CbtA - PFAM28P - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

CbtA - Probable cobalt transporter subunit (CbtA)

PFAM:	PF09490	Sequences: FRRLLLRGLLAGLLAGLLAFLFQRVFVEPLIDRAIAYEEAAAAAAGAAAAAAHEHAEAWEPELVSRGVQRTAGLLLANVLYGVAFGLLFALVFALAGGRLGGLSPRRTGLLLALAGFVAVYLVPFLKYPPNPPGVGAADTIGARQAWYLATVAASAAGLALAVFLRRRLAARGWNATLAAAAAYLVVVGVALLLLPHVIGAPDPESHESGFPADLLWQFRVASLGTQAVFWAVLGLLFGALAQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	243 (239)
Sequences:	3647 (2509)
Seq/√Len:	162.3
META:	0.743

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
20_F	75_L	3.459	1.00
69_Q	73_G	3.385	1.00
18_L	233_V	3.257	1.00
113_A	235_G	3.088	1.00
20_F	78_N	3.012	1.00
32_D	70_R	2.971	1.00
233_V	237_L	2.893	1.00
82_G	230_F	2.888	1.00
117_F	122_L	2.783	1.00
178_L	182_A	2.577	1.00
123_V	155_S	2.473	1.00
158_G	187_V	2.463	1.00
155_S	184_Y	2.344	1.00
33_R	36_A	2.330	1.00
119_A	159_L	2.303	1.00
22_F	229_V	2.292	1.00
121_Y	227_Q	2.289	1.00
119_A	156_A	2.276	1.00
139_D	142_G	2.250	1.00
115_A	159_L	2.204	1.00
165_L	183_A	2.181	1.00
135_V	211_F	2.165	1.00
158_G	189_G	2.152	1.00
131_N	137_A	2.090	1.00
154_A	191_A	2.042	1.00
2_R	6_L	2.034	1.00
121_Y	224_L	1.997	1.00
117_F	228_A	1.969	1.00
237_L	241_L	1.957	1.00
90_A	238_F	1.852	1.00
125_F	130_P	1.842	1.00
68_V	72_A	1.801	1.00
150_A	199_I	1.739	1.00
213_A	216_L	1.733	1.00
5_L	8_G	1.731	1.00
21_L	25_V	1.708	1.00
32_D	36_A	1.670	1.00
11_A	237_L	1.666	1.00
93_F	238_F	1.636	1.00
187_V	191_A	1.622	1.00
59_W	67_G	1.592	1.00
30_L	218_Q	1.584	1.00
88_L	92_V	1.581	1.00
214_D	218_Q	1.557	1.00
24_R	28_E	1.541	1.00
89_F	109_G	1.539	1.00
23_Q	78_N	1.533	1.00
111_L	115_A	1.465	1.00
216_L	220_R	1.463	1.00
8_G	86_G	1.433	1.00
12_G	83_V	1.432	1.00
125_F	224_L	1.426	1.00
22_F	26_F	1.423	1.00
14_L	237_L	1.420	1.00
20_F	24_R	1.415	1.00
90_A	93_F	1.403	1.00
157_A	160_A	1.381	1.00
161_L	165_L	1.381	1.00
116_G	234_L	1.379	1.00
184_Y	188_V	1.371	1.00
85_F	116_G	1.371	1.00
39_E	42_A	1.370	1.00
136_G	139_D	1.363	1.00
44_A	47_A	1.357	1.00
146_A	150_A	1.352	1.00
110_L	232_A	1.334	1.00
116_G	120_V	1.333	1.00
122_L	224_L	1.322	1.00
42_A	45_A	1.320	1.00
30_L	132_P	1.319	1.00
151_T	195_L	1.314	1.00
13_L	79_V	1.301	1.00
11_A	241_L	1.298	1.00
33_R	37_Y	1.277	1.00
16_G	79_V	1.276	1.00
180_A	183_A	1.276	1.00
