GREMLIN Database
Hypoth_Ymh - Protein of unknown function (Hypoth_ymh)
PFAM: PF09509 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 120 (117)
Sequences: 6214 (4713)
Seq/√Len: 435.7
META: 0.927

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_R82_A3.7101.00
22_H26_E3.1141.00
25_F29_K2.5901.00
35_V49_M2.3851.00
32_E85_F2.1531.00
75_E79_N2.0761.00
108_E118_R2.0641.00
14_L22_H1.8901.00
89_R93_A1.8861.00
50_R79_N1.7691.00
79_N82_A1.7671.00
25_F93_A1.7621.00
34_R38_K1.7361.00
12_R16_L1.7311.00
6_E9_K1.7281.00
68_E72_S1.6991.00
46_A50_R1.6601.00
76_G86_G1.6511.00
28_F84_A1.6071.00
50_R78_M1.5831.00
49_M85_F1.5591.00
31_V113_A1.5351.00
75_E78_M1.5181.00
28_F113_A1.5021.00
33_D37_E1.4821.00
78_M82_A1.4801.00
32_E44_D1.4771.00
46_A86_G1.4651.00
34_R117_L1.4651.00
47_D50_R1.4641.00
63_N70_E1.4491.00
6_E34_R1.4401.00
55_P75_E1.4381.00
41_L51_K1.4321.00
13_A17_D1.4241.00
77_F87_A1.4201.00
31_V81_F1.4081.00
47_D51_K1.3801.00
81_F116_L1.3731.00
14_L19_H1.3611.00
46_A75_E1.3521.00
109_I115_L1.3381.00
33_D36_R1.3181.00
21_D29_K1.2851.00
84_A112_L1.2771.00
41_L52_A1.2651.00
8_L12_R1.2281.00
39_S52_A1.2211.00
43_D51_K1.2161.00
55_P78_M1.2021.00
14_L26_E1.1931.00
34_R37_E1.1901.00
75_E86_G1.1791.00
55_P71_K1.1261.00
6_E30_A1.1201.00
102_D105_E1.1111.00
84_A113_A1.1081.00
67_T70_E1.0691.00
71_K75_E1.0661.00
54_S74_Q1.0531.00
35_V52_A1.0511.00
33_D96_P1.0331.00
54_S78_M1.0291.00
7_I117_L1.0291.00
54_S57_N1.0271.00
19_H22_H1.0021.00
30_A34_R1.0001.00
108_E111_S0.9791.00
33_D95_R0.9751.00
85_F89_R0.9681.00
32_E36_R0.9651.00
30_A96_P0.9651.00
51_K54_S0.9621.00
7_I11_C0.9621.00
80_L112_L0.9521.00
56_K71_K0.9481.00
4_H114_S0.9361.00
8_L11_C0.9331.00
90_N94_H0.9201.00
24_V106_A0.9051.00
88_I115_L0.9041.00
63_N66_T0.8901.00
79_N86_G0.8861.00
64_D70_E0.8831.00
49_M81_F0.8721.00
46_A82_A0.8711.00
61_A65_L0.8601.00
88_I109_I0.8521.00
108_E114_S0.8451.00
26_E29_K0.8431.00
35_V53_F0.8361.00
38_K60_L0.8351.00
105_E108_E0.8341.00
27_A113_A0.8261.00
32_E45_G0.7991.00
13_A19_H0.7921.00
45_G48_L0.7921.00
14_L17_D0.7801.00
67_T74_Q0.7611.00
107_L111_S0.7511.00
68_E71_K0.7511.00
51_K59_L0.7511.00
50_R75_E0.7471.00
30_A117_L0.7381.00
28_F109_I0.7261.00
115_L119_R0.7241.00
62_L77_F0.7171.00
9_K12_R0.7171.00
89_R94_H0.7151.00
66_T70_E0.7111.00
24_V109_I0.7101.00
25_F92_T0.7071.00
112_L116_L0.7061.00
56_K75_E0.7021.00
10_A19_H0.6961.00
111_S114_S0.6931.00
4_H7_I0.6931.00
29_K96_P0.6921.00
81_F84_A0.6881.00
92_T101_I0.6871.00
108_E115_L0.6861.00
75_E82_A0.6801.00
3_L8_L0.6761.00
63_N73_E0.6741.00
13_A16_L0.6661.00
101_I109_I0.6390.99
43_D47_D0.6370.99
11_C30_A0.6310.99
77_F119_R0.6280.99
29_K93_A0.6120.99
67_T71_K0.6110.99
29_K33_D0.6090.99
10_A26_E0.6070.99
22_H25_F0.6070.99
92_T99_D0.5980.99
10_A30_A0.5960.99
20_Y103_P0.5950.99
51_K57_N0.5930.99
62_L65_L0.5860.99
45_G90_N0.5840.99
111_S115_L0.5800.99
104_E118_R0.5790.99
31_V117_L0.5770.99
103_P107_L0.5770.99
88_I119_R0.5760.99
15_F20_Y0.5680.99
46_A79_N0.5660.99
6_E37_E0.5660.99
105_E109_I0.5570.98
36_R44_D0.5570.98
6_E10_A0.5560.98
27_A110_L0.5530.98
23_A110_L0.5520.98
12_R15_F0.5500.98
101_I106_A0.5480.98
21_D92_T0.5470.98
51_K56_K0.5460.98
39_S59_L0.5390.98
69_S87_A0.5360.98
98_I101_I0.5320.98
110_L114_S0.5290.98
21_D25_F0.5270.98
53_F78_M0.5260.98
28_F85_F0.5250.98
69_S91_P0.5210.98
21_D26_E0.5210.98
35_V39_S0.5200.97
72_S86_G0.5170.97
41_L48_L0.5150.97
105_E118_R0.5140.97
92_T109_I0.5100.97
4_H34_R0.5100.97
108_E112_L0.5070.97
112_L115_L0.5050.97
61_A64_D0.5010.97
3_L110_L0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wolA 1 0.875 54.1 0.873 Contact Map
2hsbA 2 0.8917 32.5 0.889 Contact Map
1o3uA 2 0.85 32.2 0.889 Contact Map
3pvhA 1 0.3667 28.2 0.892 Contact Map
4i8oA 2 0.9583 26.1 0.894 Contact Map
4oa3A 1 0.4583 25.3 0.895 Contact Map
1ufbA 3 0.9167 17.8 0.902 Contact Map
4uxvA 1 0.375 17 0.902 Contact Map
3o10A 2 0.9083 15.2 0.905 Contact Map
2kw7A 1 0.3833 14.5 0.905 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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