Cas_TM1802 - PFAM28P - GREMLIN Contacts

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Cas_TM1802 - CRISPR-associated protein TM1802 (cas_TM1802)

PFAM:	PF09484	Sequences: MIEAIKEIGEYLLEGKEGKDPLDILIENPKSKYKYVLVINFDLDNGKIEFDGVEEIDPLEEFDEEKLKKYLYLKVGSANGPNITPTSKTTDELEKTLSKKILNWLDLEKLKKKKELSKEEKEFLKKIKKELKEKKNKEKILKELKEKLKEIKNEKKEIVLLTLKIDGKYLGDIEEYKKILLKKLLEKYFEKKGKKSSAKNGVCSICGEKKEEVYGFVSTRLKFKFYTTDKPGFASGFDKKNAWKNFPVCEDCALKLEAGKKYIEENLSFRFYGLNYYLIPKFLLGLEEDLEEILDILKDLKKLKKLEKLEKELKKRLTSDEEEILEILSEEKDYLSLNFLFYERKDQSAFKILLLIEDVLPSRLRKIFEAKEKVDKLFKELFKEKKDLNFNFGTIRYFFPVRKKKGDFDKYKKFLEIVDAIFTGKPIDYNFLIKFFMEKIRKDFKNDEYEDFYLKFSVLKALLLLLFLEKLGLLKGGEKMEEGEEEEKLEDEEKLEEFFEEYLDFFDYSPEKKALFLLGVLTQKLLNIQYKKRGSKPFLKKLNGLGMDEKDIKRLLPEVQNKLEQYDKNYYGYRELEEAISKYLLDAGDNWKLSPDEISFYFLLGMSLA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_10
Length:	609 (596)
Sequences:	930 (839)
Seq/√Len:	34.4
META:	0.81

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
206_C	249_C	8.032	1.00
249_C	252_C	7.974	1.00
206_C	252_C	7.838	1.00
461_A	600_F	5.815	1.00
6_K	10_E	5.036	1.00
541_K	558_E	4.977	1.00
543_N	551_D	4.899	1.00
268_S	342_Y	4.604	1.00
10_E	255_K	4.392	1.00
50_F	143_E	4.194	1.00
518_L	559_V	4.058	1.00
530_Y	536_K	3.960	1.00
522_T	559_V	3.938	1.00
373_K	470_K	3.896	1.00
367_I	467_F	3.824	1.00
521_L	563_L	3.736	1.00
238_D	241_N	3.699	1.00
562_K	565_Q	3.560	1.00
561_N	565_Q	3.539	1.00
35_Y	61_E	3.501	1.00
436_F	461_A	3.151	1.00
554_R	558_E	3.051	1.00
346_D	349_A	2.979	1.00
76_G	80_G	2.885	1.00
136_N	139_K	2.880	1.00
432_L	436_F	2.833	1.00
536_K	539_L	2.790	1.00
241_N	244_K	2.785	1.00
507_D	512_K	2.780	1.00
549_E	553_K	2.656	1.00
235_S	245_N	2.624	1.00
367_I	471_L	2.602	1.00
229_D	232_G	2.558	1.00
338_N	355_L	2.529	1.00
92_E	95_K	2.511	1.00
268_S	275_N	2.504	1.00
13_L	255_K	2.494	1.00
552_I	598_I	2.480	1.00
515_L	552_I	2.434	1.00
270_R	275_N	2.345	0.99
547_M	599_S	2.307	0.99
477_G	480_M	2.275	0.99
230_K	233_F	2.269	0.99
63_D	66_K	2.232	0.99
203_C	252_C	2.159	0.99
515_L	547_M	2.148	0.99
395_I	417_I	2.135	0.99
371_K	375_D	2.132	0.99
37_L	147_K	2.072	0.99
262_Y	267_L	2.063	0.98
555_L	559_V	2.037	0.98
515_L	598_I	2.018	0.98
511_E	591_W	2.001	0.98
96_T	100_K	1.978	0.98
279_I	340_L	1.958	0.98
124_L	417_I	1.955	0.98
530_Y	534_G	1.952	0.98
82_N	87_S	1.930	0.98
264_E	277_Y	1.924	0.98
342_Y	350_F	1.909	0.97
79_N	82_N	1.904	0.97
552_I	602_F	1.900	0.97
548_D	595_P	1.897	0.97
74_K	77_S	1.888	0.97
532_K	568_K	1.886	0.97
419_D	423_T	1.885	0.97
82_N	88_K	1.884	0.97
146_E	150_E	1.875	0.97
228_T	234_A	1.871	0.97
363_R	424_G	1.860	0.97
462_L	604_L	1.855	0.97
440_I	458_V	1.853	0.97
526_L	538_F	1.852	0.97
582_K	586_D	1.841	0.97
417_I	427_I	1.814	0.97
542_L	545_L	1.772	0.96
203_C	206_C	1.768	0.96
