148_L	218_G	0.868	0.89
47_V	146_V	0.861	0.89
268_L	298_L	0.853	0.89
83_A	290_C	0.852	0.88
104_F	312_F	0.852	0.88
283_G	288_V	0.843	0.88
180_V	184_L	0.840	0.88
123_T	126_A	0.835	0.87
192_L	196_S	0.835	0.87
150_L	183_L	0.835	0.87
97_A	101_M	0.833	0.87
56_K	60_S	0.833	0.87
231_A	275_A	0.831	0.87
92_G	95_K	0.829	0.87
57_N	279_I	0.828	0.87
33_K	37_A	0.827	0.87
134_F	138_L	0.827	0.87
228_L	303_A	0.826	0.87
193_G	317_T	0.824	0.87
260_F	282_I	0.824	0.87
43_G	223_V	0.821	0.87
111_V	114_T	0.820	0.87
134_F	238_S	0.817	0.86
299_G	314_I	0.814	0.86
36_L	39_L	0.812	0.86
90_A	298_L	0.812	0.86
30_Y	263_L	0.812	0.86
76_Y	80_I	0.806	0.86
233_D	236_L	0.804	0.85
45_L	83_A	0.803	0.85
11_L	32_F	0.802	0.85
260_F	264_K	0.801	0.85
219_N	228_L	0.800	0.85
184_L	307_T	0.800	0.85
130_P	214_K	0.797	0.85
102_V	144_K	0.796	0.85
269_A	295_G	0.796	0.85
138_L	190_V	0.794	0.85
280_Q	283_G	0.791	0.85
257_I	262_L	0.787	0.84
219_N	250_G	0.786	0.84
279_I	291_L	0.783	0.84
317_T	320_I	0.783	0.84
32_F	224_V	0.779	0.84
108_L	316_I	0.776	0.83
255_L	313_F	0.774	0.83
98_I	300_L	0.769	0.83
242_L	317_T	0.766	0.83
142_L	146_V	0.765	0.82
284_D	287_I	0.764	0.82
255_L	289_K	0.764	0.82
73_Y	163_L	0.763	0.82
187_L	266_L	0.762	0.82
183_L	187_L	0.756	0.82
73_Y	258_C	0.755	0.82
116_L	124_S	0.754	0.82
9_D	16_L	0.750	0.81
41_L	183_L	0.748	0.81
231_A	235_V	0.745	0.81
46_L	319_I	0.744	0.81
41_L	45_L	0.739	0.80
26_G	30_Y	0.738	0.80
49_A	125_A	0.738	0.80
80_I	290_C	0.737	0.80
254_L	313_F	0.735	0.80
222_P	225_G	0.734	0.80
89_S	92_G	0.732	0.80
236_L	295_G	0.730	0.79
157_L	169_L	0.728	0.79
188_L	224_V	0.728	0.79
188_L	231_A	0.725	0.79
120_G	206_D	0.721	0.79
239_S	313_F	0.717	0.78
43_G	131_L	0.717	0.78
199_G	233_D	0.713	0.78
131_L	194_V	0.712	0.78
131_L	147_L	0.711	0.78
269_A	273_K	0.711	0.78
167_Y	185_G	0.709	0.77
123_T	310_L	0.708	0.77
66_S	163_L	0.708	0.77
129_H	154_S	0.707	0.77
230_D	298_L	0.706	0.77
166_E	242_L	0.703	0.77
71_A	74_V	0.702	0.77
24_L	28_L	0.701	0.77
212_T	215_F	0.700	0.77
272_Y	298_L	0.700	0.77
165_E	194_V	0.700	0.77
28_L	35_V	0.700	0.77
174_G	296_K	0.699	0.76
64_N	142_L	0.697	0.76
305_L	314_I	0.696	0.76
139_I	195_L	0.696	0.76
161_N	254_L	0.692	0.76
129_H	221_I	0.690	0.76
112_L	193_G	0.689	0.75
47_V	199_G	0.682	0.75
105_M	163_L	0.681	0.75
17_G	27_L	0.681	0.75
52_C	283_G	0.680	0.74
128_F	241_L	0.680	0.74
202_A	292_D	0.680	0.74
18_L	23_I	0.678	0.74