81_Y	85_F	1.268	1.00
230_F	234_L	1.252	1.00
147_W	198_V	1.245	1.00
66_R	69_Q	1.244	1.00
22_F	225_G	1.239	1.00
210_G	214_D	1.232	1.00
115_A	119_A	1.219	1.00
114_L	118_V	1.211	1.00
19_A	226_T	1.201	1.00
43_A	46_G	1.188	1.00
136_G	208_E	1.180	1.00
199_I	214_D	1.177	1.00
104_S	107_R	1.174	1.00
30_L	33_R	1.171	1.00
150_A	195_L	1.169	1.00
154_A	187_V	1.165	1.00
68_V	71_T	1.162	1.00
115_A	160_A	1.156	1.00
132_P	135_V	1.147	1.00
173_G	176_A	1.147	1.00
110_L	114_L	1.142	1.00
154_A	158_G	1.137	1.00
225_G	229_V	1.128	1.00
105_P	108_T	1.126	1.00
28_E	32_D	1.125	1.00
188_V	192_L	1.124	1.00
158_G	193_L	1.117	1.00
183_A	187_V	1.096	1.00
39_E	60_E	1.090	1.00
189_G	193_L	1.090	1.00
121_Y	125_F	1.082	0.99
151_T	192_L	1.079	0.99
209_S	212_P	1.072	0.99
149_L	153_A	1.066	0.99
66_R	73_G	1.062	0.99
211_F	216_L	1.051	0.99
31_I	134_G	1.044	0.99
179_A	183_A	1.032	0.99
117_F	224_L	1.027	0.99
46_G	49_A	1.024	0.99
178_L	181_A	1.019	0.99
236_L	240_A	1.018	0.99
14_L	241_L	1.017	0.99
37_Y	41_A	1.007	0.99
5_L	87_L	1.006	0.99
22_F	226_T	1.004	0.99
209_S	213_A	1.000	0.99
11_A	242_A	0.995	0.99
34_A	38_E	0.982	0.99
164_F	168_R	0.979	0.99
116_G	231_W	0.978	0.99
135_V	217_W	0.978	0.99
59_W	69_Q	0.963	0.99
30_L	215_L	0.959	0.99
118_V	122_L	0.959	0.99
15_A	234_L	0.957	0.99
166_R	177_T	0.957	0.99
118_V	123_V	0.951	0.99
186_V	189_G	0.949	0.99
92_V	156_A	0.936	0.99
150_A	154_A	0.934	0.98
185_L	188_V	0.929	0.98
143_A	147_W	0.927	0.98
3_R	7_R	0.927	0.98
213_A	217_W	0.923	0.98
9_L	87_L	0.917	0.98
47_A	50_A	0.917	0.98
23_Q	27_V	0.916	0.98
155_S	193_L	0.912	0.98
45_A	48_A	0.907	0.98
59_W	73_G	0.902	0.98
65_S	68_V	0.902	0.98
185_L	189_G	0.899	0.98
103_L	111_L	0.898	0.98
175_N	179_A	0.890	0.98
48_A	51_A	0.890	0.98
19_A	227_Q	0.887	0.98
16_G	78_N	0.885	0.98
148_Y	152_V	0.883	0.98
57_E	60_E	0.881	0.98
32_D	35_I	0.875	0.98
15_A	233_V	0.871	0.98
117_F	227_Q	0.870	0.98
84_A	88_L	0.867	0.98
174_W	177_T	0.865	0.98
103_L	107_R	0.865	0.98
118_V	184_Y	0.861	0.97
26_F	222_A	0.859	0.97
154_A	195_L	0.856	0.97
211_F	215_L	0.855	0.97
127_K	147_W	0.841	0.97
160_A	164_F	0.834	0.97
142_G	146_A	0.832	0.97
123_V	184_Y	0.830	0.97
171_A	176_A	0.830	0.97
28_E	66_R	0.829	0.97
139_D	143_A	0.829	0.97
176_A	180_A	0.823	0.97
93_F	109_G	0.822	0.97
59_W	66_R	0.822	0.97
179_A	182_A	0.820	0.97
