GREMLIN Database
ATPase_gene1 - Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter
PFAM: PF09527 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 54 (51)
Sequences: 45040 (25878)
Seq/√Len: 3623.6
META: 0.958

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_L24_W2.6221.00
24_W28_W2.5741.00
24_W27_R2.4171.00
20_L23_Y2.1801.00
10_E50_N2.0651.00
25_L35_F1.9951.00
19_A23_Y1.7781.00
19_A36_T1.6771.00
23_Y27_R1.6111.00
31_T35_F1.5541.00
34_W38_V1.5361.00
26_D31_T1.5331.00
48_F52_Y1.4221.00
29_L35_F1.3751.00
6_G10_E1.2631.00
45_A49_Y1.2051.00
5_S8_G1.1961.00
9_L13_A1.1771.00
18_G39_G1.1421.00
16_L20_L1.1251.00
25_L29_L1.0641.00
3_R6_G1.0451.00
49_Y53_R1.0311.00
5_S9_L1.0311.00
19_A40_L1.0261.00
14_A18_G1.0181.00
21_L39_G1.0111.00
25_L39_G1.0031.00
22_G26_D0.9981.00
43_G47_G0.9871.00
35_F39_G0.9681.00
14_A50_N0.9661.00
26_D35_F0.9581.00
42_L46_A0.8911.00
40_L44_V0.8901.00
14_A46_A0.8841.00
23_Y32_S0.8341.00
21_L24_W0.8321.00
6_G9_L0.8291.00
44_V48_F0.8091.00
26_D33_P0.8061.00
37_L41_L0.8011.00
32_S36_T0.7841.00
18_G43_G0.7561.00
38_V42_L0.7561.00
33_P37_L0.7491.00
48_F51_V0.7431.00
33_P36_T0.7421.00
50_N53_R0.7351.00
4_A10_E0.7301.00
7_L51_V0.7281.00
16_L23_Y0.7051.00
26_D36_T0.6931.00
21_L25_L0.6831.00
46_A50_N0.6771.00
41_L45_A0.6731.00
35_F38_V0.6661.00
47_G50_N0.6601.00
25_L28_W0.6591.00
10_E14_A0.6541.00
46_A49_Y0.6521.00
17_L20_L0.6311.00
11_L51_V0.6231.00
13_A17_L0.6121.00
12_V16_L0.6001.00
11_L47_G0.5971.00
37_L40_L0.5761.00
17_L21_L0.5721.00
33_P38_V0.5641.00
18_G47_G0.5451.00
23_Y36_T0.5381.00
14_A43_G0.5271.00
26_D32_S0.5151.00
14_A17_L0.5131.00
8_G15_I0.5121.00
15_I19_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tphA 2 1 11.8 0.786 Contact Map
4xnjA 1 1 9.3 0.797 Contact Map
4uvmA 1 1 8.4 0.801 Contact Map
4ikvA 1 0.9815 7.4 0.806 Contact Map
4m64A 1 1 6.1 0.812 Contact Map
4oh3A 2 1 5.6 0.816 Contact Map
2kv5A 1 0.5556 5.6 0.816 Contact Map
4q65A 1 1 4.8 0.821 Contact Map
4w6vA 1 1 4.6 0.824 Contact Map
2cfqA 1 0.9815 3.9 0.83 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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