107_L	110_L	1.766	0.96
427_I	513_K	1.760	0.96
339_F	359_V	1.748	0.96
269_F	278_L	1.747	0.96
401_V	410_K	1.740	0.96
40_N	167_G	1.730	0.95
203_C	249_C	1.723	0.95
509_S	512_K	1.713	0.95
405_K	410_K	1.706	0.95
6_K	255_K	1.704	0.95
97_L	102_L	1.701	0.95
308_K	311_K	1.697	0.95
379_K	382_F	1.695	0.95
84_T	88_K	1.681	0.95
526_L	606_M	1.676	0.95
480_M	484_E	1.673	0.94
23_D	26_I	1.669	0.94
370_A	374_V	1.638	0.94
234_A	242_A	1.633	0.94
511_E	552_I	1.633	0.94
5_I	259_G	1.632	0.94
410_K	413_K	1.624	0.94
401_V	408_F	1.620	0.93
370_A	373_K	1.613	0.93
547_M	552_I	1.610	0.93
408_F	411_Y	1.605	0.93
147_K	150_E	1.604	0.93
42_D	49_E	1.602	0.93
144_L	417_I	1.599	0.93
128_K	132_K	1.581	0.93
276_Y	341_F	1.574	0.92
174_E	178_K	1.566	0.92
498_F	502_Y	1.563	0.92
598_I	606_M	1.524	0.91
391_N	394_T	1.511	0.91
502_Y	506_F	1.508	0.91
429_Y	433_I	1.487	0.90
340_L	355_L	1.485	0.90
38_V	164_K	1.484	0.90
547_M	598_I	1.477	0.90
367_I	421_I	1.471	0.90
536_K	575_E	1.471	0.90
600_F	604_L	1.465	0.89
261_K	265_E	1.459	0.89
5_I	263_I	1.458	0.89
580_I	583_Y	1.456	0.89
377_L	470_K	1.445	0.89
28_N	62_F	1.424	0.88
548_D	554_R	1.418	0.88
421_I	468_L	1.414	0.88
570_Y	573_Y	1.413	0.88
201_G	213_V	1.409	0.87
43_L	166_D	1.408	0.87
498_F	503_L	1.401	0.87
165_I	172_D	1.399	0.87
441_R	444_F	1.397	0.87
77_S	80_G	1.396	0.87
23_D	62_F	1.394	0.87
42_D	51_D	1.385	0.87
262_Y	266_N	1.382	0.86
30_K	33_Y	1.378	0.86
471_L	474_L	1.377	0.86
100_K	104_W	1.376	0.86
267_L	341_F	1.361	0.86
84_T	87_S	1.357	0.85
78_A	85_P	1.342	0.85
313_L	316_R	1.337	0.85
40_N	164_K	1.336	0.84
405_K	411_Y	1.335	0.84
50_F	53_V	1.333	0.84
139_K	143_E	1.331	0.84
110_L	113_K	1.330	0.84
511_E	514_A	1.308	0.83
366_K	370_A	1.304	0.83
89_T	96_T	1.299	0.83
542_L	602_F	1.293	0.82
371_K	467_F	1.291	0.82
370_A	429_Y	1.290	0.82
308_K	367_I	1.288	0.82
319_S	323_E	1.287	0.82
403_K	410_K	1.285	0.82
107_L	111_K	1.281	0.82
293_I	301_K	1.277	0.82
84_T	89_T	1.265	0.81
537_P	565_Q	1.262	0.81
541_K	555_L	1.252	0.80
51_D	488_K	1.252	0.80
79_N	86_T	1.251	0.80
234_A	239_K	1.249	0.80
523_Q	606_M	1.249	0.80
373_K	376_K	1.247	0.80
523_Q	527_N	1.247	0.80
85_P	89_T	1.245	0.80
575_E	578_E	1.240	0.80
585_L	604_L	1.234	0.79
263_I	267_L	1.231	0.79
560_Q	607_S	1.228	0.79
78_A	348_S	1.228	0.79
38_V	162_T	1.226	0.79
143_E	146_E	1.223	0.79
215_G	257_E	1.214	0.78
525_L	559_V	1.213	0.78
112_K	129_K	1.210	0.78
548_D	551_D	1.209	0.78
404_K	408_F	1.203	0.78
82_N	170_L	1.202	0.78
43_L	48_I	1.199	0.77
27_E	74_K	1.197	0.77
509_S	593_L	1.192	0.77
262_Y	547_M	1.179	0.76
35_Y	72_Y	1.177	0.76
543_N	599_S	1.169	0.76
87_S	547_M	1.168	0.75
323_E	326_E	1.166	0.75
200_N	209_K	1.164	0.75
343_E	346_D	1.152	0.74
344_R	347_Q	1.148	0.74
576_L	580_I	1.144	0.74
70_Y	74_K	1.143	0.74
213_V	432_L	1.142	0.74
414_F	418_V	1.140	0.74
