GREMLIN Database
Spore_III_AE - Stage III sporulation protein AE (spore_III_AE)
PFAM: PF09546 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 323 (318)
Sequences: 2172 (1685)
Seq/√Len: 94.5
META: 0.725

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
93_L97_A3.9951.00
49_A279_I3.6171.00
94_A305_L3.3741.00
262_L302_L3.3231.00
9_D15_E3.2571.00
273_K292_D3.1191.00
42_L275_A3.0421.00
108_L250_G2.9701.00
177_K296_K2.9481.00
69_K286_R2.8611.00
147_L304_A2.7671.00
104_F257_I2.7171.00
238_S317_T2.7011.00
265_I305_L2.6751.00
146_V183_L2.6301.00
177_K181_V2.6281.00
99_D103_D2.5851.00
99_D144_K2.5701.00
72_Y286_R2.5641.00
179_I183_L2.5441.00
182_W186_L2.5301.00
86_S272_Y2.5211.00
246_V250_G2.5131.00
151_I304_A2.4921.00
5_E9_D2.4681.00
147_L180_V2.3741.00
143_I184_L2.3581.00
34_E264_K2.3551.00
170_S280_Q2.3291.00
258_C309_A2.2771.00
19_S22_E2.2621.00
147_L183_L2.2541.00
155_A297_S2.2441.00
52_C75_C2.2211.00
273_K295_G2.2021.00
158_S293_S2.1961.00
4_K8_K2.1291.00
175_L277_A2.1281.00
269_A299_G2.1091.00
72_Y76_Y2.0581.00
40_K44_K2.0311.00
43_G46_L1.9721.00
106_K141_T1.9681.00
251_L313_F1.9571.00
96_E100_N1.9441.00
94_A301_L1.9191.00
45_L79_L1.9091.00
104_F253_I1.9071.00
193_G197_I1.8971.00
80_I159_I1.8341.00
48_L75_C1.8341.00
142_L187_L1.8171.00
188_L307_T1.7491.00
25_K29_K1.7391.00
142_L183_L1.7121.00
266_L270_L1.7071.00
155_A294_I1.6881.00
185_G215_F1.6751.00
7_V249_A1.6721.00
217_V221_I1.6721.00
178_K182_W1.6631.00
21_K25_K1.6611.00
12_K15_E1.6391.00
135_L194_V1.6181.00
124_S206_D1.6111.00
285_K289_K1.6001.00
240_L244_N1.5991.00
122_V126_A1.5841.00
98_I308_V1.5801.00
45_L275_A1.5641.00
238_S314_I1.5611.00
70_I74_V1.5391.00
235_V310_L1.5301.00
247_G320_I1.5261.00
175_L274_L1.5141.00
266_L302_L1.5121.00
188_L227_A1.5091.00
226_G230_D1.5051.00
307_T311_M1.4881.00
97_A305_L1.4871.00
208_V241_L1.4831.00
45_L82_L1.4721.00
95_K99_D1.4721.00
262_L306_A1.4391.00
117_A125_A1.4120.99
8_K12_K1.3920.99
305_L309_A1.3820.99
46_L279_I1.3780.99
90_A268_L1.3760.99
76_Y162_N1.3630.99
92_G96_E1.3570.99
165_E286_R1.3430.99
234_T238_S1.3390.99
20_L24_L1.3220.99
95_K148_L1.3220.99
5_E8_K1.2980.99
31_L267_A1.2930.99
15_E18_L1.2920.99
113_L125_A1.2690.99
202_A248_I1.2500.99
90_A265_I1.2460.99
215_F219_N1.2450.99
8_K11_L1.2340.99
27_L259_L1.2250.98
124_S128_F1.2140.98
211_R215_F1.2120.98
55_L62_F1.2120.98
124_S202_A1.2090.98
139_I187_L1.1910.98
184_L304_A1.1870.98
96_E99_D1.1820.98
106_K137_N1.1810.98
83_A272_Y1.1740.98
135_L138_L1.1700.98
207_G233_D1.1650.98
259_L267_A1.1650.98
