GREMLIN Database
CbtA - Probable cobalt transporter subunit (CbtA)
PFAM: PF09490 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 243 (239)
Sequences: 3647 (2509)
Seq/√Len: 162.3
META: 0.743

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_F75_L3.4591.00
69_Q73_G3.3851.00
18_L233_V3.2571.00
113_A235_G3.0881.00
20_F78_N3.0121.00
32_D70_R2.9711.00
233_V237_L2.8931.00
82_G230_F2.8881.00
117_F122_L2.7831.00
178_L182_A2.5771.00
123_V155_S2.4731.00
158_G187_V2.4631.00
155_S184_Y2.3441.00
33_R36_A2.3301.00
119_A159_L2.3031.00
22_F229_V2.2921.00
121_Y227_Q2.2891.00
119_A156_A2.2761.00
139_D142_G2.2501.00
115_A159_L2.2041.00
165_L183_A2.1811.00
135_V211_F2.1651.00
158_G189_G2.1521.00
131_N137_A2.0901.00
154_A191_A2.0421.00
2_R6_L2.0341.00
121_Y224_L1.9971.00
117_F228_A1.9691.00
237_L241_L1.9571.00
90_A238_F1.8521.00
125_F130_P1.8421.00
68_V72_A1.8011.00
150_A199_I1.7391.00
213_A216_L1.7331.00
5_L8_G1.7311.00
21_L25_V1.7081.00
32_D36_A1.6701.00
11_A237_L1.6661.00
93_F238_F1.6361.00
187_V191_A1.6221.00
59_W67_G1.5921.00
30_L218_Q1.5841.00
88_L92_V1.5811.00
214_D218_Q1.5571.00
24_R28_E1.5411.00
89_F109_G1.5391.00
23_Q78_N1.5331.00
111_L115_A1.4651.00
216_L220_R1.4631.00
8_G86_G1.4331.00
12_G83_V1.4321.00
125_F224_L1.4261.00
22_F26_F1.4231.00
14_L237_L1.4201.00
20_F24_R1.4151.00
90_A93_F1.4031.00
157_A160_A1.3811.00
161_L165_L1.3811.00
116_G234_L1.3791.00
184_Y188_V1.3711.00
85_F116_G1.3711.00
39_E42_A1.3701.00
136_G139_D1.3631.00
44_A47_A1.3571.00
146_A150_A1.3521.00
110_L232_A1.3341.00
116_G120_V1.3331.00
122_L224_L1.3221.00
42_A45_A1.3201.00
30_L132_P1.3191.00
151_T195_L1.3141.00
13_L79_V1.3011.00
11_A241_L1.2981.00
33_R37_Y1.2771.00
16_G79_V1.2761.00
180_A183_A1.2761.00
81_Y85_F1.2681.00
230_F234_L1.2521.00
147_W198_V1.2451.00
66_R69_Q1.2441.00
22_F225_G1.2391.00
210_G214_D1.2321.00
115_A119_A1.2191.00
114_L118_V1.2111.00
19_A226_T1.2011.00
43_A46_G1.1881.00
136_G208_E1.1801.00
199_I214_D1.1771.00
104_S107_R1.1741.00
30_L33_R1.1711.00
150_A195_L1.1691.00
154_A187_V1.1651.00
68_V71_T1.1621.00
115_A160_A1.1561.00
132_P135_V1.1471.00
173_G176_A1.1471.00
110_L114_L1.1421.00
154_A158_G1.1371.00
225_G229_V1.1281.00
105_P108_T1.1261.00
28_E32_D1.1251.00
188_V192_L1.1241.00
158_G193_L1.1171.00
183_A187_V1.0961.00
39_E60_E1.0901.00
189_G193_L1.0901.00
121_Y125_F1.0820.99
151_T192_L1.0790.99
209_S212_P1.0720.99
149_L153_A1.0660.99
66_R73_G1.0620.99
211_F216_L1.0510.99
31_I134_G1.0440.99
179_A183_A1.0320.99
117_F224_L1.0270.99
46_G49_A1.0240.99
178_L181_A1.0190.99
236_L240_A1.0180.99
14_L241_L1.0170.99
