GREMLIN Database
UTP15_C - UTP15 C terminal
PFAM: PF09384 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 148 (143)
Sequences: 615 (478)
Seq/√Len: 40.0
META: 0.275

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_Y63_A4.5921.00
31_R34_K4.5851.00
37_D71_R4.5341.00
112_G118_D4.2191.00
52_V82_F3.4901.00
83_L124_L3.1931.00
100_A124_L3.1341.00
20_L28_R2.6871.00
48_P86_H2.6451.00
71_R107_Y2.6381.00
68_L79_L2.5711.00
68_L99_V2.5561.00
39_V60_H2.3221.00
82_F96_L2.1180.99
33_S70_G2.0660.99
72_D75_S2.0590.99
48_P92_F1.9960.99
52_V96_L1.9770.99
135_Q138_L1.9210.99
103_V121_F1.8950.98
71_R78_P1.8940.98
55_L99_V1.8480.98
59_R98_D1.8430.98
40_L79_L1.8120.98
26_L38_A1.7480.97
99_V107_Y1.6970.97
73_E114_S1.6540.96
93_T97_V1.5560.95
113_Q118_D1.5210.94
32_Y67_A1.4970.93
43_V51_V1.4860.93
84_I120_L1.4820.93
75_S133_E1.4240.92
57_E61_R1.3600.90
22_K38_A1.3480.89
30_F57_E1.3250.88
32_Y61_R1.3080.88
56_E98_D1.3040.87
84_I146_D1.2850.87
4_G11_V1.2810.87
37_D78_P1.2740.86
71_R121_F1.2670.86
39_V50_V1.2530.85
72_D114_S1.2390.85
77_E117_L1.1930.82
51_V74_E1.1670.81
58_L64_L1.1470.80
23_Y30_F1.1310.79
106_L110_V1.1280.79
46_K86_H1.1250.78
16_K19_K1.1160.78
80_L117_L1.0930.76
28_R110_V1.0910.76
81_R84_I1.0540.74
52_V92_F1.0490.73
128_V141_L1.0370.72
16_K22_K1.0310.72
117_L120_L1.0260.72
94_R120_L0.9890.69
79_L147_M0.9760.68
23_Y26_L0.9730.68
10_V16_K0.9690.67
5_E13_G0.9630.67
54_V148_L0.9450.65
68_L107_Y0.9400.65
132_V135_Q0.9320.64
26_L31_R0.9300.64
64_L108_S0.9260.64
8_D28_R0.9250.64
137_E145_L0.9220.63
113_Q117_L0.9200.63
39_V119_E0.9170.63
24_D30_F0.8980.61
47_N51_V0.8920.61
59_R144_M0.8890.60
73_E116_E0.8800.60
111_L132_V0.8720.59
33_S65_R0.8620.58
52_V95_L0.8460.57
34_K132_V0.8450.57
29_K86_H0.8410.56
58_L110_V0.8410.56
64_L68_L0.8250.55
107_Y112_G0.8240.55
53_A91_R0.8230.55
64_L99_V0.8190.54
53_A82_F0.8070.53
34_K74_E0.8040.53
85_K94_R0.8020.53
91_R100_A0.7970.52
27_L61_R0.7920.52
37_D68_L0.7860.51
29_K137_E0.7830.51
4_G147_M0.7750.50
103_V139_L0.7750.50
81_R116_E0.7730.50
25_K31_R0.7570.49
133_E136_Q0.7570.49
37_D79_L0.7540.48
137_E140_E0.7530.48
60_H98_D0.7480.48
10_V14_K0.7480.48
103_V145_L0.7310.46
83_L103_V0.7300.46
76_L120_L0.7280.46
134_L144_M0.7240.45
50_V134_L0.7220.45
89_D142_Q0.7210.45
71_R76_L0.7180.45
128_V132_V0.7180.45
60_H69_A0.7120.44
117_L141_L0.7110.44
125_R129_R0.7070.44
56_E95_L0.7040.44
68_L106_L0.7040.44