231_A234_T1.1630.98
91_I301_L1.1620.98
223_V303_A1.1590.98
157_L173_A1.1540.98
265_I298_L1.1490.98
201_I248_I1.1480.98
133_L137_N1.1470.98
95_K144_K1.1410.98
105_M312_F1.1290.97
176_L221_I1.1220.97
108_L112_L1.1200.97
23_I27_L1.0990.97
150_L176_L1.0840.97
38_N268_L1.0830.97
29_K33_K1.0700.96
232_A236_L1.0680.96
213_A216_A1.0620.96
217_V282_I1.0520.96
55_L70_I1.0490.96
174_G177_K1.0480.96
272_Y281_P1.0380.96
151_I300_L1.0360.96
73_Y77_L1.0360.96
31_L35_V1.0350.96
115_L246_V1.0340.96
203_A207_G1.0310.95
210_L213_A1.0230.95
179_I270_L1.0210.95
188_L311_M1.0200.95
302_L306_A1.0160.95
116_L121_G1.0160.95
185_G189_T1.0160.95
24_L190_V1.0090.95
53_A282_I1.0010.95
45_L139_I0.9990.95
52_C251_L0.9950.95
209_T213_A0.9940.94
102_V106_K0.9900.94
241_L244_N0.9870.94
120_G191_F0.9810.94
238_S247_G0.9790.94
181_V185_G0.9780.94
30_Y260_F0.9780.94
265_I302_L0.9690.94
72_Y284_D0.9630.93
181_V252_I0.9620.93
191_F211_R0.9550.93
154_S177_K0.9410.93
279_I288_V0.9380.93
171_K292_D0.9370.93
97_A264_K0.9360.93
21_K33_K0.9350.92
183_L186_L0.9330.92
151_I180_V0.9300.92
89_S263_L0.9210.92
29_K36_L0.9170.92
170_S174_G0.9150.92
127_V202_A0.9140.92
60_S221_I0.9060.91
6_L9_D0.9030.91
83_A294_I0.8990.91
244_N247_G0.8960.91
98_I228_L0.8910.91
94_A148_L0.8870.90
6_L18_L0.8780.90
65_G69_K0.8780.90
103_D106_K0.8770.90
264_K268_L0.8760.90
83_A291_L0.8690.89
112_L138_L0.8690.89
73_Y124_S0.8680.89
148_L218_G0.8680.89
47_V146_V0.8610.89
268_L298_L0.8530.89
83_A290_C0.8520.88
104_F312_F0.8520.88
283_G288_V0.8430.88
180_V184_L0.8400.88
123_T126_A0.8350.87
192_L196_S0.8350.87
150_L183_L0.8350.87
97_A101_M0.8330.87
56_K60_S0.8330.87
231_A275_A0.8310.87
92_G95_K0.8290.87
57_N279_I0.8280.87
33_K37_A0.8270.87
134_F138_L0.8270.87
228_L303_A0.8260.87
193_G317_T0.8240.87
260_F282_I0.8240.87
43_G223_V0.8210.87
111_V114_T0.8200.87
134_F238_S0.8170.86
299_G314_I0.8140.86
36_L39_L0.8120.86
90_A298_L0.8120.86
30_Y263_L0.8120.86
76_Y80_I0.8060.86
233_D236_L0.8040.85
45_L83_A0.8030.85
11_L32_F0.8020.85
260_F264_K0.8010.85
219_N228_L0.8000.85
184_L307_T0.8000.85
130_P214_K0.7970.85
102_V144_K0.7960.85
269_A295_G0.7960.85
138_L190_V0.7940.85
280_Q283_G0.7910.85
257_I262_L0.7870.84
219_N250_G0.7860.84
279_I291_L0.7830.84
317_T320_I0.7830.84
32_F224_V0.7790.84
108_L316_I0.7760.83
255_L313_F0.7740.83
98_I300_L0.7690.83
242_L317_T0.7660.83
142_L146_V0.7650.82
284_D287_I0.7640.82
255_L289_K0.7640.82
73_Y163_L0.7630.82
187_L266_L0.7620.82
183_L187_L0.7560.82
73_Y258_C0.7550.82
116_L124_S0.7540.82
9_D16_L0.7500.81
41_L183_L0.7480.81