37_Y41_A1.0070.99
5_L87_L1.0060.99
22_F226_T1.0040.99
209_S213_A1.0000.99
11_A242_A0.9950.99
34_A38_E0.9820.99
164_F168_R0.9790.99
116_G231_W0.9780.99
135_V217_W0.9780.99
59_W69_Q0.9630.99
30_L215_L0.9590.99
118_V122_L0.9590.99
15_A234_L0.9570.99
166_R177_T0.9570.99
118_V123_V0.9510.99
186_V189_G0.9490.99
92_V156_A0.9360.99
150_A154_A0.9340.98
185_L188_V0.9290.98
143_A147_W0.9270.98
3_R7_R0.9270.98
213_A217_W0.9230.98
9_L87_L0.9170.98
47_A50_A0.9170.98
23_Q27_V0.9160.98
155_S193_L0.9120.98
45_A48_A0.9070.98
59_W73_G0.9020.98
65_S68_V0.9020.98
185_L189_G0.8990.98
103_L111_L0.8980.98
175_N179_A0.8900.98
48_A51_A0.8900.98
19_A227_Q0.8870.98
16_G78_N0.8850.98
148_Y152_V0.8830.98
57_E60_E0.8810.98
32_D35_I0.8750.98
15_A233_V0.8710.98
117_F227_Q0.8700.98
84_A88_L0.8670.98
174_W177_T0.8650.98
103_L107_R0.8650.98
118_V184_Y0.8610.97
26_F222_A0.8590.97
154_A195_L0.8560.97
211_F215_L0.8550.97
127_K147_W0.8410.97
160_A164_F0.8340.97
142_G146_A0.8320.97
123_V184_Y0.8300.97
171_A176_A0.8300.97
28_E66_R0.8290.97
139_D143_A0.8290.97
176_A180_A0.8230.97
93_F109_G0.8220.97
59_W66_R0.8220.97
179_A182_A0.8200.97
166_R186_V0.8200.97
209_S214_D0.8180.97
30_L222_A0.8140.96
159_L181_A0.8120.96
26_F225_G0.8120.96
136_G209_S0.8110.96
149_L152_V0.8070.96
84_A127_K0.8020.96
109_G235_G0.8010.96
19_A230_F0.8000.96
106_R236_L0.7990.96
9_L83_V0.7980.96
222_A226_T0.7940.96
27_V222_A0.7930.96
27_V226_T0.7930.96
105_P239_G0.7900.96
10_L241_L0.7870.96
9_L80_L0.7820.96
89_F112_L0.7810.95
33_R215_L0.7800.95
59_W62_E0.7800.95
109_G113_A0.7730.95
86_G234_L0.7670.95
198_V203_D0.7640.95
203_D210_G0.7600.95
5_L9_L0.7600.95
115_A181_A0.7560.95
72_A76_L0.7540.95
85_F230_F0.7450.94
16_G130_P0.7440.94
209_S216_L0.7430.94
24_R71_T0.7430.94
21_L24_R0.7410.94
98_G101_G0.7400.94
175_N178_L0.7390.94
118_V159_L0.7380.94
4_L238_F0.7360.94
199_I203_D0.7320.94
217_W220_R0.7300.94
21_L27_V0.7280.93
237_L240_A0.7260.93
13_L83_V0.7220.93
116_G177_T0.7220.93
20_F77_A0.7220.93
228_A232_A0.7160.93
159_L184_Y0.7150.93
19_A23_Q0.7130.93
85_F120_V0.7110.93
151_T155_S0.7010.92
15_A29_P0.6990.92
67_G70_R0.6960.92
171_A179_A0.6950.92
147_W197_H0.6910.92
190_V193_L0.6900.92
100_L108_T0.6860.91
168_R172_R0.6850.91
4_L10_L0.6850.91
60_E66_R0.6830.91
106_R239_G0.6820.91
12_G16_G0.6760.91
232_A235_G0.6730.91
43_A47_A0.6720.90
23_Q226_T0.6720.90
31_I35_I0.6620.90
35_I38_E0.6600.90
41_A210_G0.6600.90
225_G228_A0.6600.90
93_F98_G0.6570.89
18_L237_L0.6570.89
173_G179_A0.6550.89
6_L83_V0.6540.89
120_V125_F0.6530.89
172_R177_T0.6510.89
165_L169_L0.6490.89
34_A136_G0.6440.88