200_N	427_I	1.140	0.74
133_E	138_E	1.136	0.73
6_K	205_I	1.132	0.73
246_F	438_E	1.132	0.73
168_K	173_I	1.131	0.73
367_I	473_L	1.126	0.73
395_I	399_F	1.125	0.73
464_L	468_L	1.123	0.73
343_E	409_D	1.123	0.73
551_D	599_S	1.119	0.72
515_L	604_L	1.119	0.72
499_F	503_L	1.116	0.72
499_F	506_F	1.116	0.72
297_L	359_V	1.111	0.72
20_D	263_I	1.111	0.72
145_K	149_K	1.109	0.72
69_K	172_D	1.107	0.71
97_L	104_W	1.106	0.71
198_A	201_G	1.103	0.71
581_S	587_A	1.102	0.71
454_L	458_V	1.102	0.71
42_D	45_N	1.099	0.71
82_N	85_P	1.098	0.71
62_F	160_L	1.098	0.71
557_P	581_S	1.098	0.71
404_K	412_K	1.095	0.71
324_I	493_E	1.093	0.70
526_L	539_L	1.089	0.70
577_E	580_I	1.087	0.70
401_V	406_G	1.086	0.70
570_Y	577_E	1.085	0.70
113_K	129_K	1.081	0.70
517_L	563_L	1.081	0.70
16_K	19_K	1.080	0.70
131_L	163_L	1.080	0.70
218_S	224_K	1.075	0.69
51_D	183_K	1.070	0.69
117_S	168_K	1.065	0.68
9_G	259_G	1.065	0.68
546_G	606_M	1.065	0.68
401_V	404_K	1.064	0.68
181_L	339_F	1.061	0.68
161_L	343_E	1.060	0.68
224_K	246_F	1.060	0.68
214_Y	253_A	1.058	0.68
159_V	162_T	1.058	0.68
256_L	421_I	1.057	0.68
345_K	350_F	1.057	0.68
186_E	190_E	1.043	0.67
36_V	70_Y	1.042	0.67
236_G	367_I	1.039	0.66
476_G	480_M	1.038	0.66
534_G	537_P	1.035	0.66
94_E	145_K	1.035	0.66
234_A	537_P	1.034	0.66
374_V	395_I	1.032	0.66
229_D	467_F	1.031	0.66
366_K	424_G	1.031	0.66
20_D	41_F	1.030	0.66
116_L	121_K	1.029	0.66
60_E	70_Y	1.025	0.65
502_Y	591_W	1.020	0.65
356_I	422_F	1.016	0.65
204_S	247_P	1.016	0.65
22_L	27_E	1.015	0.65
600_F	605_G	1.014	0.65
208_E	211_E	1.012	0.64
402_R	405_K	1.012	0.64
538_F	606_M	1.011	0.64
522_T	555_L	1.010	0.64
581_S	585_L	1.007	0.64
33_Y	88_K	1.006	0.64
8_I	263_I	1.004	0.64
42_D	46_G	1.004	0.64
163_L	170_L	1.002	0.64
225_F	352_I	0.999	0.63
587_A	591_W	0.996	0.63
180_L	216_F	0.996	0.63
390_F	398_F	0.996	0.63
290_L	297_L	0.995	0.63
291_E	479_K	0.994	0.63
297_L	300_L	0.988	0.63
392_F	421_I	0.988	0.63
271_F	276_Y	0.985	0.62
588_G	591_W	0.984	0.62
210_K	251_D	0.980	0.62
356_I	372_E	0.978	0.62
568_K	571_Y	0.976	0.62
596_D	599_S	0.973	0.61
234_A	565_Q	0.972	0.61
229_D	362_S	0.969	0.61
2_I	9_G	0.969	0.61
574_R	578_E	0.969	0.61
289_D	294_L	0.968	0.61
283_L	525_L	0.967	0.61
429_Y	465_L	0.965	0.61
367_I	468_L	0.963	0.61
314_K	372_E	0.961	0.60
439_K	457_S	0.955	0.60
75_V	78_A	0.954	0.60
523_Q	536_K	0.951	0.60
339_F	595_P	0.950	0.59
267_L	361_P	0.950	0.59
178_K	494_K	0.949	0.59
79_N	84_T	0.948	0.59
236_G	414_F	0.945	0.59
90_T	100_K	0.943	0.59
174_E	377_L	0.941	0.59
6_K	252_C	0.941	0.59
97_L	144_L	0.937	0.58
535_S	574_R	0.936	0.58
4_A	7_E	0.932	0.58
599_S	602_F	0.931	0.58
392_F	418_V	0.930	0.58
10_E	127_I	0.929	0.58
361_P	562_K	0.924	0.57
378_F	391_N	0.920	0.57
434_K	596_D	0.916	0.57
237_F	522_T	0.913	0.56
401_V	405_K	0.912	0.56