37_D107_Y0.7030.44
49_E111_L0.6940.43
10_V127_K0.6900.42
84_I124_L0.6890.42
76_L103_V0.6860.42
56_E60_H0.6850.42
53_A62_G0.6830.42
25_K29_K0.6830.42
144_M148_L0.6820.42
80_L124_L0.6790.41
22_K119_E0.6790.41
71_R89_D0.6780.41
23_Y92_F0.6770.41
48_P51_V0.6720.41
82_F138_L0.6720.41
87_I96_L0.6720.41
59_R82_F0.6690.41
109_E136_Q0.6680.40
45_T85_K0.6670.40
141_L146_D0.6660.40
31_R56_E0.6640.40
77_E119_E0.6580.40
49_E53_A0.6550.39
72_D107_Y0.6530.39
61_R105_D0.6480.39
137_E148_L0.6410.38
9_I70_G0.6400.38
85_K98_D0.6320.37
125_R137_E0.6300.37
69_A107_Y0.6290.37
95_L100_A0.6280.37
62_G98_D0.6240.37
102_V147_M0.6180.36
95_L128_V0.6180.36
39_V57_E0.6160.36
29_K94_R0.6160.36
73_E118_D0.6150.36
21_K31_R0.6060.35
78_P107_Y0.6060.35
20_L24_D0.6030.35
52_V60_H0.5950.34
33_S75_S0.5930.34
72_D85_K0.5920.34
20_L26_L0.5910.34
116_E123_R0.5910.34
118_D146_D0.5910.34
11_V104_L0.5900.34
81_R120_L0.5880.34
79_L99_V0.5870.34
99_V108_S0.5840.33
93_T100_A0.5840.33
73_E115_P0.5840.33
96_L100_A0.5820.33
97_V114_S0.5810.33
34_K141_L0.5810.33
77_E116_E0.5790.33
29_K97_V0.5790.33
7_A12_E0.5790.33
122_R126_R0.5750.33
86_H91_R0.5710.32
21_K87_I0.5690.32
139_L142_Q0.5670.32
132_V137_E0.5650.32
46_K97_V0.5640.32
51_V55_L0.5640.32
28_R40_L0.5630.32
33_S79_L0.5580.31
106_L114_S0.5560.31
10_V116_E0.5540.31
48_P101_N0.5530.31
46_K125_R0.5510.31
53_A65_R0.5490.31
19_K123_R0.5470.30
63_A111_L0.5470.30
53_A102_V0.5450.30
76_L145_L0.5420.30
141_L147_M0.5420.30
20_L49_E0.5410.30
60_H147_M0.5410.30
15_P18_K0.5400.30
55_L142_Q0.5360.30
10_V146_D0.5360.30
24_D131_E0.5350.29
60_H91_R0.5320.29
85_K146_D0.5320.29
53_A132_V0.5300.29
114_S128_V0.5300.29
130_E133_E0.5270.29
13_G18_K0.5250.29
24_D124_L0.5220.28
36_L71_R0.5120.28
81_R129_R0.5050.27
43_V87_I0.5040.27
45_T51_V0.5040.27
37_D76_L0.5030.27
82_F141_L0.5020.27
30_F92_F0.5020.27
5_E9_I0.5000.27
84_I100_A0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1k8kG 1 0.7838 63.1 0.896 Contact Map
3dwlG 1 0.6892 51.3 0.904 Contact Map
4cr2Z 1 0.8243 36.9 0.912 Contact Map
4bzjA 2 0.7973 31.2 0.915 Contact Map
4kmoB 1 0.8311 18.5 0.924 Contact Map
2rq5A 1 0.8176 8.6 0.934 Contact Map
4adyA 1 0.8784 7 0.937 Contact Map
3wozA 1 0.7432 6.3 0.938 Contact Map
2vj4A 1 0.8919 5.7 0.939 Contact Map
4uxvA 1 0.3378 5.5 0.94 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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