166_R	186_V	0.820	0.97
209_S	214_D	0.818	0.97
30_L	222_A	0.814	0.96
159_L	181_A	0.812	0.96
26_F	225_G	0.812	0.96
136_G	209_S	0.811	0.96
149_L	152_V	0.807	0.96
84_A	127_K	0.802	0.96
109_G	235_G	0.801	0.96
19_A	230_F	0.800	0.96
106_R	236_L	0.799	0.96
9_L	83_V	0.798	0.96
222_A	226_T	0.794	0.96
27_V	222_A	0.793	0.96
27_V	226_T	0.793	0.96
105_P	239_G	0.790	0.96
10_L	241_L	0.787	0.96
9_L	80_L	0.782	0.96
89_F	112_L	0.781	0.95
33_R	215_L	0.780	0.95
59_W	62_E	0.780	0.95
109_G	113_A	0.773	0.95
86_G	234_L	0.767	0.95
198_V	203_D	0.764	0.95
203_D	210_G	0.760	0.95
5_L	9_L	0.760	0.95
115_A	181_A	0.756	0.95
72_A	76_L	0.754	0.95
85_F	230_F	0.745	0.94
16_G	130_P	0.744	0.94
209_S	216_L	0.743	0.94
24_R	71_T	0.743	0.94
21_L	24_R	0.741	0.94
98_G	101_G	0.740	0.94
175_N	178_L	0.739	0.94
118_V	159_L	0.738	0.94
4_L	238_F	0.736	0.94
199_I	203_D	0.732	0.94
217_W	220_R	0.730	0.94
21_L	27_V	0.728	0.93
237_L	240_A	0.726	0.93
13_L	83_V	0.722	0.93
116_G	177_T	0.722	0.93
20_F	77_A	0.722	0.93
228_A	232_A	0.716	0.93
159_L	184_Y	0.715	0.93
19_A	23_Q	0.713	0.93
85_F	120_V	0.711	0.93
151_T	155_S	0.701	0.92
15_A	29_P	0.699	0.92
67_G	70_R	0.696	0.92
171_A	179_A	0.695	0.92
147_W	197_H	0.691	0.92
190_V	193_L	0.690	0.92
100_L	108_T	0.686	0.91
168_R	172_R	0.685	0.91
4_L	10_L	0.685	0.91
60_E	66_R	0.683	0.91
106_R	239_G	0.682	0.91
12_G	16_G	0.676	0.91
232_A	235_G	0.673	0.91
43_A	47_A	0.672	0.90
23_Q	226_T	0.672	0.90
31_I	35_I	0.662	0.90
35_I	38_E	0.660	0.90
41_A	210_G	0.660	0.90
225_G	228_A	0.660	0.90
93_F	98_G	0.657	0.89
18_L	237_L	0.657	0.89
173_G	179_A	0.655	0.89
6_L	83_V	0.654	0.89
120_V	125_F	0.653	0.89
172_R	177_T	0.651	0.89
165_L	169_L	0.649	0.89
34_A	136_G	0.644	0.88
217_W	221_V	0.644	0.88
24_R	75_L	0.642	0.88
188_V	191_A	0.642	0.88
12_G	82_G	0.639	0.88
161_L	164_F	0.638	0.88
38_E	133_P	0.637	0.88
90_A	94_A	0.635	0.88
117_F	121_Y	0.633	0.88
93_F	112_L	0.633	0.88
123_V	188_V	0.632	0.88
4_L	94_A	0.632	0.88
67_G	71_T	0.628	0.87
158_G	191_A	0.627	0.87
97_G	105_P	0.625	0.87
16_G	85_F	0.623	0.87
156_A	160_A	0.620	0.87
90_A	96_A	0.619	0.86
215_L	218_Q	0.619	0.86
128_Y	147_W	0.618	0.86
205_E	209_S	0.615	0.86
26_F	30_L	0.613	0.86
216_L	227_Q	0.612	0.86
19_A	82_G	0.610	0.86
175_N	239_G	0.610	0.86
176_A	181_A	0.609	0.86
133_P	219_F	0.609	0.86
