GREMLIN Database
Trp_oprn_chp - Tryptophan-associated transmembrane protein (Trp_oprn_chp)
PFAM: PF09534 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 180 (179)
Sequences: 2462 (1876)
Seq/√Len: 140.2
META: 0.657

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_A129_L4.4361.00
7_G125_G3.9901.00
51_V77_A3.9011.00
68_R141_R3.7181.00
11_A81_A3.5041.00
71_G133_G3.3701.00
7_G132_A3.3351.00
78_G126_G3.0151.00
78_G133_G2.6751.00
78_G130_L2.6421.00
17_Q118_W2.4331.00
82_A126_G2.3461.00
168_D171_D2.2651.00
55_A74_L2.2381.00
59_V136_A2.2341.00
120_W124_A2.1751.00
71_G136_A2.1681.00
85_A126_G2.0871.00
9_A13_L2.0461.00
74_L133_G1.9991.00
64_G68_R1.9771.00
81_A126_G1.9411.00
76_L80_G1.9271.00
10_L125_G1.9141.00
26_D29_G1.8391.00
4_L56_A1.8201.00
14_A122_A1.8161.00
140_G143_W1.8161.00
58_A61_A1.7831.00
65_V69_V1.7531.00
10_L13_L1.7481.00
8_A52_A1.7481.00
61_A146_M1.7061.00
171_D174_D1.7011.00
71_G137_L1.5421.00
3_L132_A1.5401.00
42_A84_A1.4511.00
72_V76_L1.4111.00
86_V123_L1.4091.00
172_A177_E1.4081.00
18_T21_T1.4031.00
127_V131_A1.4001.00
48_L80_G1.3861.00
11_A125_G1.3791.00
19_W38_G1.3321.00
8_A53_L1.3291.00
42_A45_L1.3141.00
165_D168_D1.3131.00
68_R140_G1.3111.00
18_T37_T1.2931.00
66_G70_V1.2821.00
37_T40_D1.2751.00
167_R171_D1.2581.00
5_A9_A1.2461.00
75_A130_L1.2281.00
50_L54_A1.2111.00
86_V89_L1.2041.00
176_G179_P1.2011.00
52_A78_G1.1981.00
176_G180_T1.1751.00
54_A58_A1.1630.99
75_A133_G1.1610.99
45_L55_A1.1600.99
89_L92_P1.1550.99
85_A122_A1.1360.99
45_L77_A1.1080.99
62_T70_V1.1010.99
78_G129_L1.0990.99
118_W143_W1.0880.99
65_V68_R1.0860.99
165_D169_L1.0690.99
120_W123_L1.0680.99
6_A10_L1.0680.99
78_G85_A1.0670.99
101_A104_T1.0650.99
4_L132_A1.0650.99
63_R145_A1.0630.99
96_A100_A1.0580.99
15_S45_L1.0540.99
36_V100_A1.0520.99
83_A87_A1.0490.99
101_A105_G1.0470.99
7_G128_L1.0440.99
14_A125_G1.0440.99
129_L132_A1.0290.99
21_T35_T1.0280.99
109_G112_A1.0190.99
88_G92_P1.0150.99
164_D168_D0.9950.98
47_A58_A0.9920.98
80_G84_A0.9880.98
156_R161_A0.9750.98
131_A134_V0.9730.98
96_A99_A0.9600.98
7_G129_L0.9460.98
157_R163_A0.9300.97
85_A123_L0.9220.97
62_T66_G0.9090.97
12_L46_T0.9050.97
111_A114_S0.8920.97
58_A98_A0.8870.97
44_A84_A0.8830.97
92_P95_A0.8800.96
23_T27_G0.8800.96
49_A59_V0.8760.96
24_V27_G0.8730.96
84_A87_A0.8640.96
82_A86_V0.8640.96
125_G132_A0.8600.96
169_L173_L0.8590.96
43_P118_W0.8530.96
54_A57_V0.8520.96
71_G78_G0.8500.96
109_G113_V0.8490.96
50_L119_P0.8480.96
158_A161_A0.8350.95
47_A51_V0.8350.95
13_L17_Q0.8280.95
75_A137_L0.8250.95
27_G30_P0.8200.95
60_L68_R0.8150.95
2_L161_A0.8150.95
126_G130_L0.8110.94
8_A56_A0.8020.94
158_A164_D0.8010.94
45_L56_A0.8000.94
18_T35_T0.8000.94
166_P175_R0.7910.94
51_V55_A0.7890.94
105_G108_G0.7890.94
166_P171_D0.7880.94
135_L139_R0.7850.93
110_V114_S0.7790.93
62_T146_M0.7720.93
50_L60_L0.7680.93
67_R143_W0.7660.93
53_L57_V0.7640.93
81_A129_L0.7610.92
36_V41_A0.7610.92
55_A77_A0.7610.92
166_P169_L0.7590.92
