GREMLIN Database
DUF1998 - Domain of unknown function (DUF1998)
PFAM: PF09369 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_10
Length: 80 (80)
Sequences: 28118 (15563)
Seq/√Len: 1740.0
META: 0.922

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
9_A66_L3.0411.00
3_A23_G2.9491.00
10_A52_L2.6251.00
55_R58_E2.6101.00
13_L62_A2.6001.00
5_A67_I2.4171.00
64_L68_A2.3331.00
13_L58_E2.2671.00
5_A63_A2.2031.00
51_R55_R2.1451.00
62_A65_E2.0941.00
65_E69_S1.7721.00
13_L55_R1.7571.00
7_I23_G1.7531.00
22_G41_A1.6421.00
51_R54_E1.6411.00
22_G39_Y1.5611.00
58_E62_A1.4991.00
57_E61_R1.4241.00
42_Y46_A1.4181.00
8_R11_P1.4041.00
3_A25_S1.3121.00
9_A62_A1.2961.00
61_R65_E1.2821.00
12_L66_L1.2781.00
26_Y29_H1.2671.00
56_L60_L1.2531.00
8_R18_R1.2481.00
8_R66_L1.1921.00
12_L62_A1.1441.00
26_Y35_T1.1061.00
65_E68_A1.1031.00
24_R37_F1.0861.00
58_E61_R1.0801.00
4_H8_R1.0781.00
16_C48_L1.0591.00
7_I18_R1.0341.00
28_R33_R1.0281.00
10_A21_L1.0091.00
26_Y30_P0.9781.00
8_R12_L0.9771.00
61_R64_L0.9651.00
1_A80_V0.9571.00
6_L63_A0.9381.00
75_G80_V0.9151.00
7_I11_P0.9101.00
9_A13_L0.9041.00
27_P33_R0.8821.00
50_E54_E0.8651.00
4_H7_I0.8641.00
76_C79_C0.8631.00
62_A66_L0.8551.00
10_A14_L0.8511.00
1_A4_H0.8441.00
4_H23_G0.8431.00
5_A8_R0.8401.00
2_L60_L0.8391.00
13_L59_L0.8371.00
56_L59_L0.8341.00
26_Y37_F0.8341.00
9_A59_L0.8341.00
3_A36_I0.8211.00
52_L56_L0.8181.00
6_L60_L0.7831.00
2_L6_L0.7821.00
6_L38_L0.7771.00
29_H33_R0.7751.00
71_P78_S0.7701.00
27_P34_P0.7601.00
2_L36_I0.7411.00
26_Y31_D0.7281.00
52_L59_L0.7231.00
64_L67_I0.7201.00
49_L53_F0.6991.00
16_C20_D0.6891.00
12_L43_P0.6831.00
25_S34_P0.6751.00
40_D45_G0.6751.00
14_L55_R0.6751.00
26_Y32_G0.6731.00
28_R32_G0.6621.00
11_P16_C0.6571.00
15_M19_R0.6491.00
48_L78_S0.6451.00
22_G25_S0.6451.00
6_L59_L0.6271.00
28_R35_T0.6211.00
23_G38_L0.6211.00
2_L64_L0.6131.00
53_F57_E0.6091.00
40_D44_G0.5951.00
9_A63_A0.5861.00
19_R22_G0.5851.00
46_A52_L0.5811.00
7_I25_S0.5781.00
27_P31_D0.5771.00
40_D49_L0.5731.00
50_E53_F0.5711.00
28_R31_D0.5691.00
43_P46_A0.5671.00
14_L48_L0.5631.00
27_P32_G0.5601.00
66_L69_S0.5461.00
42_Y48_L0.5411.00
75_G78_S0.5401.00
44_G47_G0.5381.00
10_A38_L0.5311.00
10_A59_L0.5261.00
3_A7_I0.5251.00
69_S73_E0.5191.00
38_L59_L0.5171.00
34_P39_Y0.5131.00
32_G35_T0.5131.00
15_M80_V0.5111.00
17_D46_A0.5051.00
10_A48_L0.5051.00
6_L36_I0.5041.00
60_L64_L0.5021.00
25_S36_I0.5021.00
49_L52_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ekfA 1 0.875 29.8 0.84 Contact Map
2pa8D 1 0.85 10.8 0.87 Contact Map
3hrdA 2 0.775 8.5 0.876 Contact Map
1twfC 1 0.8375 7.4 0.879 Contact Map
3h0gC 1 0.9 5.7 0.885 Contact Map
3mb2B 3 0.5 5.3 0.887 Contact Map
1b63A 2 0.6625 5 0.888 Contact Map
1sqsA 2 0.5875 4.9 0.889 Contact Map
1rypG 1 0.75 3.7 0.895 Contact Map
4cpyA 2 0.925 3.2 0.899 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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