151_T	188_V	0.608	0.85
38_E	219_F	0.601	0.85
44_A	48_A	0.601	0.85
151_T	154_A	0.601	0.85
159_L	193_L	0.598	0.85
37_Y	212_P	0.596	0.84
11_A	15_A	0.596	0.84
5_L	168_R	0.593	0.84
129_P	203_D	0.591	0.84
127_K	132_P	0.591	0.84
223_S	227_Q	0.590	0.84
36_A	39_E	0.589	0.84
42_A	46_G	0.587	0.83
218_Q	222_A	0.586	0.83
170_A	183_A	0.585	0.83
107_R	110_L	0.584	0.83
56_A	59_W	0.584	0.83
171_A	175_N	0.582	0.83
28_E	74_L	0.581	0.83
80_L	150_A	0.580	0.83
73_G	76_L	0.576	0.82
205_E	208_E	0.576	0.82
134_G	163_V	0.576	0.82
19_A	81_Y	0.574	0.82
189_G	192_L	0.573	0.82
7_R	10_L	0.568	0.81
22_F	222_A	0.568	0.81
131_N	135_V	0.567	0.81
26_F	189_G	0.567	0.81
168_R	186_V	0.566	0.81
138_A	141_I	0.566	0.81
112_L	115_A	0.565	0.81
135_V	216_L	0.564	0.81
2_R	5_L	0.563	0.81
41_A	45_A	0.563	0.81
67_G	180_A	0.559	0.80
223_S	226_T	0.559	0.80
127_K	151_T	0.559	0.80
99_R	136_G	0.559	0.80
112_L	156_A	0.556	0.80
109_G	191_A	0.551	0.79
101_G	112_L	0.548	0.79
18_L	21_L	0.547	0.79
34_A	135_V	0.546	0.79
158_G	188_V	0.544	0.79
42_A	55_H	0.541	0.78
22_F	82_G	0.540	0.78
24_R	70_R	0.539	0.78
7_R	241_L	0.536	0.78
145_Q	148_Y	0.535	0.77
97_G	101_G	0.534	0.77
131_N	138_A	0.534	0.77
182_A	189_G	0.534	0.77
123_V	151_T	0.533	0.77
28_E	141_I	0.532	0.77
109_G	112_L	0.532	0.77
172_R	180_A	0.531	0.77
120_V	156_A	0.529	0.77
106_R	220_R	0.528	0.77
113_A	159_L	0.528	0.77
53_H	59_W	0.525	0.76
123_V	192_L	0.521	0.76
64_V	74_L	0.520	0.75
171_A	183_A	0.518	0.75
89_F	234_L	0.517	0.75
32_D	132_P	0.515	0.75
135_V	210_G	0.514	0.75
132_P	216_L	0.514	0.75
191_A	199_I	0.513	0.75
153_A	157_A	0.511	0.74
67_G	179_A	0.508	0.74
170_A	175_N	0.508	0.74
45_A	50_A	0.507	0.74
134_G	201_A	0.505	0.73
86_G	90_A	0.505	0.73
190_V	194_L	0.503	0.73
217_W	224_L	0.502	0.73
6_L	9_L	0.502	0.73
161_L	188_V	0.500	0.73
15_A	19_A	0.500	0.73

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2gfpA	2	0.856	8.2	0.961	Contact Map
3llqA	3	0.716	7.5	0.962	Contact Map
4humA	1	0.5926	7.5	0.962	Contact Map
2xq2A	2	0.1646	7.2	0.962	Contact Map
4c7rA	3	0.6091	7	0.962	Contact Map
3rmtA	4	0.1975	6.5	0.963	Contact Map
2llmA	1	0.177	6.5	0.963	Contact Map
1v54L	1	0.1893	6.1	0.964	Contact Map
3mktA	1	0.5885	5.8	0.964	Contact Map
4tkrA	2	0.4815	5.6	0.964	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0079 seconds.