570_Y	574_R	0.911	0.56
374_V	466_L	0.909	0.56
599_S	606_M	0.909	0.56
1_M	9_G	0.905	0.56
311_K	366_K	0.904	0.56
514_A	559_V	0.903	0.56
516_F	608_L	0.900	0.55
436_F	465_L	0.898	0.55
556_L	598_I	0.898	0.55
36_V	504_D	0.898	0.55
122_E	125_K	0.897	0.55
599_S	603_L	0.895	0.55
306_L	309_L	0.894	0.55
417_I	421_I	0.894	0.55
64_E	356_I	0.894	0.55
481_E	484_E	0.892	0.55
294_L	297_L	0.891	0.55
260_K	507_D	0.887	0.54
580_I	584_L	0.885	0.54
172_D	594_S	0.884	0.54
238_D	283_L	0.882	0.54
515_L	602_F	0.882	0.54
277_Y	342_Y	0.879	0.54
11_Y	14_E	0.879	0.54
229_D	517_L	0.879	0.54
264_E	345_K	0.878	0.53
45_N	51_D	0.877	0.53
406_G	438_E	0.877	0.53
223_F	233_F	0.872	0.53
86_T	179_I	0.869	0.53
595_P	599_S	0.868	0.53
116_L	127_I	0.865	0.52
82_N	541_K	0.862	0.52
287_E	590_N	0.862	0.52
401_V	413_K	0.862	0.52
97_L	369_E	0.861	0.52
192_K	196_S	0.861	0.52
402_R	409_D	0.860	0.52
556_L	581_S	0.858	0.52
245_N	351_K	0.858	0.52
234_A	240_K	0.857	0.52
36_V	129_K	0.855	0.51
510_P	588_G	0.854	0.51
121_K	223_F	0.852	0.51
403_K	406_G	0.851	0.51
37_L	144_L	0.845	0.51
38_V	41_F	0.843	0.50
584_L	587_A	0.839	0.50
244_K	542_L	0.839	0.50
526_L	536_K	0.836	0.50
234_A	422_F	0.836	0.50
272_Y	414_F	0.835	0.50
544_G	602_F	0.834	0.50
525_L	542_L	0.833	0.50
361_P	467_F	0.832	0.50
47_K	365_R	0.831	0.49
564_E	574_R	0.831	0.49
309_L	313_L	0.829	0.49
225_F	361_P	0.828	0.49
232_G	414_F	0.826	0.49
365_R	369_E	0.826	0.49
396_R	409_D	0.825	0.49
516_F	519_G	0.823	0.49
205_I	248_V	0.821	0.49
225_F	341_F	0.821	0.49
510_P	513_K	0.820	0.49
598_I	601_Y	0.816	0.48
436_F	439_K	0.814	0.48
138_E	142_K	0.813	0.48
345_K	349_A	0.809	0.48
36_V	160_L	0.809	0.48
537_P	558_E	0.807	0.47
97_L	100_K	0.807	0.47
338_N	358_D	0.806	0.47
434_K	553_K	0.805	0.47
4_A	249_C	0.803	0.47
420_A	583_Y	0.800	0.47
178_K	181_L	0.800	0.47
519_G	605_G	0.799	0.47
324_I	391_N	0.797	0.47
318_T	323_E	0.797	0.47
137_K	140_I	0.797	0.47
363_R	422_F	0.796	0.46
87_S	96_T	0.795	0.46
252_C	563_L	0.794	0.46
272_Y	598_I	0.794	0.46
271_F	418_V	0.794	0.46
234_A	363_R	0.793	0.46
270_R	432_L	0.792	0.46
87_S	90_T	0.789	0.46
164_K	169_Y	0.787	0.46
293_I	470_K	0.786	0.46
255_K	275_N	0.785	0.46
313_L	317_L	0.785	0.46
271_F	374_V	0.785	0.46
19_K	24_I	0.785	0.46
279_I	330_E	0.780	0.45
82_N	86_T	0.780	0.45
597_E	605_G	0.779	0.45
89_T	93_L	0.779	0.45
27_E	88_K	0.777	0.45
40_N	51_D	0.776	0.45
84_T	170_L	0.776	0.45
354_L	419_D	0.776	0.45
538_F	563_L	0.772	0.44
164_K	332_K	0.771	0.44
120_E	124_L	0.771	0.44
139_K	291_E	0.770	0.44
565_Q	591_W	0.768	0.44
41_F	198_A	0.768	0.44
17_E	366_K	0.767	0.44
343_E	353_L	0.767	0.44
521_L	545_L	0.762	0.44
19_K	30_K	0.761	0.44
249_C	563_L	0.761	0.44
4_A	9_G	0.761	0.44
547_M	595_P	0.759	0.43
182_K	428_D	0.759	0.43
32_K	298_K	0.759	0.43
144_L	339_F	0.758	0.43
