GREMLIN Database
DUF2017 - Domain of unknown function (DUF2017)
PFAM: PF09438 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 176 (173)
Sequences: 2270 (1390)
Seq/√Len: 105.7
META: 0.705

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_V130_A5.3451.00
113_D116_Q4.4261.00
25_L127_V3.8741.00
94_A122_R3.2041.00
20_S24_Q3.1821.00
101_T120_W2.9891.00
169_E173_E2.9751.00
101_T116_Q2.9621.00
84_E88_R2.7371.00
97_T119_A2.6731.00
22_V127_V2.6641.00
29_L65_L2.5451.00
98_V123_A2.5381.00
72_D75_A2.3771.00
161_Y165_G2.3751.00
22_V98_V2.2361.00
58_D134_R2.2101.00
97_T116_Q2.1321.00
68_A79_F2.0911.00
22_V99_L1.9301.00
60_V133_T1.8951.00
94_A119_A1.8031.00
97_T101_T1.7991.00
2_R5_G1.7601.00
89_D93_A1.7591.00
133_T138_T1.7551.00
69_Y75_A1.7441.00
65_L91_K1.7381.00
91_K126_D1.7381.00
19_R103_P1.7271.00
67_D76_A1.7251.00
60_V134_R1.6501.00
80_R84_E1.6251.00
98_V120_W1.6001.00
26_L96_R1.5891.00
26_L92_R1.5631.00
42_L47_G1.5601.00
139_E142_D1.5571.00
42_L46_L1.5421.00
78_E81_R1.5351.00
25_L65_L1.5311.00
42_L45_L1.4991.00
23_G99_L1.4951.00
104_A116_Q1.4731.00
79_F83_T1.4661.00
156_P160_V1.4031.00
30_G92_R1.4021.00
139_E158_L1.3781.00
91_K168_Q1.3701.00
165_G169_E1.3651.00
166_W170_S1.3250.99
162_D165_G1.3080.99
23_G26_L1.3000.99
76_A80_R1.2850.99
67_D73_P1.2700.99
96_R100_D1.2520.99
59_P133_T1.2450.99
32_R88_R1.2310.99
43_A46_L1.2150.99
67_D80_R1.2010.99
5_G111_E1.1910.99
91_K123_A1.1890.99
123_A127_V1.1830.99
76_A79_F1.1400.98
45_L48_I1.1240.98
95_A99_L1.1220.98
22_V123_A1.1200.98
125_N132_G1.1030.98
165_G168_Q1.1020.98
100_D116_Q1.0950.98
26_L30_G1.0820.98
103_P107_G1.0680.97
83_T88_R1.0660.97
90_A94_A1.0530.97
21_L127_V1.0530.97
51_G55_P1.0490.97
41_P48_I1.0490.97
76_A83_T1.0410.97
68_A81_R1.0400.97
2_R9_R1.0320.97
138_T142_D1.0280.97
132_G136_G1.0280.97
162_D166_W1.0140.96
133_T137_I1.0100.96
92_R96_R0.9970.96
55_P67_D0.9730.95
78_E82_L0.9660.95
105_A109_G0.9640.95
155_A159_A0.9640.95
24_Q87_L0.9610.95
42_L48_I0.9590.95
103_P106_G0.9460.95
126_D168_Q0.9380.94
19_R99_L0.9250.94
68_A78_E0.9240.94
21_L24_Q0.9230.94
55_P62_A0.9160.94
24_Q130_A0.9080.93
141_D158_L0.9050.93
132_G137_I0.8810.92
79_F82_L0.8620.92
14_E18_L0.8500.91
80_R83_T0.8470.91
30_G96_R0.8390.90
95_A123_A0.8390.90
69_Y120_W0.8380.90
15_A95_A0.8370.90
148_L153_P0.8270.90
28_L61_L0.8270.90
6_V95_A0.8250.90
44_A47_G0.8230.90
148_L151_D0.8230.90
86_D89_D0.8130.89
10_L167_L0.8060.89
45_L51_G0.8000.88
150_D155_A0.7920.88
61_L84_E0.7920.88
7_V11_D0.7910.88
27_E30_G0.7830.87
17_L21_L0.7790.87
117_A174_A0.7770.87
13_V20_S0.7760.87
125_N139_E0.7740.87
163_W172_V0.7540.85
135_L161_Y0.7450.84
15_A19_R0.7440.84
50_T53_S0.7420.84
41_P46_L0.7330.83
163_W167_L0.7320.83
13_V16_A0.7270.83
78_E83_T0.7220.83
43_A48_I0.7180.82
122_R125_N0.7160.82
61_L156_P0.7070.81
148_L154_R0.7050.81
166_W169_E0.7050.81
17_L160_V0.7050.81