231_A235_V0.7450.81
46_L319_I0.7440.81
41_L45_L0.7390.80
26_G30_Y0.7380.80
49_A125_A0.7380.80
80_I290_C0.7370.80
254_L313_F0.7350.80
222_P225_G0.7340.80
89_S92_G0.7320.80
236_L295_G0.7300.79
157_L169_L0.7280.79
188_L224_V0.7280.79
188_L231_A0.7250.79
120_G206_D0.7210.79
239_S313_F0.7170.78
43_G131_L0.7170.78
199_G233_D0.7130.78
131_L194_V0.7120.78
131_L147_L0.7110.78
269_A273_K0.7110.78
167_Y185_G0.7090.77
123_T310_L0.7080.77
66_S163_L0.7080.77
129_H154_S0.7070.77
230_D298_L0.7060.77
166_E242_L0.7030.77
71_A74_V0.7020.77
24_L28_L0.7010.77
212_T215_F0.7000.77
272_Y298_L0.7000.77
165_E194_V0.7000.77
28_L35_V0.7000.77
174_G296_K0.6990.76
64_N142_L0.6970.76
305_L314_I0.6960.76
139_I195_L0.6960.76
161_N254_L0.6920.76
129_H221_I0.6900.76
112_L193_G0.6890.75
47_V199_G0.6820.75
105_M163_L0.6810.75
17_G27_L0.6810.75
52_C283_G0.6800.74
128_F241_L0.6800.74
202_A292_D0.6800.74
18_L23_I0.6780.74
85_N159_I0.6770.74
63_E67_V0.6760.74
166_E176_L0.6750.74
108_L265_I0.6740.74
265_I277_A0.6740.74
26_G33_K0.6740.74
199_G243_K0.6740.74
42_L276_A0.6740.74
215_F229_S0.6740.74
254_L316_I0.6730.74
48_L63_E0.6720.74
134_F319_I0.6720.74
7_V245_A0.6680.73
162_N289_K0.6660.73
206_D247_G0.6630.73
6_L16_L0.6620.72
125_A319_I0.6590.72
142_L145_N0.6570.72
188_L228_L0.6570.72
116_L240_L0.6570.72
134_F182_W0.6570.72
214_K275_A0.6540.72
277_A281_P0.6540.72
143_I304_A0.6540.72
28_L36_L0.6530.71
8_K19_S0.6530.71
98_I169_L0.6520.71
171_K284_D0.6500.71
37_A263_L0.6490.71
23_I45_L0.6480.71
121_G318_I0.6470.71
219_N223_V0.6430.70
199_G213_A0.6380.70
221_I228_L0.6370.70
44_K82_L0.6370.70
141_T145_N0.6360.69
109_L227_A0.6350.69
171_K174_G0.6330.69
39_L195_L0.6310.69
143_I151_I0.6290.69
97_A250_G0.6280.69
7_V11_L0.6260.68
26_G46_L0.6240.68
85_N171_K0.6230.68
209_T244_N0.6180.67
46_L266_L0.6170.67
148_L320_I0.6170.67
98_I311_M0.6170.67
192_L228_L0.6150.67
303_A306_A0.6130.67
109_L188_L0.6130.67
130_P140_G0.6120.67
194_V200_I0.6120.67
273_K320_I0.6120.67
120_G214_K0.6080.66
158_S242_L0.6070.66
153_L156_V0.6060.66
201_I247_G0.6050.66
242_L309_A0.6030.65
76_Y286_R0.6010.65
172_L264_K0.5980.65
224_V229_S0.5970.65
261_P273_K0.5950.64
45_L291_L0.5950.64
84_L94_A0.5940.64
60_S67_V0.5910.64
216_A220_F0.5910.64
77_L166_E0.5900.64
69_K72_Y0.5890.64
37_A109_L0.5890.64
196_S303_A0.5870.63
251_L304_A0.5840.63
228_L231_A0.5830.63
161_N273_K0.5830.63
134_F296_K0.5820.63
140_G191_F0.5820.63
138_L274_L0.5820.63
16_L252_I0.5810.63
56_K84_L0.5800.62
66_S77_L0.5800.62
218_G303_A0.5780.62
182_W288_V0.5770.62
171_K280_Q0.5770.62
