GREMLIN Database
CbtB - Probable cobalt transporter subunit (CbtB)
PFAM: PF09489 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 50 (46)
Sequences: 4589 (2202)
Seq/√Len: 324.7
META: 0.886

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_G47_F3.2641.00
41_G45_L3.2461.00
5_A8_R2.5511.00
21_F25_F2.2341.00
32_A36_E1.9661.00
8_R12_A1.9431.00
7_S11_W1.7181.00
16_A19_G1.6411.00
19_G22_L1.5431.00
6_S9_L1.5131.00
7_S10_L1.4461.00
41_G44_A1.4401.00
12_A16_A1.3471.00
31_G34_V1.2811.00
34_V38_A1.2371.00
10_L13_L1.2001.00
23_L27_G1.1371.00
31_G36_E1.0231.00
5_A9_L1.0131.00
28_F33_A0.9901.00
18_L22_L0.9811.00
24_Y29_A0.9801.00
25_F28_F0.9251.00
16_A20_L0.8991.00
29_A34_V0.8911.00
20_L24_Y0.8721.00
15_A19_G0.8621.00
28_F44_A0.8601.00
13_L17_L0.8571.00
21_F24_Y0.8531.00
10_L14_F0.8431.00
8_R11_W0.8271.00
36_E46_G0.8241.00
41_G46_G0.8231.00
30_Q33_A0.8071.00
29_A32_A0.8051.00
12_A41_G0.7901.00
23_L28_F0.7861.00
18_L25_F0.7761.00
24_Y31_G0.7711.00
40_D48_P0.7360.99
6_S10_L0.7300.99
40_D47_F0.7210.99
39_H43_H0.7180.99
9_L13_L0.7150.99
26_V47_F0.7010.99
6_S24_Y0.6940.99
38_A41_G0.6880.99
35_H40_D0.6840.99
38_A47_F0.6810.99
15_A33_A0.6730.99
23_L38_A0.6710.99
29_A33_A0.6710.99
5_A11_W0.6610.99
24_Y47_F0.6540.98
31_G45_L0.6510.98
11_W15_A0.6500.98
44_A47_F0.5890.97
38_A44_A0.5810.97
12_A15_A0.5590.96
17_L20_L0.5590.96
43_H50_H0.5480.96
37_A41_G0.5440.95
27_G40_D0.5390.95
36_E40_D0.5390.95
20_L27_G0.5380.95
6_S34_V0.5300.95
6_S17_L0.5130.94
38_A46_G0.5000.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ywhA 4 0 2.9 0.874 Contact Map
1kzqA 2 0.06 2.5 0.879 Contact Map
2w61A 1 0 2.2 0.883 Contact Map
4wl1A 3 0.08 1.8 0.888 Contact Map
2m8rA 1 0.62 1.6 0.891 Contact Map
3ujzA 2 0.98 1.3 0.896 Contact Map
2wdqD 2 0.52 1.2 0.899 Contact Map
2g7hA 1 0.98 1.2 0.899 Contact Map
3fymA 1 0 1.1 0.9 Contact Map
2j7aC 2 0.66 1.1 0.901 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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