GREMLIN Database
Intg_mem_TP0381 - Integral membrane protein (intg_mem_TP0381)
PFAM: PF09529 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 224 (214)
Sequences: 6546 (5310)
Seq/√Len: 363.0
META: 0.863

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
161_N209_E4.4871.00
93_F141_V4.0641.00
94_E152_S2.9561.00
170_V174_L2.9171.00
13_I131_G2.8571.00
7_L11_A2.6511.00
171_N176_T2.4011.00
188_A192_D2.3371.00
36_R40_R2.2861.00
41_I45_L2.2681.00
99_W160_L2.2561.00
138_L142_F2.2091.00
167_V170_V2.1851.00
10_L108_L2.1831.00
102_A215_L2.1441.00
9_A123_F2.0911.00
168_G182_N2.0621.00
74_C103_G2.0611.00
168_G172_L2.0181.00
95_F99_W1.9991.00
199_G207_V1.9811.00
165_V169_L1.9681.00
37_R41_I1.9261.00
5_S117_G1.9221.00
154_L158_L1.9211.00
79_L83_I1.8991.00
47_L82_A1.8931.00
94_E155_R1.8911.00
171_N182_N1.8831.00
151_K155_R1.8661.00
139_Y143_V1.8521.00
163_Y179_M1.8241.00
83_I92_L1.8181.00
50_E53_W1.8081.00
151_K154_L1.7821.00
40_R86_L1.7641.00
169_L173_L1.7521.00
90_R94_E1.7451.00
40_R44_I1.6641.00
44_I48_L1.6481.00
4_P8_I1.6191.00
189_S192_D1.5981.00
201_W204_Y1.5881.00
24_G27_L1.5871.00
116_Y120_H1.5741.00
160_L164_A1.5521.00
83_I87_T1.5421.00
106_Q110_T1.5201.00
32_E35_R1.5141.00
21_V24_G1.5061.00
81_A136_A1.5041.00
80_L92_L1.5031.00
119_P124_F1.4951.00
13_I17_I1.4921.00
150_W154_L1.4861.00
84_A140_L1.4801.00
54_Q63_W1.4801.00
169_L172_L1.4801.00
18_V22_L1.4791.00
149_T152_S1.4701.00
17_I135_L1.4531.00
33_R37_R1.4511.00
17_I21_V1.4231.00
31_P34_K1.4091.00
90_R152_S1.4081.00
53_W57_L1.4021.00
89_N92_L1.3891.00
172_L182_N1.3721.00
3_G7_L1.3561.00
16_L135_L1.3191.00
43_A82_A1.3101.00
107_A126_F1.3001.00
168_G181_L1.2451.00
156_V160_L1.2401.00
93_F146_Y1.2371.00
198_L207_V1.2351.00
66_Q176_T1.2241.00
166_I169_L1.2221.00
163_Y167_V1.2211.00
93_F140_L1.2131.00
97_Y219_L1.1821.00
168_G171_N1.1821.00
63_W68_S1.1681.00
77_A104_A1.1661.00
81_A96_L1.1561.00
210_L214_V1.1421.00
207_V210_L1.1261.00
64_S67_E1.1221.00
91_R159_I1.1211.00
157_F161_N1.0861.00
206_L210_L1.0851.00
49_N52_A1.0811.00
50_E54_Q1.0801.00
121_F125_Q1.0741.00
49_N53_W1.0741.00
22_L26_R1.0711.00
183_E186_E1.0681.00
102_A105_L1.0671.00
90_R149_T1.0651.00
184_K192_D1.0581.00
212_A216_F1.0531.00
35_R39_R1.0531.00
51_I55_I1.0521.00
164_A179_M1.0351.00
43_A85_L1.0331.00
34_K38_I1.0121.00
164_A181_L1.0091.00
52_A121_F1.0061.00
84_A96_L1.0001.00
14_I17_I0.9981.00
30_K34_K0.9961.00
150_W217_L0.9761.00
52_A55_I0.9701.00
49_N129_S0.9691.00
84_A92_L0.9651.00
77_A80_L0.9641.00
74_C133_I0.9611.00
8_I12_L0.9561.00
98_F152_S0.9551.00
171_N181_L0.9401.00
25_R28_R0.9391.00
95_F159_I0.9381.00
158_L162_I0.9321.00
175_G182_N0.9311.00
50_E78_A0.9311.00
158_L161_N0.9201.00
162_I166_I0.9061.00
55_I59_L0.9031.00
16_L20_L0.9021.00
84_A93_F0.9011.00
203_W206_L0.8991.00
68_S178_Y0.8971.00
159_I162_I0.8941.00
215_L219_L0.8931.00
100_G133_I0.8931.00
101_L134_V0.8891.00
74_C130_H0.8841.00
91_R155_R0.8811.00
104_A134_V0.8771.00
72_H107_A0.8641.00
49_N125_Q0.8511.00
39_R42_L0.8471.00
42_L49_N0.8451.00
73_L103_G0.8421.00
108_L131_G0.8291.00
9_A127_F0.8271.00
72_H179_M0.8261.00
58_L63_W0.8261.00
56_W116_Y0.8221.00
118_F123_F0.8161.00
112_D180_F0.8141.00
107_A111_P0.8131.00
57_L68_S0.8131.00
53_W125_Q0.8081.00
69_L178_Y0.8071.00
14_I18_V0.8061.00
50_E79_L0.8061.00
26_R29_R0.8051.00
154_L157_F0.8041.00
50_E125_Q0.7981.00
164_A168_G0.7961.00
40_R43_A0.7931.00
72_H75_D0.7921.00
77_A99_W0.7871.00
30_K33_R0.7831.00
75_D125_Q0.7801.00
203_W207_V0.7761.00