406_G	409_D	0.758	0.43
77_S	99_K	0.758	0.43
211_E	241_N	0.756	0.43
102_L	309_L	0.755	0.43
267_L	321_E	0.755	0.43
354_L	415_L	0.754	0.43
278_L	456_F	0.754	0.43
169_Y	259_G	0.752	0.43
406_G	410_K	0.751	0.43
90_T	93_L	0.750	0.43
69_K	163_L	0.749	0.43
174_E	177_K	0.749	0.43
585_L	588_G	0.748	0.42
432_L	495_L	0.748	0.42
375_D	390_F	0.748	0.42
543_N	588_G	0.747	0.42
556_L	559_V	0.746	0.42
398_F	422_F	0.745	0.42
269_F	276_Y	0.742	0.42
216_F	599_S	0.741	0.42
400_P	514_A	0.741	0.42
49_E	392_F	0.741	0.42
23_D	27_E	0.740	0.42
421_I	467_F	0.740	0.42
495_L	499_F	0.740	0.42
216_F	253_A	0.739	0.42
372_E	375_D	0.737	0.42
200_N	434_K	0.736	0.41
561_N	564_E	0.735	0.41
395_I	421_I	0.735	0.41
344_R	349_A	0.735	0.41
223_F	260_K	0.734	0.41
546_G	598_I	0.734	0.41
261_K	335_L	0.733	0.41
436_F	456_F	0.732	0.41
186_E	189_F	0.731	0.41
543_N	554_R	0.730	0.41
72_Y	368_F	0.729	0.41
174_E	292_E	0.728	0.41
186_E	241_N	0.728	0.41
421_I	464_L	0.728	0.41
542_L	606_M	0.727	0.41
422_F	467_F	0.726	0.41
390_F	463_L	0.726	0.41
578_E	584_L	0.723	0.40
94_E	590_N	0.722	0.40
259_G	553_K	0.721	0.40
554_R	596_D	0.720	0.40
292_E	295_D	0.719	0.40
280_P	529_Q	0.716	0.40
546_G	599_S	0.716	0.40
77_S	86_T	0.715	0.40
228_T	242_A	0.714	0.40
511_E	593_L	0.713	0.40
2_I	50_F	0.712	0.39
69_K	138_E	0.712	0.39
216_F	342_Y	0.712	0.39
137_K	141_L	0.711	0.39
127_I	311_K	0.711	0.39
149_K	373_K	0.711	0.39
533_R	540_K	0.711	0.39
495_L	498_F	0.711	0.39
371_K	422_F	0.710	0.39
546_G	552_I	0.708	0.39
212_E	251_D	0.708	0.39
228_T	608_L	0.707	0.39
129_K	133_E	0.707	0.39
97_L	103_N	0.707	0.39
116_L	120_E	0.705	0.39
419_D	425_K	0.705	0.39
229_D	363_R	0.705	0.39
581_S	607_S	0.703	0.39
518_L	584_L	0.703	0.39
469_E	600_F	0.703	0.39
90_T	96_T	0.699	0.38
466_L	469_E	0.698	0.38
237_F	414_F	0.697	0.38
204_S	525_L	0.697	0.38
555_L	562_K	0.697	0.38
290_L	294_L	0.695	0.38
515_L	589_D	0.694	0.38
63_D	234_A	0.694	0.38
425_K	518_L	0.694	0.38
10_E	14_E	0.694	0.38
233_F	502_Y	0.693	0.38
14_E	174_E	0.692	0.38
138_E	330_E	0.692	0.38
541_K	606_M	0.691	0.38
182_K	429_Y	0.691	0.38
174_E	332_K	0.690	0.38
224_K	228_T	0.689	0.38
111_K	114_K	0.689	0.38
279_I	460_K	0.688	0.38
214_Y	228_T	0.688	0.38
146_E	444_F	0.687	0.37
340_L	585_L	0.687	0.37
541_K	554_R	0.686	0.37
216_F	272_Y	0.686	0.37
337_L	422_F	0.684	0.37
78_A	82_N	0.682	0.37
172_D	465_L	0.681	0.37
524_K	607_S	0.681	0.37
205_I	238_D	0.681	0.37
545_L	562_K	0.680	0.37
14_E	23_D	0.679	0.37
277_Y	458_V	0.678	0.37
206_C	563_L	0.678	0.37
205_I	256_L	0.676	0.37
602_F	605_G	0.675	0.37
163_L	426_P	0.674	0.36
253_A	547_M	0.674	0.36
204_S	347_Q	0.674	0.36
44_D	131_L	0.673	0.36
350_F	460_K	0.671	0.36
560_Q	588_G	0.671	0.36
468_L	473_L	0.671	0.36
11_Y	248_V	0.671	0.36
604_L	607_S	0.670	0.36
346_D	421_I	0.670	0.36
