GREMLIN Database
Phg_2220_C - Conserved phage C-terminus (Phg_2220_C)
PFAM: PF09524 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 74 (73)
Sequences: 3639 (3206)
Seq/√Len: 375.3
META: 0.883

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
4_Y42_D3.0551.00
39_K43_K2.5731.00
44_K47_E2.4051.00
27_R30_E2.4031.00
61_E71_S2.3751.00
41_I64_F2.3721.00
59_R71_S2.0901.00
47_E56_K2.0731.00
28_L33_T1.9321.00
8_K42_D1.8701.00
9_T45_V1.8571.00
50_N55_E1.8361.00
34_L38_K1.8021.00
45_V49_L1.7231.00
68_K71_S1.7091.00
8_K45_V1.5821.00
61_E68_K1.5231.00
18_K22_K1.4651.00
4_Y38_K1.4381.00
45_V58_L1.4261.00
19_K22_K1.4231.00
1_I28_L1.4141.00
4_Y8_K1.3151.00
33_T36_D1.2841.00
4_Y64_F1.2101.00
51_D55_E1.2091.00
9_T58_L1.1391.00
19_K61_E1.1181.00
13_Y60_P1.1171.00
48_W54_M1.1151.00
54_M57_Y1.1131.00
37_F69_F1.0911.00
4_Y41_I1.0871.00
35_E39_K1.0751.00
14_R32_F1.0391.00
52_T55_E1.0341.00
25_K29_K1.0201.00
3_D7_E1.0051.00
36_D39_K1.0001.00
59_R62_T0.9301.00
3_D16_T0.9241.00
17_T20_T0.9231.00
40_V69_F0.9161.00
38_K42_D0.9121.00
45_V50_N0.9111.00
35_E38_K0.9071.00
28_L34_L0.9041.00
44_K63_L0.8781.00
43_K74_N0.8691.00
3_D15_P0.8611.00
11_K55_E0.8551.00
19_K23_L0.8531.00
43_K47_E0.8471.00
18_K25_K0.8331.00
70_E74_N0.8171.00
14_R17_T0.8081.00
5_L13_Y0.7881.00
21_L25_K0.7871.00
51_D54_M0.7861.00
34_L37_F0.7781.00
10_G49_L0.7721.00
53_K56_K0.7681.00
40_V44_K0.7601.00
16_T21_L0.7571.00
2_I20_T0.7571.00
1_I37_F0.7491.00
22_K66_G0.7401.00
5_L60_P0.7381.00
24_I37_F0.7361.00
18_K21_L0.7351.00
32_F70_E0.7341.00
20_T70_E0.7321.00
37_F41_I0.7091.00
40_V73_L0.6870.99
23_L67_T0.6850.99
61_E67_T0.6830.99
5_L63_L0.6820.99
49_L55_E0.6540.99
5_L58_L0.6320.99
15_P21_L0.6290.99
55_E58_L0.6280.99
5_L9_T0.6060.98
23_L61_E0.6050.98
32_F36_D0.5980.98
42_D46_A0.5950.98
25_K28_L0.5890.98
5_L8_K0.5850.98
36_D73_L0.5800.98
6_N11_K0.5600.97
33_T37_F0.5550.97
18_K66_G0.5360.97
27_R37_F0.5350.97
5_L45_V0.5350.97
30_E70_E0.5320.97
26_A66_G0.5310.96
36_D40_V0.5280.96
32_F69_F0.5220.96
19_K30_E0.5190.96
24_I64_F0.5190.96
40_V63_L0.5180.96
12_N16_T0.5170.96
60_P63_L0.5160.96
11_K43_K0.5150.96
48_W51_D0.5140.96
48_W53_K0.5080.96
2_I15_P0.5060.95
57_Y62_T0.5050.95
49_L52_T0.5020.95
20_T24_I0.5010.95
48_W62_T0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dfgA 1 0.5811 12.4 0.877 Contact Map
3c1dA 2 0.5541 9.7 0.882 Contact Map
3h0gD 1 0.8919 8.8 0.884 Contact Map
1wthD 3 0.8108 5.9 0.893 Contact Map
3mqzA 1 0.6081 5.7 0.894 Contact Map
2ragA 2 0.7838 5.3 0.896 Contact Map
4nomA 2 0.6081 5.2 0.896 Contact Map
4jdfA 1 0.9459 4.7 0.898 Contact Map
2i2oA 2 0.7973 4.6 0.899 Contact Map
3ttnA 1 0.9459 4.6 0.899 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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