GREMLIN Database
DUF2389 - Tryptophan-rich protein (DUF2389)
PFAM: PF09493 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 60 (58)
Sequences: 2692 (1603)
Seq/√Len: 210.5
META: 0.847

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_R42_F2.9301.00
29_W43_R2.9181.00
31_E41_S2.7781.00
12_E39_R2.3031.00
31_E43_R2.2701.00
12_E37_S2.1441.00
51_D54_K2.1091.00
18_T41_S2.0411.00
11_K36_L2.0031.00
48_E54_K1.9611.00
19_E31_E1.8661.00
34_A37_S1.6821.00
33_E38_K1.6721.00
16_L33_E1.6431.00
32_L42_F1.5831.00
45_D48_E1.4461.00
9_I12_E1.4381.00
22_D26_K1.4131.00
29_W45_D1.4101.00
33_E41_S1.4021.00
6_V56_L1.3671.00
21_E25_G1.2551.00
22_D25_G1.2091.00
20_V27_V1.2051.00
20_V29_W1.1631.00
5_A8_P1.1551.00
12_E36_L1.0701.00
18_T31_E1.0281.00
9_I42_F1.0161.00
7_K54_K0.9931.00
19_E41_S0.9711.00
52_S57_Q0.9621.00
23_E28_V0.9511.00
32_L44_I0.9450.99
12_E42_F0.9430.99
17_V30_V0.8760.99
23_E44_I0.8650.99
37_S57_Q0.8100.98
28_V57_Q0.7840.98
26_K42_F0.7680.98
5_A9_I0.7600.98
30_V45_D0.7430.97
33_E37_S0.7340.97
1_S17_V0.7100.96
30_V49_L0.6980.96
24_E57_Q0.6670.95
36_L42_F0.6580.94
24_E28_V0.6460.94
44_I51_D0.6400.94
18_T33_E0.6390.94
1_S10_N0.6350.93
55_W58_G0.6340.93
4_T55_W0.6340.93
19_E33_E0.6200.93
26_K53_S0.6190.92
14_H17_V0.6140.92
55_W59_W0.6140.92
21_E29_W0.6120.92
45_D50_K0.6090.92
11_K46_W0.6060.92
13_K37_S0.6040.92
5_A37_S0.6020.91
50_K56_L0.5920.91
2_K5_A0.5830.90
48_E51_D0.5780.90
20_V25_G0.5630.88
47_R54_K0.5600.88
26_K30_V0.5580.88
8_P33_E0.5520.88
9_I54_K0.5480.87
25_G29_W0.5430.87
26_K45_D0.5330.86
8_P13_K0.5310.85
38_K48_E0.5260.85
17_V32_L0.5250.85
52_S56_L0.5240.85
2_K59_W0.5230.85
20_V43_R0.5200.84
30_V44_I0.5200.84
13_K56_L0.5180.84
47_R50_K0.5170.84
39_R49_L0.5130.83
8_P12_E0.5120.83
23_E30_V0.5100.83
17_V33_E0.5070.83
18_T39_R0.5000.82
38_K52_S0.5000.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2x5rA 2 0.7333 6.8 0.876 Contact Map
2lt3A 1 0.6 3.8 0.89 Contact Map
3v22V 1 0.6667 2.2 0.902 Contact Map
2jrmA 1 0.7 2.2 0.903 Contact Map
1eexG 1 0.9667 1.7 0.909 Contact Map
3bqoB 1 0 1.7 0.909 Contact Map
4cvuA 2 0.9667 1.6 0.91 Contact Map
4ipuA 1 0.8167 1.5 0.912 Contact Map
3znvA 1 0.9333 1.3 0.914 Contact Map
1iwpG 1 0.9833 1.3 0.914 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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