522_T	526_L	0.668	0.36
13_L	24_I	0.668	0.36
144_L	149_K	0.668	0.36
268_S	277_Y	0.668	0.36
393_G	471_L	0.667	0.36
486_E	489_L	0.667	0.36
37_L	173_I	0.666	0.36
229_D	566_Y	0.666	0.36
244_K	429_Y	0.666	0.36
427_I	594_S	0.665	0.36
5_I	377_L	0.664	0.36
549_E	591_W	0.662	0.36
499_F	608_L	0.662	0.36
138_E	141_L	0.661	0.35
547_M	555_L	0.659	0.35
148_L	340_L	0.659	0.35
223_F	512_K	0.659	0.35
294_L	298_K	0.659	0.35
545_L	565_Q	0.657	0.35
136_N	141_L	0.657	0.35
205_I	278_L	0.655	0.35
82_N	97_L	0.651	0.35
589_D	593_L	0.649	0.35
400_P	403_K	0.649	0.35
526_L	537_P	0.648	0.34
517_L	521_L	0.648	0.34
526_L	563_L	0.647	0.34
283_L	534_G	0.647	0.34
77_S	91_D	0.646	0.34
99_K	103_N	0.645	0.34
8_I	504_D	0.644	0.34
227_T	230_K	0.643	0.34
518_L	539_L	0.643	0.34
514_A	518_L	0.640	0.34
517_L	597_E	0.640	0.34
142_K	147_K	0.639	0.34
545_L	557_P	0.638	0.34
437_M	551_D	0.638	0.34
30_K	163_L	0.637	0.34
38_V	54_E	0.637	0.34
2_I	538_F	0.637	0.34
425_K	473_L	0.634	0.33
279_I	432_L	0.634	0.33
108_E	114_K	0.633	0.33
98_S	102_L	0.633	0.33
569_N	577_E	0.633	0.33
17_E	22_L	0.632	0.33
93_L	97_L	0.632	0.33
246_F	467_F	0.631	0.33
232_G	360_L	0.630	0.33
209_K	266_N	0.630	0.33
146_E	359_V	0.629	0.33
123_F	315_K	0.629	0.33
331_E	504_D	0.629	0.33
256_L	554_R	0.629	0.33
507_D	567_D	0.629	0.33
69_K	366_K	0.628	0.33
317_L	428_D	0.628	0.33
226_Y	423_T	0.625	0.33
2_I	5_I	0.625	0.33
310_E	364_L	0.625	0.33
229_D	361_P	0.625	0.33
278_L	360_L	0.624	0.33
560_Q	574_R	0.623	0.33
204_S	259_G	0.622	0.32
23_D	72_Y	0.622	0.32
271_F	544_G	0.621	0.32
85_P	96_T	0.620	0.32
506_F	588_G	0.618	0.32
22_L	349_A	0.618	0.32
4_A	206_C	0.618	0.32
127_I	442_K	0.617	0.32
23_D	28_N	0.617	0.32
23_D	337_L	0.617	0.32
39_I	286_L	0.616	0.32
406_G	487_E	0.615	0.32
274_L	600_F	0.614	0.32
223_F	232_G	0.614	0.32
226_Y	350_F	0.614	0.32
328_L	370_A	0.614	0.32
151_I	352_I	0.613	0.32
60_E	66_K	0.613	0.32
81_P	85_P	0.613	0.32
221_L	257_E	0.613	0.32
541_K	599_S	0.612	0.32
347_Q	395_I	0.612	0.32
32_K	347_Q	0.612	0.32
563_L	576_L	0.612	0.32
454_L	461_A	0.611	0.32
410_K	414_F	0.611	0.32
111_K	359_V	0.611	0.32
48_I	160_L	0.611	0.32
480_M	486_E	0.610	0.32
371_K	390_F	0.610	0.32
170_L	447_D	0.610	0.32
215_G	253_A	0.609	0.31
39_I	346_D	0.609	0.31
460_K	514_A	0.608	0.31
281_K	379_K	0.608	0.31
559_V	585_L	0.607	0.31
176_Y	321_E	0.607	0.31
346_D	351_K	0.606	0.31
213_V	540_K	0.606	0.31
72_Y	82_N	0.605	0.31
68_K	170_L	0.604	0.31
146_E	178_K	0.604	0.31
276_Y	352_I	0.604	0.31
260_K	545_L	0.603	0.31
374_V	467_F	0.603	0.31
253_A	342_Y	0.603	0.31
323_E	327_I	0.602	0.31
525_L	557_P	0.602	0.31
115_E	118_K	0.602	0.31
515_L	546_G	0.602	0.31
353_L	415_L	0.602	0.31
218_S	235_S	0.601	0.31
215_G	547_M	0.601	0.31
298_K	407_D	0.599	0.31
48_I	209_K	0.598	0.31
464_L	576_L	0.598	0.31