85_N	159_I	0.677	0.74
63_E	67_V	0.676	0.74
166_E	176_L	0.675	0.74
108_L	265_I	0.674	0.74
265_I	277_A	0.674	0.74
26_G	33_K	0.674	0.74
199_G	243_K	0.674	0.74
42_L	276_A	0.674	0.74
215_F	229_S	0.674	0.74
254_L	316_I	0.673	0.74
48_L	63_E	0.672	0.74
134_F	319_I	0.672	0.74
7_V	245_A	0.668	0.73
162_N	289_K	0.666	0.73
206_D	247_G	0.663	0.73
6_L	16_L	0.662	0.72
125_A	319_I	0.659	0.72
142_L	145_N	0.657	0.72
188_L	228_L	0.657	0.72
116_L	240_L	0.657	0.72
134_F	182_W	0.657	0.72
214_K	275_A	0.654	0.72
277_A	281_P	0.654	0.72
143_I	304_A	0.654	0.72
28_L	36_L	0.653	0.71
8_K	19_S	0.653	0.71
98_I	169_L	0.652	0.71
171_K	284_D	0.650	0.71
37_A	263_L	0.649	0.71
23_I	45_L	0.648	0.71
121_G	318_I	0.647	0.71
219_N	223_V	0.643	0.70
199_G	213_A	0.638	0.70
221_I	228_L	0.637	0.70
44_K	82_L	0.637	0.70
141_T	145_N	0.636	0.69
109_L	227_A	0.635	0.69
171_K	174_G	0.633	0.69
39_L	195_L	0.631	0.69
143_I	151_I	0.629	0.69
97_A	250_G	0.628	0.69
7_V	11_L	0.626	0.68
26_G	46_L	0.624	0.68
85_N	171_K	0.623	0.68
209_T	244_N	0.618	0.67
46_L	266_L	0.617	0.67
148_L	320_I	0.617	0.67
98_I	311_M	0.617	0.67
192_L	228_L	0.615	0.67
303_A	306_A	0.613	0.67
109_L	188_L	0.613	0.67
130_P	140_G	0.612	0.67
194_V	200_I	0.612	0.67
273_K	320_I	0.612	0.67
120_G	214_K	0.608	0.66
158_S	242_L	0.607	0.66
153_L	156_V	0.606	0.66
201_I	247_G	0.605	0.66
242_L	309_A	0.603	0.65
76_Y	286_R	0.601	0.65
172_L	264_K	0.598	0.65
224_V	229_S	0.597	0.65
261_P	273_K	0.595	0.64
45_L	291_L	0.595	0.64
84_L	94_A	0.594	0.64
60_S	67_V	0.591	0.64
216_A	220_F	0.591	0.64
77_L	166_E	0.590	0.64
69_K	72_Y	0.589	0.64
37_A	109_L	0.589	0.64
196_S	303_A	0.587	0.63
251_L	304_A	0.584	0.63
228_L	231_A	0.583	0.63
161_N	273_K	0.583	0.63
134_F	296_K	0.582	0.63
140_G	191_F	0.582	0.63
138_L	274_L	0.582	0.63
16_L	252_I	0.581	0.63
56_K	84_L	0.580	0.62
66_S	77_L	0.580	0.62
218_G	303_A	0.578	0.62
182_W	288_V	0.577	0.62
171_K	280_Q	0.577	0.62
85_N	151_I	0.577	0.62
91_I	169_L	0.576	0.62
84_L	159_I	0.576	0.62
129_H	232_A	0.575	0.62
22_E	267_A	0.575	0.62
125_A	205_A	0.574	0.62
247_G	316_I	0.574	0.62
33_K	36_L	0.573	0.61
185_G	220_F	0.570	0.61
198_Q	205_A	0.570	0.61
77_L	228_L	0.570	0.61
194_V	322_A	0.569	0.61
70_I	272_Y	0.568	0.61
42_L	277_A	0.567	0.61
109_L	231_A	0.566	0.61
262_L	266_L	0.566	0.61
280_Q	292_D	0.565	0.60
249_A	253_I	0.563	0.60
86_S	165_E	0.562	0.60
192_L	295_G	0.562	0.60
24_L	285_K	0.560	0.60
242_L	265_I	0.559	0.60