217_W221_V0.6440.88
24_R75_L0.6420.88
188_V191_A0.6420.88
12_G82_G0.6390.88
161_L164_F0.6380.88
38_E133_P0.6370.88
90_A94_A0.6350.88
117_F121_Y0.6330.88
93_F112_L0.6330.88
123_V188_V0.6320.88
4_L94_A0.6320.88
67_G71_T0.6280.87
158_G191_A0.6270.87
97_G105_P0.6250.87
16_G85_F0.6230.87
156_A160_A0.6200.87
90_A96_A0.6190.86
215_L218_Q0.6190.86
128_Y147_W0.6180.86
205_E209_S0.6150.86
26_F30_L0.6130.86
216_L227_Q0.6120.86
19_A82_G0.6100.86
175_N239_G0.6100.86
176_A181_A0.6090.86
133_P219_F0.6090.86
151_T188_V0.6080.85
38_E219_F0.6010.85
44_A48_A0.6010.85
151_T154_A0.6010.85
159_L193_L0.5980.85
37_Y212_P0.5960.84
11_A15_A0.5960.84
5_L168_R0.5930.84
129_P203_D0.5910.84
127_K132_P0.5910.84
223_S227_Q0.5900.84
36_A39_E0.5890.84
42_A46_G0.5870.83
218_Q222_A0.5860.83
170_A183_A0.5850.83
107_R110_L0.5840.83
56_A59_W0.5840.83
171_A175_N0.5820.83
28_E74_L0.5810.83
80_L150_A0.5800.83
73_G76_L0.5760.82
205_E208_E0.5760.82
134_G163_V0.5760.82
19_A81_Y0.5740.82
189_G192_L0.5730.82
7_R10_L0.5680.81
22_F222_A0.5680.81
131_N135_V0.5670.81
26_F189_G0.5670.81
168_R186_V0.5660.81
138_A141_I0.5660.81
112_L115_A0.5650.81
135_V216_L0.5640.81
2_R5_L0.5630.81
41_A45_A0.5630.81
67_G180_A0.5590.80
223_S226_T0.5590.80
127_K151_T0.5590.80
99_R136_G0.5590.80
112_L156_A0.5560.80
109_G191_A0.5510.79
101_G112_L0.5480.79
18_L21_L0.5470.79
34_A135_V0.5460.79
158_G188_V0.5440.79
42_A55_H0.5410.78
22_F82_G0.5400.78
24_R70_R0.5390.78
7_R241_L0.5360.78
145_Q148_Y0.5350.77
97_G101_G0.5340.77
131_N138_A0.5340.77
182_A189_G0.5340.77
123_V151_T0.5330.77
28_E141_I0.5320.77
109_G112_L0.5320.77
172_R180_A0.5310.77
120_V156_A0.5290.77
106_R220_R0.5280.77
113_A159_L0.5280.77
53_H59_W0.5250.76
123_V192_L0.5210.76
64_V74_L0.5200.75
171_A183_A0.5180.75
89_F234_L0.5170.75
32_D132_P0.5150.75
135_V210_G0.5140.75
132_P216_L0.5140.75
191_A199_I0.5130.75
153_A157_A0.5110.74
67_G179_A0.5080.74
170_A175_N0.5080.74
45_A50_A0.5070.74
134_G201_A0.5050.73
86_G90_A0.5050.73
190_V194_L0.5030.73
217_W224_L0.5020.73
6_L9_L0.5020.73
161_L188_V0.5000.73
15_A19_A0.5000.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gfpA 2 0.856 8.2 0.961 Contact Map
3llqA 3 0.716 7.5 0.962 Contact Map
4humA 1 0.5926 7.5 0.962 Contact Map
2xq2A 2 0.1646 7.2 0.962 Contact Map
4c7rA 3 0.6091 7 0.962 Contact Map
3rmtA 4 0.1975 6.5 0.963 Contact Map
2llmA 1 0.177 6.5 0.963 Contact Map
1v54L 1 0.1893 6.1 0.964 Contact Map
3mktA 1 0.5885 5.8 0.964 Contact Map
4tkrA 2 0.4815 5.6 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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