GREMLIN Database
DUF2387 - Probable metal-binding protein (DUF2387)
PFAM: PF09526 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 75 (71)
Sequences: 740 (461)
Seq/√Len: 54.7
META: 0.764

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_E19_K3.8861.00
19_K35_A3.0931.00
16_E35_A2.3541.00
24_E29_D2.2431.00
28_V41_E2.2341.00
31_R40_D1.9811.00
31_R56_R1.9531.00
68_E72_V1.8070.99
30_Y41_E1.7600.99
65_A69_V1.7330.99
52_E58_N1.6730.99
22_M29_D1.6560.99
13_R17_M1.5740.98
24_E27_G1.5590.98
15_S37_G1.5230.98
9_A22_M1.4880.97
55_T58_N1.4730.97
53_L57_V1.4410.97
31_R55_T1.4120.96
29_D42_L1.3930.96
3_K21_V1.3880.96
64_E67_T1.3530.95
31_R38_F1.3250.95
52_E55_T1.3070.94
53_L56_R1.2780.94
52_E56_R1.2680.93
63_K66_E1.2670.93
66_E71_V1.2190.92
68_E73_Q1.1480.89
10_V13_R1.1340.89
10_V15_S1.1320.89
67_T70_Q1.1290.88
7_A56_R1.1030.87
25_D28_V1.1000.87
59_R62_E1.0760.86
37_G40_D1.0650.85
23_Y43_P1.0630.85
44_E48_S1.0540.85
21_V32_E1.0300.83
30_Y44_E1.0260.83
6_I38_F0.9900.81
70_Q73_Q0.9710.80
67_T73_Q0.9700.79
23_Y32_E0.9700.79
68_E71_V0.9650.79
60_S68_E0.9640.79
3_K22_M0.9370.77
20_I34_V0.8870.73
4_R20_I0.8800.72
64_E68_E0.8760.72
22_M40_D0.8240.67
67_T71_V0.8200.67
52_E57_V0.8200.67
22_M42_L0.7760.63
38_F50_P0.7570.61
11_C14_C0.7560.61
51_R54_E0.7450.60
60_S65_A0.7400.59
65_A68_E0.7270.58
20_I42_L0.7030.55
30_Y39_S0.6910.54
53_L58_N0.6900.54
41_E62_E0.6790.53
31_R42_L0.6690.52
22_M32_E0.6670.51
22_M44_E0.6650.51
2_K22_M0.6570.50
31_R53_L0.6510.50
60_S64_E0.6470.49
41_E44_E0.6400.48
29_D41_E0.6310.47
19_K32_E0.6280.47
26_D45_Q0.6250.47
23_Y30_Y0.6240.47
32_E52_E0.6240.47
2_K60_S0.6200.46
17_M21_V0.6140.46
19_K58_N0.6090.45
41_E45_Q0.6060.45
29_D43_P0.6050.45
7_A18_D0.5890.43
48_S51_R0.5870.43
5_F8_G0.5840.42
3_K23_Y0.5840.42
61_A68_E0.5820.42
15_S27_G0.5750.42
45_Q50_P0.5700.41
24_E45_Q0.5690.41
63_K67_T0.5660.41
45_Q48_S0.5630.40
7_A55_T0.5620.40
62_E65_A0.5580.40
64_E71_V0.5570.40
33_C36_C0.5570.40
59_R69_V0.5520.39
40_D56_R0.5510.39
59_R64_E0.5490.39
69_V73_Q0.5400.38
10_V17_M0.5390.38
13_R42_L0.5370.38
29_D44_E0.5330.37
69_V72_V0.5270.37
18_D34_V0.5210.36
6_I30_Y0.5160.36
44_E49_A0.5140.35
9_A13_R0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1neeA 1 0.5867 71.2 0.844 Contact Map
3cw2K 1 0.5867 68.7 0.847 Contact Map
3j81l 1 0 67.5 0.848 Contact Map
3po3S 1 0.5733 66.7 0.849 Contact Map
2k4xA 1 0.5333 65.2 0.85 Contact Map
1pqvS 1 0.5733 63.7 0.852 Contact Map
1nuiA 1 0.8133 62.6 0.853 Contact Map
2e9hA 1 0.8133 60.2 0.855 Contact Map
2g2kA 1 0.7733 57.6 0.858 Contact Map
2d74B 1 0.5733 56.9 0.858 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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