28_L130_A0.7040.81
29_L88_R0.7020.81
148_L152_D0.6990.80
6_V114_E0.6920.80
7_V111_E0.6900.80
65_L84_E0.6900.80
76_A87_L0.6860.79
118_Q122_R0.6850.79
116_Q119_A0.6830.79
85_P89_D0.6810.79
75_A82_L0.6780.78
4_G175_L0.6730.78
48_I53_S0.6720.78
95_A159_A0.6710.78
75_A79_F0.6690.77
23_G27_E0.6670.77
147_R151_D0.6660.77
2_R111_E0.6630.77
75_A78_E0.6620.77
130_A133_T0.6610.77
172_V175_L0.6590.76
89_D114_E0.6570.76
121_L172_V0.6540.76
46_L81_R0.6540.76
69_Y82_L0.6530.76
68_A83_T0.6510.76
3_G7_V0.6480.75
89_D118_Q0.6470.75
29_L92_R0.6430.75
41_P57_E0.6420.75
70_R76_A0.6400.74
145_L148_L0.6370.74
65_L88_R0.6370.74
69_Y163_W0.6350.74
136_G139_E0.6350.74
15_A107_G0.6260.73
5_G11_D0.6260.73
87_L126_D0.6230.72
43_A47_G0.6190.72
117_A175_L0.6100.71
56_P61_L0.6060.70
8_A112_L0.6050.70
101_T112_L0.6030.70
143_A158_L0.6010.70
145_L165_G0.5990.69
91_K125_N0.5960.69
155_A160_V0.5950.69
132_G165_G0.5940.69
94_A126_D0.5940.69
26_L95_A0.5920.68
125_N159_A0.5900.68
125_N138_T0.5900.68
135_L165_G0.5890.68
101_T113_D0.5880.68
98_V121_L0.5870.68
48_I89_D0.5850.68
112_L126_D0.5830.67
69_Y79_F0.5820.67
121_L165_G0.5780.67
122_R126_D0.5780.67
9_R15_A0.5770.67
39_A45_L0.5760.66
57_E62_A0.5750.66
132_G164_L0.5750.66
125_N129_L0.5710.66
39_A47_G0.5680.65
165_G172_V0.5660.65
69_Y81_R0.5640.65
25_L130_A0.5640.65
68_A88_R0.5620.64
114_E118_Q0.5600.64
27_E82_L0.5550.64
11_D18_L0.5540.63
15_A130_A0.5510.63
48_I52_P0.5500.63
137_I165_G0.5490.63
69_Y78_E0.5480.63
6_V117_A0.5470.62
158_L165_G0.5450.62
59_P136_G0.5440.62
3_G6_V0.5440.62
118_Q175_L0.5430.62
34_A37_P0.5410.62
35_E39_A0.5400.61
140_D171_L0.5400.61
73_P111_E0.5400.61
56_P80_R0.5400.61
80_R168_Q0.5400.61
120_W163_W0.5400.61
146_E149_P0.5370.61
7_V26_L0.5370.61
57_E111_E0.5360.61
156_P159_A0.5330.60
70_R75_A0.5310.60
76_A91_K0.5310.60
132_G138_T0.5290.60
40_D45_L0.5270.60
39_A70_R0.5260.59
25_L123_A0.5250.59
137_I162_D0.5240.59
33_A37_P0.5240.59
12_P105_A0.5240.59
101_T106_G0.5230.59
21_L129_L0.5230.59
39_A46_L0.5230.59
90_A93_A0.5220.59
151_D155_A0.5190.58
159_A162_D0.5190.58
159_A166_W0.5180.58
157_L162_D0.5180.58
40_D48_I0.5160.58
16_A123_A0.5160.58
145_L149_P0.5140.58
117_A126_D0.5130.58
33_A39_A0.5120.57
35_E38_D0.5100.57
24_Q28_L0.5070.57
162_D173_E0.5070.57
39_A44_A0.5060.57
132_G139_E0.5020.56
2_R7_V0.5010.56
69_Y133_T0.5010.56
113_D118_Q0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ofdA 1 0.3636 5.2 0.952 Contact Map
2qibA 2 0.3864 3.2 0.956 Contact Map
2kkeA 2 0.2614 3.2 0.957 Contact Map
1kyqA 2 0.4318 2.6 0.959 Contact Map
1g2yA 4 0.0966 2.3 0.96 Contact Map
3oq9A 3 0.3295 2.1 0.961 Contact Map
3encA 2 0.2045 2 0.961 Contact Map
2o71A 1 0.3864 1.8 0.962 Contact Map
2of5A 5 0.3864 1.8 0.962 Contact Map
1gcvB 1 0.75 1.5 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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