224_K	351_K	0.598	0.31
242_A	246_F	0.598	0.31
556_L	580_I	0.597	0.31
36_V	171_G	0.597	0.31
497_E	501_E	0.594	0.30
538_F	566_Y	0.593	0.30
96_T	102_L	0.593	0.30
519_G	529_Q	0.593	0.30
62_F	256_L	0.593	0.30
198_A	213_V	0.592	0.30
14_E	145_K	0.590	0.30
367_I	567_D	0.590	0.30
518_L	599_S	0.590	0.30
145_K	148_L	0.588	0.30
342_Y	349_A	0.588	0.30
361_P	542_L	0.587	0.30
578_E	583_Y	0.586	0.30
42_D	48_I	0.586	0.30
552_I	599_S	0.585	0.30
151_I	159_V	0.585	0.30
125_K	209_K	0.585	0.30
398_F	467_F	0.585	0.30
163_L	287_E	0.585	0.30
241_N	421_I	0.584	0.30
12_L	259_G	0.584	0.30
165_I	372_E	0.584	0.30
480_M	487_E	0.584	0.30
163_L	198_A	0.583	0.30
526_L	598_I	0.582	0.30
350_F	415_L	0.580	0.29
127_I	372_E	0.580	0.29
130_E	468_L	0.580	0.29
133_E	426_P	0.579	0.29
347_Q	351_K	0.579	0.29
427_I	537_P	0.579	0.29
168_K	172_D	0.578	0.29
221_L	342_Y	0.578	0.29
279_I	369_E	0.577	0.29
234_A	246_F	0.576	0.29
213_V	367_I	0.575	0.29
551_D	554_R	0.575	0.29
22_L	25_L	0.575	0.29
20_D	23_D	0.574	0.29
235_S	536_K	0.573	0.29
77_S	83_I	0.572	0.29
81_P	84_T	0.572	0.29
249_C	363_R	0.572	0.29
36_V	244_K	0.571	0.29
260_K	263_I	0.571	0.29
12_L	59_L	0.570	0.29
330_E	370_A	0.570	0.29
542_L	599_S	0.570	0.29
42_D	170_L	0.569	0.29
164_K	167_G	0.569	0.29
127_I	323_E	0.569	0.29
31_S	46_G	0.569	0.29
234_A	245_N	0.568	0.29
291_E	346_D	0.568	0.29
2_I	425_K	0.568	0.29
278_L	452_F	0.568	0.29
448_E	474_L	0.568	0.29
320_D	323_E	0.567	0.28
288_E	295_D	0.567	0.28
309_L	312_E	0.567	0.28
8_I	338_N	0.566	0.28
120_E	126_K	0.566	0.28
493_E	496_E	0.564	0.28
401_V	411_Y	0.564	0.28
48_I	474_L	0.563	0.28
139_K	199_K	0.563	0.28
78_A	93_L	0.563	0.28
369_E	373_K	0.562	0.28
359_V	447_D	0.562	0.28
102_L	374_V	0.562	0.28
3_E	63_D	0.562	0.28
231_P	263_I	0.562	0.28
596_D	600_F	0.561	0.28
593_L	598_I	0.561	0.28
256_L	513_K	0.560	0.28
152_K	428_D	0.560	0.28
514_A	591_W	0.559	0.28
269_F	538_F	0.558	0.28
245_N	338_N	0.558	0.28
522_T	599_S	0.558	0.28
5_I	60_E	0.558	0.28
338_N	448_E	0.557	0.28
440_I	530_Y	0.556	0.28
237_F	247_P	0.556	0.28
182_K	187_K	0.555	0.28
348_S	594_S	0.554	0.28
95_K	241_N	0.554	0.28
8_I	202_V	0.554	0.28
543_N	560_Q	0.553	0.28
166_D	265_E	0.553	0.28
192_K	351_K	0.553	0.28
277_Y	587_A	0.553	0.28
74_K	78_A	0.552	0.27
350_F	459_L	0.552	0.27
332_K	395_I	0.552	0.27
575_E	580_I	0.551	0.27
306_L	427_I	0.551	0.27
297_L	302_K	0.550	0.27
558_E	565_Q	0.550	0.27
528_I	568_K	0.550	0.27
80_G	83_I	0.549	0.27
185_L	250_E	0.548	0.27
29_P	62_F	0.548	0.27
502_Y	505_F	0.547	0.27
24_I	254_L	0.547	0.27
318_T	322_E	0.547	0.27
278_L	510_P	0.546	0.27
111_K	118_K	0.546	0.27
451_D	536_K	0.546	0.27
233_F	459_L	0.545	0.27
227_T	361_P	0.545	0.27
176_Y	180_L	0.544	0.27
119_E	311_K	0.543	0.27
23_D	168_K	0.543	0.27
343_E	349_A	0.542	0.27
477_G	481_E	0.541	0.27
170_L	177_K	0.541	0.27