215_F	230_D	0.558	0.59
67_V	258_C	0.558	0.59
80_I	152_F	0.556	0.59
117_A	224_V	0.555	0.59
192_L	240_L	0.555	0.59
203_A	246_V	0.554	0.59
162_N	280_Q	0.554	0.59
259_L	263_L	0.553	0.59
269_A	302_L	0.552	0.59
181_V	300_L	0.551	0.59
137_N	319_I	0.551	0.59
147_L	173_A	0.550	0.58
148_L	263_L	0.550	0.58
139_I	236_L	0.550	0.58
23_I	148_L	0.548	0.58
67_V	243_K	0.548	0.58
164_S	200_I	0.547	0.58
142_L	174_G	0.547	0.58
9_D	17_G	0.547	0.58
75_C	124_S	0.545	0.58
193_G	310_L	0.545	0.58
34_E	37_A	0.545	0.58
87_F	294_I	0.545	0.58
186_L	190_V	0.544	0.58
55_L	71_A	0.542	0.57
219_N	226_G	0.542	0.57
16_L	91_I	0.542	0.57
11_L	36_L	0.541	0.57
126_A	218_G	0.541	0.57
141_T	192_L	0.541	0.57
17_G	22_E	0.540	0.57
198_Q	202_A	0.540	0.57
166_E	187_L	0.539	0.57
109_L	321_A	0.538	0.57
135_L	237_G	0.537	0.57
4_K	221_I	0.536	0.56
122_V	209_T	0.534	0.56
161_N	170_S	0.534	0.56
129_H	239_S	0.533	0.56
161_N	192_L	0.532	0.56
105_M	306_A	0.531	0.56
100_N	221_I	0.531	0.56
314_I	317_T	0.531	0.56
109_L	117_A	0.530	0.56
190_V	285_K	0.529	0.55
178_K	245_A	0.527	0.55
124_S	155_A	0.526	0.55
38_N	108_L	0.526	0.55
188_L	230_D	0.524	0.55
259_L	289_K	0.524	0.55
172_L	286_R	0.524	0.55
224_V	303_A	0.524	0.55
220_F	237_G	0.523	0.55
138_L	248_I	0.523	0.55
237_G	292_D	0.521	0.54
84_L	257_I	0.521	0.54
192_L	281_P	0.521	0.54
102_V	140_G	0.520	0.54
167_Y	295_G	0.520	0.54
105_M	152_F	0.519	0.54
206_D	243_K	0.516	0.54
128_F	198_Q	0.514	0.53
121_G	219_N	0.512	0.53
248_I	273_K	0.511	0.53
121_G	255_L	0.510	0.53
319_I	322_A	0.510	0.53
49_A	53_A	0.510	0.53
125_A	218_G	0.507	0.52
242_L	246_V	0.507	0.52
285_K	316_I	0.506	0.52
41_L	44_K	0.506	0.52
237_G	241_L	0.505	0.52
82_L	292_D	0.504	0.52
229_S	250_G	0.504	0.52
156_V	176_L	0.502	0.52
37_A	89_S	0.502	0.52
154_S	297_S	0.502	0.52
22_E	25_K	0.501	0.52
158_S	173_A	0.501	0.52
195_L	211_R	0.500	0.51
19_S	168_K	0.500	0.51

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4dhxB	1	0.1207	4.2	0.967	Contact Map
3e8tA	1	0.195	3.5	0.969	Contact Map
4q4lA	1	0.2198	3	0.97	Contact Map
2whnA	1	0.1176	2.8	0.97	Contact Map
2kygA	2	0.1176	2.6	0.97	Contact Map
2izxA	2	0.1146	2.6	0.971	Contact Map
1rp3B	1	0.096	2.5	0.971	Contact Map
3mktA	1	0.3529	2.4	0.971	Contact Map
3mhsB	1	0.1238	2.2	0.972	Contact Map
1ciiA	1	0.2446	2.1	0.972	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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