6_A156_R0.7550.92
72_V137_L0.7470.92
99_A102_A0.7460.92
60_L177_E0.7420.91
74_L129_L0.7390.91
24_V32_V0.7300.91
5_A56_A0.7280.91
130_L133_G0.7250.90
146_M150_Y0.7180.90
98_A131_A0.7170.90
70_V113_V0.7160.90
7_G52_A0.7130.90
114_S148_S0.7050.89
46_T50_L0.7030.89
60_L80_G0.7000.89
159_A163_A0.7000.89
157_R161_A0.6950.89
85_A89_L0.6930.88
170_W178_D0.6910.88
12_L17_Q0.6910.88
51_V57_V0.6900.88
2_L173_L0.6850.88
92_P96_A0.6840.88
8_A12_L0.6820.88
93_A97_R0.6810.88
11_A49_A0.6800.87
45_L119_P0.6800.87
52_A74_L0.6770.87
91_D94_A0.6730.87
153_P156_R0.6710.87
61_A149_R0.6670.86
160_A163_A0.6670.86
22_V28_L0.6650.86
82_A123_L0.6650.86
138_R142_R0.6630.86
47_A54_A0.6550.85
17_Q143_W0.6540.85
153_P157_R0.6510.85
101_A106_V0.6500.85
120_W127_V0.6440.84
105_G113_V0.6430.84
167_R174_D0.6420.84
73_L76_L0.6360.84
136_A143_W0.6290.83
11_A126_G0.6250.83
170_W176_G0.6220.82
60_L64_G0.6180.82
52_A81_A0.6160.82
59_V143_W0.6130.81
93_A138_R0.6120.81
53_L67_R0.6110.81
16_R49_A0.6110.81
144_P147_S0.6110.81
8_A129_L0.6090.81
15_S55_A0.6050.81
154_A159_A0.6040.80
163_A168_D0.6040.80
69_V72_V0.5990.80
3_L131_A0.5980.80
156_R160_A0.5960.80
49_A53_L0.5960.80
63_R66_G0.5890.79
55_A80_G0.5840.78
132_A147_S0.5840.78
161_A164_D0.5830.78
55_A62_T0.5800.78
3_L72_V0.5780.78
133_G137_L0.5780.78
22_V96_A0.5760.77
94_A98_A0.5760.77
5_A152_R0.5740.77
82_A127_V0.5740.77
156_R169_L0.5700.77
104_T109_G0.5640.76
171_D175_R0.5640.76
4_L149_R0.5610.75
173_L179_P0.5610.75
18_T157_R0.5600.75
18_T99_A0.5580.75
64_G140_G0.5570.75
60_L153_P0.5560.75
147_S152_R0.5550.75
3_L128_L0.5540.75
38_G69_V0.5510.74
22_V36_V0.5510.74
57_V145_A0.5490.74
16_R39_A0.5490.74
164_D171_D0.5480.74
50_L156_R0.5470.74
90_A123_L0.5450.73
26_D30_P0.5440.73
14_A144_P0.5430.73
104_T108_G0.5410.73
63_R67_R0.5410.73
2_L9_A0.5400.73
106_V109_G0.5400.73
56_A62_T0.5390.73
158_A163_A0.5350.72
45_L84_A0.5330.72
146_M151_E0.5310.71
3_L18_T0.5290.71
25_A29_G0.5290.71
170_W180_T0.5250.71
21_T33_T0.5250.71
21_T107_A0.5220.70
52_A80_G0.5200.70
23_T28_L0.5200.70
12_L140_G0.5200.70
7_G14_A0.5200.70
51_V118_W0.5190.70
61_A70_V0.5180.70
131_A135_L0.5160.69
137_L141_R0.5140.69
13_L121_L0.5130.69
103_A106_V0.5130.69
108_G113_V0.5120.69
80_G83_A0.5120.69
37_T41_A0.5120.69
43_P59_V0.5110.69
6_A83_A0.5110.69
20_A39_A0.5100.68
123_L126_G0.5080.68
38_G41_A0.5040.67
12_L16_R0.5040.67
110_V113_V0.5040.67
170_W179_P0.5000.67
86_V94_A0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2m20A 2 0.3167 16.2 0.919 Contact Map
2kncB 1 0.3444 5.6 0.934 Contact Map
2l2tA 2 0.2389 4.6 0.937 Contact Map
2kncA 1 0.2944 3.5 0.94 Contact Map
3wdoA 1 0.9556 3.4 0.941 Contact Map
2ks1B 1 0.2333 2.7 0.944 Contact Map
3iozB 1 0.0444 1.8 0.949 Contact Map
2kluA 1 0.3889 1.8 0.949 Contact Map
1iijA 1 0.1889 1.3 0.953 Contact Map
4a01A 2 0.2333 1.2 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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