440_I	454_L	0.541	0.27
528_I	539_L	0.541	0.27
238_D	395_I	0.541	0.27
468_L	474_L	0.541	0.27
577_E	583_Y	0.540	0.27
556_L	560_Q	0.540	0.27
421_I	471_L	0.540	0.27
4_A	534_G	0.540	0.27
23_D	468_L	0.539	0.27
364_L	391_N	0.539	0.27
54_E	59_L	0.539	0.27
26_I	469_E	0.539	0.27
123_F	161_L	0.537	0.26
215_G	271_F	0.537	0.26
562_K	591_W	0.537	0.26
38_V	60_E	0.536	0.26
465_L	469_E	0.534	0.26
25_L	28_N	0.534	0.26
599_S	604_L	0.534	0.26
448_E	453_Y	0.533	0.26
118_K	127_I	0.533	0.26
483_G	487_E	0.533	0.26
122_E	126_K	0.532	0.26
561_N	601_Y	0.532	0.26
169_Y	279_I	0.532	0.26
542_L	580_I	0.531	0.26
162_T	201_G	0.531	0.26
146_E	317_L	0.531	0.26
576_L	579_A	0.531	0.26
161_L	294_L	0.529	0.26
292_E	323_E	0.528	0.26
400_P	406_G	0.528	0.26
162_T	333_D	0.528	0.26
127_I	132_K	0.526	0.26
363_R	399_F	0.525	0.26
46_G	251_D	0.524	0.26
29_P	257_E	0.524	0.26
226_Y	246_F	0.523	0.26
436_F	607_S	0.523	0.26
301_K	304_K	0.522	0.25
184_L	188_Y	0.522	0.25
21_P	359_V	0.521	0.25
110_L	559_V	0.521	0.25
278_L	353_L	0.521	0.25
108_E	112_K	0.520	0.25
434_K	509_S	0.520	0.25
462_L	498_F	0.519	0.25
127_I	248_V	0.519	0.25
219_T	223_F	0.519	0.25
499_F	513_K	0.518	0.25
480_M	483_G	0.518	0.25
390_F	395_I	0.518	0.25
443_D	479_K	0.517	0.25
520_V	556_L	0.517	0.25
333_D	367_I	0.517	0.25
144_L	459_L	0.516	0.25
251_D	372_E	0.516	0.25
223_F	230_K	0.516	0.25
275_N	348_S	0.515	0.25
493_E	497_E	0.515	0.25
417_I	461_A	0.515	0.25
443_D	457_S	0.515	0.25
368_F	371_K	0.514	0.25
195_K	309_L	0.513	0.25
286_L	290_L	0.513	0.25
352_I	525_L	0.513	0.25
293_I	372_E	0.512	0.25
405_K	413_K	0.512	0.25
150_E	310_E	0.512	0.25
91_D	155_K	0.511	0.25
368_F	600_F	0.511	0.25
92_E	295_D	0.510	0.25
327_I	372_E	0.510	0.25
359_V	440_I	0.510	0.25
16_K	21_P	0.510	0.25
34_K	37_L	0.510	0.25
499_F	502_Y	0.509	0.25
524_K	571_Y	0.509	0.25
538_F	562_K	0.509	0.25
83_I	547_M	0.508	0.25
40_N	49_E	0.507	0.25
569_N	573_Y	0.507	0.25
49_E	92_E	0.507	0.25
325_L	339_F	0.506	0.24
560_Q	578_E	0.506	0.24
337_L	502_Y	0.506	0.24
232_G	560_Q	0.505	0.24
273_G	401_V	0.505	0.24
277_Y	348_S	0.503	0.24
346_D	406_G	0.503	0.24
179_I	183_K	0.502	0.24
198_A	594_S	0.502	0.24
593_L	601_Y	0.502	0.24
352_I	380_E	0.501	0.24
88_K	160_L	0.501	0.24
396_R	401_V	0.500	0.24

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2ds5A	2	0.0722	41.9	0.972	Contact Map
2zjrU	1	0.0969	38.5	0.972	Contact Map
4tp8N	1	0.1576	22.4	0.975	Contact Map
4rb61	1	0.1379	22.1	0.975	Contact Map
4tp9X	1	0.1133	19.4	0.976	Contact Map
3bbnN	1	0.1626	15.6	0.977	Contact Map
4lh9A	4	0.0657	15.6	0.977	Contact Map
1ovxA	2	0.0624	7.2	0.98	Contact Map
4rb5N	1	0.0985	6.9	0.98	Contact Map
2jz6A	1	0.1166	5.4	0.981	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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