41_I44_I0.7721.00
38_I41_I0.7711.00
47_L50_E0.7661.00
104_A133_I0.7591.00
9_A12_L0.7571.00
36_R39_R0.7561.00
81_A137_A0.7531.00
39_R139_Y0.7531.00
217_L220_Y0.7411.00
157_F209_E0.7401.00
39_R88_K0.7381.00
34_K37_R0.7311.00
98_F148_P0.7241.00
205_I209_E0.7241.00
90_R146_Y0.7221.00
211_L214_V0.7221.00
71_L167_V0.7190.99
122_R125_Q0.7170.99
33_R40_R0.7150.99
85_L136_A0.7130.99
33_R36_R0.7090.99
82_A86_L0.7090.99
153_L217_L0.7060.99
106_Q189_S0.7040.99
106_Q190_L0.7010.99
45_L49_N0.6990.99
198_L202_P0.6990.99
71_L178_Y0.6970.99
108_L134_V0.6950.99
105_L109_L0.6950.99
153_L157_F0.6950.99
23_L27_L0.6940.99
9_A13_I0.6940.99
15_L19_L0.6920.99
71_L76_I0.6910.99
2_F9_A0.6890.99
140_L144_L0.6850.99
209_E213_L0.6830.99
118_F124_F0.6810.99
155_R158_L0.6790.99
18_V21_V0.6790.99
83_I89_N0.6780.99
54_Q57_L0.6780.99
112_D115_G0.6780.99
22_L25_R0.6730.99
112_D187_G0.6730.99
28_R31_P0.6720.99
136_A140_L0.6680.99
182_N204_Y0.6660.99
141_V145_G0.6640.99
171_N178_Y0.6620.99
88_K144_L0.6620.99
39_R144_L0.6590.99
44_I86_L0.6580.99
73_L99_W0.6560.99
206_L209_E0.6560.99
71_L170_V0.6550.99
13_I24_G0.6480.99
97_Y141_V0.6460.99
100_G137_A0.6450.99
43_A46_L0.6410.99
12_L16_L0.6370.99
190_L197_L0.6360.99
198_L209_E0.6360.99
200_P207_V0.6350.99
161_N165_V0.6300.99
50_E57_L0.6300.99
20_L24_G0.6280.99
22_L27_L0.6280.99
5_S9_A0.6250.99
67_E176_T0.6200.99
9_A131_G0.6150.98
152_S156_V0.6130.98
97_Y148_P0.6110.98
21_V142_F0.6070.98
184_K191_L0.6060.98
39_R43_A0.6040.98
49_N128_I0.6010.98
54_Q125_Q0.6010.98
110_T123_F0.5970.98
124_F128_I0.5920.98
163_Y166_I0.5900.98
187_G190_L0.5890.98
6_H10_L0.5860.98
157_F213_L0.5840.98
146_Y152_S0.5810.98
42_L132_L0.5800.98
150_W220_Y0.5800.98
58_L61_G0.5790.98
37_R40_R0.5760.98
31_P35_R0.5760.98
170_V178_Y0.5750.98
139_Y144_L0.5740.98
58_L62_G0.5740.98
103_G133_I0.5740.98
102_A106_Q0.5710.97
48_L52_A0.5700.97
94_E98_F0.5700.97
211_L215_L0.5680.97
117_G123_F0.5680.97
13_I16_L0.5670.97
76_I167_V0.5660.97
207_V211_L0.5660.97
11_A15_L0.5660.97
177_N183_E0.5650.97
102_A219_L0.5640.97
170_V176_T0.5640.97
70_P180_F0.5630.97
100_G104_A0.5620.97
200_P203_W0.5620.97
78_A129_S0.5610.97
167_V179_M0.5600.97
119_P123_F0.5600.97
84_A136_A0.5580.97
73_L160_L0.5580.97
93_F137_A0.5580.97
53_W122_R0.5560.97
207_V212_A0.5510.97
44_I51_I0.5450.97
11_A14_I0.5430.97
152_S155_R0.5420.97
35_R139_Y0.5370.96
68_S176_T0.5360.96
166_I170_V0.5360.96
77_A133_I0.5350.96
61_G64_S0.5350.96
20_L135_L0.5350.96
201_W205_I0.5340.96
214_V218_L0.5340.96
22_L30_K0.5320.96
53_W56_W0.5300.96
19_L22_L0.5290.96
89_N93_F0.5280.96
56_W120_H0.5270.96
156_V159_I0.5270.96
97_Y146_Y0.5260.96
74_C107_A0.5260.96
52_A57_L0.5200.96
8_I11_A0.5190.96
55_I58_L0.5180.96
18_V24_G0.5160.95
165_V168_G0.5150.95
77_A126_F0.5110.95
57_L121_F0.5110.95
4_P10_L0.5070.95
105_L187_G0.5050.95
184_K200_P0.5040.95
77_A100_G0.5040.95
44_I47_L0.5030.95
78_A125_Q0.5010.95
101_L137_A0.5010.95
75_D180_F0.5010.95
72_H112_D0.5000.95
97_Y153_L0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
5a2fA 1 0 3.3 0.947 Contact Map
2ks1B 1 0.1473 3 0.948 Contact Map
2l2tA 2 0.1518 2.8 0.949 Contact Map
2kv5A 1 0.1473 2.8 0.949 Contact Map
4oh3A 2 0.1875 2.4 0.951 Contact Map
3mk7C 2 0.317 2.1 0.952 Contact Map
2jwaA 2 0.1429 2 0.953 Contact Map
2rddB 1 0.1607 1.8 0.954 Contact Map
4u0qB 1 0 1.5 0.956 Contact Map
1fftA 1 0 1.4 0.957 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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