85_N151_I0.5770.62
91_I169_L0.5760.62
84_L159_I0.5760.62
129_H232_A0.5750.62
22_E267_A0.5750.62
125_A205_A0.5740.62
247_G316_I0.5740.62
33_K36_L0.5730.61
185_G220_F0.5700.61
198_Q205_A0.5700.61
77_L228_L0.5700.61
194_V322_A0.5690.61
70_I272_Y0.5680.61
42_L277_A0.5670.61
109_L231_A0.5660.61
262_L266_L0.5660.61
280_Q292_D0.5650.60
249_A253_I0.5630.60
86_S165_E0.5620.60
192_L295_G0.5620.60
24_L285_K0.5600.60
242_L265_I0.5590.60
215_F230_D0.5580.59
67_V258_C0.5580.59
80_I152_F0.5560.59
117_A224_V0.5550.59
192_L240_L0.5550.59
203_A246_V0.5540.59
162_N280_Q0.5540.59
259_L263_L0.5530.59
269_A302_L0.5520.59
181_V300_L0.5510.59
137_N319_I0.5510.59
147_L173_A0.5500.58
148_L263_L0.5500.58
139_I236_L0.5500.58
23_I148_L0.5480.58
67_V243_K0.5480.58
164_S200_I0.5470.58
142_L174_G0.5470.58
9_D17_G0.5470.58
75_C124_S0.5450.58
193_G310_L0.5450.58
34_E37_A0.5450.58
87_F294_I0.5450.58
186_L190_V0.5440.58
55_L71_A0.5420.57
219_N226_G0.5420.57
16_L91_I0.5420.57
11_L36_L0.5410.57
126_A218_G0.5410.57
141_T192_L0.5410.57
17_G22_E0.5400.57
198_Q202_A0.5400.57
166_E187_L0.5390.57
109_L321_A0.5380.57
135_L237_G0.5370.57
4_K221_I0.5360.56
122_V209_T0.5340.56
161_N170_S0.5340.56
129_H239_S0.5330.56
161_N192_L0.5320.56
105_M306_A0.5310.56
100_N221_I0.5310.56
314_I317_T0.5310.56
109_L117_A0.5300.56
190_V285_K0.5290.55
178_K245_A0.5270.55
124_S155_A0.5260.55
38_N108_L0.5260.55
188_L230_D0.5240.55
259_L289_K0.5240.55
172_L286_R0.5240.55
224_V303_A0.5240.55
220_F237_G0.5230.55
138_L248_I0.5230.55
237_G292_D0.5210.54
84_L257_I0.5210.54
192_L281_P0.5210.54
102_V140_G0.5200.54
167_Y295_G0.5200.54
105_M152_F0.5190.54
206_D243_K0.5160.54
128_F198_Q0.5140.53
121_G219_N0.5120.53
248_I273_K0.5110.53
121_G255_L0.5100.53
319_I322_A0.5100.53
49_A53_A0.5100.53
125_A218_G0.5070.52
242_L246_V0.5070.52
285_K316_I0.5060.52
41_L44_K0.5060.52
237_G241_L0.5050.52
82_L292_D0.5040.52
229_S250_G0.5040.52
156_V176_L0.5020.52
37_A89_S0.5020.52
154_S297_S0.5020.52
22_E25_K0.5010.52
158_S173_A0.5010.52
195_L211_R0.5000.51
19_S168_K0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4dhxB 1 0.1207 4.2 0.967 Contact Map
3e8tA 1 0.195 3.5 0.969 Contact Map
4q4lA 1 0.2198 3 0.97 Contact Map
2whnA 1 0.1176 2.8 0.97 Contact Map
2kygA 2 0.1176 2.6 0.97 Contact Map
2izxA 2 0.1146 2.6 0.971 Contact Map
1rp3B 1 0.096 2.5 0.971 Contact Map
3mktA 1 0.3529 2.4 0.971 Contact Map
3mhsB 1 0.1238 2.2 0.972 Contact Map
1ciiA 1 0.2446 2.1 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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