GREMLIN Database
DUF2390 - Protein of unknown function (DUF2390)
PFAM: PF09523 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 106 (105)
Sequences: 3855 (2830)
Seq/√Len: 276.2
META: 0.836

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
29_D62_R3.6971.00
24_D74_R3.3241.00
89_E92_K3.2951.00
6_S103_Q3.0901.00
31_N103_Q2.8391.00
21_A25_R2.5631.00
72_L75_A2.2991.00
90_R97_E2.2381.00
64_E75_A2.1371.00
2_F103_Q2.1341.00
55_D62_R2.0861.00
47_D50_D2.0051.00
35_F54_L1.9531.00
8_A12_R1.7861.00
88_R92_K1.7551.00
88_R91_V1.7491.00
62_R67_R1.7081.00
2_F6_S1.7011.00
90_R93_A1.6771.00
90_R94_L1.6701.00
63_E67_R1.6391.00
62_R102_E1.6011.00
36_A51_L1.5941.00
100_R104_E1.5281.00
87_L94_L1.5261.00
77_K88_R1.5221.00
59_A63_E1.5121.00
5_F9_L1.5001.00
32_L54_L1.4621.00
3_W100_R1.3971.00
69_L98_A1.3741.00
69_L91_V1.3731.00
97_E100_R1.3711.00
6_S31_N1.3701.00
76_L88_R1.2911.00
39_L44_R1.2651.00
2_F35_F1.2181.00
15_V19_C1.2171.00
76_L91_V1.1861.00
66_V102_E1.1811.00
61_W65_V1.1661.00
60_P64_E1.1551.00
58_V102_E1.1221.00
2_F31_N1.0841.00
92_K96_L1.0841.00
66_V98_A1.0611.00
31_N35_F1.0461.00
91_V94_L1.0301.00
85_E89_E1.0241.00
28_V33_L1.0201.00
52_A56_A1.0131.00
79_G82_P1.0021.00
69_L88_R0.9991.00
55_D59_A0.9911.00
36_A40_A0.9731.00
18_A22_L0.9641.00
93_A97_E0.9631.00
55_D58_V0.9421.00
32_L55_D0.9271.00
29_D102_E0.9141.00
29_D32_L0.9121.00
5_F37_L0.8981.00
29_D58_V0.8941.00
75_A79_G0.8921.00
70_R73_R0.8901.00
39_L42_R0.8731.00
9_L37_L0.8711.00
102_E105_R0.8681.00
35_F38_W0.8651.00
31_N66_V0.8381.00
101_L105_R0.8271.00
39_L46_L0.8250.99
89_E93_A0.8190.99
53_A56_A0.8080.99
76_L87_L0.8080.99
10_Y20_L0.8070.99
52_A55_D0.7900.99
31_N102_E0.7880.99
86_A90_R0.7850.99
16_A92_K0.7590.99
48_A52_A0.7540.99
61_W102_E0.7370.99
62_R66_V0.7340.99
2_F38_W0.7200.99
101_L104_E0.7200.99
10_Y70_R0.7020.98
16_A20_L0.7010.98
60_P63_E0.6940.98
82_P89_E0.6940.98
87_L101_L0.6920.98
6_S34_L0.6890.98
48_A82_P0.6880.98
49_A71_A0.6870.98
61_W98_A0.6730.98
87_L90_R0.6670.98
35_F46_L0.6660.98
85_E92_K0.6640.98
19_C30_V0.6620.98
14_G17_E0.6570.97
50_D54_L0.6570.97
65_V98_A0.6510.97
39_L43_G0.6410.97
56_A59_A0.6390.97
64_E79_G0.6360.97
67_R71_A0.6340.97
35_F39_L0.6300.97
65_V75_A0.6300.97
10_Y30_V0.6300.97
18_A21_A0.6270.97
72_L76_L0.6230.97
102_E106_L0.6220.97
19_C22_L0.6220.97
23_Q73_R0.6220.97
72_L87_L0.6210.96
98_A101_L0.6200.96
37_L40_A0.6200.96
7_L11_A0.6090.96
33_L37_L0.6060.96
65_V72_L0.6030.96
74_R77_K0.5980.96
71_A75_A0.5950.96
6_S20_L0.5950.96
92_K98_A0.5940.95
50_D53_A0.5920.95
15_V18_A0.5910.95
51_L55_D0.5850.95
95_E99_E0.5790.95
94_L97_E0.5770.95
98_A102_E0.5700.94
97_E101_L0.5690.94
23_Q95_E0.5650.94
61_W101_L0.5640.94
19_C33_L0.5640.94
36_A46_L0.5600.94
27_G52_A0.5480.93
66_V69_L0.5440.93
61_W85_E0.5420.93
36_A54_L0.5380.92
94_L98_A0.5340.92
51_L54_L0.5320.92
87_L98_A0.5260.92
38_W41_A0.5240.91
9_L18_A0.5240.91
54_L106_L0.5200.91
72_L79_G0.5170.91
4_R8_A0.5130.91
79_G85_E0.5110.90
74_R92_K0.5100.90
96_L103_Q0.5080.90
81_A85_E0.5080.90
5_F35_F0.5080.90
40_A43_G0.5070.90
26_H42_R0.5060.90
34_L70_R0.5060.90
80_P83_D0.5040.90
17_E21_A0.5010.90
41_A44_R0.5010.90
58_V62_R0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2wt7B 1 0.5943 5.6 0.924 Contact Map
2zc2A 1 0.6698 5.3 0.925 Contact Map
3a5tA 2 0.6226 4.9 0.926 Contact Map
3fd9A 3 0.3679 3.6 0.931 Contact Map
2qkwB 1 0.6226 3.5 0.931 Contact Map
3zuzA 1 0.8868 3.4 0.932 Contact Map
4po6A 1 0.8208 3.1 0.933 Contact Map
4kruA 1 0.3208 2.8 0.935 Contact Map
3q4uA 4 0.5566 2.4 0.937 Contact Map
4mwiA 1 0.5566 2 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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